{"id":"https://openalex.org/W4282942923","doi":"https://doi.org/10.1152/jn.00015.2022","title":"Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats","display_name":"Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282942923","doi":"https://doi.org/10.1152/jn.00015.2022","pmid":"https://pubmed.ncbi.nlm.nih.gov/35704395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9448344"},"language":"en","primary_location":{"id":"doi:10.1152/jn.00015.2022","doi":"https://doi.org/10.1152/jn.00015.2022","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00015.2022","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9448344","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082691755","display_name":"Cleyton Roberto Sobrinho","orcid":"https://orcid.org/0000-0002-1472-7169","observed_orcids":["https://orcid.org/0000-0002-1472-7169"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"C. R. Sobrinho","raw_affiliation_strings":["Department of Physiology and Biophysics, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":"https://orcid.org/0000-0002-1472-7169","affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045239655","display_name":"Brenda M. Milla","orcid":"https://orcid.org/0000-0002-4362-3879","observed_orcids":["https://orcid.org/0000-0002-4362-3879"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. M. Milla","raw_affiliation_strings":["Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":"https://orcid.org/0000-0002-4362-3879","affiliations":[{"raw_affiliation_string":"Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080304855","display_name":"Jaseph Soto\u2010Perez","orcid":"https://orcid.org/0000-0001-9602-9796","observed_orcids":["https://orcid.org/0000-0001-9602-9796"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Soto-Perez","raw_affiliation_strings":["Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":"https://orcid.org/0000-0001-9602-9796","affiliations":[{"raw_affiliation_string":"Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000159819","display_name":"Thiago Santos Moreira","orcid":"https://orcid.org/0000-0002-9789-8296","observed_orcids":["https://orcid.org/0000-0002-9789-8296"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"T. S. Moreira","raw_affiliation_strings":["Department of Physiology and Biophysics, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016747509","display_name":"Daniel Kent Mulkey","orcid":"https://orcid.org/0000-0002-7040-3927","observed_orcids":["https://orcid.org/0000-0002-7040-3927"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. K. Mulkey","raw_affiliation_strings":["Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":"https://orcid.org/0000-0002-7040-3927","affiliations":[{"raw_affiliation_string":"Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000159819","https://openalex.org/A5016747509"],"corresponding_institution_ids":["https://openalex.org/I140172145","https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":0.3949,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.4965035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"128","issue":"1","first_page":"218","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.7559999823570251},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/retrotrapezoid-nucleus","display_name":"retrotrapezoid nucleus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chemosensitive-neurons","display_name":"chemosensitive neurons","score":0.9610000252723694},{"id":"https://openalex.org/keywords/respiratory-activity","display_name":"respiratory activity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gq-coupled-receptors","display_name":"Gq-coupled receptors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/receptor-coactivation","display_name":"receptor coactivation","score":0.4449999928474426},{"id":"https://openalex.org/keywords/chemosensory-neurons","display_name":"chemosensory neurons","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6871498227119446},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6179558038711548},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5799206495285034},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5585541725158691},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5100396275520325},{"id":"https://openalex.org/C159545944","wikidata":"https://www.wikidata.org/wiki/Q424228","display_name":"Histamine receptor","level":4,"score":0.4682304263114929},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.46095114946365356},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.45944416522979736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41544508934020996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3773611783981323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32952550053596497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30742624402046204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25767531991004944},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.07878756523132324}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002628","descriptor_name":"Chemoreceptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011969","descriptor_name":"Receptors, Histamine H1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012125","descriptor_name":"Respiratory Center","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/jn.00015.2022","doi":"https://doi.org/10.1152/jn.00015.2022","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00015.2022","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9448344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9448344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurophysiol","raw_type":"Text"},{"id":"pmid:35704395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35704395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9448344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9448344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurophysiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1017732764","display_name":"Proposed roles of KCNQ2 Channels in Respiratory Homeostasis","funder_award_id":"F31HL156470","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3497616225","display_name":"Roles of glycinergic neurons in Dravet syndrome-associated disordered breathing and mortality","funder_award_id":"F31NS120467","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5120052177","display_name":null,"funder_award_id":"2016/23077-7 and 2015/12827-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G6168591780","display_name":null,"funder_award_id":"302334/2019-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G706045820","display_name":null,"funder_award_id":"2015/23376- 1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7516160743","display_name":"Glial chemosensitivity and control of breathing in Rett syndrome","funder_award_id":"R01HL104101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8122396338","display_name":null,"funder_award_id":"302334/2019-0","funder_id":"https://openalex.org/F4320321992","funder_display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o"},{"id":"https://openalex.org/G9000919101","display_name":"Role of KCNQ2 Channels in Control of Breathing","funder_award_id":"R01HL137094","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W170103974","https://openalex.org/W172319011","https://openalex.org/W1562584139","https://openalex.org/W1608536970","https://openalex.org/W1630221132","https://openalex.org/W1965692586","https://openalex.org/W1966673781","https://openalex.org/W1979393415","https://openalex.org/W1995529564","https://openalex.org/W2009922675","https://openalex.org/W2022086733","https://openalex.org/W2028620427","https://openalex.org/W2035415038","https://openalex.org/W2037495834","https://openalex.org/W2040641770","https://openalex.org/W2045581716","https://openalex.org/W2055603755","https://openalex.org/W2057992483","https://openalex.org/W2058128613","https://openalex.org/W2070440536","https://openalex.org/W2070533285","https://openalex.org/W2076493317","https://openalex.org/W2080497068","https://openalex.org/W2093718419","https://openalex.org/W2123035658","https://openalex.org/W2137964190","https://openalex.org/W2201267419","https://openalex.org/W2216283412","https://openalex.org/W2256519349","https://openalex.org/W2287935024","https://openalex.org/W2430628868","https://openalex.org/W2752237874","https://openalex.org/W2785600426","https://openalex.org/W2794520513","https://openalex.org/W2891266274","https://openalex.org/W2911854457","https://openalex.org/W2981089455","https://openalex.org/W3001428179","https://openalex.org/W3035695799","https://openalex.org/W3179879510","https://openalex.org/W3203558537"],"related_works":["https://openalex.org/W3172657621","https://openalex.org/W2072640381","https://openalex.org/W1978788897","https://openalex.org/W1980905046","https://openalex.org/W1979208669","https://openalex.org/W261954364","https://openalex.org/W2137964190","https://openalex.org/W786156271","https://openalex.org/W2430628868","https://openalex.org/W2033870227"],"abstract_inverted_index":{"Histamine/H1":[0],"receptor":[1],"signaling":[2],"activates":[3],"retrotrapezoid":[4],"(RTN)":[5],"neurons":[6,25],"under":[7],"control":[8],"conditions":[9],"and":[10],"to":[11,30,32],"a":[12,27],"lesser":[13],"extent":[14],"in":[15],"the":[16],"presence":[17],"of":[18,35],"serotonin.":[19],"These":[20],"results":[21],"suggest":[22],"that":[23],"RTN":[24],"have":[26],"limited":[28],"capacity":[29],"respond":[31],"simultaneous":[33],"activation":[34],"multiple":[36],"Gq-coupled":[37],"receptors.":[38]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-06-16T00:00:00"}