{"id":"https://openalex.org/W4282961278","doi":"https://doi.org/10.1158/1538-7445.am2022-3545","title":"Abstract 3545: New hybrid molecular modalities comprised of DNA-origami and interfering peptides as inhibitors of protein-protein interactions","display_name":"Abstract 3545: New hybrid molecular modalities comprised of DNA-origami and interfering peptides as inhibitors of protein-protein interactions","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282961278","doi":"https://doi.org/10.1158/1538-7445.am2022-3545"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-3545","doi":"https://doi.org/10.1158/1538-7445.am2022-3545","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-3545","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091208916","display_name":"Jessica A. Roman","orcid":"https://orcid.org/0000-0003-0454-1974","observed_orcids":["https://orcid.org/0000-0003-0454-1974"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Roman","raw_affiliation_strings":["1George Mason University, Manassas, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1George Mason University, Manassas, VA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rachel Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Carter","raw_affiliation_strings":["1George Mason University, Manassas, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1George Mason University, Manassas, VA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001497347","display_name":"Alessandra Luchini","orcid":"https://orcid.org/0000-0003-1599-0214","observed_orcids":["https://orcid.org/0000-0003-1599-0214"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandra Luchini","raw_affiliation_strings":["1George Mason University, Manassas, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1George Mason University, Manassas, VA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113550070","display_name":"L. A. Liotta","orcid":"https://orcid.org/0000-0001-5155-7907","observed_orcids":["https://orcid.org/0000-0001-5155-7907"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance Liotta","raw_affiliation_strings":["1George Mason University, Manassas, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1George Mason University, Manassas, VA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027369686","display_name":"R\u00e9mi Veneziano","orcid":"https://orcid.org/0000-0002-2726-3770","observed_orcids":["https://orcid.org/0000-0002-2726-3770"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remi Veneziano","raw_affiliation_strings":["1George Mason University, Manassas, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1George Mason University, Manassas, VA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073996940","display_name":"Amanda N Haymond","orcid":"https://orcid.org/0000-0002-9553-275X","observed_orcids":["https://orcid.org/0000-0002-9553-275X"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Haymond","raw_affiliation_strings":["1George Mason University, Manassas, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1George Mason University, Manassas, VA","institution_ids":["https://openalex.org/I162714631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I162714631"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"3545","last_page":"3545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0869000032544136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-origami","display_name":"DNA origami","score":0.8889999985694885},{"id":"https://openalex.org/keywords/interfering-peptide","display_name":"interfering peptide","score":0.8799999952316284},{"id":"https://openalex.org/keywords/protein-protein-interaction-inhibitors","display_name":"protein-protein interaction inhibitors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/il-33-st2-signaling","display_name":"IL-33/ST2 signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8690000176429749},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8259999752044678},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/myd88-signaling","display_name":"MyD88 signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7110000252723694},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.6539999842643738},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6867622137069702},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5340081453323364},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.507567286491394},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4904782474040985},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43696293234825134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43102675676345825},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.41396501660346985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35858094692230225},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33260881900787354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32334256172180176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2892107367515564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09810683131217957}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-3545","doi":"https://doi.org/10.1158/1538-7445.am2022-3545","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-3545","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6922442252","https://openalex.org/W4395669258","https://openalex.org/W6941134820","https://openalex.org/W6884888378","https://openalex.org/W4405374870","https://openalex.org/W3172457967","https://openalex.org/W4402248226","https://openalex.org/W4405374175","https://openalex.org/W7134197385","https://openalex.org/W4405374296"],"abstract_inverted_index":{"Abstract":[0],"Immunotherapy":[1],"has":[2,47,166],"shown":[3],"tremendous":[4],"promise":[5],"in":[6,33,87,117,209,228,236],"the":[7,26,36,52,57,88,108,177,194,200,274],"treatment":[8,13],"of":[9,43,64,95,111,172,233,260,267,273],"blood":[10],"cancers;":[11],"however,":[12],"typically":[14],"fails":[15],"when":[16],"attempted":[17],"with":[18,199],"solid":[19],"tumors,":[20],"such":[21],"as":[22,211,265],"breast":[23,34],"cancer.":[24],"However,":[25],"cases":[27],"where":[28],"immunotherapies":[29],"have":[30,38],"been":[31,39,48],"successful":[32,82],"cancer,":[35],"results":[37],"remarkable:":[40],"full":[41],"remission":[42],"stage":[44],"4":[45,168],"disease":[46,136],"observed.":[49],"This":[50,113],"highlights":[51],"need":[53],"to":[54,70,80,92,149,154,221],"elucidate":[55],"how":[56],"tumor":[58,101,132,161],"microenvironment":[59],"(TME)":[60],"fosters":[61],"a":[62,77,158],"context":[63],"molecular":[65,257],"crosstalk":[66],"that":[67,75,99,130,197],"is":[68,90,145],"hostile":[69],"inflammatory,":[71],"anti-tumor":[72],"immunological":[73],"responses":[74],"present":[76,86],"significant":[78],"roadblock":[79],"consistently":[81],"immunotherapy.":[83],"Aberrant":[84],"IL-33":[85],"TME":[89],"believed":[91],"be":[93],"one":[94],"these":[96,191],"major":[97],"factors":[98],"drives":[100],"progression":[102],"via":[103],"its":[104],"ligand,":[105],"ST2,":[106],"and":[107,122,134,156,176,183,193,215,224,230,262],"subsequent":[109,135],"recruitment":[110],"IL1RAcP.":[112],"activates":[114],"MyD88":[115],"cascades":[116],"dysfunctional":[118],"myeloid":[119,123],"immune":[120,152],"cells":[121,126,153],"derived":[124],"suppressor":[125],"(MDSCs),":[127],"eliciting":[128],"immunosuppression":[129],"promotes":[131],"tolerance":[133],"progression.":[137],"To":[138],"this":[139],"end,":[140],"preventing":[141],"IL-33/ST2":[142],"signaling":[143,235],"activation":[144],"an":[146],"attractive":[147],"target":[148],"possibly":[150],"manipulate":[151],"recognize":[155],"mount":[157],"response":[159],"against":[160],"cells.":[162],"Our":[163],"previous":[164],"work":[165],"identified":[167],"IL1RAcP":[169],"hotspot":[170],"residues":[171,196],"interaction":[173],"between":[174],"it":[175],"ST2/IL-33":[178,201],"complex:":[179],"R157,":[180],"K238,":[181],"K343,":[182],"K346.":[184],"Here,":[185],"we":[186],"designed":[187],"peptides,":[188],"which":[189],"mimic":[190],"hotspots":[192],"adjacent":[195],"interact":[198],"complex.":[202],"Wild":[203],"type":[204],"peptides":[205,264],"inhibit":[206],"trimer":[207],"formation":[208],"vitro":[210,229],"determined":[212],"by":[213],"immunoprecipitation":[214],"chemical":[216],"crosslinking":[217],"experiments.":[218],"Modifications":[219],"introduced":[220],"increase":[222],"rigidity":[223],"stability":[225],"increased":[226],"affinity":[227],"showed":[231],"inhibition":[232],"downstream":[234],"reporter":[237],"gene":[238],"cell":[239],"models.":[240],"Citation":[241],"Format:":[242],"Jessica":[243],"Roman,":[244],"Rachel":[245],"Carter,":[246],"Alessandra":[247],"Luchini,":[248],"Lance":[249],"Liotta,":[250],"Remi":[251],"Veneziano,":[252],"Amanda":[253],"Haymond.":[254],"New":[255],"hybrid":[256],"modalities":[258],"comprised":[259],"DNA-origami":[261],"interfering":[263],"inhibitors":[266],"protein-protein":[268],"interactions":[269],"[abstract].":[270],"In:":[271],"Proceedings":[272],"American":[275],"Association":[276],"for":[277],"Cancer":[278,289],"Research":[279],"Annual":[280],"Meeting":[281],"2022;":[282],"2022":[283],"Apr":[284],"8-13.":[285],"Philadelphia":[286],"(PA):":[287],"AACR;":[288],"Res":[290],"2022;82(12_Suppl):Abstract":[291],"nr":[292],"3545.":[293]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-06-17T00:00:00"}