{"id":"https://openalex.org/W4282962471","doi":"https://doi.org/10.1002/pro.4336","title":"Odd one out? Functional tuning of Zymomonas mobilis pyruvate kinase is narrower than its allosteric, human counterpart","display_name":"Odd one out? Functional tuning of Zymomonas mobilis pyruvate kinase is narrower than its allosteric, human counterpart","publication_year":2022,"publication_date":"2022-06-16","ids":{"openalex":"https://openalex.org/W4282962471","doi":"https://doi.org/10.1002/pro.4336","pmid":"https://pubmed.ncbi.nlm.nih.gov/35762709","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9202079"},"language":"en","primary_location":{"id":"doi:10.1002/pro.4336","doi":"https://doi.org/10.1002/pro.4336","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.4336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4336","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4336","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076574921","display_name":"Braelyn M. Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Braelyn M. Page","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032219866","display_name":"Tyler A. Martin","orcid":"https://orcid.org/0000-0003-2425-7516","observed_orcids":["https://orcid.org/0000-0003-2425-7516"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler A. Martin","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048597532","display_name":"Collette L. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Collette L. Wright","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025836419","display_name":"Lauren A. Fenton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren A. Fenton","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084910678","display_name":"Maite T. Villar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maite T. Villar","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046709679","display_name":"Qingling Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingling Tang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032528153","display_name":"Antonio Artigues","orcid":"https://orcid.org/0009-0001-7599-1035","observed_orcids":["https://orcid.org/0009-0001-7599-1035"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Artigues","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087071965","display_name":"Audrey L. Lamb","orcid":"https://orcid.org/0000-0002-2352-2130","observed_orcids":["https://orcid.org/0000-0002-2352-2130"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Lamb","raw_affiliation_strings":["Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas, USA","Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005042866","display_name":"Aron W. Fenton","orcid":"https://orcid.org/0000-0001-8214-4785","observed_orcids":["https://orcid.org/0000-0001-8214-4785"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aron W. Fenton","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":"https://orcid.org/0000-0001-8214-4785","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035852381","display_name":"Liskin Swint\u2010Kruse","orcid":"https://orcid.org/0000-0002-5925-9741","observed_orcids":["https://orcid.org/0000-0002-5925-9741"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liskin Swint\u2010Kruse","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":"https://orcid.org/0000-0002-5925-9741","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005042866","https://openalex.org/A5035852381"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":null,"fwci":0.8031,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6466775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"31","issue":"7","first_page":"e4336","last_page":"e4336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.23350000381469727,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.1062999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyruvate-kinase","display_name":"pyruvate kinase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/zymomonas-mobilis","display_name":"Zymomonas mobilis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/functional-tuning","display_name":"functional tuning","score":0.640999972820282},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.6470000147819519},{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"multiple sequence alignment","score":0.7379999756813049},{"id":"https://openalex.org/keywords/homologous-proteins","display_name":"homologous proteins","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6905226111412048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6500289440155029},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6304105520248413},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5099481344223022},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4698604345321655},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4644601047039032},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4484618902206421},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4193160831928253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35239481925964355},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25654304027557373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1462085247039795}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017355","descriptor_name":"Zymomonas","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017355","descriptor_name":"Zymomonas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/pro.4336","doi":"https://doi.org/10.1002/pro.4336","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.4336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4336","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmid:35762709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35762709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9202079","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9202079/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/pro.4336","doi":"https://doi.org/10.1002/pro.4336","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.4336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4336","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1671877688","display_name":"Towards exome analyses: Surprising outcomes from mutating nonconserved positions","funder_award_id":"R01GM118589","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000869322","display_name":"Kansas IDeA Network of Biomedical Research Excellence 5","funder_award_id":"P20GM103418","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4282962471.pdf"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W562291458","https://openalex.org/W1765065671","https://openalex.org/W1964500675","https://openalex.org/W1983582043","https://openalex.org/W1986742054","https://openalex.org/W1989636195","https://openalex.org/W2004203527","https://openalex.org/W2016251356","https://openalex.org/W2020047292","https://openalex.org/W2021312899","https://openalex.org/W2024620705","https://openalex.org/W2026465178","https://openalex.org/W2055043387","https://openalex.org/W2055981655","https://openalex.org/W2061042699","https://openalex.org/W2062475405","https://openalex.org/W2069663555","https://openalex.org/W2070331825","https://openalex.org/W2086235515","https://openalex.org/W2087790513","https://openalex.org/W2091097623","https://openalex.org/W2108462000","https://openalex.org/W2124279235","https://openalex.org/W2125184944","https://openalex.org/W2128995100","https://openalex.org/W2135668486","https://openalex.org/W2145338618","https://openalex.org/W2146213764","https://openalex.org/W2151457629","https://openalex.org/W2152207030","https://openalex.org/W2156125289","https://openalex.org/W2158714788","https://openalex.org/W2166962872","https://openalex.org/W2259199383","https://openalex.org/W2313802681","https://openalex.org/W2331911623","https://openalex.org/W2376573086","https://openalex.org/W2423210081","https://openalex.org/W2563121704","https://openalex.org/W2582396271","https://openalex.org/W2593070627","https://openalex.org/W2606362592","https://openalex.org/W2750791471","https://openalex.org/W2774928686","https://openalex.org/W2883984694","https://openalex.org/W2886182154","https://openalex.org/W2950954328","https://openalex.org/W2970783812","https://openalex.org/W2979256289","https://openalex.org/W2985602324","https://openalex.org/W2993164685","https://openalex.org/W3022563902","https://openalex.org/W3026933860","https://openalex.org/W3033676124","https://openalex.org/W3048845581","https://openalex.org/W3096305909","https://openalex.org/W3096485033","https://openalex.org/W3101539570","https://openalex.org/W3104285666","https://openalex.org/W3115121373","https://openalex.org/W3121957686","https://openalex.org/W3132773556","https://openalex.org/W3154360897","https://openalex.org/W3156458251","https://openalex.org/W3163595068","https://openalex.org/W3164263519","https://openalex.org/W3197923082","https://openalex.org/W3210044786","https://openalex.org/W3215456302","https://openalex.org/W4221036182","https://openalex.org/W4230447108","https://openalex.org/W4251751280"],"related_works":["https://openalex.org/W4319915585","https://openalex.org/W3164263519","https://openalex.org/W4382657598","https://openalex.org/W1975684289","https://openalex.org/W2004203527","https://openalex.org/W3026933860","https://openalex.org/W2372248145","https://openalex.org/W2080685692","https://openalex.org/W2051156625","https://openalex.org/W2078216357"],"abstract_inverted_index":{"Abstract":[0],"Various":[1],"protein":[2,11,241],"properties":[3],"are":[4,47],"often":[5],"illuminated":[6],"using":[7],"sequence":[8,22,101,192],"comparisons":[9,193],"of":[10,17,26,59,84,150,173,208],"homologs.":[12],"For":[13],"example,":[14],"in":[15,39,127,218,247],"analyses":[16,220],"the":[18,24,63,76,151,166,170,206,209,222,232,239],"pyruvate":[19,42],"kinase":[20,43],"multiple":[21,71,120],"alignment,":[23],"set":[25],"positions":[27,38,46,110,246],"that":[28,182,195,203,213],"changed":[29],"during":[30,79],"speciation":[31],"(\u201cphylogenetic\u201d":[32],"positions)":[33],"were":[34,111,155],"enriched":[35],"for":[36,125,165,184],"\u201crheostat\u201d":[37],"human":[40],"liver":[41],"(hLPYK).":[44],"(Rheostat":[45],"those":[48],"which,":[49],"when":[50],"substituted":[51,118],"with":[52,119],"various":[53,82],"amino":[54,121],"acids,":[55,122],"yield":[56],"a":[57],"range":[58,172],"functional":[60,189,199],"outcomes).":[61],"However,":[62],"correlation":[64],"was":[65,145,178],"moderate,":[66],"which":[67,98],"could":[68],"result":[69],"from":[70,205],"biophysical":[72,234],"constraints":[73],"acting":[74],"on":[75,114],"same":[77,240],"position":[78,144],"evolution":[80],"and/or":[81,200],"sources":[83],"noise.":[85],"To":[86],"further":[87],"examine":[88],"this":[89],"correlation,":[90],"we":[91,132],"here":[92],"tested":[93],"Zymomonas":[94],"mobilis":[95],"PYK":[96,106],"(ZmPYK),":[97],"has":[99,197],"<65%":[100],"identity":[102],"to":[103,134,225,237],"any":[104],"other":[105],"sequence.":[107],"Twenty\u2010six":[108],"ZmPYK":[109,153,168,196],"selected":[112],"based":[113],"their":[115],"phylogenetic":[116],"scores,":[117],"and":[123,157,191],"assessed":[124],"changes":[126],"K":[128,174],"app\u2010PEP":[129],".":[130],"Although":[131],"expected":[133],"identify":[135],"multiple,":[136],"strong":[137],"rheostat":[138,143,227,245],"positions,":[139],"only":[140],"one":[141,248],"moderate":[142],"detected.":[146],"Instead,":[147],"nearly":[148],"half":[149],"271":[152],"variants":[154],"inactive":[156],"most":[158],"others":[159],"showed":[160],"near":[161],"wild\u2010type":[162],"function.":[163],"Indeed,":[164],"active":[167],"variants,":[169],"total":[171],"app,PEP":[175],"values":[176],"(\u201dtunability\u201d)":[177],"40\u2010fold":[179],"less":[180],"than":[181],"observed":[183],"hLPYK":[185],"variants.":[186],"The":[187],"combined":[188],"studies":[190],"suggest":[194],"evolved":[198],"structural":[201],"attributes":[202],"differ":[204],"rest":[207],"family.":[210],"We":[211],"hypothesize":[212],"including":[214],"such":[215],"\u201corphan\u201d":[216],"sequences":[217],"MSA":[219],"obscures":[221],"correlations":[223],"used":[224],"predict":[226],"positions.":[228],"Finally,":[229],"results":[230],"raise":[231],"intriguing":[233],"question":[235],"as":[236],"how":[238],"fold":[242],"can":[243],"support":[244],"homolog":[249],"but":[250],"not":[251],"another.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-17T00:00:00"}
