{"id":"https://openalex.org/W4282964510","doi":"https://doi.org/10.3389/fcvm.2022.855181","title":"Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor","display_name":"Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor","publication_year":2022,"publication_date":"2022-06-16","ids":{"openalex":"https://openalex.org/W4282964510","doi":"https://doi.org/10.3389/fcvm.2022.855181","pmid":"https://pubmed.ncbi.nlm.nih.gov/35783863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9243458"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2022.855181","doi":"https://doi.org/10.3389/fcvm.2022.855181","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.855181","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcvm.2022.855181","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015891213","display_name":"Malik Bisserier","orcid":"https://orcid.org/0000-0001-8826-4649","observed_orcids":["https://orcid.org/0000-0001-8826-4649"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malik Bisserier","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036641057","display_name":"Agnieszka Brojakowska","orcid":"https://orcid.org/0000-0002-7319-9685","observed_orcids":["https://orcid.org/0000-0002-7319-9685"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agnieszka Brojakowska","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067092149","display_name":"Nathaniel Saffran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Saffran","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084702955","display_name":"Amit Kumar Rai","orcid":"https://orcid.org/0000-0002-3724-4805","observed_orcids":["https://orcid.org/0000-0002-3724-4805"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Kumar Rai","raw_affiliation_strings":["Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077057236","display_name":"Brooke Lee","orcid":"https://orcid.org/0000-0001-8795-8470","observed_orcids":["https://orcid.org/0000-0001-8795-8470"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Lee","raw_affiliation_strings":["Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082234024","display_name":"Matthew A. Coleman","orcid":"https://orcid.org/0000-0003-1389-4018","observed_orcids":["https://orcid.org/0000-0003-1389-4018","https://orcid.org/0000-0001-9488-2777"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Coleman","raw_affiliation_strings":["Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States","Lawrence Livermore National Laboratory, Livermore, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Livermore, CA, United States","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025969818","display_name":"Aimy Sebastian","orcid":"https://orcid.org/0000-0002-7822-7040","observed_orcids":["https://orcid.org/0000-0002-7822-7040"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aimy Sebastian","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Livermore, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Livermore, CA, United States","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034649568","display_name":"Angela Clare Evans","orcid":"https://orcid.org/0000-0002-9825-9381","observed_orcids":["https://orcid.org/0000-0002-9825-9381"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Evans","raw_affiliation_strings":["Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States","Lawrence Livermore National Laboratory, Livermore, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Livermore, CA, United States","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022067503","display_name":"Paul J. Mills","orcid":"https://orcid.org/0000-0003-4263-7686","observed_orcids":["https://orcid.org/0000-0003-4263-7686"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Mills","raw_affiliation_strings":["Center of Excellence for Research and Training in Integrative Health, University of California, San Diego, La Jolla, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Research and Training in Integrative Health, University of California, San Diego, La Jolla, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109397727","display_name":"Sankar Addya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sankar Addya","raw_affiliation_strings":["Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052114174","display_name":"Arsen Arakelyan","orcid":"https://orcid.org/0000-0002-6851-1056","observed_orcids":["https://orcid.org/0000-0002-6851-1056"]},"institutions":[{"id":"https://openalex.org/I188529364","display_name":"Russian-Armenian University","ror":"https://ror.org/01v4e7289","country_code":"AM","type":"education","lineage":["https://openalex.org/I188529364"]},{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Arsen Arakelyan","raw_affiliation_strings":["Bioinformatics Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia (NAS RA), Yerevan, Armenia","Department of Bioengineering, Bioinformatics, and Molecular Biology, Russian-Armenian University, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia (NAS RA), Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]},{"raw_affiliation_string":"Department of Bioengineering, Bioinformatics, and Molecular Biology, Russian-Armenian University, Yerevan, Armenia","institution_ids":["https://openalex.org/I188529364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071738730","display_name":"Venkata Naga Srikanth Garikipati","orcid":"https://orcid.org/0009-0006-7811-9302","observed_orcids":["https://orcid.org/0009-0006-7811-9302","https://orcid.org/0000-0001-5803-5335"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata Naga Srikanth Garikipati","raw_affiliation_strings":["Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004010364","display_name":"Lahouaria Hadri","orcid":"https://orcid.org/0000-0001-8108-7993","observed_orcids":["https://orcid.org/0000-0001-8108-7993"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lahouaria Hadri","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037949855","display_name":"David A. Goukassian","orcid":"https://orcid.org/0000-0001-5270-5270","observed_orcids":["https://orcid.org/0000-0001-5270-5270"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A. Goukassian","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Cardiovascular Research Institute, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5004010364","https://openalex.org/A5037949855"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":1.1987,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.72787693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"855181","last_page":"855181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.2865999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-extracellular-vesicles","display_name":"small extracellular vesicles","score":0.8769999742507935},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.8199999928474426},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.7820000052452087},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.949999988079071},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ac16-cells","display_name":"AC16 cells","score":0.75},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7095072269439697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6440668106079102},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.6204931735992432},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5687110424041748},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5456801056861877},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4887787997722626},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.48233315348625183},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4606459438800812},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.445825457572937},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.42861008644104004},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.4208529591560364},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.41655999422073364},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3827804625034332},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.3467644453048706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33809977769851685},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3209817409515381},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29248082637786865},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.22171810269355774},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.14505726099014282}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fcvm.2022.855181","doi":"https://doi.org/10.3389/fcvm.2022.855181","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.855181","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:35783863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35783863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9243458","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9243458/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1880941","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1880941","pdf_url":"https://www.osti.gov/servlets/purl/1880941","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:jdc.jefferson.edu:kimmelccfp-1093","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/kimmelccfp/93","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kimmel Cancer Center Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bbefd550bc9e444082b1c7e3af1d6abf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bbefd550bc9e444082b1c7e3af1d6abf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 9 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2931723f","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2931723f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, vol 9","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2022.855181","doi":"https://doi.org/10.3389/fcvm.2022.855181","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2022.855181","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356433355","display_name":null,"funder_award_id":"DE\u2010AC5207NA27344","funder_id":"https://openalex.org/F4320338286","funder_display_name":"Lawrence Livermore National Laboratory"},{"id":"https://openalex.org/G14554683","display_name":null,"funder_award_id":"DEAC5207NA27344","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2102758578","display_name":null,"funder_award_id":"R01 HL133554","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G2525748994","display_name":"Role of CircRNAs in Ischemic Tissue Repair and Regeneration","funder_award_id":"18CDA34110277","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G3368592426","display_name":null,"funder_award_id":"18CDA34110277","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G3608168065","display_name":null,"funder_award_id":"18IPA34170321","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5424590383","display_name":"Investigating circular RNA as novel therapeutic targets for cardiac repair and regeneration","funder_award_id":"915681","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5776719013","display_name":null,"funder_award_id":"FIP0005","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G6018559898","display_name":"Training Program in Molecular and Cellular Cardiology","funder_award_id":"T32HL007824","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6240043616","display_name":null,"funder_award_id":"80NSSC19K1079","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G6330837451","display_name":"Extracellular vesicles secreted by human Induced Pluripotent Stem Cells (iPSC)-derived Vascular Cells as Novel Biomarker","funder_award_id":"18IPA34170321","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6670844962","display_name":null,"funder_award_id":"5T32HL007824-22","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G895790057","display_name":null,"funder_award_id":"DE-AC52","funder_id":"https://openalex.org/F4320338286","funder_display_name":"Lawrence Livermore National Laboratory"},{"id":"https://openalex.org/G9000092217","display_name":"Interactions of SERCA2a and BMPRII in Vascular Disease","funder_award_id":"R01HL133554","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000868941","display_name":"Role of Epac1 in the Pathogenesis of Pulmonary Fibrosis","funder_award_id":"R01HL158998","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320310749","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267"},{"id":"https://openalex.org/F4320316601","display_name":"Cardiovascular Medical Research and Education Fund","ror":"https://ror.org/00f1t9w57"},{"id":"https://openalex.org/F4320322037","display_name":"Nuclear Safety and Security Commission","ror":"https://ror.org/05qk3ge34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338286","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282964510.pdf","grobid_xml":"https://content.openalex.org/works/W4282964510.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W197255355","https://openalex.org/W1066172147","https://openalex.org/W1505844373","https://openalex.org/W1600015917","https://openalex.org/W1601681275","https://openalex.org/W1866826175","https://openalex.org/W1973212998","https://openalex.org/W1975355918","https://openalex.org/W2006350053","https://openalex.org/W2009628603","https://openalex.org/W2014346055","https://openalex.org/W2017290871","https://openalex.org/W2019169633","https://openalex.org/W2020992406","https://openalex.org/W2024373518","https://openalex.org/W2045660560","https://openalex.org/W2058767592","https://openalex.org/W2060608189","https://openalex.org/W2074827979","https://openalex.org/W2100365251","https://openalex.org/W2102517059","https://openalex.org/W2109823903","https://openalex.org/W2111387420","https://openalex.org/W2118026566","https://openalex.org/W2119846536","https://openalex.org/W2121792192","https://openalex.org/W2155220548","https://openalex.org/W2194885575","https://openalex.org/W2480872114","https://openalex.org/W2560379682","https://openalex.org/W2610653692","https://openalex.org/W2732831519","https://openalex.org/W2747620054","https://openalex.org/W2759198044","https://openalex.org/W2769917707","https://openalex.org/W2791938564","https://openalex.org/W2793237841","https://openalex.org/W2796494566","https://openalex.org/W2797292560","https://openalex.org/W2807921276","https://openalex.org/W2887768610","https://openalex.org/W2899572198","https://openalex.org/W2933304441","https://openalex.org/W2939018266","https://openalex.org/W2942984533","https://openalex.org/W2963275287","https://openalex.org/W2968643140","https://openalex.org/W2994675744","https://openalex.org/W2999277102","https://openalex.org/W3092528836","https://openalex.org/W3112724787","https://openalex.org/W3113574091","https://openalex.org/W3130034549","https://openalex.org/W3139030169","https://openalex.org/W3164944391","https://openalex.org/W3165796232","https://openalex.org/W3193937245","https://openalex.org/W3207376946","https://openalex.org/W4206614069"],"related_works":["https://openalex.org/W7155559127","https://openalex.org/W3110664300","https://openalex.org/W4399535314","https://openalex.org/W4281648676","https://openalex.org/W4283377195","https://openalex.org/W4411758045","https://openalex.org/W3109743953","https://openalex.org/W7165380130","https://openalex.org/W4409436329","https://openalex.org/W3131239152"],"abstract_inverted_index":{"There":[0],"are":[1],"unique":[2],"stressors":[3,11],"in":[4,38,50,154,183,207,226],"the":[5,65,88,133,143,171,177,188,208,221,224,232,235],"spaceflight":[6,56],"environment.":[7],"Exposure":[8],"to":[9,47,142,161,187],"such":[10],"may":[12,218],"be":[13],"associated":[14],"with":[15,99,158,164],"adverse":[16],"effects":[17],"on":[18],"astronauts'":[19],"health,":[20],"including":[21],"increased":[22],"cancer":[23],"and":[24,41,81,101,112,149,238],"cardiovascular":[25],"disease":[26,51],"risks.":[27],"Small":[28],"extracellular":[29],"vesicles":[30],"(sEVs,":[31],"i.e.,":[32],"exosomes)":[33],"play":[34],"a":[35],"vital":[36],"role":[37,49],"intercellular":[39],"communication":[40],"regulate":[42],"various":[43],"biological":[44],"processes":[45],"contributing":[46],"their":[48],"pathogenesis.":[52],"To":[53],"assess":[54],"whether":[55],"alters":[57],"sEVs":[58,61,217],"transcriptome":[59],"profile,":[60],"were":[62,97],"isolated":[63,111],"from":[64,87,176],"blood":[66],"plasma":[67],"of":[68,170,194,205,223,234],"3":[69,82],"astronauts":[70],"at":[71],"two":[72],"different":[73],"time":[74],"points:":[75],"10":[76],"days":[77,83],"before":[78],"launch":[79],"(L-10)":[80],"after":[84],"return":[85],"(R+3)":[86],"Shuttle":[89],"mission.":[90],"AC16":[91,155],"cells":[92,156,162],"(human":[93],"cardiomyocyte":[94],"cell":[95],"line)":[96],"treated":[98,157,163],"L-10":[100,165],"R+3":[102,159],"astronauts-derived":[103,166],"exosomes":[104],"for":[105,114],"24":[106],"h.":[107],"Total":[108],"RNA":[109],"was":[110,123],"analyzed":[113],"gene":[115,139,184],"expression":[116,222],"profiling":[117],"using":[118,125,132,174],"Affymetrix":[119],"microarrays.":[120],"Enrichment":[121],"analysis":[122,131,169,193],"performed":[124],"Enrichr.":[126],"Transcription":[127],"factor":[128],"(TF)":[129],"enrichment":[130,182,204],"ENCODE/ChEA":[134],"Consensus":[135],"TF":[136],"database":[137],"identified":[138],"sets":[140,185],"related":[141,186],"polycomb":[144],"repressive":[145,190],"complex":[146,237],"2":[147],"(PRC2)":[148],"Vitamin":[150],"D":[151],"receptor":[152],"(VDR)":[153],"compared":[160],"exosomes.":[167],"Further":[168],"histone":[172],"modifications":[173],"datasets":[175,202],"Roadmap":[178],"Epigenomics":[179],"Project":[180],"confirmed":[181],"H3K27me3":[189,206,239],"mark.":[191],"Interestingly,":[192],"previously":[195],"published":[196],"H3K27me3-chromatin":[197],"immunoprecipitation":[198],"sequencing":[199],"(ChIP-Seq)":[200],"ENCODE":[201],"showed":[203],"VDR":[209,225],"promoter.":[210],"Collectively,":[211],"our":[212],"results":[213],"suggest":[214],"that":[215],"astronaut-derived":[216],"epigenetically":[219],"repress":[220],"human":[227],"adult":[228],"cardiomyocytes":[229],"by":[230],"promoting":[231],"activation":[233],"PRC2":[236],"levels.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-17T00:00:00"}
