{"id":"https://openalex.org/W4282929336","doi":"https://doi.org/10.1158/1538-7445.am2022-2509","title":"Abstract 2509: Cytokines derived from tumor initiating osteosarcoma cells mediate a novel self-seeding mechanism relevant to growth of primary and metastatic tumors","display_name":"Abstract 2509: Cytokines derived from tumor initiating osteosarcoma cells mediate a novel self-seeding mechanism relevant to growth of primary and metastatic tumors","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282929336","doi":"https://doi.org/10.1158/1538-7445.am2022-2509"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-2509","doi":"https://doi.org/10.1158/1538-7445.am2022-2509","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-2509","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049545563","display_name":"Amy C. Gross","orcid":"https://orcid.org/0000-0002-0123-5085","observed_orcids":["https://orcid.org/0000-0002-0123-5085"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy C. Gross","raw_affiliation_strings":["1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031410870","display_name":"James Brandon Reinecke","orcid":"https://orcid.org/0000-0002-6498-7479","observed_orcids":["https://orcid.org/0000-0002-6498-7479"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Reinecke","raw_affiliation_strings":["1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091380386","display_name":"Amanda J. Saraf","orcid":"https://orcid.org/0000-0002-0167-8716","observed_orcids":["https://orcid.org/0000-0002-0167-8716"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Saraf","raw_affiliation_strings":["2Riley Children's Health, Indianapolis, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Riley Children's Health, Indianapolis, IN;","institution_ids":["https://openalex.org/I2802740592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082294958","display_name":"Helene LePommellet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helene LePommellet","raw_affiliation_strings":["3The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074934167","display_name":"Sophia Vatelle","orcid":"https://orcid.org/0009-0004-6260-8465","observed_orcids":["https://orcid.org/0009-0004-6260-8465"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia Vatelle","raw_affiliation_strings":["1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028367199","display_name":"Ryan David Roberts","orcid":"https://orcid.org/0000-0001-5028-744X","observed_orcids":["https://orcid.org/0000-0001-5028-744X"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Roberts","raw_affiliation_strings":["1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I1314135232"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"2509","last_page":"2509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/self-seeding","display_name":"self-seeding","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7390000224113464},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-cell-chemotaxis","display_name":"tumor cell chemotaxis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.597000002861023},{"id":"https://openalex.org/keywords/tumor-cell-recruitment","display_name":"tumor cell recruitment","score":0.4650000035762787},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.5249999761581421},{"id":"https://openalex.org/keywords/tumor-niche","display_name":"tumor niche","score":0.3240000009536743},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.5490000247955322},{"id":"https://openalex.org/keywords/pediatric-bone-tumors","display_name":"pediatric bone tumors","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.9230749607086182},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.7126772403717041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6697477698326111},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6444971561431885},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6063427329063416},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5312787294387817},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43179547786712646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35938435792922974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33939066529273987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22173884510993958}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-2509","doi":"https://doi.org/10.1158/1538-7445.am2022-2509","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-2509","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296230870","https://openalex.org/W3047655686","https://openalex.org/W7033555006","https://openalex.org/W2886146524","https://openalex.org/W2911599528","https://openalex.org/W2077416366","https://openalex.org/W2964619134","https://openalex.org/W2178255700","https://openalex.org/W4413818120","https://openalex.org/W4232863527"],"abstract_inverted_index":{"Abstract":[0],"Osteosarcoma":[1],"is":[2,12],"the":[3,20,26,40,71,76,168,172,217,257,262,300,352,360,380,396,446],"most":[4],"common":[5],"pediatric":[6],"bone":[7],"tumor.":[8,246,365],"Death":[9],"from":[10,167,223,424],"osteosarcoma":[11,60,86,92,100,115,124,160,232,291,308,321,376,427],"almost":[13],"always":[14],"due":[15],"to":[16,19,70,171,277,293,337,391,435],"metastatic":[17,384,403,440],"spread":[18],"lungs,":[21],"which":[22],"largely":[23],"occurs":[24],"after":[25],"primary":[27,41,59,159,169,196,202,227,245,258,364,381,438],"tumor":[28,42,67,72,132,136,161,165,170,197,213,251,334,344,382,425],"has":[29],"been":[30,55],"resected":[31],"and":[32,104,439],"treated":[33],"with":[34,225,288,305],"chemotherapy.":[35],"Others":[36],"have":[37,53,149,243,326],"suggested":[38,57,128],"that":[39,45,58,85,99,109,207,240,313,328,370,401],"elaborates":[43],"factors":[44],"suppress":[46,62],"metastasis,":[47],"though":[48,75],"mechanisms":[49,147],"explaining":[50],"this":[51,180,269,282,393],"phenomenon":[52],"not":[54,242],"well-validated":[56],"tumors":[61,186,228,441],"metastasis":[63],"by":[64],"recruiting":[65],"circulating":[66,164,333,343],"cells":[68,87,93,101,133,137,166,252,292,345,428],"back":[69],"via":[73,138],"self-seeding,":[74],"mechanism(s)":[77],"of":[78,90,114,119,157,191,195,248,330,362,373,379,398,437,445],"recruitment":[79,336],"remained":[80],"poorly":[81],"defined.":[82],"We":[83,96,153,386],"found":[84,108,312],"induce":[88,294],"chemotaxis":[89,113],"other":[91,135],"in":[94,187,216,238,354,359,375,395],"vitro.":[95],"previously":[97],"demonstrated":[98,327],"produce":[102],"IL6":[103],"CXCL8.":[105],"Here,":[106],"we":[107,182,266,311,325],"both":[110,120],"cytokines":[111,121],"induced":[112],"cells.":[116,309,322],"Conversely,":[117],"inhibition":[118,329],"prevented":[122],"osteosarcoma-induced":[123],"chemotaxis.":[125],"These":[126],"results":[127],"a":[129,143,158,244,363,371,430],"model":[130],"wherein":[131],"attract":[134],"inflammatory":[139],"cytokine":[140],"signaling.":[141],"Within":[142],"living":[144],"organism,":[145],"such":[146],"might":[148,162,273],"implications":[150],"for":[151,449],"therapy.":[152],"wondered":[154],"whether":[155,268],"resection":[156],"redirect":[163],"lung":[173,233,278,295,339,353],"(the":[174],"\u201cnext":[175],"best\u201d":[176],"site).":[177],"To":[178,280],"test":[179,281],"hypothesis,":[181,283],"generated":[183],"orthotopic":[184],"tibial":[185],"mice.":[188],"One":[189],"cohort":[190],"mice":[192,206,224,239,284,302],"underwent":[193,208],"amputation":[194,209],"while":[198],"another":[199],"retained":[200],"their":[201],"tumors.":[203],"At":[204],"euthanasia,":[205],"had":[210],"significantly":[211,230],"increased":[212],"cell":[214,335],"burden":[215,234],"lungs.":[218],"In":[219,323],"separate":[220],"experiments,":[221],"lungs":[222],"established":[226,338,349],"showed":[229],"less":[231],"than":[235,319],"was":[236],"seen":[237],"did":[241],"Many":[247],"infiltrating":[249],"(labeled)":[250],"were":[253,285],"subsequently":[254],"identified":[255],"within":[256,351],"tumor,":[259],"strongly":[260],"supporting":[261],"self-seeding":[263,271,374,432],"model.":[264],"Finally,":[265],"asked":[267],"same":[270,301],"mechanism":[272,433],"drive":[274],"events":[275],"important":[276],"metastasis.":[279,296],"first":[286],"inoculated":[287],"green":[289],"labelled":[290,307],"Fourteen":[297],"days":[298],"later,":[299],"received":[303],"inoculation":[304],"red":[306],"Strikingly,":[310],"lesions":[314],"contained":[315],"many":[316],"more":[317],"red-":[318],"green-labeled":[320],"addition,":[324],"IL6/CXCL8":[331,356],"blocks":[332],"niches.":[340],"This":[341],"suggests":[342,369],"preferentially":[346],"target":[347],"an":[348,355],"niche":[350],"dependent":[357],"manner":[358],"absence":[361],"Collectively,":[366],"our":[367],"data":[368],"loss":[372],"on":[377],"excision":[378],"increases":[383],"burden.":[385],"are":[387],"now":[388],"exploring":[389],"ways":[390],"leverage":[392],"biology":[394],"development":[397],"novel":[399,431],"therapies":[400],"prevent":[402],"disease.":[404],"Citation":[405],"Format:":[406],"Amy":[407],"C.":[408],"Gross,":[409],"James":[410],"B.":[411],"Reinecke,":[412],"Amanda":[413],"Saraf,":[414],"Helene":[415],"LePommellet,":[416],"Sophia":[417],"Vatelle,":[418],"Ryan":[419],"D.":[420],"Roberts.":[421],"Cytokines":[422],"derived":[423],"initiating":[426],"mediate":[429],"relevant":[434],"growth":[436],"[abstract].":[442],"In:":[443],"Proceedings":[444],"American":[447],"Association":[448],"Cancer":[450,461],"Research":[451],"Annual":[452],"Meeting":[453],"2022;":[454],"2022":[455],"Apr":[456],"8-13.":[457],"Philadelphia":[458],"(PA):":[459],"AACR;":[460],"Res":[462],"2022;82(12_Suppl):Abstract":[463],"nr":[464],"2509.":[465]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-06-16T00:00:00"}