{"id":"https://openalex.org/W4282931371","doi":"https://doi.org/10.14670/hh-18-475","title":"DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.","display_name":"DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.","publication_year":2022,"publication_date":"2022-08-01","ids":{"openalex":"https://openalex.org/W4282931371","doi":"https://doi.org/10.14670/hh-18-475","pmid":"https://pubmed.ncbi.nlm.nih.gov/35642329"},"language":"en","primary_location":{"id":"pmid:35642329","doi":"https://doi.org/10.14670/hh-18-475","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35642329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039217643","display_name":"Kristina Jansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristina Jansen","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090488652","display_name":"Martina Kluth","orcid":"https://orcid.org/0000-0003-4782-4616","observed_orcids":["https://orcid.org/0000-0003-4782-4616"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Kluth","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011033854","display_name":"Niclas Christian Blessin","orcid":"https://orcid.org/0000-0001-8043-3081","observed_orcids":["https://orcid.org/0000-0001-8043-3081"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niclas C Blessin","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065312050","display_name":"Claudia Hube\u2010Magg","orcid":"https://orcid.org/0000-0001-7542-4340","observed_orcids":["https://orcid.org/0000-0001-7542-4340"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Hube-Magg","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025653427","display_name":"Michael Neipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104827","display_name":"Klinikum Itzehoe","ror":"https://ror.org/01kkgy069","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210104827"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Neipp","raw_affiliation_strings":["General, Vascular and Visceral Surgery Clinic, Itzehoe Medical Center, Itzehoe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Vascular and Visceral Surgery Clinic, Itzehoe Medical Center, Itzehoe, Germany","institution_ids":["https://openalex.org/I4210104827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089321667","display_name":"Hamid Mofid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107688","display_name":"Regio Kliniken","ror":"https://ror.org/01prj4323","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107688"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hamid Mofid","raw_affiliation_strings":["General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany","institution_ids":["https://openalex.org/I4210107688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003117376","display_name":"Hannes L\u00e1russon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107688","display_name":"Regio Kliniken","ror":"https://ror.org/01prj4323","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107688"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannes L\u00e1russon","raw_affiliation_strings":["General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany","institution_ids":["https://openalex.org/I4210107688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030303378","display_name":"Thies Daniels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thies Daniels","raw_affiliation_strings":["General, Visceral and Tumor Surgery Clinic, Albertinen Hospital, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Tumor Surgery Clinic, Albertinen Hospital, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046077722","display_name":"Christoph M. Isbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Isbert","raw_affiliation_strings":["Department of General, Gastrointestinal and Colorectal Surgery, Amalie Sieveking Hospital, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Gastrointestinal and Colorectal Surgery, Amalie Sieveking Hospital, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051509734","display_name":"Stephan Coerper","orcid":"https://orcid.org/0000-0002-0197-0995","observed_orcids":["https://orcid.org/0000-0002-0197-0995"]},"institutions":[{"id":"https://openalex.org/I4210142939","display_name":"Martha-Maria Hospital","ror":"https://ror.org/053darw66","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210142939"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Coerper","raw_affiliation_strings":["Department of Surgery, General Hospital Martha-Maria Hospital Nuernberg, Nuernberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, General Hospital Martha-Maria Hospital Nuernberg, Nuernberg, Germany","institution_ids":["https://openalex.org/I4210142939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035554695","display_name":"Daniel Ditterich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127969","display_name":"Sch\u00f6n Klinik Neustadt","ror":"https://ror.org/02devh349","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088209","https://openalex.org/I4210127969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Ditterich","raw_affiliation_strings":["Department of Surgery, General Hospital Neustadt/Aisch, Neustadt an der Aisch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, General Hospital Neustadt/Aisch, Neustadt an der Aisch, Germany","institution_ids":["https://openalex.org/I4210127969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062960007","display_name":"Holger Rupprecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holger Rupprecht","raw_affiliation_strings":["Department of Thoracic Surgery, Academic Hospital Neumarkt, Neumarkt/Oberpfalz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Academic Hospital Neumarkt, Neumarkt/Oberpfalz, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Albert Goetz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albert Goetz","raw_affiliation_strings":["Department of Surgery, General Hospital Roth, Roth, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, General Hospital Roth, Roth, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083166298","display_name":"Christian Bernreuther","orcid":"https://orcid.org/0000-0003-3939-322X","observed_orcids":["https://orcid.org/0000-0003-3939-322X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Bernreuther","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021421424","display_name":"Guido Sauter","orcid":"https://orcid.org/0000-0002-9024-4978","observed_orcids":["https://orcid.org/0000-0002-9024-4978"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guido Sauter","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008273506","display_name":"Ria Uhlig","orcid":"https://orcid.org/0000-0002-4880-6519","observed_orcids":["https://orcid.org/0000-0002-4880-6519"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ria Uhlig","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072001228","display_name":"Waldemar Wilczak","orcid":"https://orcid.org/0009-0000-8438-9110","observed_orcids":["https://orcid.org/0009-0000-8438-9110"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Waldemar Wilczak","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086499788","display_name":"Ronald Simon","orcid":"https://orcid.org/0000-0003-0158-4258","observed_orcids":["https://orcid.org/0000-0003-0158-4258"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronald Simon","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049914905","display_name":"Stefan A. Steurer","orcid":"https://orcid.org/0000-0002-7199-3615","observed_orcids":["https://orcid.org/0000-0002-7199-3615","https://orcid.org/0000-0003-3313-0453"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Steurer","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034204447","display_name":"Eike Burandt","orcid":"https://orcid.org/0000-0002-5705-9084","observed_orcids":["https://orcid.org/0000-0002-5705-9084"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eike Burandt","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074421872","display_name":"Daniel R. Perez","orcid":"https://orcid.org/0000-0002-3154-7311","observed_orcids":["https://orcid.org/0000-0002-3154-7311"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Perez","raw_affiliation_strings":["General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039983309","display_name":"Jakob Robert Izbicki","orcid":"https://orcid.org/0000-0001-6807-8224","observed_orcids":["https://orcid.org/0000-0001-6807-8224"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jakob R Izbicki","raw_affiliation_strings":["General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071506845","display_name":"Frank Jacobsen","orcid":"https://orcid.org/0009-0009-8047-580X","observed_orcids":["https://orcid.org/0009-0009-8047-580X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Jacobsen","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079884607","display_name":"Till Sebastian Clauditz","orcid":"https://orcid.org/0000-0002-4257-856X","observed_orcids":["https://orcid.org/0000-0002-4257-856X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Till S Clauditz","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102929453","display_name":"Andreas Holger Marx","orcid":"https://orcid.org/0000-0002-5182-8364","observed_orcids":["https://orcid.org/0000-0002-5182-8364"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas H Marx","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053478291","display_name":"Till Krech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210135668","display_name":"Klinikum Osnabr\u00fcck","ror":"https://ror.org/04dc9g452","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210135668"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Till Krech","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany","institution_ids":["https://openalex.org/I4210135668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2266,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49772072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"8","first_page":"739","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmem16a","display_name":"TMEM16A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.9810000061988831},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5860000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.597000002861023},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.753000020980835},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7789826393127441},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6709692478179932},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5931891202926636},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5608446598052979},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.5514460802078247},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5381401777267456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4987967014312744},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4832342565059662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4789460301399231},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.468943327665329},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40274855494499207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3583250045776367},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33317428827285767}],"mesh":[{"descriptor_ui":"D000075369","descriptor_name":"Anoctamin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009386","descriptor_name":"Neoplastic Syndromes, Hereditary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:35642329","doi":"https://doi.org/10.14670/hh-18-475","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35642329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Journal Article"},{"id":"pmh:oai:hispana.mcu.es:61742172","doi":"https://doi.org/10.14670/hh-18-475","is_oa":true,"landing_page_url":"https://doi.org/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:hispana.mcu.es:61742172","doi":"https://doi.org/10.14670/hh-18-475","is_oa":true,"landing_page_url":"https://doi.org/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W25562819","https://openalex.org/W192633127","https://openalex.org/W326116216","https://openalex.org/W1940693565","https://openalex.org/W1981193117","https://openalex.org/W1996708800","https://openalex.org/W2040110858","https://openalex.org/W2044422249","https://openalex.org/W2049314578","https://openalex.org/W2060638607","https://openalex.org/W2068085200","https://openalex.org/W2078571865","https://openalex.org/W2087810003","https://openalex.org/W2100125385","https://openalex.org/W2104895779","https://openalex.org/W2115989257","https://openalex.org/W2116945755","https://openalex.org/W2133766224","https://openalex.org/W2136738215","https://openalex.org/W2154436353","https://openalex.org/W2159814827","https://openalex.org/W2161080750","https://openalex.org/W2195800670","https://openalex.org/W2218134618","https://openalex.org/W2408255244","https://openalex.org/W2472873013","https://openalex.org/W2529828769","https://openalex.org/W2549360305","https://openalex.org/W2555798811","https://openalex.org/W2573152477","https://openalex.org/W2586174404","https://openalex.org/W2606849884","https://openalex.org/W2754848079","https://openalex.org/W2774705825","https://openalex.org/W2808641528","https://openalex.org/W2889646458","https://openalex.org/W2893338070","https://openalex.org/W2903112818","https://openalex.org/W2917872086","https://openalex.org/W2921024060","https://openalex.org/W2922093882","https://openalex.org/W2941578357","https://openalex.org/W2942384831","https://openalex.org/W2950290441","https://openalex.org/W2952528465","https://openalex.org/W2955274025","https://openalex.org/W2968089552","https://openalex.org/W2976742560","https://openalex.org/W2979776638","https://openalex.org/W2979881558","https://openalex.org/W3039259060","https://openalex.org/W3081909758","https://openalex.org/W3097715866","https://openalex.org/W3114280202","https://openalex.org/W3117886022","https://openalex.org/W3165235757","https://openalex.org/W3168762936","https://openalex.org/W3210025592","https://openalex.org/W4252728309","https://openalex.org/W6998328668"],"related_works":["https://openalex.org/W7134185645","https://openalex.org/W2387125653","https://openalex.org/W2154436353","https://openalex.org/W2326679927","https://openalex.org/W7000258943","https://openalex.org/W205552070","https://openalex.org/W2321093325","https://openalex.org/W2800306859","https://openalex.org/W188899085","https://openalex.org/W7211997950"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"transmembrane":[2],"channel":[3],"protein":[4],"DOG1":[5,39,53,81,109,141,183,198],"(Discovered":[6],"on":[7],"GIST1)":[8],"is":[9,31,185,200],"normally":[10],"expressed":[11],"in":[12,21,41,85,96,100,105,128,187],"the":[13,173],"gastrointestinal":[14,22],"interstitial":[15],"cells":[16],"of":[17,38,88,130,175,206],"Cajal":[18],"and":[19,55,59,93,103,118,135,163,172,190,209],"also":[20,32],"stroma":[23],"tumors":[24],"arising":[25],"from":[26,69],"these":[27,123],"cells.":[28],"However,":[29,197],"there":[30],"evidence":[33],"for":[34,50,218],"a":[35,215],"relevant":[36],"role":[37],"expression":[40,54,165,184],"colorectal":[42,73,91,188],"cancers.":[43],"This":[44],"study":[45],"was":[46,76,83,111,143],"undertaken":[47],"to":[48,146,169,193,203],"search":[49],"associations":[51,124],"between":[52],"colon":[56],"cancer":[57,74,189,207],"phenotype":[58],"key":[60],"molecular":[61,148,195],"alterations.":[62,196],"METHODS:":[63],"A":[64],"tissue":[65],"microarray":[66],"containing":[67],"samples":[68],"more":[70],"than":[71],"1,800":[72],"patients":[75],"analyzed":[77],"by":[78],"immunohistochemistry.":[79],"RESULTS:":[80],"immunostaining":[82,110],"detected":[84],"503":[86],"(30.2%)":[87],"1,666":[89],"analyzable":[90],"cancers":[92],"considered":[94],"weak":[95],"360":[97],"(21.6%),":[98],"moderate":[99],"78":[101],"(4.7%),":[102],"strong":[104],"65":[106],"(3.9%).":[107],"Strong":[108],"associated":[112],"with":[113],"advanced":[114],"pT":[115],"stage":[116],"(p=0.0367)":[117],"nodal":[119],"metastases":[120],"(p=0.0145)":[121],"but":[122,167],"were":[125],"not":[126,212],"retained":[127],"subgroups":[129],"1,135":[131],"mismatch":[132,137,152],"repair":[133,138,153],"proficient":[134],"86":[136],"deficient":[139],"tumors.":[140],"positivity":[142],"significantly":[144,191],"linked":[145,192],"several":[147],"tumor":[149,176,220],"features":[150],"including":[151],"deficiency":[154],"(p=0.0034),":[155],"BRAF":[156],"mutations":[157,171],"(p<0.0001),":[158],"nuclear":[159],"p53":[160],"accumulation":[161],"(p=0.0157),":[162],"PD-L1":[164],"(p=0.0199)":[166],"unrelated":[168,202],"KRAS":[170],"density":[174],"infiltrating":[177],"CD8":[178],"positive":[179],"lymphocytes.":[180],"CONCLUSION:":[181],"Elevated":[182],"frequent":[186],"important":[194],"overexpression":[199],"largely":[201],"histopathological":[204],"parameters":[205],"aggressiveness":[208],"may":[210],"thus":[211],"serve":[213],"as":[214],"prognostic":[216],"parameter":[217],"this":[219],"entity.":[221]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-16T00:00:00"}
