{"id":"https://openalex.org/W4282945860","doi":"https://doi.org/10.1021/acs.jproteome.2c00198","title":"In Vitro Kinase-to-Phosphosite Database (iKiP-DB) Predicts Kinase Activity in Phosphoproteomic Datasets","display_name":"In Vitro Kinase-to-Phosphosite Database (iKiP-DB) Predicts Kinase Activity in Phosphoproteomic Datasets","publication_year":2022,"publication_date":"2022-05-24","ids":{"openalex":"https://openalex.org/W4282945860","doi":"https://doi.org/10.1021/acs.jproteome.2c00198","pmid":"https://pubmed.ncbi.nlm.nih.gov/35608653"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jproteome.2c00198","doi":"https://doi.org/10.1021/acs.jproteome.2c00198","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.2c00198","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/14/2022.01.13.476159.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027796815","display_name":"Tommaso Mari","orcid":"https://orcid.org/0000-0001-6011-9386","observed_orcids":["https://orcid.org/0000-0001-6011-9386"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tommaso Mari","raw_affiliation_strings":["Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6011-9386","affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006074825","display_name":"Kirstin M\u00f6sbauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kirstin M\u00f6sbauer","raw_affiliation_strings":["Institute of Virology, Charit\u00e9\u2212Universit\u00e4tsmedizin, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Charit\u00e9\u2212Universit\u00e4tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074877560","display_name":"Emanuel Wyler","orcid":"https://orcid.org/0000-0002-9884-1806","observed_orcids":["https://orcid.org/0000-0002-9884-1806","https://orcid.org/0000-0002-0468-0117","https://orcid.org/0000-0001-9860-2007"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Emanuel Wyler","raw_affiliation_strings":["Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052259098","display_name":"Markus Landthaler","orcid":"https://orcid.org/0000-0002-1075-8734","observed_orcids":["https://orcid.org/0000-0002-1075-8734"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Landthaler","raw_affiliation_strings":["Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011461272","display_name":"Christian Drosten","orcid":"https://orcid.org/0000-0001-7923-0519","observed_orcids":["https://orcid.org/0000-0001-7923-0519","https://orcid.org/0000-0003-2085-767X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Drosten","raw_affiliation_strings":["Institute of Virology, Charit\u00e9\u2212Universit\u00e4tsmedizin, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Charit\u00e9\u2212Universit\u00e4tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042757297","display_name":"Matthias Selbach","orcid":"https://orcid.org/0000-0003-2454-8751","observed_orcids":["https://orcid.org/0000-0003-2454-8751"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Selbach","raw_affiliation_strings":["Charit\u00e9\u2212Universit\u00e4tsmedizin, 10117 Berlin, Germany","Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2454-8751","affiliations":[{"raw_affiliation_string":"Charit\u00e9\u2212Universit\u00e4tsmedizin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042757297"],"corresponding_institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.4689,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.91265995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":"6","first_page":"1575","last_page":"1587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-substrates","display_name":"kinase substrates","score":0.6869999766349792},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.6980000138282776},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8360000252723694},{"id":"https://openalex.org/keywords/lung-epithelial-cells","display_name":"lung epithelial cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/host-cell-signaling","display_name":"host cell signaling","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.8464843034744263},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6772255897521973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5992545485496521},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5562324523925781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5123330354690552},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.4338369369506836},{"id":"https://openalex.org/C163035849","wikidata":"https://www.wikidata.org/wiki/Q15326910","display_name":"MAPK14","level":5,"score":0.4225625991821289},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4095659852027893},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.3737521767616272},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.3666444420814514},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35914134979248047},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.31308698654174805}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jproteome.2c00198","doi":"https://doi.org/10.1021/acs.jproteome.2c00198","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.2c00198","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"doi:10.1101/2022.01.13.476159","doi":"https://doi.org/10.1101/2022.01.13.476159","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.13.476159","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/14/2022.01.13.476159.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:35608653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35608653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2022.01.13.476159","doi":"https://doi.org/10.1101/2022.01.13.476159","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.13.476159","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/14/2022.01.13.476159.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2556487760","display_name":"MSCoreSys-Forschungskern: MSTARS - Multimodale klinische Massenspektometrie f\u00fcr die Untersuchung von Therapieresistenz, Teilprojekt B","funder_award_id":"031L0220B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282945860.pdf","grobid_xml":"https://content.openalex.org/works/W4282945860.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W2012750155","https://openalex.org/W2013743510","https://openalex.org/W2018872127","https://openalex.org/W2022492842","https://openalex.org/W2026926544","https://openalex.org/W2027662098","https://openalex.org/W2035509260","https://openalex.org/W2043274355","https://openalex.org/W2045401053","https://openalex.org/W2079948123","https://openalex.org/W2103174201","https://openalex.org/W2116386978","https://openalex.org/W2130410032","https://openalex.org/W2160379034","https://openalex.org/W2160493566","https://openalex.org/W2266222342","https://openalex.org/W2321570512","https://openalex.org/W2346627954","https://openalex.org/W2395887422","https://openalex.org/W2396033476","https://openalex.org/W2402959660","https://openalex.org/W2519691041","https://openalex.org/W2544360569","https://openalex.org/W2615601352","https://openalex.org/W2683363718","https://openalex.org/W2737196618","https://openalex.org/W2768695173","https://openalex.org/W2786505886","https://openalex.org/W2792087494","https://openalex.org/W2794968531","https://openalex.org/W2805978177","https://openalex.org/W2857722519","https://openalex.org/W2899760200","https://openalex.org/W2900564926","https://openalex.org/W2900884817","https://openalex.org/W2904372598","https://openalex.org/W2912820434","https://openalex.org/W2923849202","https://openalex.org/W2928665623","https://openalex.org/W2951715575","https://openalex.org/W2963950918","https://openalex.org/W2994464657","https://openalex.org/W3009912996","https://openalex.org/W3011725683","https://openalex.org/W3012233242","https://openalex.org/W3016489853","https://openalex.org/W3037945517","https://openalex.org/W3045552416","https://openalex.org/W3108149956","https://openalex.org/W3123118461","https://openalex.org/W3123786390","https://openalex.org/W3127474681","https://openalex.org/W3128962620","https://openalex.org/W3153101885","https://openalex.org/W3184524984","https://openalex.org/W3192210502","https://openalex.org/W3199725740","https://openalex.org/W3216618416"],"related_works":["https://openalex.org/W2266222342","https://openalex.org/W3129695142","https://openalex.org/W4404547573","https://openalex.org/W4280530904","https://openalex.org/W4297237740","https://openalex.org/W3042089959","https://openalex.org/W6902036221","https://openalex.org/W2683363718","https://openalex.org/W2951125349","https://openalex.org/W2442313203"],"abstract_inverted_index":{"ABSTRACT":[0],"Phosphoproteomics":[1],"routinely":[2],"quantifies":[3],"changes":[4,47,98,134],"in":[5,48,68,86,99,102,135],"the":[6,33,49,52,151],"levels":[7],"of":[8,10,16,36,54,122,154],"thousands":[9],"phosphorylation":[11,31],"sites,":[12,32],"but":[13],"functional":[14,152],"analysis":[15,121,153],"such":[17],"data":[18,82],"remains":[19,58],"a":[20,59,117],"major":[21],"challenge.":[22],"While":[23],"databases":[24],"like":[25],"PhosphoSitePlus":[26],"contain":[27],"information":[28],"about":[29],"many":[30],"vast":[34],"majority":[35],"known":[37],"sites":[38],"are":[39],"not":[40],"assigned":[41],"to":[42,51,83,116,149],"any":[43],"protein":[44,74],"kinase.":[45],"Assigning":[46],"phosphoproteome":[50],"activity":[53,101],"individual":[55],"kinases":[56],"therefore":[57],"key":[60],"challenge..":[61],"A":[62],"recent":[63],"large-scale":[64],"study":[65],"systematically":[66],"identified":[67],"vitro":[69,87],"substrates":[70],"for":[71,106,132],"most":[72],"human":[73,125],"kinases.":[75,112],"Here,":[76],"we":[77,142],"reprocessed":[78],"and":[79,109,129],"filtered":[80],"these":[81],"generate":[84],"an":[85],"Kinase-to-Phosphosite":[88],"database":[89],"(iKiP-DB).":[90],"We":[91,113],"show":[92,143],"that":[93,144],"iKiP-DB":[94,115,145],"can":[95],"accurately":[96],"predict":[97],"kinase":[100,138],"published":[103],"phosphoproteomic":[104,120,155],"datasets":[105],"both":[107],"well-studied":[108],"poorly":[110],"characterized":[111],"apply":[114],"newly":[118],"generated":[119],"SARS-CoV-2":[123],"infected":[124],"lung":[126],"epithelial":[127],"cells":[128],"provide":[130],"evidence":[131],"coronavirus-induced":[133],"host":[136],"cell":[137],"activity.":[139],"In":[140],"summary,":[141],"is":[146],"widely":[147],"applicable":[148],"facilitate":[150],"datasets.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":43},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-06-16T00:00:00"}
