{"id":"https://openalex.org/W4282932886","doi":"https://doi.org/10.3389/fmars.2022.904376","title":"Migration of Primordial Germ Cells Is Regulated by miR-430 During Embryonic Development of Japanese Flounder","display_name":"Migration of Primordial Germ Cells Is Regulated by miR-430 During Embryonic Development of Japanese Flounder","publication_year":2022,"publication_date":"2022-06-14","ids":{"openalex":"https://openalex.org/W4282932886","doi":"https://doi.org/10.3389/fmars.2022.904376"},"language":"en","primary_location":{"id":"doi:10.3389/fmars.2022.904376","doi":"https://doi.org/10.3389/fmars.2022.904376","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmars.2022.904376","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmars.2022.904376/pdf","source":{"id":"https://openalex.org/S2596539584","display_name":"Frontiers in Marine Science","issn_l":"2296-7745","issn":["2296-7745"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Marine Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmars.2022.904376/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063446205","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0001-9234-035X","observed_orcids":["https://orcid.org/0000-0001-9234-035X"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["Hainan Yazhou Bay Seed Laboratory, Sanya, China","Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Yazhou Bay Seed Laboratory, Sanya, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101590645","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-8679-4803","observed_orcids":["https://orcid.org/0000-0002-8679-4803"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":["Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103028388","display_name":"Chaofan Jin","orcid":"https://orcid.org/0009-0004-0865-5340","observed_orcids":["https://orcid.org/0009-0004-0865-5340","https://orcid.org/0000-0003-0998-2920"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaofan Jin","raw_affiliation_strings":["Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646426","display_name":"Jingjie Hu","orcid":"https://orcid.org/0000-0002-0715-7137","observed_orcids":["https://orcid.org/0000-0002-0715-7137"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjie Hu","raw_affiliation_strings":["Hainan Yazhou Bay Seed Laboratory, Sanya, China","Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Yazhou Bay Seed Laboratory, Sanya, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101923300","display_name":"Jie Qi","orcid":"https://orcid.org/0000-0002-0635-653X","observed_orcids":["https://orcid.org/0000-0002-0635-653X"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Qi","raw_affiliation_strings":["Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056065330","display_name":"Quanqi Zhang","orcid":"https://orcid.org/0000-0002-4628-4884","observed_orcids":["https://orcid.org/0000-0002-4628-4884"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quanqi Zhang","raw_affiliation_strings":["Hainan Yazhou Bay Seed Laboratory, Sanya, China","Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Yazhou Bay Seed Laboratory, Sanya, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya, China","institution_ids":["https://openalex.org/I59028903"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056065330","https://openalex.org/A5101923300"],"corresponding_institution_ids":["https://openalex.org/I59028903"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.1633,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.35157357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primordial-germ-cells","display_name":"primordial germ cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/germ-cell-migration","display_name":"germ cell migration","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mir-430","display_name":"miR-430","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6840000152587891},{"id":"https://openalex.org/keywords/olive-flounder","display_name":"Paralichthys olivaceus","score":0.9769999980926514},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nanos3","display_name":"Nanos3","score":0.7279999852180481},{"id":"https://openalex.org/keywords/piwil2","display_name":"PIWIL2","score":1.0},{"id":"https://openalex.org/keywords/3-utr-target-regulation","display_name":"3' UTR target regulation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/vas-deferens","display_name":"vas deferens","score":0.3889999985694885},{"id":"https://openalex.org/keywords/marine-teleosts","display_name":"marine teleosts","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.76436448097229},{"id":"https://openalex.org/C2776367567","wikidata":"https://www.wikidata.org/wiki/Q4246303","display_name":"Flounder","level":3,"score":0.6498727202415466},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.591865599155426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5421229004859924},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5146740078926086},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5084854364395142},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5008742809295654},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.46272554993629456},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.4475838541984558},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.44111689925193787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4384270906448364},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4243302345275879},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3183669447898865},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.20859503746032715},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.11815884709358215}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmars.2022.904376","doi":"https://doi.org/10.3389/fmars.2022.904376","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmars.2022.904376","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmars.2022.904376/pdf","source":{"id":"https://openalex.org/S2596539584","display_name":"Frontiers in Marine Science","issn_l":"2296-7745","issn":["2296-7745"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Marine Science","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4a0b5dfb81a84fa5a05f0ec77acfce46","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4a0b5dfb81a84fa5a05f0ec77acfce46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Marine Science, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmars.2022.904376","doi":"https://doi.org/10.3389/fmars.2022.904376","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmars.2022.904376","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmars.2022.904376/pdf","source":{"id":"https://openalex.org/S2596539584","display_name":"Frontiers in Marine Science","issn_l":"2296-7745","issn":["2296-7745"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Marine Science","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","score":0.8899999856948853,"display_name":"Life below water"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5211454093","display_name":null,"funder_award_id":"2018YFD0901205","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282932886.pdf","grobid_xml":"https://content.openalex.org/works/W4282932886.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W928910886","https://openalex.org/W1595011252","https://openalex.org/W1892455518","https://openalex.org/W1965306643","https://openalex.org/W1968328026","https://openalex.org/W1981186391","https://openalex.org/W1983538883","https://openalex.org/W1988344228","https://openalex.org/W1996241322","https://openalex.org/W1996315467","https://openalex.org/W1999097906","https://openalex.org/W2012320318","https://openalex.org/W2024302390","https://openalex.org/W2026664850","https://openalex.org/W2030393062","https://openalex.org/W2033669284","https://openalex.org/W2034500416","https://openalex.org/W2035930185","https://openalex.org/W2039538566","https://openalex.org/W2047429202","https://openalex.org/W2049255037","https://openalex.org/W2049868101","https://openalex.org/W2056981693","https://openalex.org/W2064747653","https://openalex.org/W2066118199","https://openalex.org/W2066900919","https://openalex.org/W2072245647","https://openalex.org/W2078142069","https://openalex.org/W2083381199","https://openalex.org/W2086682164","https://openalex.org/W2088558156","https://openalex.org/W2094015672","https://openalex.org/W2104377074","https://openalex.org/W2105874583","https://openalex.org/W2108284151","https://openalex.org/W2108834771","https://openalex.org/W2112785261","https://openalex.org/W2113067101","https://openalex.org/W2114354957","https://openalex.org/W2117936467","https://openalex.org/W2136400757","https://openalex.org/W2138433638","https://openalex.org/W2141578449","https://openalex.org/W2148581571","https://openalex.org/W2150014745","https://openalex.org/W2152083180","https://openalex.org/W2159203603","https://openalex.org/W2161282555","https://openalex.org/W2322855050","https://openalex.org/W2474215406","https://openalex.org/W2498567991","https://openalex.org/W2554695178","https://openalex.org/W2601645471","https://openalex.org/W2940983844","https://openalex.org/W3096598897","https://openalex.org/W4211184426"],"related_works":["https://openalex.org/W928910886","https://openalex.org/W2990778209","https://openalex.org/W2024302390","https://openalex.org/W2950037668","https://openalex.org/W2084031512","https://openalex.org/W2159203603","https://openalex.org/W4289745119","https://openalex.org/W2338082971","https://openalex.org/W3208084789","https://openalex.org/W2136400757"],"abstract_inverted_index":{"The":[0],"origin":[1],"and":[2,36,77,83,152],"migration":[3,37,153],"of":[4,31,38,58,65,71,98,106,125,144,149,154],"primordial":[5],"germ":[6],"cells":[7],"(PGCs)":[8],"were":[9,90],"regulated":[10],"by":[11],"miRNA":[12],"during":[13],"embryogenesis,":[14],"but":[15],"the":[16,29,34,56,63,69,94,102,116,123,142,147,150],"underlying":[17],"mechanism":[18],"in":[19,33,40,60,146],"marine":[20],"teleost":[21],"species":[22],"was":[23,109],"still":[24],"unclear.":[25],"Here,":[26],"we":[27,50],"studied":[28],"function":[30],"miR-430":[32,45,53,66,89,103,145],"development":[35,151],"PGCs":[39,59],"Japanese":[41],"flounder.":[42,61],"By":[43],"co-injecting":[44],"with":[46],"eGFP-vasa":[47],"3\u2019UTR":[48,108],"mRNA,":[49],"found":[51],"that":[52,88],"could":[54],"cause":[55],"mis-localization":[57],"Besides,":[62],"overexpression":[64],"also":[67],"inhibited":[68],"expression":[70],"three":[72],"PGC-related":[73],"genes":[74],"(nanos3,":[75],"piwil2":[76,107],"tdrd7a),":[78],"both":[79],"target":[80,96,104],"gene":[81],"prediction":[82],"dual-luciferase":[84],"reporter":[85],"assay":[86],"showed":[87],"directly":[91],"binding":[92,117],"on":[93,141],"canonical":[95],"site":[97,105],"their":[99],"3\u2019UTRs.":[100],"Significantly,":[101],"necessary":[110],"for":[111],"PGC":[112],"specific":[113],"expression,":[114],"where":[115],"seeds":[118],"\u201cGCACTTT\u201d":[119],"sequence":[120],"mutation":[121],"lead":[122],"distribution":[124],"eGFP-piwil2":[126],"mRNA":[127],"turned":[128],"from":[129],"PGC-specific":[130],"(wild-type)":[131],"to":[132],"ubiquitous":[133],"(mutant).":[134],"These":[135],"findings":[136],"will":[137],"provide":[138],"further":[139],"evidence":[140],"role":[143],"regulation":[148],"PGCs.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-06-16T00:00:00"}
