{"id":"https://openalex.org/W4282932839","doi":"https://doi.org/10.3390/antiox11050831","title":"Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents","display_name":"Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents","publication_year":2022,"publication_date":"2022-04-25","ids":{"openalex":"https://openalex.org/W4282932839","doi":"https://doi.org/10.3390/antiox11050831","pmid":"https://pubmed.ncbi.nlm.nih.gov/35624695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9138159"},"language":"en","primary_location":{"id":"doi:10.3390/antiox11050831","doi":"https://doi.org/10.3390/antiox11050831","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11050831","pdf_url":"https://www.mdpi.com/2076-3921/11/5/831/pdf?version=1650869831","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/11/5/831/pdf?version=1650869831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078633619","display_name":"Shima Ghareh Bashlouei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183859904","display_name":"Islamic Azad University, Mashhad","ror":"https://ror.org/00bvysh61","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I183859904"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shima Ghareh Bashlouei","raw_affiliation_strings":["Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad 917568, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad 917568, Iran","institution_ids":["https://openalex.org/I183859904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040262788","display_name":"Ehsan Karimi","orcid":"https://orcid.org/0000-0002-5011-9611","observed_orcids":["https://orcid.org/0000-0002-5011-9611"]},"institutions":[{"id":"https://openalex.org/I183859904","display_name":"Islamic Azad University, Mashhad","ror":"https://ror.org/00bvysh61","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I183859904"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Ehsan Karimi","raw_affiliation_strings":["Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad 917568, Iran"],"raw_orcid":"https://orcid.org/0000-0002-5011-9611","affiliations":[{"raw_affiliation_string":"Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad 917568, Iran","institution_ids":["https://openalex.org/I183859904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055584149","display_name":"Mohsen Zareian","orcid":"https://orcid.org/0000-0002-5860-8639","observed_orcids":["https://orcid.org/0000-0002-5860-8639"]},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mohsen Zareian","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101573176","display_name":"Ehsan Oskoueian","orcid":"https://orcid.org/0000-0003-4821-190X","observed_orcids":["https://orcid.org/0000-0003-4821-190X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ehsan Oskoueian","raw_affiliation_strings":["Department of Research and Development, Arka Industrial Cluster, Mashhad 9188944586, Iran"],"raw_orcid":"https://orcid.org/0000-0003-4821-190X","affiliations":[{"raw_affiliation_string":"Department of Research and Development, Arka Industrial Cluster, Mashhad 9188944586, Iran","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005978896","display_name":"Majid Shakeri","orcid":"https://orcid.org/0000-0002-1857-2133","observed_orcids":["https://orcid.org/0000-0002-1857-2133"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Majid Shakeri","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA 98109, USA"],"raw_orcid":"https://orcid.org/0000-0002-1857-2133","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005978896","https://openalex.org/A5040262788","https://openalex.org/A5101573176"],"corresponding_institution_ids":["https://openalex.org/I183859904","https://openalex.org/I201448701"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":2.8056,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92716722,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"5","first_page":"831","last_page":"831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.13529999554157257,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heracleum-persicum","display_name":"Heracleum persicum","score":0.9279999732971191},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.6000000238418579},{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.8889999985694885},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/anethole","display_name":"anethole","score":0.8190000057220459},{"id":"https://openalex.org/keywords/terpinolene","display_name":"terpinolene","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5669999718666077},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.875},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7820000052452087},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6600000262260437},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7310000061988831},{"id":"https://openalex.org/keywords/intestinal-morphology","display_name":"intestinal morphology","score":0.5659999847412109},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7280205488204956},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.5478647351264954},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5443070530891418},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.5347335338592529},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.4885214567184448},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4289029836654663},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.35685738921165466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3231770992279053},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2229219377040863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15296784043312073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/antiox11050831","doi":"https://doi.org/10.3390/antiox11050831","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11050831","pdf_url":"https://www.mdpi.com/2076-3921/11/5/831/pdf?version=1650869831","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmid:35624695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35624695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9138159","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9138159/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmh:oai:research.chalmers.se:530196","doi":null,"is_oa":true,"landing_page_url":"https://research.chalmers.se/en/publication/530196","pdf_url":"https://research.chalmers.se/publication/530196/file/530196_Fulltext.pdf","source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:770078f5b48e449597d5953593f0a2b9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/770078f5b48e449597d5953593f0a2b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 11, Iss 5, p 831 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antiox11050831","doi":"https://doi.org/10.3390/antiox11050831","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11050831","pdf_url":"https://www.mdpi.com/2076-3921/11/5/831/pdf?version=1650869831","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282932839.pdf","grobid_xml":"https://content.openalex.org/works/W4282932839.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1974251195","https://openalex.org/W2011125013","https://openalex.org/W2026748373","https://openalex.org/W2043744435","https://openalex.org/W2066950767","https://openalex.org/W2122910156","https://openalex.org/W2130287947","https://openalex.org/W2214527760","https://openalex.org/W2309273744","https://openalex.org/W2534670839","https://openalex.org/W2745288280","https://openalex.org/W2778684355","https://openalex.org/W2803703677","https://openalex.org/W2804846127","https://openalex.org/W2886311165","https://openalex.org/W2945482009","https://openalex.org/W2949707505","https://openalex.org/W2955141070","https://openalex.org/W2969289454","https://openalex.org/W2978122627","https://openalex.org/W2991475829","https://openalex.org/W2994736503","https://openalex.org/W2999840844","https://openalex.org/W3000531005","https://openalex.org/W3005061733","https://openalex.org/W3006594701","https://openalex.org/W3012126725","https://openalex.org/W3022653409","https://openalex.org/W3036131095","https://openalex.org/W3037833184","https://openalex.org/W3042836528","https://openalex.org/W3045240522","https://openalex.org/W3085882491","https://openalex.org/W3100578076","https://openalex.org/W3114041529","https://openalex.org/W3132823909","https://openalex.org/W3186386709","https://openalex.org/W3201199524","https://openalex.org/W4200021960","https://openalex.org/W4211019459","https://openalex.org/W4235089501"],"related_works":["https://openalex.org/W7214146586","https://openalex.org/W4379376244","https://openalex.org/W3006594701","https://openalex.org/W3135136472","https://openalex.org/W3028054705","https://openalex.org/W4387258283","https://openalex.org/W3122237667","https://openalex.org/W2256309826","https://openalex.org/W4406772920","https://openalex.org/W7202296941"],"abstract_inverted_index":{"Essential":[0],"oils":[1],"are":[2],"important":[3],"compounds":[4],"for":[5,194],"the":[6,129,163,176],"prevention":[7],"and/or":[8],"treatment":[9],"of":[10,85,121,134,156,172,178],"various":[11],"diseases":[12],"in":[13,82,128,145,162],"which":[14],"solubility":[15],"and":[16,31,41,50,59,76,99,111,117,132,142,151,167,181,197],"bio-accessibility":[17],"can":[18],"be":[19,189],"improved":[20],"by":[21],"nanoemulsion":[22,27,173,187],"systems.":[23],"Heracleum":[24,184],"persicum":[25,185],"oil":[26,186],"(HAE-NE)":[28],"was":[29,80,93],"prepared":[30],"biological":[32],"properties":[33],"were":[34,54],"investigated":[35],"against":[36],"human":[37,43],"breast":[38],"cancer":[39,86],"cells":[40,87,144],"normal":[42],"fibroblasts":[44],"foreskin.":[45],"Particle":[46],"size,":[47],"zeta":[48],"potential":[49],"poly":[51],"dispersity":[52],"index":[53],"153":[55],"nm,":[56],"\u221247.9":[57],"mV":[58],"0.35,":[60],"respectively.":[61],"(E)anethole":[62],"(57.9%),":[63],"terpinolene":[64],"(13.8%),":[65],"\u0263-terpinene":[66],"(8.1%),":[67],"myrcene":[68],"(6.8%),":[69],"hexyl":[70],"butyrate":[71],"(5.2%),":[72],"octyl":[73,77],"butanoate":[74],"(4.5%)":[75],"acetate":[78],"(3.7%)":[79],"detected":[81],"nanoemulsion.":[83],"Proliferation":[84],"at":[88,103,108],"IC50":[89],"=":[90],"2.32":[91],"\u03bcg/mL":[92],"significantly":[94,174],"(p":[95],"<":[96],"0.05)":[97],"inhibited,":[98],"cell":[100,122],"migration":[101],"occurred":[102],"1.5":[104],"\u03bcL/mL.":[105],"The":[106],"HAE-NE":[107,157],"1.5,":[109],"2.5":[110],"3.5":[112],"\u00b5g/concentration":[113],"up-regulated":[114,175],"caspase":[115],"3":[116],"enhanced":[118],"sub-G1":[119],"peak":[120],"cycle":[123],"with":[124,149],"nil":[125],"cytotoxic":[126],"effects":[127],"liver,":[130],"kidney":[131],"jejunum":[133],"mice.":[135],"Villus":[136],"height,":[137],"villus":[138],"width,":[139],"crypt":[140],"depth":[141],"goblet":[143],"mice":[146],"group":[147],"fed":[148],"10":[150,166],"20":[152,168],"mg/kg":[153,169],"body":[154,170],"weight":[155,171],"improved.":[158],"Cellular":[159],"redox":[160],"state":[161],"liver":[164],"indicated":[165],"expression":[177],"SOD,":[179],"CAT":[180],"GPx":[182],"genes.":[183],"could":[188],"an":[190],"eco-friendly":[191],"nanotherapeutic":[192],"option":[193],"pharmaceutical,":[195],"cosmetological":[196],"food":[198],"applications.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-16T00:00:00"}
