{"id":"https://openalex.org/W4282923209","doi":"https://doi.org/10.1158/1538-7445.am2022-506","title":"Abstract 506: Dissecting the genomic and tumor immune microenvironment factors associated with disease recurrence in resected stage I NSCLC","display_name":"Abstract 506: Dissecting the genomic and tumor immune microenvironment factors associated with disease recurrence in resected stage I NSCLC","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282923209","doi":"https://doi.org/10.1158/1538-7445.am2022-506"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-506","doi":"https://doi.org/10.1158/1538-7445.am2022-506","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-506","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085305921","display_name":"Joao V. Alessi","orcid":"https://orcid.org/0000-0002-8072-5946","observed_orcids":["https://orcid.org/0000-0002-8072-5946"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao Victor Alessi","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089358409","display_name":"Zihan Wei","orcid":"https://orcid.org/0000-0001-9234-3497","observed_orcids":["https://orcid.org/0000-0001-9234-3497","https://orcid.org/0009-0003-1483-8162"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zihan Wei","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030450694","display_name":"Biagio Ricciuti","orcid":"https://orcid.org/0000-0002-0651-2678","observed_orcids":["https://orcid.org/0000-0002-0651-2678"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biagio Ricciuti","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064325544","display_name":"James R. Lindsay","orcid":"https://orcid.org/0000-0002-6295-098X","observed_orcids":["https://orcid.org/0000-0002-6295-098X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lindsay","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035581993","display_name":"Victor R. Vaz","orcid":"https://orcid.org/0000-0003-3714-2814","observed_orcids":["https://orcid.org/0000-0003-3714-2814"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor R. Vaz","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008091222","display_name":"Adriana Paula de Castro Barrichello","orcid":"https://orcid.org/0000-0003-1633-8236","observed_orcids":["https://orcid.org/0000-0003-1633-8236"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Barrichello","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012223543","display_name":"Bijaya Sharma","orcid":"https://orcid.org/0000-0003-3432-1876","observed_orcids":["https://orcid.org/0000-0003-3432-1876"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bijaya Sharma","raw_affiliation_strings":["2Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028264464","display_name":"Kristen D. Felt","orcid":"https://orcid.org/0000-0001-7063-8374","observed_orcids":["https://orcid.org/0000-0001-7063-8374"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen D. Felt","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075568815","display_name":"Fangxin Hong","orcid":"https://orcid.org/0000-0001-8049-0086","observed_orcids":["https://orcid.org/0000-0001-8049-0086"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fangxin Hong","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090956629","display_name":"Lynette Marie Sholl","orcid":"https://orcid.org/0000-0002-9532-9735","observed_orcids":["https://orcid.org/0000-0002-9532-9735"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynette M. Sholl","raw_affiliation_strings":["3Brigham and Women\u2019s Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Brigham and Women\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J. Rodig","raw_affiliation_strings":["3Brigham and Women\u2019s Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Brigham and Women\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086249998","display_name":"Mark Magdi Awad","orcid":"https://orcid.org/0000-0003-0928-5244","observed_orcids":["https://orcid.org/0000-0003-0928-5244"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M. Awad","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"506","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stage-i-non-small-cell-lung-cancer","display_name":"stage I non-small cell lung cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.9129999876022339},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/intratumoral-immune-cells","display_name":"intratumoral immune cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-stroma-interface","display_name":"tumor-stroma interface","score":0.9039999842643738},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.6830000281333923},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.781000018119812},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.7009999752044678},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7061557769775391},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5891887545585632},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5817500352859497},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5595723390579224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5591781735420227},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5289024710655212},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5119422674179077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45413076877593994},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.44161704182624817},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4211544692516327},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4155588150024414},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3846787214279175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2377133071422577},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.19655781984329224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1409323513507843},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-506","doi":"https://doi.org/10.1158/1538-7445.am2022-506","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-506","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205926924","https://openalex.org/W3176649120","https://openalex.org/W4317107406","https://openalex.org/W2886521490","https://openalex.org/W3183581557","https://openalex.org/W4407293153","https://openalex.org/W2954305362","https://openalex.org/W2507923789","https://openalex.org/W2898107202","https://openalex.org/W2046609236"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Patients":[2],"with":[3,41,56,101,116,145,165,210,235,557],"early-stage":[4],"non-small":[5],"cell":[6,217,225],"lung":[7],"cancer":[8],"(NSCLC)":[9],"are":[10],"at":[11,192,276,301],"substantial":[12],"risk":[13,228,278],"for":[14,68,572],"disease":[15,27,280,558],"recurrence":[16,28,42,281,559],"after":[17,43,282],"surgical":[18,283],"resection,":[19],"and":[20,37,72,88,152,171,179,188,213,227,244,267,287,514,551],"the":[21,136,193,483,486,492,500,509,549,569],"discovery":[22],"of":[23,76,123,132,138,150,159,174,229,269,279,485,489,508,568],"biomarkers":[24],"that":[25,205],"predict":[26],"has":[29],"been":[30],"challenging.":[31],"We":[32,50,219],"sought":[33],"to":[34,84,505],"identify":[35,85,274],"genomic":[36,86,550],"immunologic":[38],"factors":[39,555],"associated":[40,164,209,234,556],"surgery":[44],"in":[45,198,560],"stage":[46,58,270,562],"I":[47,59,271,563],"NSCLC.":[48],"Methods:":[49],"collected":[51],"clinicopathologic":[52],"data":[53],"from":[54,135],"patients":[55],"resected":[57,561],"NSCLC":[60,564],"(AJCC":[61],"8th":[62],"Edition)":[63],"which":[64],"underwent":[65],"multiplexed":[66],"immunofluorescence":[67],"CD8+,":[69,177],"FOXP3+,":[70],"PD-1+,":[71,178],"PD-L1.":[73],"A":[74,93,121],"subset":[75],"these":[77],"samples":[78],"also":[79],"had":[80],"next-generation":[81],"sequencing":[82],"performed":[83],"alterations":[87],"tumor":[89,194,216,490,513,552],"mutational":[90],"burden":[91],"(TMB).":[92],"bidirectional":[94],"stepwise":[95],"elimination":[96],"was":[97,114,163,208,233],"applied":[98],"on":[99],"variables":[100],"a":[102,129,146,153,221],"univariable":[103,199],"disease-free":[104],"survival":[105,156,291],"(DFS)":[106],"p-value":[107,295,299],"<0.25.":[108],"The":[109],"final":[110],"multivariable":[111,288],"Cox":[112],"model":[113,259],"validated":[115],"internal":[117],"bootstrapping":[118],"(B=300).":[119],"Results:":[120],"total":[122],"252":[124],"cases":[125,141,275],"were":[126],"included.":[127],"After":[128],"median":[130],"follow-up":[131],"25.6":[133],"months":[134],"time":[137],"surgery,":[139],"47":[140],"(18.7%)":[142],"experienced":[143],"recurrence,":[144],"2-year":[147,154],"DFS":[148,162,207,232],"rate":[149,158],"82.9%,":[151],"overall":[155],"(OS)":[157],"97.9%.":[160],"Shorter":[161],"higher":[166,214,236,245],"TMB,":[167],"increased":[168,186],"PD-L1":[169,215,449],"expression,":[170],"greater":[172],"numbers":[173],"intratumoral":[175],"(IT)":[176],"PD-1+CD8+":[180],"immune":[181,224,242,553],"cells,":[182,243],"as":[183,185,482,499],"well":[184],"CD8+":[187,388,406,423,439],"FOXP3+":[189,250,414,448],"T":[190,251],"cells":[191,252,469],"stroma":[195],"interface":[196],"(TSI)":[197],"analyses":[200],"(p<0.05).":[201],"Multivariable":[202,296],"analysis":[203,266,289],"showed":[204,257],"shorter":[206,231],"increasing":[211],"TMB":[212],"expression.":[218],"observed":[220],"difference":[222],"by":[223],"localization":[226],"recurrence:":[230],"IT":[237,246],"but":[238,247],"lower":[239,248],"TSI":[240,249],"PD-1+":[241,397,405,431,438],"(Table).":[253],"Internal":[254],"bootstrap":[255],"validation":[256],"good":[258],"performance":[260],"(C-index":[261],"=":[262],"0.74).":[263],"Conclusion:":[264],"Genomic":[265],"immunophenotyping":[268],"NSCLCs":[272],"can":[273],"greatest":[277],"resection.":[284],"Table.":[285],"Univariable":[286,292],"Disease-free":[290],"HR":[293,297],"[95%CI]":[294,298],"Stage":[300],"diagnosis":[302],"-":[303,321,354,369,371,386,402,421,422,436,437,466,467],"0.10":[304],"\u2013":[305,306,333,334,350,351,356,357,387,403],"IA1":[307],"1.52":[308],"[0.58,":[309],"3.97]":[310],"IA2":[311],"2.61":[312,316],"[0.95,":[313],"7.20]":[314],"IA3":[315],"[1.03,":[317,383,441],"6.63]":[318],"IB":[319],"Histology":[320],"0.42":[322],"Adenocarcinoma":[323],"1.38":[324],"[0.65,":[325],"2.97]":[326],"Squamous":[327],"Age*":[328],"1.02":[329,451,463],"[0.99,":[330,433],"1.06]":[331],"0.19":[332],"TMB*":[335],"1.09":[336,340,382],"[1.05,":[337,341],"1.12]":[338],"<0.001":[339,343,447,454,458],"1.13]":[342],"Smoking*":[344],"(pack-years)":[345],"1.01":[346],"[1.00,":[347],"1.02]":[348],"0.008":[349],"Smoking":[352],"history":[353],"0.012":[355],"Never":[358],"5.24":[359],"[1.27,":[360],"21.7]":[361],"Former":[362],"Current":[363],"4.92":[364],"[0.82,":[365],"29.5]":[366],"Surgical":[367],"treatment":[368],"0.084":[370],"0.074":[372],"Lobectomy":[373],"1.80":[374,393],"[0.89,":[375],"3.62]":[376],"2.18":[377],"[0.93,":[378],"5.14]":[379],"Sublobar":[380],"Intratumoral**":[381],"1.16]":[384],"0.015":[385],"1.22":[389,407],"[1.10,":[390],"1.36]":[391],"0.002":[392],"[1.13,":[394],"2.87]":[395],"0.014":[396],"1.51":[398],"[1.20,":[399],"1.90]":[400],"0.004":[401,404],"[1.04,":[408],"1.44]":[409],"0.053":[410],"0.15":[411],"[0.04,":[412],"0.55]":[413],"Tumor-Stroma":[415,495],"Interface**":[416],"1.06":[417],"[1.01,":[418,452,456,464],"1.11]":[419],"0.033":[420],"1.10":[424],"[1.01,1.20]":[425],"0.056":[426],"0.71":[427],"[0.56,":[428],"0.91]":[429],"0.007":[430],"1.21":[432],"1.48]":[434],"0.100":[435],"1.28":[440],"1.59]":[442],"0.037":[443],"2.42":[444],"[1.49,":[445],"3.95]":[446],"expression*":[450],"1.03]":[453],"1.03":[455],"1.04]":[457,465],"Tumor":[459],"Proportion":[460],"Score":[461],"(TPS)":[462],"Immune":[468],"0.011":[470],"*Per":[471],"unit":[472],"increase.":[473,478],"**":[474],"Per":[475],"100":[476],"units":[477],"Intratumoral,":[479],"is":[480,497],"defined":[481,498,510],"region":[484,501],"slide":[487],"consisting":[488],"beyond":[491],"tumor-stroma":[493],"interface.":[494],"Interface":[496],"within":[502],"40":[503],"microns":[504],"either":[506],"side":[507],"border":[511],"between":[512],"stroma.":[515],"Citation":[516],"Format:":[517],"Joao":[518],"Victor":[519,527],"Alessi,":[520],"Zihan":[521],"Wei,":[522],"Biagio":[523],"Ricciuti,":[524],"James":[525],"Lindsay,":[526],"R.":[528],"Vaz,":[529],"Adriana":[530],"Barrichello,":[531],"Bijaya":[532],"Sharma,":[533],"Kristen":[534],"D.":[535],"Felt,":[536],"Fangxin":[537],"Hong,":[538],"Lynette":[539],"M.":[540,546],"Sholl,":[541],"Scott":[542],"J.":[543],"Rodig,":[544],"Mark":[545],"Awad.":[547],"Dissecting":[548],"microenvironment":[554],"[abstract].":[565],"In:":[566],"Proceedings":[567],"American":[570],"Association":[571],"Cancer":[573,584],"Research":[574],"Annual":[575],"Meeting":[576],"2022;":[577],"2022":[578],"Apr":[579],"8-13.":[580],"Philadelphia":[581],"(PA):":[582],"AACR;":[583],"Res":[585],"2022;82(12_Suppl):Abstract":[586],"nr":[587],"506.":[588]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-06-16T00:00:00"}