{"id":"https://openalex.org/W4282925993","doi":null,"title":"Brilacidin, a Non-Peptide Defensin-Mimetic Molecule, Inhibits SARS-CoV-2 Infection by Blocking Viral Entry.","display_name":"Brilacidin, a Non-Peptide Defensin-Mimetic Molecule, Inhibits SARS-CoV-2 Infection by Blocking Viral Entry.","publication_year":2022,"publication_date":"2022-04-01","ids":{"openalex":"https://openalex.org/W4282925993","pmid":"https://pubmed.ncbi.nlm.nih.gov/35695877","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9186380"},"language":"en","primary_location":{"id":"pmid:35695877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35695877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EC microbiology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9186380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064589732","display_name":"Chuan Xu","orcid":"https://orcid.org/0000-0003-4291-3820","observed_orcids":["https://orcid.org/0000-0003-4291-3820"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan Xu","raw_affiliation_strings":["Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717324","display_name":"Annie Wang","orcid":"https://orcid.org/0000-0002-1024-9294","observed_orcids":["https://orcid.org/0000-0002-1024-9294","https://orcid.org/0009-0006-6565-7101"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie Wang","raw_affiliation_strings":["Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035006967","display_name":"William J. Honnen","orcid":"https://orcid.org/0000-0003-3320-2162","observed_orcids":["https://orcid.org/0000-0003-3320-2162"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Honnen","raw_affiliation_strings":["Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039853127","display_name":"Abraham Pinter","orcid":"https://orcid.org/0000-0002-3262-3304","observed_orcids":["https://orcid.org/0000-0002-3262-3304"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Pinter","raw_affiliation_strings":["Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035537076","display_name":"Warren Weston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166298","display_name":"Innovation Pharmaceuticals (United States)","ror":"https://ror.org/05j53g380","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren K Weston","raw_affiliation_strings":["Innovation Pharmaceuticals, Inc., Wakefield, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Pharmaceuticals, Inc., Wakefield, Massachusetts, USA","institution_ids":["https://openalex.org/I4210166298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043906653","display_name":"Jane A. Harness","orcid":"https://orcid.org/0000-0002-4837-1594","observed_orcids":["https://orcid.org/0000-0002-4837-1594"]},"institutions":[{"id":"https://openalex.org/I4210166298","display_name":"Innovation Pharmaceuticals (United States)","ror":"https://ror.org/05j53g380","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane A Harness","raw_affiliation_strings":["Innovation Pharmaceuticals, Inc., Wakefield, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Pharmaceuticals, Inc., Wakefield, Massachusetts, USA","institution_ids":["https://openalex.org/I4210166298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055970298","display_name":"Aarthi Narayanan","orcid":"https://orcid.org/0000-0002-4889-4416","observed_orcids":["https://orcid.org/0000-0002-4889-4416"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aarthi Narayanan","raw_affiliation_strings":["National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082847051","display_name":"Theresa Li-Yun Chang","orcid":"https://orcid.org/0000-0003-0696-9755","observed_orcids":["https://orcid.org/0000-0003-0696-9755"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa L Chang","raw_affiliation_strings":["Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5889,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.844869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"18","issue":"4","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/covid-19-antiviral-therapy","display_name":"COVID-19 antiviral therapy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.9559999704360962},{"id":"https://openalex.org/keywords/virus-attachment","display_name":"viral attachment","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hace2","display_name":"hACE2","score":0.8379999995231628},{"id":"https://openalex.org/keywords/spike-receptor-binding-domain","display_name":"spike protein receptor-binding domain","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sars-cov-2-variants","display_name":"SARS-CoV-2 variants","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pseudovirus","display_name":"pseudovirus","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.7473706007003784},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.6549134850502014},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5297319293022156},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5294997692108154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5226423740386963},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.51127028465271},{"id":"https://openalex.org/C10852380","wikidata":"https://www.wikidata.org/wiki/Q7933613","display_name":"Viral structural protein","level":5,"score":0.499896764755249},{"id":"https://openalex.org/C2994541485","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral infection","level":3,"score":0.4986586570739746},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.456913560628891},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.4482569098472595},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4133400321006775},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.26491379737854004},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2536531388759613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10407894849777222},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:35695877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35695877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9186380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9186380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"EC Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9186380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9186380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"EC Microbiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6449842734","display_name":"Role of IFNe in immune modulation and HIV infection","funder_award_id":"R01AI136948","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1557583703","https://openalex.org/W1664985344","https://openalex.org/W2015271074","https://openalex.org/W2018308755","https://openalex.org/W2052300481","https://openalex.org/W2126369637","https://openalex.org/W2135458582","https://openalex.org/W2139690794","https://openalex.org/W2149789513","https://openalex.org/W2161237274","https://openalex.org/W2166249720","https://openalex.org/W2513757666","https://openalex.org/W3003217347","https://openalex.org/W3003668884","https://openalex.org/W3015751519","https://openalex.org/W3035459690","https://openalex.org/W3046463683","https://openalex.org/W3085153423","https://openalex.org/W3098697637","https://openalex.org/W3127589090","https://openalex.org/W3127713302","https://openalex.org/W3133921607","https://openalex.org/W3140446408","https://openalex.org/W3156343712","https://openalex.org/W3157838450","https://openalex.org/W3159697887","https://openalex.org/W3160918102","https://openalex.org/W3165479483","https://openalex.org/W3165852093","https://openalex.org/W3174879999","https://openalex.org/W4210582755"],"related_works":["https://openalex.org/W3097177146","https://openalex.org/W4210582755","https://openalex.org/W3127713302","https://openalex.org/W4286292983","https://openalex.org/W3118794874","https://openalex.org/W4287200885","https://openalex.org/W3152621001","https://openalex.org/W4220933243","https://openalex.org/W7122580860","https://openalex.org/W4205838243"],"abstract_inverted_index":{"Brilacidin":[0,32,43,61],"(PMX-30063),":[1],"a":[2],"non-peptide":[3],"defensin-mimetic":[4],"small":[5],"molecule,":[6],"inhibits":[7,104],"SARS-CoV-2":[8,34,46,105,115],"viral":[9,29,41,63,78,109],"infection":[10,35,106],"but":[11,36],"the":[12,24,28,52,57,72,85,89,94],"anti-viral":[13],"mechanism":[14],"is":[15,112],"not":[16,81],"defined.":[17],"Here":[18],"we":[19],"determined":[20],"its":[21],"effect":[22,39,76],"on":[23,71,77],"specific":[25],"step":[26],"of":[27,87],"life":[30],"cycle.":[31],"blocked":[33],"had":[37],"no":[38],"after":[40],"entry.":[42],"inhibited":[44],"pseudotyped":[45],"viruses":[47],"expressing":[48],"spike":[49,90,95],"proteins":[50],"from":[51],"P.1":[53],"Brazil":[54],"strain":[55],"and":[56,67,111],"B.1.1.7":[58],"UK":[59],"strain.":[60],"affected":[62],"attachment":[64],"in":[65],"hACE2-dependent":[66],"independent":[68],"manners":[69],"depending":[70],"concentrations.":[73],"The":[74],"inhibitory":[75],"entry":[79,110],"was":[80],"mediated":[82],"through":[83],"blocking":[84,108],"binding":[86],"either":[88],"receptor-binding":[91],"domain":[92],"or":[93],"S1":[96],"protein":[97],"to":[98],"hACE2":[99],"proteins.":[100],"Taken":[101],"together,":[102],"brilacidin":[103],"by":[107],"active":[113],"against":[114],"variants.":[116]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-06-16T00:00:00"}