{"id":"https://openalex.org/W4282945787","doi":"https://doi.org/10.4103/ijo.ijo_3066_21","title":"Patterns of treatment discontinuation in patients receiving anti-vascular endothelial growth factor for neovascular age-related macular degeneration","display_name":"Patterns of treatment discontinuation in patients receiving anti-vascular endothelial growth factor for neovascular age-related macular degeneration","publication_year":2022,"publication_date":"2022-05-31","ids":{"openalex":"https://openalex.org/W4282945787","doi":"https://doi.org/10.4103/ijo.ijo_3066_21","pmid":"https://pubmed.ncbi.nlm.nih.gov/35647983","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9359266"},"language":"en","primary_location":{"id":"doi:10.4103/ijo.ijo_3066_21","doi":"https://doi.org/10.4103/ijo.ijo_3066_21","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijo.ijo_3066_21","pdf_url":null,"source":{"id":"https://openalex.org/S191336577","display_name":"Indian Journal of Ophthalmology","issn_l":"0301-4738","issn":["0301-4738","1998-3689"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/ijo.ijo_3066_21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070489336","display_name":"Narendra Dhingra","orcid":"https://orcid.org/0000-0002-2785-057X","observed_orcids":["https://orcid.org/0000-0002-2785-057X"]},"institutions":[{"id":"https://openalex.org/I4210160067","display_name":"Mid Yorkshire Hospitals NHS Trust","ror":"https://ror.org/05g23q746","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Narendra Dhingra","raw_affiliation_strings":["Macula Service, Eye Centre, Mid Yorkshire NHS Trust, Wakefield, WF1 2DG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macula Service, Eye Centre, Mid Yorkshire NHS Trust, Wakefield, WF1 2DG, UK","institution_ids":["https://openalex.org/I4210160067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089181046","display_name":"Deepa Upasani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160067","display_name":"Mid Yorkshire Hospitals NHS Trust","ror":"https://ror.org/05g23q746","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deepa Upasani","raw_affiliation_strings":["Macula Service, Eye Centre, Mid Yorkshire NHS Trust, Wakefield, WF1 2DG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macula Service, Eye Centre, Mid Yorkshire NHS Trust, Wakefield, WF1 2DG, UK","institution_ids":["https://openalex.org/I4210160067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030971775","display_name":"Faruque D. Ghanchi","orcid":"https://orcid.org/0000-0002-4448-8162","observed_orcids":["https://orcid.org/0000-0002-4448-8162"]},"institutions":[{"id":"https://openalex.org/I4210166758","display_name":"Bradford Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/05gekvn04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210166758"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faruque D Ghanchi","raw_affiliation_strings":["Bradford Teaching Hospitals, NHS Foundation Trust, Duckworth Lane, Bradford, BD9 6RJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradford Teaching Hospitals, NHS Foundation Trust, Duckworth Lane, Bradford, BD9 6RJ, UK","institution_ids":["https://openalex.org/I4210166758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070489336"],"corresponding_institution_ids":["https://openalex.org/I4210160067"],"apc_list":null,"apc_paid":null,"fwci":2.3966,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.87898502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"6","first_page":"2065","last_page":"2070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9760000109672546},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.8790000081062317},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reasons-for-discontinuation","display_name":"reasons for discontinuation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.49399998784065247},{"id":"https://openalex.org/keywords/visual-acuity-stability","display_name":"visual acuity stability","score":0.7829999923706055},{"id":"https://openalex.org/keywords/baseline-age","display_name":"baseline age","score":0.675000011920929},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7599999904632568},{"id":"https://openalex.org/keywords/follow-up-completion","display_name":"follow-up completion","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9673264026641846},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.936850905418396},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8462471961975098},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.703218936920166},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.48240911960601807},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.42401671409606934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.274647057056427},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.22873979806900024},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.2216096818447113},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0957297682762146}],"mesh":[{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4103/ijo.ijo_3066_21","doi":"https://doi.org/10.4103/ijo.ijo_3066_21","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijo.ijo_3066_21","pdf_url":null,"source":{"id":"https://openalex.org/S191336577","display_name":"Indian Journal of Ophthalmology","issn_l":"0301-4738","issn":["0301-4738","1998-3689"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9359266","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9359266","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Ophthalmol","raw_type":"Text"},{"id":"pmid:35647983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35647983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e369bfcce9ae47f292d4c406cf53697c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e369bfcce9ae47f292d4c406cf53697c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Ophthalmology, Vol 70, Iss 6, Pp 2065-2070 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/ijo.ijo_3066_21","doi":"https://doi.org/10.4103/ijo.ijo_3066_21","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijo.ijo_3066_21","pdf_url":null,"source":{"id":"https://openalex.org/S191336577","display_name":"Indian Journal of Ophthalmology","issn_l":"0301-4738","issn":["0301-4738","1998-3689"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W633153563","https://openalex.org/W1992612246","https://openalex.org/W2004117352","https://openalex.org/W2029718336","https://openalex.org/W2030859223","https://openalex.org/W2068742492","https://openalex.org/W2079794035","https://openalex.org/W2083043469","https://openalex.org/W2093646832","https://openalex.org/W2124415048","https://openalex.org/W2160226180","https://openalex.org/W2322467860","https://openalex.org/W2323455961","https://openalex.org/W2419186472","https://openalex.org/W2509759140","https://openalex.org/W2545751468","https://openalex.org/W2620988129","https://openalex.org/W2766090454","https://openalex.org/W2801761853","https://openalex.org/W2888464051","https://openalex.org/W2913437590","https://openalex.org/W2963350486","https://openalex.org/W2979467486","https://openalex.org/W2989989541","https://openalex.org/W2997212676","https://openalex.org/W3002562981","https://openalex.org/W3008426762","https://openalex.org/W3013512820","https://openalex.org/W3014487234","https://openalex.org/W3047590017","https://openalex.org/W3089306714","https://openalex.org/W3093144182","https://openalex.org/W3110220146"],"related_works":["https://openalex.org/W4324144950","https://openalex.org/W4408775549","https://openalex.org/W4283216963","https://openalex.org/W2322467860","https://openalex.org/W4383822389","https://openalex.org/W3179706923","https://openalex.org/W3125729878","https://openalex.org/W7220705040","https://openalex.org/W2770668652","https://openalex.org/W3195747806"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"report":[2],"the":[3,69,73,88,97,150,169,221,239],"reasons":[4,50,101],"for":[5,21,37,51,83,102,171,243],"treatment":[6,52,103,116,170,195,207,244,257],"discontinuation":[7,104],"within":[8],"5":[9,43,226],"years":[10,44],"in":[11,60,194,213,220,233],"patients":[12,33,92,215,231],"receiving":[13],"intravitreal":[14],"anti-vascular":[15],"endothelial":[16],"growth":[17],"factor":[18,193],"(anti-VEGF)":[19],"therapy":[20,253],"neovascular":[22],"age-related":[23],"macular":[24],"degeneration":[25],"(nAMD).":[26],"Methods:":[27],"A":[28],"retrospective":[29],"case-notes":[30],"review":[31],"of":[32,45,132,146,230],"commenced":[34],"on":[35],"anti-VEGF":[36],"nAMD":[38],"who":[39,148,167],"failed":[40,94],"to":[41,95,111,121],"complete":[42,96],"follow-up":[46,75,152],"was":[47,81,140,162,190,204,216,238],"undertaken.":[48],"The":[49,100,142,209],"discontinuation,":[53],"baseline":[54,56,144,188,247],"age,":[55],"visual":[57,198],"acuity":[58],"(VA)":[59],"Early":[61],"Treatment":[62],"Diabetic":[63],"Retinopathy":[64],"Study":[65],"(ETDRS)":[66],"letters,":[67],"and":[68,130,236,249],"VA":[70,189,250],"change":[71],"at":[72],"last":[74],"were":[76,105,254],"recorded.":[77],"Age-specific":[78],"all-cause":[79,211],"mortality":[80,212],"calculated":[82],"deceased":[84,214],"patients.":[85],"Results:":[86],"Of":[87],"1177":[89],"patients,":[90,137],"551":[91],"(46.8%)":[93],"5-year":[98,151],"follow-up.":[99],"death":[106,237],"(251),":[107],"early":[108],"discharge":[109],"due":[110],"stable":[112],"disease":[113],"(110),":[114],"further":[115],"deemed":[117],"futile":[118],"(100),":[119],"failure":[120],"attend":[122],"(15),":[123],"ill":[124],"health":[125],"(14),":[126],"patient":[127],"choice":[128],"(7),":[129],"transfer":[131],"care":[133],"(1).":[134],"In":[135],"53":[136],"no":[138],"reason":[139,173,242],"documented.":[141],"mean":[143],"age":[145,248],"those":[147,166],"completed":[149],"(77.4":[153],"\u00b1":[154,175],"7.8":[155],"years,":[156,177,227],"95%":[157,178],"confidence":[158],"interval":[159],"(CI):":[160],"76.8-77.9)":[161],"significantly":[163],"lower":[164,217],"than":[165,218],"discontinued":[168],"any":[172],"(82":[174],"7.7":[176],"CI:":[179],"81.4-82.6)":[180],"(P":[181],"<":[182],"0.0001).":[183],"Survival":[184],"analysis":[185],"showed":[186],"that":[187,219],"not":[191],"a":[192],"discontinuation;":[196],"however,":[197],"stability":[199,251],"(\u00b15":[200],"letters":[201],"from":[202],"baseline)":[203],"associated":[205,255],"with":[206,256],"continuation.":[208,258],"age-specific":[210],"general":[222],"population.":[223],"Conclusion:":[224],"At":[225],"only":[228],"53%":[229],"remained":[232],"active":[234],"care,":[235],"most":[240],"common":[241],"discontinuation.":[245],"Lower":[246],"during":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-16T00:00:00"}
