{"id":"https://openalex.org/W4282942840","doi":"https://doi.org/10.1039/d2ay00068g","title":"Simultaneous quantification of oligo-nucleic acids and a ferritin nanocage by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry for developing drug delivery systems","display_name":"Simultaneous quantification of oligo-nucleic acids and a ferritin nanocage by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry for developing drug delivery systems","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4282942840","doi":"https://doi.org/10.1039/d2ay00068g","pmid":"https://pubmed.ncbi.nlm.nih.gov/35616084"},"language":"en","primary_location":{"id":"doi:10.1039/d2ay00068g","doi":"https://doi.org/10.1039/d2ay00068g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2ay00068g","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056551425","display_name":"Junko Yamazaki","orcid":"https://orcid.org/0000-0001-5818-607X","observed_orcids":["https://orcid.org/0000-0001-5818-607X"]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junko Yamazaki","raw_affiliation_strings":["Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5818-607X","affiliations":[{"raw_affiliation_string":"Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan","institution_ids":["https://openalex.org/I4210146667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036607084","display_name":"Ippei Inoue","orcid":"https://orcid.org/0000-0001-8329-4822","observed_orcids":["https://orcid.org/0000-0001-8329-4822"]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ippei Inoue","raw_affiliation_strings":["Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8329-4822","affiliations":[{"raw_affiliation_string":"Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan","institution_ids":["https://openalex.org/I4210146667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028496075","display_name":"Akihiro Arakawa","orcid":"https://orcid.org/0000-0001-7144-1928","observed_orcids":["https://orcid.org/0000-0001-7144-1928"]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Arakawa","raw_affiliation_strings":["Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7144-1928","affiliations":[{"raw_affiliation_string":"Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan","institution_ids":["https://openalex.org/I4210146667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025324284","display_name":"Sachise Karakawa","orcid":"https://orcid.org/0000-0003-1272-3348","observed_orcids":["https://orcid.org/0000-0003-1272-3348"]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sachise Karakawa","raw_affiliation_strings":["Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan","institution_ids":["https://openalex.org/I4210146667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062265263","display_name":"Kazutoshi Takahashi","orcid":"https://orcid.org/0000-0003-3275-4109","observed_orcids":["https://orcid.org/0000-0003-3275-4109"]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutoshi Takahashi","raw_affiliation_strings":["Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan","institution_ids":["https://openalex.org/I4210146667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021870144","display_name":"Akira Nakayama","orcid":"https://orcid.org/0000-0002-1084-494X","observed_orcids":["https://orcid.org/0000-0002-1084-494X"]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Nakayama","raw_affiliation_strings":["Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-8681, Japan","institution_ids":["https://openalex.org/I4210146667"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056551425"],"corresponding_institution_ids":["https://openalex.org/I4210146667"],"apc_list":null,"apc_paid":null,"fwci":0.3538,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.40859724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"22","first_page":"2219","last_page":"2226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.11720000207424164,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferritin-nanocages","display_name":"ferritin nanocages","score":0.9290000200271606},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.734000027179718},{"id":"https://openalex.org/keywords/external-calibration","display_name":"external calibration","score":0.6600000262260437},{"id":"https://openalex.org/keywords/encapsulation-mechanism","display_name":"encapsulation mechanism","score":0.7480000257492065},{"id":"https://openalex.org/keywords/surface-charge","display_name":"surface charge","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C128355301","wikidata":"https://www.wikidata.org/wiki/Q6964001","display_name":"Nanocages","level":3,"score":0.7944240570068359},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7500221133232117},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7008213996887207},{"id":"https://openalex.org/C165697059","wikidata":"https://www.wikidata.org/wiki/Q900680","display_name":"Inductively coupled plasma mass spectrometry","level":3,"score":0.5618870258331299},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5546582341194153},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.4552742838859558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08786317706108093},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d2ay00068g","doi":"https://doi.org/10.1039/d2ay00068g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2ay00068g","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},{"id":"pmid:35616084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35616084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical methods : advancing methods and applications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1611419331","https://openalex.org/W1640556854","https://openalex.org/W1976684284","https://openalex.org/W1986584436","https://openalex.org/W1991185679","https://openalex.org/W2003193147","https://openalex.org/W2010700500","https://openalex.org/W2020065558","https://openalex.org/W2024911412","https://openalex.org/W2026042343","https://openalex.org/W2035110063","https://openalex.org/W2046059896","https://openalex.org/W2056603750","https://openalex.org/W2073424598","https://openalex.org/W2073485851","https://openalex.org/W2075996059","https://openalex.org/W2098820480","https://openalex.org/W2103244649","https://openalex.org/W2125944823","https://openalex.org/W2127099679","https://openalex.org/W2166869734","https://openalex.org/W2343116876","https://openalex.org/W2346093878","https://openalex.org/W2592524531","https://openalex.org/W2593574576","https://openalex.org/W2608650209","https://openalex.org/W2783757852","https://openalex.org/W2795569119","https://openalex.org/W2810909862","https://openalex.org/W2883853054","https://openalex.org/W2893168313","https://openalex.org/W2909972664","https://openalex.org/W2970857327","https://openalex.org/W2981778602","https://openalex.org/W3017832738","https://openalex.org/W3042904291","https://openalex.org/W3048788919","https://openalex.org/W3097547374","https://openalex.org/W3116314583","https://openalex.org/W3121560287","https://openalex.org/W3139242990","https://openalex.org/W3161179695"],"related_works":["https://openalex.org/W4380358561","https://openalex.org/W4248728278","https://openalex.org/W2057489002","https://openalex.org/W1982933653","https://openalex.org/W4294859133","https://openalex.org/W2077177787","https://openalex.org/W7163197998","https://openalex.org/W2785535190","https://openalex.org/W4366251445","https://openalex.org/W92026218"],"abstract_inverted_index":{"An":[0],"analytical":[1,126],"methodology,":[2],"which":[3],"can":[4],"quantify":[5],"nucleic":[6,50,66,77,83,169],"acids,":[7],"ferritin":[8,39,86],"nanocages,":[9],"and":[10,38,54,85,95,130],"their":[11],"complexes":[12],"in":[13,143,148,189,208],"a":[14,110],"single":[15],"injection,":[16],"was":[17,69,101,132],"established":[18],"by":[19,79,104,161],"means":[20],"of":[21,49,93,112,152,168,180,199],"size-exclusion":[22],"chromatography":[23],"hyphenated":[24],"with":[25],"inductively":[26],"coupled":[27],"plasma":[28],"mass":[29],"spectrometry":[30],"(SEC-ICP-MS).":[31],"In":[32],"this":[33,153,190],"study,":[34,154],"several":[35],"oligo-nucleic":[36],"acids":[37,78,84,170],"(a":[40],"human-derived":[41],"cage-shaped":[42],"protein)":[43],"were":[44,87],"used":[45],"as":[46],"model":[47],"compounds":[48],"acid":[51],"drugs":[52],"(NAD)":[53],"drug":[55,123],"delivery":[56],"system":[57],"(DDS)":[58],"carriers,":[59],"respectively.":[60,98],"A":[61],"fraction":[62],"based":[63,74,89,202],"on":[64,75,90,203],"the":[65,91,139,144,149,155,164,173,178,186,193,197,209],"acid-ferritin":[67],"complex":[68],"completely":[70],"distinguished":[71],"from":[72],"one":[73],"free":[76],"SEC":[80],"separation.":[81],"The":[82,99,125],"quantified":[88],"number":[92,179],"phosphorus":[94],"sulfur":[96],"atoms,":[97],"quantification":[100],"carried":[102],"out":[103],"an":[105],"external":[106],"calibration":[107],"method":[108],"using":[109],"series":[111],"elemental":[113],"standard":[114,119],"solutions":[115],"without":[116],"preparing":[117],"designated":[118],"materials":[120],"for":[121,137],"each":[122],"candidate.":[124],"performance,":[127],"including":[128],"sensitivity":[129],"accuracy,":[131],"evaluated":[133],"to":[134,177,195,205],"be":[135],"appropriate":[136],"evaluating":[138],"medicines":[140],"already":[141],"launched":[142],"market.":[145],"As":[146],"demonstrated":[147],"latter":[150],"part":[151],"encapsulation":[156],"mechanism":[157],"is":[158],"possibly":[159],"regulated":[160],"not":[162],"only":[163],"averaged":[165],"molecular":[166],"size":[167],"but":[171],"also":[172],"surface":[174],"charge":[175],"related":[176],"(deoxy-)":[181],"ribonucleotides.":[182],"We":[183],"believe":[184],"that":[185],"methodology":[187],"presented":[188],"study":[191],"has":[192],"potential":[194],"accelerate":[196],"development":[198],"new":[200],"modalities":[201],"NAD-DDS":[204],"realize":[206],"therapies":[207],"future.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-16T00:00:00"}
