{"id":"https://openalex.org/W4282969895","doi":"https://doi.org/10.1158/1538-7445.am2022-2121","title":"Abstract 2121: Gene expression and functional characterization of obesity-induced MDSC to uncover the link between obesity and cancer risk","display_name":"Abstract 2121: Gene expression and functional characterization of obesity-induced MDSC to uncover the link between obesity and cancer risk","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282969895","doi":"https://doi.org/10.1158/1538-7445.am2022-2121"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-2121","doi":"https://doi.org/10.1158/1538-7445.am2022-2121","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-2121","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025648556","display_name":"Maria Dulfary Sanchez\u2010Pino","orcid":"https://orcid.org/0000-0001-5271-9840","observed_orcids":["https://orcid.org/0000-0001-5271-9840"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria D. Sanchez-Pino","raw_affiliation_strings":["1Louisiana State University, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Louisiana State University, New Orleans, LA;","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074432953","display_name":"Ramesh Thylur Puttalingaiah","orcid":"https://orcid.org/0000-0001-8935-6780","observed_orcids":["https://orcid.org/0000-0001-8935-6780"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Thylur Puttalingaiah","raw_affiliation_strings":["1Louisiana State University, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Louisiana State University, New Orleans, LA;","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031094469","display_name":"Jone Garai","orcid":"https://orcid.org/0009-0003-3702-2190","observed_orcids":["https://orcid.org/0009-0003-3702-2190"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jone Garai","raw_affiliation_strings":["1Louisiana State University, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Louisiana State University, New Orleans, LA;","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030449403","display_name":"Jovanny Zabaleta","orcid":"https://orcid.org/0000-0002-5961-6761","observed_orcids":["https://orcid.org/0000-0002-5961-6761"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jovanny Zabaleta","raw_affiliation_strings":["1Louisiana State University, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Louisiana State University, New Orleans, LA;","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008448236","display_name":"Randall L. Mynatt","orcid":"https://orcid.org/0000-0003-4399-0019","observed_orcids":["https://orcid.org/0000-0003-4399-0019"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall L. Mynatt","raw_affiliation_strings":["2Pennington Biomedical Research Center, Baton Rouge, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Pennington Biomedical Research Center, Baton Rouge, LA;","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Richardson","raw_affiliation_strings":["3Ochsner Medical Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Ochsner Medical Center, New Orleans, LA","institution_ids":["https://openalex.org/I2799767083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004037751","display_name":"Augusto C. Ochoa","orcid":"https://orcid.org/0000-0001-6457-8029","observed_orcids":["https://orcid.org/0000-0001-6457-8029"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Augusto Ochoa","raw_affiliation_strings":["1Louisiana State University, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Louisiana State University, New Orleans, LA;","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"2121","last_page":"2121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/obesity-related-cancer","display_name":"obesity-related cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5519999861717224},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7789999842643738},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.5770000219345093},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9670000076293945},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7300000190734863},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6429674625396729},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6101395487785339},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5955079197883606},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.5284380912780762},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5159540772438049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4488631784915924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4325689375400543},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4287974238395691},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41417670249938965},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.19654682278633118}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-2121","doi":"https://doi.org/10.1158/1538-7445.am2022-2121","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-2121","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2773358176","https://openalex.org/W2790924361","https://openalex.org/W147964936","https://openalex.org/W4400094138","https://openalex.org/W3099239918","https://openalex.org/W1680358658","https://openalex.org/W6959667135","https://openalex.org/W3131059002","https://openalex.org/W2791591091","https://openalex.org/W4313359950"],"abstract_inverted_index":{"Abstract":[0],"Strong":[1],"epidemiologic":[2],"evidence":[3],"suggests":[4],"that":[5,63,89,152,192,211,224,289],"excess":[6],"body":[7],"weight":[8],"gain":[9],"is":[10,34,216,321],"a":[11,67,105,113,297],"major":[12],"risk":[13,332,371],"of":[14,20,23,77,108,140,164,195,214,243,268,306,309,317,326,333,360,375],"at":[15],"least":[16],"13":[17],"different":[18],"types":[19],"cancers.":[21,335],"One":[22],"the":[24,27,37,75,122,138,162,168,193,205,236,241,310,314,324,331,365,376],"mechanisms":[25,136],"explaining":[26],"increased":[28,52,266],"cancer":[29,147,370],"incidence":[30],"in":[31,53,58,74,143,222,240,319],"obese":[32,206,249],"patients":[33,94],"associated":[35,270],"with":[36,95,185,251,271],"chronic":[38,290],"low-grade":[39],"inflammatory":[40],"condition.":[41],"Myeloid":[42],"cells":[43,49,111,133],"including":[44,167],"macrophages":[45],"and":[46,84,126,145,158,173,256,261,280,282,357,369],"Myeloid-derived":[47],"suppressor":[48],"(MDSC)":[50],"are":[51,148],"advanced":[54],"adiposity.":[55],"Previous":[56],"studies":[57],"mouse":[59,177],"models":[60],"have":[61,104],"shown":[62],"obesity-induced":[64,119,131,361],"MDSC":[65,80,120,141,170,180,196,215,318,362],"play":[66],"protective":[68],"role":[69],"on":[70],"metabolic":[71,220],"control;":[72],"however,":[73],"presence":[76],"malignant":[78],"cells,":[79],"facilitates":[81],"tumor":[82,237],"growth":[83],"metastasis.":[85],"Our":[86,246],"data":[87,247,287],"show":[88,264],"compared":[90],"to":[91,204,228,292,300,329,363],"non-obese":[92],"individuals,":[93],"severe":[96],"obesity":[97,144,223,320,368],"(body":[98],"mass":[99],"index":[100],"[BMI]":[101],">":[102],"40)":[103],"significant":[106],"increase":[107],"circulating":[109],"granulocytic":[110],"displaying":[112],"gene":[114,311],"signature":[115],"resembling":[116],"tumor-MDSC.":[117],"Intriguingly,":[118],"lacked":[121],"potent":[123],"immunosuppressive":[124,169,315],"function;":[125],"therefore,":[127],"we":[128,209],"called":[129],"them":[130],"G-MDSC-like":[132],"(Ob-MDSC).":[134],"The":[135,304],"underlying":[137],"regulation":[139],"phenotype":[142,298,316],"obesity-related":[146,156,294],"unclear.":[149],"We":[150],"found":[151],"LDL,":[153],"one":[154],"altered":[155,258],"factor,":[157],"LPS":[159],"differentially":[160],"impact":[161],"expression":[163,312,356],"several":[165],"genes":[166],"markers,":[171],"arginase-1":[172],"iNOS,":[174],"when":[175],"comparing":[176],"bone":[178],"marrow-derived":[179],"from":[181,248],"high-fat":[182],"fed":[183,187],"mice":[184,250],"low-fat":[186],"mice.":[188],"This":[189],"finding":[190],"indicates":[191],"responsiveness":[194],"may":[197],"be":[198],"regulated":[199],"by":[200,218,235],"their":[201,226],"long-lasting":[202],"exposure":[203,291],"microenvironment.":[207],"Therefore,":[208],"propose":[210],"long-term":[212],"adaptation":[213],"induced":[217],"dysfunctional":[219],"factors":[221],"modulate":[225],"response":[227],"subsequent":[229],"triggers,":[230],"such":[231],"as":[232],"signals":[233],"derived":[234],"microenvironment":[238],"(TMA)":[239],"context":[242],"obesity-associated":[244,334],"cancer.":[245],"Diethylnitrosamine":[252],"(DEN)-induced":[253],"hepatocellular":[254],"carcinoma":[255],"genetically":[257],"hepatic":[259],"lipid":[260],"lipoprotein":[262],"metabolism":[263],"an":[265,293],"infiltration":[267],"G-MDSC":[269],"enhanced":[272],"tissue":[273],"chemokine":[274],"signaling":[275],"pathway,":[276],"ECM":[277],"remodeling/metastasis,":[278],"inflammation,":[279],"epigenetic":[281],"transcriptional":[283],"regulation.":[284],"Together":[285],"our":[286],"suggest":[288],"environment":[295],"establishes":[296],"prone":[299],"become":[301],"pro-tumor":[302],"MDSC.":[303],"identification":[305],"key":[307],"regulators":[308],"driving":[313],"critical":[322],"for":[323,379],"discovery":[325],"therapeutical":[327],"targets":[328],"reduce":[330],"Citation":[336],"Format:":[337],"Maria":[338],"D.":[339],"Sanchez-Pino,":[340],"Ramesh":[341],"Thylur":[342],"Puttalingaiah,":[343],"Jone":[344],"Garai,":[345],"Jovanny":[346],"Zabaleta,":[347],"Randall":[348],"L.":[349],"Mynatt,":[350],"William":[351],"Richardson,":[352],"Augusto":[353],"Ochoa.":[354],"Gene":[355],"functional":[358],"characterization":[359],"uncover":[364],"link":[366],"between":[367],"[abstract].":[372],"In:":[373],"Proceedings":[374],"American":[377],"Association":[378],"Cancer":[380,391],"Research":[381],"Annual":[382],"Meeting":[383],"2022;":[384],"2022":[385],"Apr":[386],"8-13.":[387],"Philadelphia":[388],"(PA):":[389],"AACR;":[390],"Res":[392],"2022;82(12_Suppl):Abstract":[393],"nr":[394],"2121.":[395]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-06-17T00:00:00"}