{"id":"https://openalex.org/W4282925545","doi":"https://doi.org/10.1038/s41598-022-13112-5","title":"Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer","display_name":"Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer","publication_year":2022,"publication_date":"2022-06-08","ids":{"openalex":"https://openalex.org/W4282925545","doi":"https://doi.org/10.1038/s41598-022-13112-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/35676394","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9177731"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-13112-5","doi":"https://doi.org/10.1038/s41598-022-13112-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-13112-5","pdf_url":"https://www.nature.com/articles/s41598-022-13112-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-13112-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088832672","display_name":"Manon Ripoll","orcid":"https://orcid.org/0000-0003-2658-2697","observed_orcids":["https://orcid.org/0000-0003-2658-2697"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manon Ripoll","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005161967","display_name":"Elian Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210094129","display_name":"Institut Pierre-Gilles de Gennes pour la Microfluidique","ror":"https://ror.org/00q8h6763","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094129"]},{"id":"https://openalex.org/I4387155376","display_name":"Chimie Biologie Innovation","ror":"https://ror.org/04bgzse17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4387155376","https://openalex.org/I98910050"]},{"id":"https://openalex.org/I98910050","display_name":"ESPCI Paris","ror":"https://ror.org/03zx86w41","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elian Martin","raw_affiliation_strings":["Microfluidics, MEMS, Nanostructures Laboratory, CNRS Chimie Biologie Innovation (CBI), UMR 8231, Institut Pierre Gilles de Gennes (IPGG), ESPCI Paris, PSL Research University, 6 rue Jean Calvin, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microfluidics, MEMS, Nanostructures Laboratory, CNRS Chimie Biologie Innovation (CBI), UMR 8231, Institut Pierre Gilles de Gennes (IPGG), ESPCI Paris, PSL Research University, 6 rue Jean Calvin, 75005, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210094129","https://openalex.org/I4387155376","https://openalex.org/I98910050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016737471","display_name":"Mathilde Enot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathilde Enot","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104031892","display_name":"Oscar Robbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Oscar Robbe","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029796766","display_name":"Chiara Rapisarda","orcid":"https://orcid.org/0000-0002-1867-1385","observed_orcids":["https://orcid.org/0000-0002-1867-1385"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chiara Rapisarda","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015046600","display_name":"Marie\u2010Claire Nicola\u00ef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Claire Nicolai","raw_affiliation_strings":["REI Department, SANOFI Pasteur, 1541 Av. Marcel M\u00e9rieux, 69280, Marcy-L'\u00c9toile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REI Department, SANOFI Pasteur, 1541 Av. Marcel M\u00e9rieux, 69280, Marcy-L'\u00c9toile, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003657785","display_name":"Aurelie Deliot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lie Deliot","raw_affiliation_strings":["REI Department, SANOFI Pasteur, 1541 Av. Marcel M\u00e9rieux, 69280, Marcy-L'\u00c9toile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REI Department, SANOFI Pasteur, 1541 Av. Marcel M\u00e9rieux, 69280, Marcy-L'\u00c9toile, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108554238","display_name":"Patrick Tabeling","orcid":"https://orcid.org/0000-0001-5468-2746","observed_orcids":["https://orcid.org/0000-0001-5468-2746"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210094129","display_name":"Institut Pierre-Gilles de Gennes pour la Microfluidique","ror":"https://ror.org/00q8h6763","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094129"]},{"id":"https://openalex.org/I4387155376","display_name":"Chimie Biologie Innovation","ror":"https://ror.org/04bgzse17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4387155376","https://openalex.org/I98910050"]},{"id":"https://openalex.org/I98910050","display_name":"ESPCI Paris","ror":"https://ror.org/03zx86w41","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Patrick Tabeling","raw_affiliation_strings":["Microfluidics, MEMS, Nanostructures Laboratory, CNRS Chimie Biologie Innovation (CBI), UMR 8231, Institut Pierre Gilles de Gennes (IPGG), ESPCI Paris, PSL Research University, 6 rue Jean Calvin, 75005, Paris, France. ptabeling30@gmail.com","Microfluidics, MEMS, Nanostructures Laboratory, CNRS Chimie Biologie Innovation (CBI), UMR 8231, Institut Pierre Gilles de Gennes (IPGG), ESPCI Paris, PSL Research University, 6 rue Jean Calvin, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microfluidics, MEMS, Nanostructures Laboratory, CNRS Chimie Biologie Innovation (CBI), UMR 8231, Institut Pierre Gilles de Gennes (IPGG), ESPCI Paris, PSL Research University, 6 rue Jean Calvin, 75005, Paris, France. ptabeling30@gmail.com","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210094129","https://openalex.org/I4387155376","https://openalex.org/I98910050"]},{"raw_affiliation_string":"Microfluidics, MEMS, Nanostructures Laboratory, CNRS Chimie Biologie Innovation (CBI), UMR 8231, Institut Pierre Gilles de Gennes (IPGG), ESPCI Paris, PSL Research University, 6 rue Jean Calvin, 75005, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210094129","https://openalex.org/I4387155376","https://openalex.org/I98910050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047063154","display_name":"Jean\u2010Ren\u00e9 Authelin","orcid":"https://orcid.org/0000-0003-1271-2833","observed_orcids":["https://orcid.org/0000-0003-1271-2833"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Ren\u00e9 Authelin","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090687284","display_name":"Mostafa Nakach","orcid":"https://orcid.org/0000-0003-1897-8798","observed_orcids":["https://orcid.org/0000-0003-1897-8798"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mostafa Nakach","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070913960","display_name":"Pierre Wils","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Wils","raw_affiliation_strings":["BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDPD Department, SANOFI, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France","institution_ids":["https://openalex.org/I3018075036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5108554238"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210094129","https://openalex.org/I4387155376","https://openalex.org/I98910050"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":5.6977,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.97760675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"9483","last_page":"9483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.1386999934911728,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microfluidic-mixing","display_name":"microfluidic mixing","score":0.7590000033378601},{"id":"https://openalex.org/keywords/self-assembly","display_name":"self-assembly","score":0.875},{"id":"https://openalex.org/keywords/flow-rate-ratio","display_name":"flow rate ratio","score":0.652999997138977},{"id":"https://openalex.org/keywords/mixing-regime","display_name":"mixing regime","score":0.8379999995231628},{"id":"https://openalex.org/keywords/temporal-instability","display_name":"temporal instability","score":0.8479999899864197},{"id":"https://openalex.org/keywords/monodispersity","display_name":"monodispersity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mrna-delivery","display_name":"mRNA delivery","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2780982322","wikidata":"https://www.wikidata.org/wiki/Q3312230","display_name":"Micromixer","level":3,"score":0.9203304052352905},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6782349348068237},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5538142323493958},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.5226052403450012},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5107017159461975},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4435425400733948},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4149724841117859},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39999085664749146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39355117082595825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20130982995033264}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-022-13112-5","doi":"https://doi.org/10.1038/s41598-022-13112-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-13112-5","pdf_url":"https://www.nature.com/articles/s41598-022-13112-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1343595/v1","doi":"https://doi.org/10.21203/rs.3.rs-1343595/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1343595/v1","pdf_url":"https://www.researchsquare.com/article/rs-1343595/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9177731","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9177731","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:35676394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35676394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:08f3075aaadd4498a6d006c52044a091","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/08f3075aaadd4498a6d006c52044a091","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-13112-5","doi":"https://doi.org/10.1038/s41598-022-13112-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-13112-5","pdf_url":"https://www.nature.com/articles/s41598-022-13112-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320321693","display_name":"\u00c9cole Sup\u00e9rieure de Physique et de Chimie Industrielles de la Ville de Paris","ror":"https://ror.org/03zx86w41"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320330140","display_name":"Institut Pierre-Gilles de Gennes","ror":"https://ror.org/00q8h6763"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282925545.pdf","grobid_xml":"https://content.openalex.org/works/W4282925545.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1902700006","https://openalex.org/W1977238598","https://openalex.org/W1986670754","https://openalex.org/W2023023576","https://openalex.org/W2026567444","https://openalex.org/W2041030576","https://openalex.org/W2048197073","https://openalex.org/W2055197219","https://openalex.org/W2080718344","https://openalex.org/W2083584983","https://openalex.org/W2097859139","https://openalex.org/W2098595939","https://openalex.org/W2109578509","https://openalex.org/W2322913813","https://openalex.org/W2566902031","https://openalex.org/W2593414577","https://openalex.org/W2600400434","https://openalex.org/W2753039646","https://openalex.org/W2768292016","https://openalex.org/W2795918326","https://openalex.org/W2799813152","https://openalex.org/W2972699656","https://openalex.org/W3006764150","https://openalex.org/W3021028979","https://openalex.org/W3023901170","https://openalex.org/W3035225041","https://openalex.org/W3103321439","https://openalex.org/W3120476558","https://openalex.org/W3174114275","https://openalex.org/W3176085539","https://openalex.org/W3188661591","https://openalex.org/W4232534878","https://openalex.org/W4388393581","https://openalex.org/W4388399941"],"related_works":["https://openalex.org/W4401374967","https://openalex.org/W2147655511","https://openalex.org/W4416733440","https://openalex.org/W4403479622","https://openalex.org/W7205328386","https://openalex.org/W4416069755","https://openalex.org/W7159732141","https://openalex.org/W7117300124","https://openalex.org/W2768292016","https://openalex.org/W4415105923"],"abstract_inverted_index":{"Lipid":[0],"nanoparticles":[1],"(LNPs)":[2],"for":[3,12,26,161],"RNA":[4],"and":[5,22,35,56,82,107,121,149,172],"DNA":[6],"delivery":[7],"have":[8,65],"attracted":[9],"considerable":[10],"attention":[11],"their":[13],"ability":[14],"to":[15,23,39,98,133],"treat":[16],"a":[17,73,151],"broad":[18],"range":[19],"of":[20,60,70,79,115,136,145,158,169],"diseases":[21],"vectorize":[24],"mRNA":[25],"COVID":[27],"vaccines.":[28],"LNPs":[29,61,138,163],"are":[30,130,177],"produced":[31,62],"by":[32],"mixing":[33,52,113,128],"biomolecules":[34],"lipids,":[36],"which":[37,94],"self-assemble":[38],"form":[40],"the":[41,91,112,116,127,134,137,143,146,156],"desired":[42],"structure.":[43],"In":[44,85],"this":[45,86],"domain,":[46],"microfluidics":[47],"shows":[48],"clear":[49],"advantages:":[50],"high":[51,99],"quality,":[53],"low-stress":[54],"conditions,":[55],"fast":[57],"preparation.":[58],"Studies":[59],"in":[63,67,75,77,167],"micromixers":[64],"revealed,":[66],"certain":[68],"ranges":[69],"flow":[71],"rates,":[72],"degradation":[74],"performance":[76,114],"terms":[78,168],"size,":[80],"monodispersity":[81,171],"encapsulation":[83,173],"efficiency.":[84],"study,":[87],"we":[88,124,139],"focus":[89],"on":[90,155],"ring":[92],"micromixer,":[93],"is":[95],"well":[96],"adapted":[97],"throughput.":[100],"We":[101,141],"reveal":[102],"three":[103],"regimes,":[104],"side-by-side,":[105],"transitional":[106],"highly":[108],"mixed,":[109],"that":[110,126],"control":[111],"device.":[117],"Furthermore,":[118],"using":[119],"cryo-TEM":[120],"biochemical":[122],"analysis,":[123],"show":[125],"performances":[129],"strongly":[131],"correlated":[132],"characteristics":[135,166],"produce.":[140],"emphasize":[142],"importance":[144],"flow-rate":[147],"ratio":[148],"propose":[150],"physical":[152],"criterion":[153],"based":[154],"onset":[157],"temporal":[159],"instabilities":[160],"producing":[162],"with":[164],"optimal":[165],"geometry,":[170],"yield.":[174],"These":[175],"criteria":[176],"generally":[178],"applicable.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":48},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-16T00:00:00"}