{"id":"https://openalex.org/W4282945181","doi":"https://doi.org/10.1158/1538-7445.am2022-5050","title":"Abstract 5050: Optimizing delivery of combination targeted and chemotherapy in a murine model of HER2+ breast cancer","display_name":"Abstract 5050: Optimizing delivery of combination targeted and chemotherapy in a murine model of HER2+ breast cancer","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282945181","doi":"https://doi.org/10.1158/1538-7445.am2022-5050"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-5050","doi":"https://doi.org/10.1158/1538-7445.am2022-5050","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5050","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060145886","display_name":"Ernesto A. B. F. Lima","orcid":"https://orcid.org/0000-0002-9219-8784","observed_orcids":["https://orcid.org/0000-0002-9219-8784"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernesto A.B.F. Lima","raw_affiliation_strings":["1The University of Texas at Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas at Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023692998","display_name":"Reid A.F. Wyde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reid Wyde","raw_affiliation_strings":["1The University of Texas at Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas at Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027284323","display_name":"Anna G. Sorace","orcid":"https://orcid.org/0000-0002-3640-3966","observed_orcids":["https://orcid.org/0000-0002-3640-3966"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna G. Sorace","raw_affiliation_strings":["2The University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027619317","display_name":"Thomas E. Yankeelov","orcid":"https://orcid.org/0000-0001-6201-3913","observed_orcids":["https://orcid.org/0000-0001-6201-3913"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Yankeelov","raw_affiliation_strings":["1The University of Texas at Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas at Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"5050","last_page":"5050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.949999988079071},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/treatment-optimization","display_name":"treatment optimization","score":0.6110000014305115},{"id":"https://openalex.org/keywords/optimal-control","display_name":"optimal control","score":0.5529999732971191},{"id":"https://openalex.org/keywords/bayesian-model-selection","display_name":"Bayesian model selection","score":0.6909999847412109},{"id":"https://openalex.org/keywords/tumor-growth-kinetics","display_name":"tumor growth kinetics","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.7310000061988831},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.5270000100135803},{"id":"https://openalex.org/keywords/tumor-growth-modeling","display_name":"tumor growth modeling","score":0.4480000138282776},{"id":"https://openalex.org/keywords/treatment-scheduling","display_name":"treatment scheduling","score":0.3050000071525574},{"id":"https://openalex.org/keywords/pharmacokinetics-pharmacodynamics","display_name":"pharmacokinetics/pharmacodynamics","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.8630451560020447},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7151707410812378},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7005209922790527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6821939945220947},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6528570055961609},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.545222818851471},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5355308651924133},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4475657045841217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4298299252986908},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3426426649093628}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-5050","doi":"https://doi.org/10.1158/1538-7445.am2022-5050","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-5050","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4292117282","https://openalex.org/W3027098635","https://openalex.org/W2944165345","https://openalex.org/W2590287097","https://openalex.org/W2100984347","https://openalex.org/W2487027151","https://openalex.org/W4412670261","https://openalex.org/W1983105868","https://openalex.org/W2887880674","https://openalex.org/W2171875712"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"combination":[2,63,374,440],"of":[3,29,40,111,164,173,193,257,287,299,326,373,404,411,439,448,455],"targeted":[4,441],"therapy":[5,64,375,406],"to":[6,23,26,79,143,169,198,218,235,261,329],"the":[7,48,57,70,108,116,145,171,181,199,205,212,220,232,238,243,254,267,277,284,292,296,308,313,342,348,356,371,456],"human":[8,41],"epidermal":[9],"growth":[10,175],"factor":[11],"receptor":[12],"2":[13],"(HER2)":[14],"and":[15,31,45,83,93,106,140,176,185,204,271,321,331,393,401,420,442],"chemotherapy":[16,443],"in":[17,50,202,231,266,269,307,323,407,444],"HER2+":[18,42,150,377,412,449],"breast":[19,43,151,327,378,413,450],"cancer":[20,152,328,418,451],"is":[21,85,89],"known":[22],"increase":[24],"time":[25],"progression,":[27],"duration":[28],"response,":[30],"survival":[32],"rates.":[33],"Previously,":[34],"we":[35,160,252,290,317],"established":[36],"a":[37,98,132,154,162,189,273,367,408,445],"murine":[38,409,446],"model":[39,136,208,233,325,410,447],"cancer,":[44],"investigated":[46],"whether":[47],"sequence":[49],"which":[51,263],"two":[52,248],"drugs":[53,259],"are":[54],"delivered":[55,301],"affected":[56],"treatment":[58,99,128,141,147,177,240,274,293,334],"outcome":[59],"[1].":[60],"However,":[61],"this":[62],"can":[65,337,360],"cause":[66],"cardiac":[67,71],"toxicity.":[68],"While":[69],"damage":[72],"induced":[73],"by":[74,120,211,303],"trastuzumab":[75],"does":[76],"not":[77],"appear":[78],"be":[80,362],"dose":[81,91,110,256],"dependent":[82],"it":[84],"reversible,":[86],"doxorubicin":[87,357],"cardiotoxicity":[88],"cumulative,":[90],"dependent,":[92],"irreversible.":[94],"Thus,":[95,316],"rigorously":[96,330],"identifying":[97],"protocol":[100,148,241],"that":[101,262,305,336],"simultaneously":[102],"maintains":[103],"tumor":[104,174,310,339,350,399],"control":[105,226,340,351],"reduces":[107],"total":[109,255,344],"doxorubicin,":[112],"would":[113],"potentially":[114],"decrease":[115],"side":[117],"effects":[118],"experienced":[119],"patients":[121],"receiving":[122],"these":[123,194],"treatments,":[124],"while":[125],"maintaining":[126],"high":[127],"efficacy.":[129],"We":[130,222,246],"propose":[131],"complete":[133,280],"framework":[134],"for":[135,149,370,376,459],"development,":[137],"calibration,":[138],"selection,":[139],"optimization":[142],"find":[144],"optimal":[146,225,239],"using":[153,242],"trastuzumab-doxorubicin":[155],"combination.":[156],"To":[157],"do":[158],"so,":[159],"constructed":[161],"family":[163],"ten":[165],"mathematical":[166,319],"models":[167,182,195],"designed":[168],"characterize":[170],"dynamics":[172],"response.":[178],"In":[179],"particular,":[180],"included":[183],"tumor-drug":[184],"drug-drug":[186],"interactions.":[187],"Using":[188],"Bayesian":[190,213],"framework,":[191],"each":[192],"were":[196],"calibrated":[197],"data":[200],"obtained":[201],"[1],":[203,270],"most":[206],"parsimonious":[207],"as":[209,312],"determined":[210],"information":[214],"criterion":[215],"was":[216,264],"selected":[217,244],"represent":[219],"system.":[221],"then":[223],"applied":[224],"theory":[227],"(while":[228],"considering":[229],"uncertainty":[230],"parameters)":[234],"systematically":[236,332],"identify":[237,333],"model.":[245],"had":[247],"major":[249],"findings.":[250],"First,":[251],"kept":[253],"both":[258],"fixed":[260],"employed":[265,318],"experiments":[268],"identified":[272],"schema":[275,294],"where":[276],"tumors":[278],"showed":[279],"regression":[281],"without":[282],"increasing":[283],"overall":[285],"amount":[286,298],"therapy.":[288],"Then,":[289],"found":[291],"with":[295,341,352],"least":[297],"drug":[300],"(decreased":[302],"58%)":[304],"resulted":[306],"same":[309,343,349],"kinetics":[311],"experimental":[314],"results.":[315,416],"modeling":[320],"an":[322],"vivo":[324],"protocols":[335],"improve":[338],"dose,":[345],"or":[346],"achieve":[347],"less":[353],"than":[354],"half":[355],"dose.":[358],"Predictions":[359],"now":[361],"tested":[363],"experimentally.":[364],"This":[365],"has":[366],"significant":[368],"impact":[369],"design":[372],"cancer.":[379],"[1]":[380],"Sorace,":[381,433],"A.G.,":[382],"Quarles,":[383],"C.C.,":[384],"Whisenant,":[385],"J.G.,":[386],"Hanker,":[387],"A.B.,":[388],"McIntyre,":[389],"J.O.,":[390],"Sanchez,":[391],"V.M.":[392],"Yankeelov,":[394],"T.E.,":[395],"2016.":[396],"Trastuzumab":[397],"improves":[398],"perfusion":[400],"vascular":[402],"delivery":[403,438],"cytotoxic":[405],"cancer:":[414],"preliminary":[415],"Breast":[417],"research":[419],"treatment,":[421],"155(2),":[422],"pp.273-284.":[423],"Citation":[424],"Format:":[425],"Ernesto":[426],"A.B.F.":[427],"Lima,":[428],"Reid":[429],"Wyde,":[430],"Anna":[431],"G.":[432],"Thomas":[434],"E.":[435],"Yankeelov.":[436],"Optimizing":[437],"[abstract].":[452],"In:":[453],"Proceedings":[454],"American":[457],"Association":[458],"Cancer":[460,471],"Research":[461],"Annual":[462],"Meeting":[463],"2022;":[464],"2022":[465],"Apr":[466],"8-13.":[467],"Philadelphia":[468],"(PA):":[469],"AACR;":[470],"Res":[472],"2022;82(12_Suppl):Abstract":[473],"nr":[474],"5050.":[475]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2022-06-16T00:00:00"}
