{"id":"https://openalex.org/W4282959628","doi":"https://doi.org/10.1017/s1466252321000189","title":"Use of cannabis in the treatment of animals: a systematic review of randomized clinical trials","display_name":"Use of cannabis in the treatment of animals: a systematic review of randomized clinical trials","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4282959628","doi":"https://doi.org/10.1017/s1466252321000189","pmid":"https://pubmed.ncbi.nlm.nih.gov/35703023"},"language":"en","primary_location":{"id":"doi:10.1017/s1466252321000189","doi":"https://doi.org/10.1017/s1466252321000189","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1466252321000189","pdf_url":null,"source":{"id":"https://openalex.org/S2111646","display_name":"Animal Health Research Reviews","issn_l":"1466-2523","issn":["1466-2523","1475-2654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Health Research Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078795558","display_name":"T\u00e1cio de Mendon\u00e7a Lima","orcid":"https://orcid.org/0000-0003-4395-2098","observed_orcids":["https://orcid.org/0000-0003-4395-2098"]},"institutions":[{"id":"https://openalex.org/I161460629","display_name":"Universidade Federal Rural do Rio de Janeiro","ror":"https://ror.org/00xwgyp12","country_code":"BR","type":"education","lineage":["https://openalex.org/I161460629"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"T\u00e1cio de Mendon\u00e7a Lima","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Federal Rural University of Rio de Janeiro, Serop\u00e9dica, RJ\u00a023897-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4395-2098","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Federal Rural University of Rio de Janeiro, Serop\u00e9dica, RJ\u00a023897-000, Brazil","institution_ids":["https://openalex.org/I161460629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038539030","display_name":"Nathania Rodrigues Santiago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nathania Rodrigues Santiago","raw_affiliation_strings":["School of Veterinary and Zootechny, Federal University of Goias, Goiania, GO\u00a074690-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary and Zootechny, Federal University of Goias, Goiania, GO\u00a074690-900, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042200090","display_name":"Elaine Cristina Ramos Alves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102088","display_name":"Centro Infantil Boldrini","ror":"https://ror.org/017qbxe07","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210102088"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elaine Cristina Ramos Alves","raw_affiliation_strings":["Centro Infantil Boldrini, Campinas, SP\u00a013083-210, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Infantil Boldrini, Campinas, SP\u00a013083-210, Brazil","institution_ids":["https://openalex.org/I4210102088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075943432","display_name":"Douglas Siqueira de Almeida Chaves","orcid":"https://orcid.org/0000-0002-0571-9538","observed_orcids":["https://orcid.org/0000-0002-0571-9538"]},"institutions":[{"id":"https://openalex.org/I161460629","display_name":"Universidade Federal Rural do Rio de Janeiro","ror":"https://ror.org/00xwgyp12","country_code":"BR","type":"education","lineage":["https://openalex.org/I161460629"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Douglas Siqueira de Almeida Chaves","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Federal Rural University of Rio de Janeiro, Serop\u00e9dica, RJ\u00a023897-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0571-9538","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Federal Rural University of Rio de Janeiro, Serop\u00e9dica, RJ\u00a023897-000, Brazil","institution_ids":["https://openalex.org/I161460629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044818031","display_name":"Mar\u00edlia Berlofa Visacri","orcid":"https://orcid.org/0000-0003-1433-4768","observed_orcids":["https://orcid.org/0000-0003-1433-4768"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mar\u00edlia Berlofa Visacri","raw_affiliation_strings":["Department of Pharmacology, School of Medical Sciences, University of Campinas, Campinas, SP\u00a013083-887, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1433-4768","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medical Sciences, University of Campinas, Campinas, SP\u00a013083-887, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078795558"],"corresponding_institution_ids":["https://openalex.org/I161460629"],"apc_list":{"value":3255,"currency":"USD","value_usd":3255},"apc_paid":null,"fwci":0.8966,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.64080683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"25","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabis","display_name":"cannabis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.9649999737739563},{"id":"https://openalex.org/keywords/canine-osteoarthritis","display_name":"canine osteoarthritis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/canine-epilepsy","display_name":"canine epilepsy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/canine-behavioral-disorders","display_name":"canine behavioral disorders","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7730000019073486},{"id":"https://openalex.org/keywords/seizure-frequency","display_name":"seizure frequency","score":0.7269999980926514},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.9107747077941895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7892923355102539},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.7296881675720215},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6458555459976196},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6209045052528381},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5577039122581482},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5256444215774536},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.49648505449295044},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.4814254939556122},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42707282304763794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3721575438976288},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2642400562763214},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.18448883295059204},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09950873255729675}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002188","descriptor_name":"Cannabis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s1466252321000189","doi":"https://doi.org/10.1017/s1466252321000189","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1466252321000189","pdf_url":null,"source":{"id":"https://openalex.org/S2111646","display_name":"Animal Health Research Reviews","issn_l":"1466-2523","issn":["1466-2523","1475-2654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Health Research Reviews","raw_type":"journal-article"},{"id":"pmid:35703023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35703023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal health research reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1714980748","https://openalex.org/W1964906165","https://openalex.org/W1973006562","https://openalex.org/W1991490766","https://openalex.org/W2000646446","https://openalex.org/W2067960394","https://openalex.org/W2115440397","https://openalex.org/W2119071913","https://openalex.org/W2137516955","https://openalex.org/W2319625579","https://openalex.org/W2555950463","https://openalex.org/W2560438049","https://openalex.org/W2565629871","https://openalex.org/W2749462161","https://openalex.org/W2790816367","https://openalex.org/W2792045546","https://openalex.org/W2803285179","https://openalex.org/W2805916693","https://openalex.org/W2883205686","https://openalex.org/W2907963677","https://openalex.org/W2918448553","https://openalex.org/W2937205465","https://openalex.org/W2943967654","https://openalex.org/W2946659053","https://openalex.org/W2970684805","https://openalex.org/W2981299512","https://openalex.org/W2981990119","https://openalex.org/W2996661314","https://openalex.org/W2997765915","https://openalex.org/W3000482183","https://openalex.org/W3010544945","https://openalex.org/W3018838240","https://openalex.org/W3033784208","https://openalex.org/W3080331246","https://openalex.org/W3124341473","https://openalex.org/W3129157413","https://openalex.org/W3136719642","https://openalex.org/W3148962211","https://openalex.org/W3171711866","https://openalex.org/W4409152208","https://openalex.org/W6767567325"],"related_works":["https://openalex.org/W4229006957","https://openalex.org/W4386813009","https://openalex.org/W7214522624","https://openalex.org/W4412414629","https://openalex.org/W3124341473","https://openalex.org/W4313318408","https://openalex.org/W3204996489","https://openalex.org/W6987877914","https://openalex.org/W7128985042","https://openalex.org/W4382791814"],"abstract_inverted_index":{"Abstract":[0],"Cannabis":[1],"is":[2,14],"used":[3,84,128,141],"in":[4,18,56,71,110,132,135,176,190,220,236],"the":[5,27,34,39,65,72,87,104,186,197,221,232],"treatment":[6,40,73],"of":[7,29,33,36,41,69,74,89,93,98,188,200,215,223,234,269,276],"several":[8],"human":[9],"conditions;":[10],"however,":[11],"its":[12],"use":[13,35,233],"still":[15],"less":[16],"explored":[17],"veterinary":[19],"medicine.":[20],"This":[21],"systematic":[22],"review":[23],"aims":[24],"to":[25,85,230,240,285],"summarize":[26],"evidence":[28,229,248,270],"efficacy":[30,66],"and":[31,120,162,173,196,212,243,251,281],"safety":[32,68],"cannabis":[37,70],"for":[38,49],"animal":[42,75,277],"disease.":[43],"A":[44,91],"literature":[45],"search":[46],"was":[47,83,227,257],"performed":[48],"studies":[50,101,127,209],"published":[51],"until":[52],"16":[53],"March":[54],"2021":[55],"five":[57],"databases.":[58],"Randomized":[59],"clinical":[60],"trials":[61],"(RCTs)":[62],"that":[63,217],"reported":[64],"or":[67,134,145,157],"disease":[76],"were":[77,96,108,207,210],"included.":[78],"The":[79],"RoB":[80],"2":[81,144],"Tool":[82],"assess":[86],"risk":[88],"bias.":[90],"total":[92],"2427":[94],"records":[95],"identified,":[97,208],"which":[99],"six":[100],"fully":[102],"met":[103],"eligibility":[105],"criteria.":[106],"RCTs":[107,265],"conducted":[109],"dogs":[111,177,191,201,237],"with":[112,116,121,137,165,178,192,238,260,266],"osteoarthritis":[113,179,239],"(n=":[114,118,124,150,153,160,167,180,194,202],"4),":[115,151],"epilepsy":[117,193,250],"1),":[119],"behavioral":[122,252],"disorders":[123],"1).":[125,203],"All":[126],"cannabidiol":[129],"(CBD)":[130],"oil":[131],"monotherapy":[133],"combination":[136],"other":[138],"drugs.":[139],"Studies":[140],"CBD":[142,164,169,183,235,256],"at":[143],"2.5":[146],"mg":[147],"kg\u22121twice":[148],"daily":[149],"orally":[152],"5),":[154],"during":[155],"4":[156],"6":[158],"weeks":[159],"3),":[161],"compared":[163],"placebo":[166],"5).":[168],"significantly":[170,184],"reduced":[171,185],"pain":[172,242],"increased":[174,244],"activity":[175],"3).":[181],"Moreover,":[182],"frequency":[187],"seizures":[189],"1)":[195],"aggressive":[198],"behavior":[199],"Although":[204],"promising":[205],"results":[206],"heterogeneous":[211],"presented":[213],"risks":[214],"bias":[216],"required":[218],"caution":[219],"interpretation":[222],"findings.":[224,288],"Therefore,":[225],"there":[226],"some":[228],"support":[231],"reduce":[241],"activity,":[245],"but":[246],"limited":[247],"against":[249],"problems.":[253],"In":[254],"addition,":[255],"well":[258],"tolerated":[259],"mild":[261],"adverse":[262],"effects.":[263],"More":[264],"high":[267],"quality":[268],"are":[271],"needed,":[272],"including":[273],"greater":[274],"numbers":[275],"subjects,":[278],"additional":[279],"species,":[280],"clear":[282],"readout":[283],"measures":[284],"confirm":[286],"these":[287]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-17T00:00:00"}
