{"id":"https://openalex.org/W4282960701","doi":"https://doi.org/10.1158/1538-7445.am2022-5829","title":"Abstract 5829: Characterizing cargoes of extracellular vesicles in promoting breast cancer growth and chemotherapy resistance","display_name":"Abstract 5829: Characterizing cargoes of extracellular vesicles in promoting breast cancer growth and chemotherapy resistance","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282960701","doi":"https://doi.org/10.1158/1538-7445.am2022-5829"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-5829","doi":"https://doi.org/10.1158/1538-7445.am2022-5829","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5829","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067001761","display_name":"Harrison Ngue","orcid":"https://orcid.org/0000-0001-9823-8209","observed_orcids":["https://orcid.org/0000-0001-9823-8209"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harrison Ngue","raw_affiliation_strings":["1Harvard University, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Harvard University, Cambridge, MA;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381252","display_name":"Hyejin Kim","orcid":"https://orcid.org/0000-0002-7937-2733","observed_orcids":["https://orcid.org/0000-0002-7937-2733"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyejin Kim","raw_affiliation_strings":["2Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014834463","display_name":"Shobha Vasudevan","orcid":"https://orcid.org/0000-0001-5938-8335","observed_orcids":["https://orcid.org/0000-0001-5938-8335"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobha Vasudevan","raw_affiliation_strings":["2Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"5829","last_page":"5829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.984000027179718},{"id":"https://openalex.org/keywords/mitochondrial-rrna","display_name":"mitochondrial ribosomal RNA","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.7599999904632568},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.9819999933242798},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6330000162124634},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5743929147720337},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5616635680198669},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.50227952003479},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4605092406272888},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.43646395206451416},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.43584829568862915},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4309753179550171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3749348521232605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18609026074409485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16024380922317505},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-5829","doi":"https://doi.org/10.1158/1538-7445.am2022-5829","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5829","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362597267","https://openalex.org/W4392588382","https://openalex.org/W4407887945","https://openalex.org/W4403440755","https://openalex.org/W7015088067","https://openalex.org/W7213426704","https://openalex.org/W4306652547","https://openalex.org/W4310206859","https://openalex.org/W4403778808","https://openalex.org/W2289431629"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1,276,287],"cells":[2,103],"employ":[3],"bidirectional":[4],"cell":[5,71],"communication":[6,19],"to":[7,59,94,196,228],"maintain":[8],"growth":[9,170,264],"and":[10,47,80,83,91,108,116,121,125,132,145,265],"metastasis":[11],"in":[12,57,153,168,186,199,260],"the":[13,26,40,149,183,211,234,272],"tumor":[14],"microenvironment.":[15],"One":[16],"mechanism":[17],"of":[18,28,42,123,162,190,214,219,232,257,271],"that":[20,35,139,159,221],"has":[21],"become":[22],"increasingly":[23],"appreciated":[24],"is":[25,53],"secretion":[27],"extracellular":[29,160,258],"vesicles":[30,259],"(EVs),":[31],"heterogeneous":[32],"multi-signal":[33],"messengers":[34],"support":[36],"cancer":[37,70,169,263],"dissemination":[38],"through":[39,130],"transfer":[41,161],"biomolecules":[43],"such":[44],"as":[45,207,209],"oncoproteins":[46],"noncoding":[48],"RNA":[49,124],"species.":[50],"However,":[51],"little":[52],"understood":[54],"about":[55],"EVs":[56,98,220],"relation":[58],"chemotherapy":[60,172,266],"resistance.":[61],"In":[62],"this":[63],"study,":[64],"we":[65],"profiled":[66],"two":[67],"different":[68],"breast":[69,262],"lines:":[72],"1)":[73],"BT549":[74],"(triple":[75],"negative),":[76],"treated":[77,88],"with":[78,89,110],"gemcitabine":[79],"paclitaxel":[81],"chemotherapy,":[82],"2)":[84],"MCF7":[85],"(estrogen":[86],"receptor-positive),":[87],"palbociclib":[90],"fulvestrant,":[92],"compared":[93],"their":[95],"wild-type":[96],"states.":[97],"were":[99,147,176],"collected":[100],"from":[101,223],"these":[102,238],"using":[104],"tangential":[105],"flow":[106],"filtration":[107],"quantified":[109],"Brownian":[111],"motion-based":[112],"nanoparticle":[113],"tracking":[114],"analysis":[115],"microfluidic":[117],"resistive":[118],"pulse":[119],"sensing,":[120],"profiling":[122],"peptide":[126],"markers":[127],"was":[128,194],"completed":[129],"RT-qPCR":[131],"Western":[133],"blotting,":[134],"respectively.":[135],"Initial":[136],"data":[137],"showed":[138],"representative":[140],"mitochondrial":[141,163,191,239],"ribosomal":[142,192],"genes":[143],"mt12S":[144],"MRPS14":[146],"among":[148],"most":[150],"upregulated":[151,198],"RNAs":[152,193],"our":[154],"drug-exposed":[155],"EV":[156],"samples,":[157],"indicating":[158],"materials":[164],"plays":[165],"a":[166,188,216],"role":[167],"under":[171],"stress.":[173],"These":[174],"findings":[175],"supported":[177],"by":[178,210,236],"prior":[179],"genetic":[180],"research":[181],"at":[182],"Vasudevan":[184],"laboratory,":[185],"which":[187,237],"set":[189],"found":[195],"be":[197,245],"cytosine":[200],"arabinoside-induced":[201],"chemoresistant":[202,242],"acute":[203],"monocytic":[204],"leukemia":[205],"cells,":[206],"well":[208],"recent":[212],"discovery":[213],"mitovesicles,":[215],"novel":[217],"population":[218],"originate":[222],"mitochondria.":[224],"Through":[225],"additional":[226],"efforts":[227],"isolate":[229],"further":[230],"subtypes":[231],"EVs,":[233],"mechanisms":[235],"cargoes":[240,256],"promote":[241],"phenotypes":[243],"will":[244],"uncovered.":[246],"Citation":[247],"Format:":[248],"Harrison":[249],"Ngue,":[250],"Hyejin":[251],"Kim,":[252],"Shobha":[253],"Vasudevan.":[254],"Characterizing":[255],"promoting":[261],"resistance":[267],"[abstract].":[268],"In:":[269],"Proceedings":[270],"American":[273],"Association":[274],"for":[275],"Research":[277],"Annual":[278],"Meeting":[279],"2022;":[280],"2022":[281],"Apr":[282],"8-13.":[283],"Philadelphia":[284],"(PA):":[285],"AACR;":[286],"Res":[288],"2022;82(12_Suppl):Abstract":[289],"nr":[290],"5829.":[291]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2022-06-17T00:00:00"}