{"id":"https://openalex.org/W4282958970","doi":"https://doi.org/10.1158/1538-7445.am2022-1717","title":"Abstract 1717: Single-cell RNA sequencing reveals insights into the intra-tumoral heterogeneity and tumor microenvironment of ocular adnexal sebaceous carcinoma","display_name":"Abstract 1717: Single-cell RNA sequencing reveals insights into the intra-tumoral heterogeneity and tumor microenvironment of ocular adnexal sebaceous carcinoma","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282958970","doi":"https://doi.org/10.1158/1538-7445.am2022-1717"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-1717","doi":"https://doi.org/10.1158/1538-7445.am2022-1717","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1717","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030513670","display_name":"Ryan A. Gallo","orcid":"https://orcid.org/0000-0002-8891-2324","observed_orcids":["https://orcid.org/0000-0002-8891-2324"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Alexander Gallo","raw_affiliation_strings":["1University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001666955","display_name":"Michelle G. Zhang","orcid":"https://orcid.org/0000-0002-4083-9009","observed_orcids":["https://orcid.org/0000-0002-4083-9009"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle G. Zhang","raw_affiliation_strings":["1University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113478479","display_name":"David T. Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Tse","raw_affiliation_strings":["1University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034794862","display_name":"Daniel Pelaez","orcid":"https://orcid.org/0000-0002-4483-5160","observed_orcids":["https://orcid.org/0000-0002-4483-5160"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Pelaez","raw_affiliation_strings":["1University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036294539","display_name":"Andrew J. Rong","orcid":"https://orcid.org/0000-0002-2593-8375","observed_orcids":["https://orcid.org/0000-0002-2593-8375"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Rong","raw_affiliation_strings":["1University of Miami Miller School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Miami Miller School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"1717","last_page":"1717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.25679999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":1.0},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/eyelid-tumors","display_name":"eyelid tumors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6704761981964111},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6344234347343445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5712864398956299},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.564498245716095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45604920387268066},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4486510753631592},{"id":"https://openalex.org/C2776835612","wikidata":"https://www.wikidata.org/wiki/Q7442319","display_name":"Sebaceous carcinoma","level":3,"score":0.4325137138366699},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3542293310165405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32268041372299194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14510399103164673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-1717","doi":"https://doi.org/10.1158/1538-7445.am2022-1717","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1717","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403312241","https://openalex.org/W3105883665","https://openalex.org/W4248753545","https://openalex.org/W3023039289","https://openalex.org/W4407650200","https://openalex.org/W3164690593","https://openalex.org/W4380084269","https://openalex.org/W7127943534","https://openalex.org/W3126261109","https://openalex.org/W1968356193"],"abstract_inverted_index":{"Abstract":[0],"Sebaceous":[1],"carcinoma":[2,237],"(SC)":[3],"is":[4,20,39],"a":[5,52],"malignant":[6,25],"neoplasm":[7,27],"that":[8],"predominantly":[9],"arises":[10],"from":[11],"the":[12,16,21,29,40,85,179,189,192,227,242],"sebaceous":[13,236],"glands":[14],"of":[15,42,55,136,161,191,233,241],"ocular":[17,67,234],"adnexa.":[18],"It":[19],"second":[22],"most":[23],"common":[24],"eyelid":[26],"in":[28,121,178],"United":[30],"States.":[31],"No":[32],"standardized":[33],"treatment":[34],"exists,":[35],"but":[36],"surgical":[37],"excision":[38],"mainstay":[41],"therapy.":[43],"Therapeutic":[44],"advances":[45],"have":[46],"been":[47],"stagnant":[48],"largely":[49],"due":[50],"to":[51,64,96,119,187],"limited":[53],"understanding":[54],"SC":[56,69,79,170],"tumor":[57,75,162,231],"biology.":[58,171],"We":[59,132],"performed":[60,95],"single-cell":[61],"RNA":[62,222],"sequencing":[63,223],"profile":[65],"primary":[66],"adnexal":[68,78,235],"and":[70,111,125,128,154,163,196,230],"gain":[71],"insights":[72,168,225],"into":[73,169,226],"its":[74],"microenvironment.":[76],"Ocular":[77],"has":[80],"extensive":[81],"intra-tumoral":[82,228],"heterogeneity":[83,229],"at":[84],"transcriptional":[86],"level.":[87],"Dimensionality":[88],"reduction":[89],"via":[90],"principal":[91],"component":[92],"analysis":[93],"was":[94],"identify":[97],"major":[98],"cell":[99],"types.":[100],"8":[101],"clusters":[102,106],"were":[103,117],"detected,":[104],"including":[105,140],"for":[107,202,245],"cancer":[108],"epithelial":[109],"cells":[110,165,195],"various":[112],"immune":[113,123,138,164,194],"cells.":[114,157],"Transcriptional":[115],"programs":[116],"related":[118],"pathways":[120],"cancer,":[122],"response,":[124],"antigen":[126],"processing":[127],"processing,":[129],"among":[130],"others.":[131],"identified":[133,193],"unique":[134],"subpopulations":[135],"tumor-infiltrating":[137],"cells,":[139,143,147,150,153],"plasma":[141],"B":[142,156],"GNLY+":[144],"natural":[145],"killer":[146],"CD8+":[148],"T":[149,152],"memory":[151],"CD20+":[155],"This":[158],"complex":[159],"ecosystem":[160],"provides":[166],"new":[167],"Additional":[172],"patient":[173],"samples":[174],"we":[175],"be":[176,200],"analyzed":[177],"immediate":[180],"future.":[181],"Follow-up":[182],"mechanistic":[183],"studies":[184],"are":[185],"needed":[186],"clarify":[188],"roles":[190],"how":[197],"they":[198],"can":[199],"exploited":[201],"immunotherapeutic":[203],"approaches.":[204],"Citation":[205],"Format:":[206],"Ryan":[207],"Alexander":[208],"Gallo,":[209],"Michelle":[210],"G.":[211],"Zhang,":[212],"David":[213],"T.":[214],"Tse,":[215],"Daniel":[216],"Pelaez,":[217],"Andrew":[218],"J.":[219],"Rong.":[220],"Single-cell":[221],"reveals":[224],"microenvironment":[232],"[abstract].":[238],"In:":[239],"Proceedings":[240],"American":[243],"Association":[244],"Cancer":[246,257],"Research":[247],"Annual":[248],"Meeting":[249],"2022;":[250],"2022":[251],"Apr":[252],"8-13.":[253],"Philadelphia":[254],"(PA):":[255],"AACR;":[256],"Res":[258],"2022;82(12_Suppl):Abstract":[259],"nr":[260],"1717.":[261]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2022-06-17T00:00:00"}
