{"id":"https://openalex.org/W4282970637","doi":"https://doi.org/10.1158/1538-7445.am2022-5674","title":"Abstract 5674: A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis","display_name":"Abstract 5674: A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282970637","doi":"https://doi.org/10.1158/1538-7445.am2022-5674"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-5674","doi":"https://doi.org/10.1158/1538-7445.am2022-5674","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5674","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074511854","display_name":"Li Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Fan","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013486666","display_name":"Qingfei Pan","orcid":"https://orcid.org/0000-0003-0243-6898","observed_orcids":["https://orcid.org/0000-0003-0243-6898"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingfei Pan","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045712727","display_name":"Wentao Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wentao Yang","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062877274","display_name":"Selene C. Koo","orcid":"https://orcid.org/0000-0001-8459-2469","observed_orcids":["https://orcid.org/0000-0001-8459-2469"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selene C. Koo","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102131997","display_name":"Cheng Lin Tian","orcid":"https://orcid.org/0000-0003-3475-5236","observed_orcids":["https://orcid.org/0000-0003-3475-5236"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Tian","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101524912","display_name":"Liyuan Li","orcid":"https://orcid.org/0000-0001-9198-9413","observed_orcids":["https://orcid.org/0000-0001-9198-9413"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyuan Li","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063828047","display_name":"Meifen Lu","orcid":"https://orcid.org/0009-0007-9828-0694","observed_orcids":["https://orcid.org/0009-0007-9828-0694"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meifen Lu","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anthony Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Brown","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113111027","display_name":"Bensheng Ju","orcid":"https://orcid.org/0000-0002-8723-316X","observed_orcids":["https://orcid.org/0000-0002-8723-316X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bensheng Ju","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025610733","display_name":"John B. Easton","orcid":"https://orcid.org/0000-0003-4503-6608","observed_orcids":["https://orcid.org/0000-0003-4503-6608"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Easton","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068381719","display_name":"Sarangarajan Ranganathan","orcid":"https://orcid.org/0000-0001-6214-9167","observed_orcids":["https://orcid.org/0000-0001-6214-9167"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarangarajan Ranganathan","raw_affiliation_strings":["2Cincinnati Children's Hospital, Cincinnati, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cincinnati Children's Hospital, Cincinnati, OH;","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052051185","display_name":"Soona Shin","orcid":"https://orcid.org/0000-0001-5696-9505","observed_orcids":["https://orcid.org/0000-0001-5696-9505"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soona Shin","raw_affiliation_strings":["3Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003683006","display_name":"Alexander J. Bondoc","orcid":"https://orcid.org/0000-0002-9802-5948","observed_orcids":["https://orcid.org/0000-0002-9802-5948"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Bondoc","raw_affiliation_strings":["3Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061426227","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0002-4233-3220","observed_orcids":["https://orcid.org/0000-0002-4233-3220"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun J. Yang","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101943051","display_name":"Jiyang Yu","orcid":"https://orcid.org/0000-0003-1244-4429","observed_orcids":["https://orcid.org/0000-0003-1244-4429","https://orcid.org/0000-0003-3629-4330"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyang Yu","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062270896","display_name":"Liqin Zhu","orcid":"https://orcid.org/0000-0002-2346-150X","observed_orcids":["https://orcid.org/0000-0002-2346-150X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liqin Zhu","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN;","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"5674","last_page":"5674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.17980000376701355,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatoblastoma","display_name":"hepatoblastoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/neonatal-liver","display_name":"neonatal liver","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.875},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7979999780654907},{"id":"https://openalex.org/keywords/activated-hepatic-stellate-cells","display_name":"activated hepatic stellate cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.7210000157356262},{"id":"https://openalex.org/keywords/orthotopic-transplantation","display_name":"orthotopic transplantation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pediatric-liver-cancer","display_name":"pediatric liver cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.8802046775817871},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.7654657959938049},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5760564208030701},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5686179399490356},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.5093468427658081},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5022475719451904},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.48624053597450256},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4790869355201721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46945542097091675},{"id":"https://openalex.org/C2776964913","wikidata":"https://www.wikidata.org/wiki/Q1671502","display_name":"Liver tumor","level":3,"score":0.418865442276001},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.41640377044677734},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3611180782318115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35756051540374756},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.33959466218948364},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.309695303440094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29041042923927307},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21112856268882751},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.1742590069770813},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15047359466552734},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.09777870774269104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.068142831325531},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-5674","doi":"https://doi.org/10.1158/1538-7445.am2022-5674","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5674","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220760557","https://openalex.org/W7221019181","https://openalex.org/W4225282351","https://openalex.org/W4412521936","https://openalex.org/W1972965212","https://openalex.org/W4294605793","https://openalex.org/W7221274717","https://openalex.org/W2082815052","https://openalex.org/W2001568293","https://openalex.org/W45062975"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,49,53,62,68,74,87,102,106,121,133,171,184,203,206,245],"Rationale:":[3],"Hepatoblastoma":[4],"(HB)":[5],"is":[6],"the":[7,25,69,109,114,119,127,145,158,177,217,238,262,273,323,330],"most":[8],"common":[9],"pediatric":[10,256],"liver":[11,27,63,147,240,264,320],"cancer.":[12],"Its":[13],"predominant":[14],"occurrence":[15],"in":[16,45,82,108,113,144,168,209,216,224,237,242,318],"very":[17],"young":[18],"children":[19],"led":[20],"us":[21],"to":[22,32,187,269,316],"investigating":[23],"whether":[24],"neonatal":[26,263,319],"provides":[28,265],"a":[29,135,231,266],"protumorigenic":[30],"niche":[31,268,315],"HB":[33,36,83,94,181,188,226,252,270],"development.":[34],"Methods:":[35],"development":[37,271],"was":[38,58,130,185,230,248],"compared":[39],"between":[40],"orthotopic":[41],"transplantation":[42],"models":[43,67,124],"established":[44],"postnatal":[46],"day":[47],"5":[48],"60":[50],"mice":[51],"(P5Tx":[52],"P60Tx":[54,115,122,159,195],"models).":[55],"Single-cell":[56],"RNA-sequencing":[57],"performed":[59],"using":[60],"tumor":[61,129,246],"tissues":[64],"from":[65,157],"both":[66],"top":[70],"candidate":[71],"cell":[72,84,95,182,189],"types":[73],"genes":[75],"identified":[76],"are":[77],"investigated":[78],"for":[79,333],"their":[80,213],"roles":[81],"growth,":[85],"migration,":[86],"survival.":[88],"Results:":[89],"We":[90,161,174,259],"found":[91,162],"that":[92,126,176,223,261],"various":[93],"lines":[96],"including":[97],"HepG2":[98,123,194,210],"cells":[99,142,211],"were":[100,165],"consistently":[101],"considerably":[103],"more":[104,131],"tumorigenic":[105],"metastatic":[107,214,225],"P5Tx":[110,120,128,218],"model":[111,196],"than":[112,155,241],"models.":[116],"Sc-RNAseq":[117],"of":[118,138,153,235,329],"revealed":[125],"hypoxic":[132],"had":[134],"larger":[136,233],"number":[137],"activated":[139],"hepatic":[140],"stellate":[141],"(aHSCs)":[143],"tumor-surrounding":[146,239],"which":[148],"express":[149],"significantly":[150],"higher":[151],"levels":[152],"Cxcl1":[154],"those":[156],"model.":[160,219],"these":[163],"differences":[164],"developmentally":[166,313],"present":[167],"normal":[169],"P5":[170],"P60":[172],"liver.":[173],"showed":[175,222],"Cxcl1/Cxcr2":[178,274,324],"axis":[179,325],"mediated":[180,321],"migration":[183],"critical":[186],"survival":[190],"under":[191],"hypoxia.":[192],"Treating":[193],"with":[197,251],"recombinant":[198],"CXCL1":[199],"protein":[200],"induced":[201],"intrahepatic":[202],"pulmonary":[204],"metastasis":[205],"CXCR2":[207],"knockout":[208],"abolished":[212],"potential":[215],"Lastly,":[220],"we":[221],"patient":[227,253],"tumors":[228],"there":[229],"similar":[232],"population":[234],"aHSCs":[236],"localized":[243],"tumors,":[244],"hypoxia":[247],"uniquely":[249],"associated":[250],"prognosis":[254],"among":[255],"cancers.":[257],"Conclusion:":[258],"demonstrated":[260],"prometastatic":[267,314],"via":[272],"axis.":[275],"Citation":[276],"Format:":[277],"Li":[278],"Fan,":[279],"Qingfei":[280],"Pan,":[281],"Wentao":[282],"Yang,":[283,307],"Selene":[284],"C.":[285],"Koo,":[286],"Cheng":[287],"Tian,":[288],"Liyuan":[289],"Li,":[290],"Meifen":[291],"Lu,":[292],"Anthony":[293],"Brown,":[294],"Bensheng":[295],"Ju,":[296],"John":[297],"Easton,":[298],"Sarangarajan":[299],"Ranganathan,":[300],"Soona":[301],"Shin,":[302],"Alexander":[303],"Bondoc,":[304],"Jun":[305],"J.":[306],"Jiyang":[308],"Yu,":[309],"Liqin":[310],"Zhu.":[311],"A":[312],"hepatoblastoma":[317],"by":[322],"[abstract].":[326],"In:":[327],"Proceedings":[328],"American":[331],"Association":[332],"Cancer":[334,345],"Research":[335],"Annual":[336],"Meeting":[337],"2022;":[338],"2022":[339],"Apr":[340],"8-13.":[341],"Philadelphia":[342],"(PA):":[343],"AACR;":[344],"Res":[346],"2022;82(12_Suppl):Abstract":[347],"nr":[348],"5674.":[349]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2022-06-17T00:00:00"}