{"id":"https://openalex.org/W4282967255","doi":"https://doi.org/10.1158/1538-7445.am2022-1371","title":"Abstract 1371: Rho-GEF hampers CD8+T cells-mediated immunosurveillance by reducing antigen presentation","display_name":"Abstract 1371: Rho-GEF hampers CD8+T cells-mediated immunosurveillance by reducing antigen presentation","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282967255","doi":"https://doi.org/10.1158/1538-7445.am2022-1371"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-1371","doi":"https://doi.org/10.1158/1538-7445.am2022-1371","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1371","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010856859","display_name":"Haniyeh Eyvani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haniyeh Eyvani","raw_affiliation_strings":["1Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072661022","display_name":"Xinna Zhang","orcid":"https://orcid.org/0000-0003-4118-2245","observed_orcids":["https://orcid.org/0000-0003-4118-2245"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinna Zhang","raw_affiliation_strings":["1Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"1371","last_page":"1371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.46700000762939453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhogef","display_name":"RhoGEF","score":0.9380000233650208},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6420000195503235},{"id":"https://openalex.org/keywords/mc38-cells","display_name":"MC38 cells","score":0.5600000023841858},{"id":"https://openalex.org/keywords/siinfekl-peptide","display_name":"SIINFEKL peptide","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5680000185966492},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.5320000052452087},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.4819999933242798},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.40700000524520874},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.5299999713897705},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.5630000233650208},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.871999979019165},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.8588753938674927},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6689338684082031},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5587152242660522},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.5583549737930298},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5416617393493652},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5410612225532532},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5302395820617676},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4997706413269043},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4981565475463867},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47643929719924927},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.45848721265792847},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.42469367384910583},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4217306673526764},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4139039218425751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39499151706695557},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3793449401855469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3728893995285034},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-1371","doi":"https://doi.org/10.1158/1538-7445.am2022-1371","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1371","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6959263646","https://openalex.org/W4393097004","https://openalex.org/W4367550696","https://openalex.org/W7169553397","https://openalex.org/W7223254507","https://openalex.org/W3199043127","https://openalex.org/W3134443156","https://openalex.org/W3163901426","https://openalex.org/W4409821466","https://openalex.org/W7111948406"],"abstract_inverted_index":{"Abstract":[0],"Immune":[1],"response":[2,7],"is":[3,52,124,281],"a":[4,128,149,159,164,290,363,378],"critical":[5],"anti-tumor":[6,20,394],"to":[8,57,76,112,117,135,147,153,162,230,242,367],"overcome":[9],"tumorigenesis.":[10],"In":[11,54,141],"line":[12],"with":[13,172,239,269,327,335],"this,":[14],"immune":[15,38,44,138,332,385],"checkpoint":[16,139],"blockade":[17],"shows":[18,92],"tremendous":[19],"efficacy":[21],"by":[22,289,320,387,407],"enhancing":[23],"cytotoxicity":[24,173,258],"of":[25,37,43,46,59,131,166,174,181,188,204,217,285,324,339,414],"CD8+":[26,175,193,344,353,392],"cytotoxic":[27],"T":[28,354],"lymphocytes":[29],"(CTLs).":[30],"However,":[31],"cancer":[32,84,89],"cells":[33,221,326,329,355],"develop":[34],"different":[35],"mechanisms":[36],"evasion,":[39],"among":[40],"which":[41],"suppression":[42],"recognition":[45],"somatic":[47],"mutations":[48],"via":[49],"tumor":[50,81,179,274,298,318,325],"antigen":[51,65,78,189,208,340,389,409],"prevalent.":[53],"fact,":[55],"65%":[56],"90%":[58],"the":[60,73,86,99,136,178,185,202,265,314,322,336,368,415],"cancers":[61],"show":[62],"reduced":[63],"MHC-I":[64,231,244],"presentation.":[66,209,236],"There":[67],"is,":[68],"nonetheless,":[69],"little":[70],"achievement":[71],"toward":[72],"therapeutic":[74],"approaches":[75],"restore":[77],"presentation":[79,190,341,390,410],"on":[80,201,207,273,309],"cells.":[82,333],"Colorectal":[83],"(CRC),":[85],"second":[87],"deadliest":[88],"in":[90,177,191,252,256,283,300,342,352,383],"U.S.,":[91],"increasing":[93],"incidence":[94],"and":[95,108,120,255,349,391],"mortality":[96],"rates":[97],"over":[98],"past":[100],"years.":[101],"Standard":[102],"conventional":[103],"CRC":[104,132,155,182,286,384],"treatments,":[105],"surgery,":[106],"chemotherapy":[107],"radiotherapy,":[109],"often":[110],"lead":[111],"many":[113],"side":[114],"effects":[115,206,272,308],"due":[116],"their":[118,205],"non-specificity":[119],"cytotoxicity.":[121],"While":[122],"immunotherapy":[123],"very":[125],"promising,":[126],"only":[127,305],"small":[129],"population":[130],"patients":[133,287],"respond":[134],"current":[137],"inhibitors.":[140],"this":[142,211],"study,":[143],"our":[144],"objective":[145],"was":[146,264],"harness":[148],"novel":[150],"immunological":[151],"approach":[152],"target":[154,268,381],"tumors.":[156,371],"We":[157],"developed":[158,214],"bioinformatics":[160],"tool":[161],"create":[163],"pool":[165],"genes":[167,199,238],"whose":[168],"expression":[169],"negatively":[170],"correlates":[171],"CTLs":[176,345,393],"microenvironment":[180],"patients.":[183],"Given":[184],"central":[186],"role":[187],"activating":[192],"CTLs,":[194],"we":[195,213,374],"further":[196],"screened":[197],"these":[198],"based":[200],"scope":[203],"To":[210],"end,":[212],"stable":[215],"clones":[216],"OVA":[218],"expressing":[219],"MC38":[220],"(MC38OVA)":[222],"where":[223],"OVA-derived":[224],"peptide,":[225],"SIINFEKL,":[226],"will":[227],"be":[228],"bound":[229],"complex":[232],"for":[233,418],"cell":[234,245],"surface":[235,246],"4":[237],"highest":[240],"capacity":[241],"alter":[243],"levels":[247,351],"were":[248],"identified.":[249],"Our":[250],"consequent":[251],"vivo":[253],"experiments":[254],"vitro":[257],"assays":[259],"identified":[260],"that":[261,313],"\u201cRho-GEF\u201d":[262],"gene":[263],"top":[266],"actionable":[267],"striking":[270],"suppressive":[271],"growth.":[275],"TCGA":[276],"database":[277],"analysis":[278],"showed":[279,306,362],"Rho-GEF":[280,293,315,358,376,402],"upregulated":[282],"22%":[284],"accompanied":[288],"poor":[291],"prognosis.":[292],"knockdown":[294],"(KD)":[295],"significantly":[296],"inhibited":[297],"growth":[299,319],"immunocompetent":[301],"mice":[302],"whereas":[303],"it":[304],"minor":[307],"immunocompromised":[310],"mice,":[311],"suggesting":[312],"may":[316],"modulate":[317],"regulating":[321],"interaction":[323],"non-tumor":[328],"such":[330],"as":[331,377],"Consistent":[334],"major":[337],"contribution":[338],"promoting":[343],"activity,":[346],"TNF\u03b1,":[347],"IFN\u03b3,":[348],"GZMB":[350],"isolated":[356],"from":[357],"KD":[359],"MC38-derived":[360],"tumors":[361],"significant":[364],"increase":[365],"compared":[366],"wild":[369],"type":[370],"Taken":[372],"together,":[373],"introduced":[375],"potential":[379],"clinical":[380],"involved":[382],"evasion":[386],"modulating":[388],"responses.":[395],"Citation":[396],"Format:":[397],"Haniyeh":[398],"Eyvani,":[399],"Xinna":[400],"Zhang.":[401],"hampers":[403],"CD8+T":[404],"cells-mediated":[405],"immunosurveillance":[406],"reducing":[408],"[abstract].":[411],"In:":[412],"Proceedings":[413],"American":[416],"Association":[417],"Cancer":[419,430],"Research":[420],"Annual":[421],"Meeting":[422],"2022;":[423],"2022":[424],"Apr":[425],"8-13.":[426],"Philadelphia":[427],"(PA):":[428],"AACR;":[429],"Res":[431],"2022;82(12_Suppl):Abstract":[432],"nr":[433],"1371.":[434]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-06-17T00:00:00"}