{"id":"https://openalex.org/W4282942500","doi":"https://doi.org/10.3390/molecules27123832","title":"Recent Developments to Cope the Antibacterial Resistance via \u03b2-Lactamase Inhibition","display_name":"Recent Developments to Cope the Antibacterial Resistance via \u03b2-Lactamase Inhibition","publication_year":2022,"publication_date":"2022-06-14","ids":{"openalex":"https://openalex.org/W4282942500","doi":"https://doi.org/10.3390/molecules27123832","pmid":"https://pubmed.ncbi.nlm.nih.gov/35744953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9227086"},"language":"en","primary_location":{"id":"doi:10.3390/molecules27123832","doi":"https://doi.org/10.3390/molecules27123832","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27123832","pdf_url":"https://www.mdpi.com/1420-3049/27/12/3832/pdf?version=1655373136","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/27/12/3832/pdf?version=1655373136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076835208","display_name":"Zafar M. Iqbal","orcid":"https://orcid.org/0000-0002-0387-0920","observed_orcids":["https://orcid.org/0000-0002-0387-0920"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zafar Iqbal","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":"https://orcid.org/0000-0002-0387-0920","affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031873929","display_name":"Jian Sun","orcid":"https://orcid.org/0000-0002-3445-5391","observed_orcids":["https://orcid.org/0000-0002-3445-5391"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Sun","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061425782","display_name":"Haikang Yang","orcid":"https://orcid.org/0000-0001-8570-7301","observed_orcids":["https://orcid.org/0000-0001-8570-7301"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haikang Yang","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037804421","display_name":"Jingwen Ji","orcid":"https://orcid.org/0009-0007-0556-6272","observed_orcids":["https://orcid.org/0009-0007-0556-6272","https://orcid.org/0009-0006-0543-2373","https://orcid.org/0000-0001-5254-4569"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Ji","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062826296","display_name":"Lili He","orcid":"https://orcid.org/0000-0002-4118-5377","observed_orcids":["https://orcid.org/0000-0002-4118-5377"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili He","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085191170","display_name":"Lijuan Zhai","orcid":"https://orcid.org/0000-0002-9029-4342","observed_orcids":["https://orcid.org/0000-0002-9029-4342"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Zhai","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032898109","display_name":"Jinbo Ji","orcid":"https://orcid.org/0009-0008-7979-2691","observed_orcids":["https://orcid.org/0009-0008-7979-2691"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinbo Ji","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080182416","display_name":"Pengjuan Zhou","orcid":"https://orcid.org/0000-0001-9743-5083","observed_orcids":["https://orcid.org/0000-0001-9743-5083"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengjuan Zhou","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080877271","display_name":"Dong Tang","orcid":"https://orcid.org/0000-0002-4667-6239","observed_orcids":["https://orcid.org/0000-0002-4667-6239"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Tang","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":"https://orcid.org/0000-0002-4667-6239","affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077879764","display_name":"Yangxiu Mu","orcid":"https://orcid.org/0000-0003-4358-9030","observed_orcids":["https://orcid.org/0000-0003-4358-9030"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangxiu Mu","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403244","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0003-2482-7638","observed_orcids":["https://orcid.org/0000-0003-2482-7638"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058670767","display_name":"Zhixiang Yang","orcid":"https://orcid.org/0000-0002-3681-3850","observed_orcids":["https://orcid.org/0000-0002-3681-3850"]},"institutions":[{"id":"https://openalex.org/I4210104344","display_name":"Ningxia Academy of Agriculture and Forestry Sciences","ror":"https://ror.org/019dkz313","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104344"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhixiang Yang","raw_affiliation_strings":["Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China","institution_ids":["https://openalex.org/I4210104344"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031873929","https://openalex.org/A5058670767","https://openalex.org/A5076835208"],"corresponding_institution_ids":["https://openalex.org/I4210104344"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.2745,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.25798526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"12","first_page":"3832","last_page":"3832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.8730000257492065},{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"clavulanic acid","score":0.8669999837875366},{"id":"https://openalex.org/keywords/avibactam","display_name":"avibactam","score":0.9940000176429749},{"id":"https://openalex.org/keywords/relebactam","display_name":"relebactam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vaborbactam","display_name":"vaborbactam","score":0.8859999775886536},{"id":"https://openalex.org/keywords/boronic-acid-derivatives","display_name":"boronic acid derivatives","score":0.7879999876022339},{"id":"https://openalex.org/keywords/metallo-beta-lactamase","display_name":"metallo-beta-lactamase","score":0.8510000109672546},{"id":"https://openalex.org/keywords/serine-beta-lactamases","display_name":"serine beta-lactamases","score":0.9440000057220459},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.3619999885559082},{"id":"https://openalex.org/keywords/synthetic-strategies","display_name":"synthetic strategies","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2777406300","wikidata":"https://www.wikidata.org/wiki/Q15410251","display_name":"Avibactam","level":5,"score":0.636635959148407},{"id":"https://openalex.org/C2777864310","wikidata":"https://www.wikidata.org/wiki/Q335768","display_name":"Boronic acid","level":2,"score":0.5312953591346741},{"id":"https://openalex.org/C2910641391","wikidata":"https://www.wikidata.org/wiki/Q310286","display_name":"Beta-Lactamase Inhibitors","level":3,"score":0.4825105667114258},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35433337092399597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3430023193359375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3086874186992645},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.28695225715637207},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2648499608039856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24050360918045044},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.12866628170013428},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules27123832","doi":"https://doi.org/10.3390/molecules27123832","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27123832","pdf_url":"https://www.mdpi.com/1420-3049/27/12/3832/pdf?version=1655373136","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9227086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9227086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:35744953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35744953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:029785a3f66c462296c76f736aebb728","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/029785a3f66c462296c76f736aebb728","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 27, Iss 12, p 3832 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules27123832","doi":"https://doi.org/10.3390/molecules27123832","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27123832","pdf_url":"https://www.mdpi.com/1420-3049/27/12/3832/pdf?version=1655373136","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5091605378","display_name":null,"funder_award_id":"2018BCG01001","funder_id":"https://openalex.org/F4320316092","funder_display_name":"Science and Technology Department of Ningxia"}],"funders":[{"id":"https://openalex.org/F4320316092","display_name":"Science and Technology Department of Ningxia","ror":"https://ror.org/040ebrp24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282942500.pdf","grobid_xml":"https://content.openalex.org/works/W4282942500.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W101545445","https://openalex.org/W1619683848","https://openalex.org/W1816216527","https://openalex.org/W1907889903","https://openalex.org/W1929522087","https://openalex.org/W1952701900","https://openalex.org/W1968310807","https://openalex.org/W1974785783","https://openalex.org/W2009005630","https://openalex.org/W2010856072","https://openalex.org/W2011886013","https://openalex.org/W2018478612","https://openalex.org/W2041092021","https://openalex.org/W2045211463","https://openalex.org/W2050384005","https://openalex.org/W2050554411","https://openalex.org/W2054730194","https://openalex.org/W2071157096","https://openalex.org/W2095685393","https://openalex.org/W2096489042","https://openalex.org/W2102208951","https://openalex.org/W2108638835","https://openalex.org/W2117208569","https://openalex.org/W2126620965","https://openalex.org/W2132915558","https://openalex.org/W2133776410","https://openalex.org/W2143874510","https://openalex.org/W2146401071","https://openalex.org/W2152127318","https://openalex.org/W2165321807","https://openalex.org/W2232240604","https://openalex.org/W2312102558","https://openalex.org/W2316777574","https://openalex.org/W2324703872","https://openalex.org/W2324834410","https://openalex.org/W2333126666","https://openalex.org/W2339454548","https://openalex.org/W2398757352","https://openalex.org/W2415189273","https://openalex.org/W2444191930","https://openalex.org/W2463871935","https://openalex.org/W2466109315","https://openalex.org/W2479850067","https://openalex.org/W2486711554","https://openalex.org/W2582232712","https://openalex.org/W2603725361","https://openalex.org/W2615200266","https://openalex.org/W2749240848","https://openalex.org/W2755049281","https://openalex.org/W2766322484","https://openalex.org/W2771721896","https://openalex.org/W2786622886","https://openalex.org/W2793619450","https://openalex.org/W2795076775","https://openalex.org/W2796289996","https://openalex.org/W2801851274","https://openalex.org/W2802472264","https://openalex.org/W2804501852","https://openalex.org/W2811512821","https://openalex.org/W2883720080","https://openalex.org/W2884524290","https://openalex.org/W2886918301","https://openalex.org/W2897704391","https://openalex.org/W2901205823","https://openalex.org/W2903347362","https://openalex.org/W2922387296","https://openalex.org/W2925800094","https://openalex.org/W2931144334","https://openalex.org/W2937013184","https://openalex.org/W2941231904","https://openalex.org/W2946816388","https://openalex.org/W2954976815","https://openalex.org/W2970048441","https://openalex.org/W2970406184","https://openalex.org/W2982637923","https://openalex.org/W2987195910","https://openalex.org/W2989135569","https://openalex.org/W2990621521","https://openalex.org/W2994812682","https://openalex.org/W2998940807","https://openalex.org/W3000242169","https://openalex.org/W3010674904","https://openalex.org/W3011147356","https://openalex.org/W3011996393","https://openalex.org/W3013411574","https://openalex.org/W3014275803","https://openalex.org/W3025075786","https://openalex.org/W3025959111","https://openalex.org/W3034560589","https://openalex.org/W3035930168","https://openalex.org/W3041793382","https://openalex.org/W3042588223","https://openalex.org/W3042826286","https://openalex.org/W3045412897","https://openalex.org/W3046173670","https://openalex.org/W3047515679","https://openalex.org/W3048688177","https://openalex.org/W3080711355","https://openalex.org/W3087348226","https://openalex.org/W3096728502","https://openalex.org/W3110735942","https://openalex.org/W3111810096","https://openalex.org/W3111856782","https://openalex.org/W3112980900","https://openalex.org/W3115903419","https://openalex.org/W3118413387","https://openalex.org/W3122460147","https://openalex.org/W3129085294","https://openalex.org/W3131373013","https://openalex.org/W3131955594","https://openalex.org/W3149688521","https://openalex.org/W3158020980","https://openalex.org/W3160802024","https://openalex.org/W3164762517","https://openalex.org/W3167324050","https://openalex.org/W3167925124","https://openalex.org/W3179283279","https://openalex.org/W3184815473","https://openalex.org/W3186020933","https://openalex.org/W3186163774","https://openalex.org/W3188414054","https://openalex.org/W3190681523","https://openalex.org/W3193258623","https://openalex.org/W3193575958","https://openalex.org/W3199974482","https://openalex.org/W3200011156","https://openalex.org/W3200987731","https://openalex.org/W3204133185","https://openalex.org/W3208314063","https://openalex.org/W4200330036","https://openalex.org/W4200605971","https://openalex.org/W4205121417","https://openalex.org/W4205757300","https://openalex.org/W4210703176","https://openalex.org/W4211258224","https://openalex.org/W4212777868","https://openalex.org/W4213392597","https://openalex.org/W4214686850","https://openalex.org/W4220667816","https://openalex.org/W4220852168","https://openalex.org/W4224076906","https://openalex.org/W4233524344","https://openalex.org/W4252726718"],"related_works":["https://openalex.org/W7203459729","https://openalex.org/W2886433327","https://openalex.org/W3046173670","https://openalex.org/W4401810988","https://openalex.org/W2410874147","https://openalex.org/W4225637217","https://openalex.org/W4393142903","https://openalex.org/W3168747212","https://openalex.org/W2156704489","https://openalex.org/W7204747493"],"abstract_inverted_index":{"Antibacterial":[0],"resistance":[1,54],"towards":[2],"the":[3,20,27,35,61,71,74,82,91,107,114,119,125,168,177,181,219,227,236],"\u03b2-lactam":[4],"(BL)":[5],"drugs":[6],"is":[7,12,43],"now":[8],"ubiquitous,":[9],"and":[10,97,131,141,165,198],"there":[11],"a":[13,64,98],"major":[14],"global":[15],"health":[16],"concern":[17],"associated":[18],"with":[19,151,167],"emergence":[21],"of":[22,30,37,63,66,73,93,116,127,171,218,231],"new":[23,38,94],"\u03b2-lactamases":[24,155,200],"(BLAs)":[25],"as":[26,186,188,213],"primary":[28],"cause":[29],"resistance.":[31],"In":[32,192],"addition":[33,160],"to":[34,51,90,161],"development":[36],"antibacterial":[39],"drugs,":[40],"\u03b2-lactamase":[41,76,84],"inhibition":[42,85],"an":[44],"alternative":[45],"modality":[46],"that":[47,202],"can":[48,134],"be":[49],"implemented":[50],"tackle":[52],"this":[53],"channel.":[55],"This":[56,173],"strategy":[57],"has":[58,87],"successfully":[59,135],"revitalized":[60],"efficacy":[62],"number":[65],"otherwise":[67],"obsolete":[68],"BLs":[69],"since":[70],"discovery":[72],"first":[75],"inhibitor":[77],"(BLI),":[78],"clavulanic":[79],"acid.":[80],"Over":[81],"years,":[83],"research":[86],"grown,":[88],"leading":[89],"introduction":[92],"synthetic":[95,182],"inhibitors,":[96],"few":[99,208],"are":[100,210],"currently":[101],"in":[102,124,149,156,159,180,206,235],"clinical":[103,169],"trials.":[104],"Of":[105],"note,":[106],"1,":[108],"6-diazabicyclo":[109],"[3,2,1]octan-7-one":[110],"(DBO)":[111],"scaffold":[112],"gained":[113],"attention":[115],"researchers":[117],"around":[118],"world,":[120],"which":[121,133],"finally":[122],"culminated":[123],"approval":[126],"two":[128],"BLIs,":[129],"avibactam":[130],"relebactam,":[132],"inhibit":[136],"Ambler":[137,152],"class":[138,153],"A,":[139,163],"C,":[140,164],"D":[142,166],"\u03b2-lactamases.":[143],"Boronic":[144],"acids":[145],"have":[146,203,222],"shown":[147],"promise":[148],"coping":[150],"B":[154],"recent":[157],"research,":[158],"classes":[162],"use":[170],"vaborbactam.":[172],"review":[174],"focuses":[175],"on":[176,226],"further":[178],"developments":[179],"strategies":[183],"using":[184],"DBO":[185],"well":[187],"boronic":[189],"acid":[190],"derivatives.":[191],"addition,":[193],"various":[194],"other":[195],"potential":[196],"serine-":[197],"metallo-":[199],"inhibitors":[201,221],"been":[204,223],"developed":[205],"last":[207],"years":[209],"discussed":[211,224],"briefly":[212],"well.":[214],"Furthermore,":[215],"binding":[216],"interactions":[217],"representative":[220],"based":[225],"crystal":[228],"structure":[229],"data":[230],"inhibitor-enzyme":[232],"complex,":[233],"published":[234],"literature.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-16T00:00:00"}
