{"id":"https://openalex.org/W4282927367","doi":"https://doi.org/10.1038/s41419-022-04976-6","title":"Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance of ovarian cancer cells via the c-Met-PI3K/Akt-miR-199a-3p signaling pathway","display_name":"Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance of ovarian cancer cells via the c-Met-PI3K/Akt-miR-199a-3p signaling pathway","publication_year":2022,"publication_date":"2022-06-08","ids":{"openalex":"https://openalex.org/W4282927367","doi":"https://doi.org/10.1038/s41419-022-04976-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/35676254","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9177676"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-022-04976-6","doi":"https://doi.org/10.1038/s41419-022-04976-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-04976-6","pdf_url":"https://www.nature.com/articles/s41419-022-04976-6.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-022-04976-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091158083","display_name":"Ayon Ahmed Hassan","orcid":"https://orcid.org/0000-0001-7783-9056","observed_orcids":["https://orcid.org/0000-0001-7783-9056"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ayon A. Hassan","raw_affiliation_strings":["School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0001-7783-9056","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070656848","display_name":"Margarita Artemenko","orcid":"https://orcid.org/0000-0002-0929-053X","observed_orcids":["https://orcid.org/0000-0002-0929-053X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Margarita Artemenko","raw_affiliation_strings":["School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053900590","display_name":"Maggie K. S. Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Maggie K. S. Tang","raw_affiliation_strings":["Laboratory for Synthetic Chemistry and Chemical Biology Limited, 17 W, Hong Kong Science and Technology Parks, Shatin, New Territories, Hong Kong","School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Synthetic Chemistry and Chemical Biology Limited, 17 W, Hong Kong Science and Technology Parks, Shatin, New Territories, Hong Kong","institution_ids":[]},{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030295817","display_name":"Zeyu Shi","orcid":"https://orcid.org/0000-0002-2773-9185","observed_orcids":["https://orcid.org/0000-0002-2773-9185"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zeyu Shi","raw_affiliation_strings":["School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004152947","display_name":"Lin\u2010Yu Chen","orcid":"https://orcid.org/0000-0003-4870-3664","observed_orcids":["https://orcid.org/0000-0003-4870-3664"]},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lin-Yu Chen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, Taipei, 23561, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4870-3664","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, Taipei, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031957353","display_name":"Hung-Cheng Lai","orcid":"https://orcid.org/0000-0001-9174-8732","observed_orcids":["https://orcid.org/0000-0001-9174-8732"]},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Cheng Lai","raw_affiliation_strings":["Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan","Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, Taipei, 23561, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, Taipei, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385","https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenyu Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhenyu Yang","raw_affiliation_strings":["Department of Mechanical Engineering, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112562173","display_name":"Ho-Cheung Shum","orcid":"https://orcid.org/0000-0002-6365-8825","observed_orcids":["https://orcid.org/0000-0002-6365-8825"]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ho-Cheung Shum","raw_affiliation_strings":["Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong","Department of Mechanical Engineering, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0002-6365-8825","affiliations":[{"raw_affiliation_string":"Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028662303","display_name":"Alice S.T. Wong","orcid":"https://orcid.org/0000-0002-0676-6475","observed_orcids":["https://orcid.org/0000-0002-0676-6475"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Alice S. T. Wong","raw_affiliation_strings":["School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong. awong1@hku.hk","School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0002-0676-6475","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong. awong1@hku.hk","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Pok Fu Lam, Pokfulam Road, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028662303"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":3.9623,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95787334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"13","issue":"6","first_page":"537","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.7179999947547913},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mir-199a-3p","display_name":"miR-199a-3p","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8650000095367432},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/microfluidic-tumor-model","display_name":"microfluidic tumor model","score":0.7369999885559082},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7017691135406494},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.6520209312438965},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6360010504722595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6055862903594971},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5509518384933472},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5116518139839172},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4427889585494995},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.44184350967407227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43769747018814087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3702194094657898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3469800353050232},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3067322373390198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.259704053401947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2190571129322052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07363858819007874},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0686434805393219},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001202","descriptor_name":"Ascitic Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001202","descriptor_name":"Ascitic Fluid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41419-022-04976-6","doi":"https://doi.org/10.1038/s41419-022-04976-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-04976-6","pdf_url":"https://www.nature.com/articles/s41419-022-04976-6.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmid:35676254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35676254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9177676","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9177676/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c2efad319cb943d690a16c5575e3aabb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c2efad319cb943d690a16c5575e3aabb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 13, Iss 6, Pp 1-11 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-022-04976-6","doi":"https://doi.org/10.1038/s41419-022-04976-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-04976-6","pdf_url":"https://www.nature.com/articles/s41419-022-04976-6.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3693823718","display_name":"Targeting miR-199a-3p to overcome chemoresistance in ovarian cancer","funder_award_id":"05163536","funder_id":"https://openalex.org/F4320335055","funder_display_name":"Health and Medical Research Fund"},{"id":"https://openalex.org/G5430754651","display_name":null,"funder_award_id":"05163536","funder_id":"https://openalex.org/F4320323291","funder_display_name":"Food and Health Bureau"}],"funders":[{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320323291","display_name":"Food and Health Bureau","ror":"https://ror.org/03qh32912"},{"id":"https://openalex.org/F4320335055","display_name":"Health and Medical Research Fund","ror":"https://ror.org/03qh32912"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282927367.pdf","grobid_xml":"https://content.openalex.org/works/W4282927367.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1455664495","https://openalex.org/W1991219544","https://openalex.org/W1993007643","https://openalex.org/W1997667183","https://openalex.org/W2006958938","https://openalex.org/W2014064723","https://openalex.org/W2016094742","https://openalex.org/W2021009690","https://openalex.org/W2035159126","https://openalex.org/W2042633087","https://openalex.org/W2044245339","https://openalex.org/W2048031659","https://openalex.org/W2053776188","https://openalex.org/W2057968053","https://openalex.org/W2061092267","https://openalex.org/W2077255241","https://openalex.org/W2086677489","https://openalex.org/W2087764699","https://openalex.org/W2090968329","https://openalex.org/W2099517697","https://openalex.org/W2106929712","https://openalex.org/W2116987967","https://openalex.org/W2119569797","https://openalex.org/W2125536613","https://openalex.org/W2149880040","https://openalex.org/W2163267648","https://openalex.org/W2169895170","https://openalex.org/W2292016096","https://openalex.org/W2370115962","https://openalex.org/W2406965650","https://openalex.org/W2411989512","https://openalex.org/W2425132249","https://openalex.org/W2586373162","https://openalex.org/W2610956165","https://openalex.org/W2763367287","https://openalex.org/W2770527543","https://openalex.org/W2772815803","https://openalex.org/W2805688581","https://openalex.org/W2951696645","https://openalex.org/W2968394742","https://openalex.org/W2975140046","https://openalex.org/W3048194554","https://openalex.org/W3080773873","https://openalex.org/W4210987384"],"related_works":["https://openalex.org/W3168295613","https://openalex.org/W3082965197","https://openalex.org/W2411989512","https://openalex.org/W7213965837","https://openalex.org/W3097098693","https://openalex.org/W2168170936","https://openalex.org/W1499327876","https://openalex.org/W2790898945","https://openalex.org/W2980957159","https://openalex.org/W4409652976"],"abstract_inverted_index":{"Abstract":[0],"Overcoming":[1],"drug":[2,148,161],"resistance":[3,162],"is":[4,221],"an":[5,24],"inevitable":[6],"challenge":[7],"to":[8,177],"the":[9,123,202],"success":[10],"of":[11,27,125,205],"cancer":[12,145,167,207],"treatment.":[13],"Recently,":[14],"in":[15,30,58,72,122,128,164,194,208,223],"ovarian":[16,166,188,206],"cancer,":[17],"a":[18,36,49,129,133,139,180,230],"highly":[19],"chemoresistant":[20,165],"tumor,":[21],"we":[22,47,61],"demonstrated":[23],"important":[25,222],"role":[26],"shear":[28,78],"stress":[29,79,121],"stem-like":[31],"phenotype":[32],"and":[33,66,101,117,147,191,215,220],"chemoresistance":[34],"using":[35],"three-dimensional":[37],"microfluidic":[38],"device,":[39],"which":[40],"most":[41,54],"closely":[42],"mimics":[43,226],"tumor":[44,102,189],"behavior.":[45],"Here,":[46],"examined":[48],"new":[50],"mechanosensitive":[51],"microRNA\u2014miR-199a-3p.":[52],"Unlike":[53],"key":[55],"microRNA":[56],"biogenesis":[57],"static":[59],"conditions,":[60],"found":[62],"that":[63,85,153],"Dicer,":[64],"Drosha,":[65],"Exportin":[67],"5":[68],"were":[69,174],"not":[70,91,118],"involved":[71],"regulating":[73],"miR-199a-3p":[74,111,154,172,184,219,225],"under":[75],"ascitic":[76,93],"fluid":[77],"(0.02":[80],"dynes/cm2).":[81],"We":[82,150],"further":[83,200],"showed":[84,152],"hepatocyte":[86],"growth":[87,99],"factor":[88,100,104],"(HGF),":[89],"but":[90],"other":[92],"cytokines/growth":[94],"factors":[95],"such":[96],"as":[97,229],"epidermal":[98],"necrosis":[103],"\u03b1":[105],"or":[106,198],"hypoxia,":[107],"could":[108],"transcriptionally":[109],"downregulate":[110],"through":[112,138],"its":[113,192],"primary":[114],"transcript":[115],"miR-199a-1":[116],"miR-199a-2.":[119],"Shear":[120],"presence":[124],"HGF":[126],"resulted":[127],"concerted":[130],"effect":[131],"via":[132],"specific":[134],"c-Met/PI3K/Akt":[135],"signaling":[136],"axis":[137],"positive":[140],"feedback":[141],"loop,":[142],"thereby":[143],"driving":[144],"stemness":[146],"resistance.":[149],"also":[151],"expression":[155,173],"was":[156],"inversely":[157],"correlated":[158],"with":[159,170,179,196],"enhanced":[160],"properties":[163],"lines.":[168],"Patients":[169],"low":[171],"more":[175],"resistant":[176],"platinum":[178],"significantly":[181,186],"poor":[182],"prognosis.":[183],"mimic":[185],"suppressed":[187],"metastasis":[190],"co-targeting":[193],"combination":[195],"cisplatin":[197],"paclitaxel":[199],"decreased":[201],"peritoneal":[203],"dissemination":[204],"mice.":[209],"These":[210],"findings":[211],"unravel":[212],"how":[213],"biophysical":[214],"biochemical":[216],"cues":[217],"regulate":[218],"chemoresistance.":[224],"may":[227],"serve":[228],"novel":[231],"targeted":[232],"therapy":[233],"for":[234],"effective":[235],"chemosensitization.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-16T00:00:00"}
