{"id":"https://openalex.org/W4282943645","doi":"https://doi.org/10.1158/1538-7445.am2022-6372","title":"Abstract 6372: Nanodrug delivery system for non-genotoxic p53 activator INZ-C","display_name":"Abstract 6372: Nanodrug delivery system for non-genotoxic p53 activator INZ-C","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282943645","doi":"https://doi.org/10.1158/1538-7445.am2022-6372"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-6372","doi":"https://doi.org/10.1158/1538-7445.am2022-6372","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-6372","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001980514","display_name":"Nimisha Bhattarai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nimisha Bhattarai","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100785368","display_name":"Jieqiong Wang","orcid":"https://orcid.org/0000-0003-3096-0208","observed_orcids":["https://orcid.org/0000-0003-3096-0208"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieqiong Wang","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061430220","display_name":"Daniel Nguyen","orcid":"https://orcid.org/0000-0003-3157-8107","observed_orcids":["https://orcid.org/0000-0003-3157-8107"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Nguyen","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003446542","display_name":"Xiaoxiao Yang","orcid":"https://orcid.org/0000-0002-7372-2931","observed_orcids":["https://orcid.org/0000-0002-7372-2931"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxiao Yang","raw_affiliation_strings":["2Georgia State University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Georgia State University, Atlanta, GA;","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084187649","display_name":"Linh Helmers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linh Helmers","raw_affiliation_strings":["3Ochsner Clinic Foundation, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Ochsner Clinic Foundation, New Orleans, LA","institution_ids":["https://openalex.org/I2799767083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062897540","display_name":"Jennifer Leigh Paruch","orcid":"https://orcid.org/0000-0003-0668-1890","observed_orcids":["https://orcid.org/0000-0003-0668-1890","https://orcid.org/0000-0001-5991-6097"]},"institutions":[{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Paruch","raw_affiliation_strings":["3Ochsner Clinic Foundation, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Ochsner Clinic Foundation, New Orleans, LA","institution_ids":["https://openalex.org/I2799767083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361348","display_name":"Li Li","orcid":"https://orcid.org/0000-0003-2342-3658","observed_orcids":["https://orcid.org/0000-0003-2342-3658","https://orcid.org/0009-0002-6853-3631"]},"institutions":[{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["3Ochsner Clinic Foundation, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Ochsner Clinic Foundation, New Orleans, LA","institution_ids":["https://openalex.org/I2799767083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030306","display_name":"Yi-Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiwei Zhang","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080310210","display_name":"Kun Meng","orcid":"https://orcid.org/0009-0008-0235-7739","observed_orcids":["https://orcid.org/0009-0008-0235-7739","https://orcid.org/0000-0002-5272-2828"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Meng","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076467690","display_name":"Alun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alun Wang","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022001087","display_name":"Janarthanan Jayawickramarajah","orcid":"https://orcid.org/0000-0001-5271-1523","observed_orcids":["https://orcid.org/0000-0001-5271-1523"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janarthanan Jayawickramarajah","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044174487","display_name":"Binghe Wang","orcid":"https://orcid.org/0000-0002-2200-5270","observed_orcids":["https://orcid.org/0000-0002-2200-5270"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binghe Wang","raw_affiliation_strings":["2Georgia State University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Georgia State University, Atlanta, GA;","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043299001","display_name":"Shelya X. Zeng","orcid":"https://orcid.org/0000-0001-5195-9420","observed_orcids":["https://orcid.org/0000-0001-5195-9420"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelya Zeng","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061151351","display_name":"Hua Lu","orcid":"https://orcid.org/0000-0002-9285-7209","observed_orcids":["https://orcid.org/0000-0002-9285-7209"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Lu","raw_affiliation_strings":["1Tulane University School of Medicine, New Orleans, LA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tulane University School of Medicine, New Orleans, LA;","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"6372","last_page":"6372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-activators","display_name":"p53 activators","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.6660000085830688},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cell-migration-inhibition","display_name":"cell migration inhibition","score":0.6800000071525574},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4440000057220459},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6019594669342041},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4101807475090027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35538920760154724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35306018590927124},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3288625478744507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09201109409332275}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-6372","doi":"https://doi.org/10.1158/1538-7445.am2022-6372","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-6372","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3161833978","https://openalex.org/W3043139925","https://openalex.org/W2093709098","https://openalex.org/W2207617810","https://openalex.org/W1232749538","https://openalex.org/W2767604091","https://openalex.org/W2766398682","https://openalex.org/W4389560287","https://openalex.org/W2066651265","https://openalex.org/W2213043382"],"abstract_inverted_index":{"Abstract":[0],"p53":[1,58,100,344],"is":[2,10,21],"a":[3,48,55,79,114,228,284,297,304],"known":[4],"tumor":[5],"suppressor":[6],"protein":[7],"whose":[8],"gene":[9],"altered":[11],"in":[12,23,78,86,107,170,183,219,268],"50%":[13],"of":[14,85,96,104,145,168,193,210,217,232,239,246,262,294,307,350],"all":[15],"human":[16],"cancers,":[17,111],"while":[18,112,212],"its":[19],"function":[20],"inactivated":[22],"the":[24,65,73,128,140,163,191,214,243,260,290,351],"many":[25],"cancers":[26],"harboring":[27],"wild":[28],"type":[29],"p53,":[30],"making":[31],"it":[32],"an":[33,61],"attractive":[34],"target":[35,231,306],"for":[36,117,134,147,266,342,354],"targeted":[37],"cancer":[38,141,252,269],"therapies.":[39],"In":[40,60,222],"this":[41],"regard,":[42],"our":[43],"lab":[44],"had":[45],"previously":[46],"discovered":[47],"small":[49,76],"molecule,":[50],"Inauhzin":[51],"(INZ":[52],"C),":[53],"as":[54,137,158,172,227,271,296],"potent":[56],"non-genotoxic":[57,343],"activator.":[59],"effort":[62],"to":[63,139,155,165,197,273],"improve":[64],"bioavailability":[66,209,291],"and":[67,90,102,109,119,178,208,234,250,292,301],"efficacy,":[68],"we":[69,224,281],"have":[70,282],"now":[71,256],"encapsulated":[72],"INZ":[74],"C":[75],"molecule":[77],"chitosan/cyclodextrin":[80],"nanoparticle":[81,94,188,204,285],"delivery":[82,340],"system.":[83],"Evaluation":[84],"vitro/in":[87],"vivo":[88,184],"activity":[89,207],"protien":[91],"expression":[92],"suggests":[93,187],"encapsulation":[95,189,205],"INZ-C":[97,194,211,218,233,247,267,295,346],"(n-INZ-C)":[98],"improved":[99,206],"induction":[101],"inhibition":[103],"cell":[105],"growth":[106],"lung":[108,249],"colorectal":[110,251],"maintaining":[113,213],"minimal":[115],"effect":[116,245],"MEF":[118],"Wi38":[120],"normal":[121,135,220,274],"cells.":[122,142,221,275],"These":[123,200],"results":[124,201,278],"are":[125],"consistent":[126],"with":[127,150],"significantly":[129],"reduced":[130],"cellular":[131,264],"uptake":[132,265],"observed":[133],"cells":[136,169,270],"compared":[138],"H/E":[143],"staining":[144],"tissues":[146],"mice":[148],"treated":[149],"n-INZ-C":[151,161],"reveals":[152],"no":[153],"toxicity":[154],"other":[156],"organs":[157],"well.":[159],"Additionally,":[160],"demonstrates":[162],"ability":[164],"block":[166],"migration":[167,180],"vitro":[171],"demonstrated":[173],"by":[174],"both":[175],"wound":[176],"healing":[177],"trans-well":[179],"assays.":[181],"Our":[182],"pharmacokinetic":[185],"evaluation":[186],"doubles":[190],"half-life":[192],"from":[195],"2.5":[196],"5":[198],"h.":[199],"suggest":[202],"that":[203,237,280,287],"non-toxic":[215],"nature":[216],"addition,":[223],"unveiled":[225],"GRP78":[226,240],"potential":[229,298],"new":[230],"found":[235],"out":[236],"knockdown":[238],"can":[241],"alleviate":[242],"inhibitory":[244],"on":[248,258],"proliferation.":[253],"Further":[254],"studies":[255],"focus":[257],"revealing":[259],"mechanism":[261],"enhanced":[263],"comapred":[272],"Thus,":[276],"these":[277],"demonstrate":[279],"established":[283],"system":[286,341],"could":[288],"enhance":[289],"efficacy":[293],"anti-cancer":[299],"therapeutic":[300],"also":[302],"identified":[303],"novel":[305],"INZ-C.":[308],"Citation":[309],"Format:":[310],"Nimisha":[311],"Bhattarai,":[312],"Jieqiong":[313],"Wang,":[314,330,334],"Daniel":[315],"Nguyen,":[316],"Xiaoxiao":[317],"Yang,":[318],"Linh":[319],"Helmers,":[320],"Jennifer":[321],"Paruch,":[322],"Li":[323],"Li,":[324],"Yiwei":[325],"Zhang,":[326],"Kun":[327],"Meng,":[328],"Alun":[329],"Janarthanan":[331],"Jayawickramarajah,":[332],"Binghe":[333],"Shelya":[335],"Zeng,":[336],"Hua":[337],"Lu.":[338],"Nanodrug":[339],"activator":[345],"[abstract].":[347],"In:":[348],"Proceedings":[349],"American":[352],"Association":[353],"Cancer":[355,366],"Research":[356],"Annual":[357],"Meeting":[358],"2022;":[359],"2022":[360],"Apr":[361],"8-13.":[362],"Philadelphia":[363],"(PA):":[364],"AACR;":[365],"Res":[367],"2022;82(12_Suppl):Abstract":[368],"nr":[369],"6372.":[370]},"counts_by_year":[],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2022-06-16T00:00:00"}