{"id":"https://openalex.org/W4282918642","doi":"https://doi.org/10.1186/s13045-022-01298-0","title":"Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence","display_name":"Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence","publication_year":2022,"publication_date":"2022-06-11","ids":{"openalex":"https://openalex.org/W4282918642","doi":"https://doi.org/10.1186/s13045-022-01298-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/35690784","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188021"},"language":"en","primary_location":{"id":"doi:10.1186/s13045-022-01298-0","doi":"https://doi.org/10.1186/s13045-022-01298-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-022-01298-0","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-022-01298-0","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-022-01298-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027276409","display_name":"Daniel C. Kreatsoulas","orcid":"https://orcid.org/0000-0002-9727-7019","observed_orcids":["https://orcid.org/0000-0002-9727-7019"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405282248","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405282248"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kreatsoulas","raw_affiliation_strings":["Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA","Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035017270","display_name":"Chelsea M. Bolyard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405282248","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405282248"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea Bolyard","raw_affiliation_strings":["Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056710085","display_name":"Bill Xingjun Wu","orcid":"https://orcid.org/0000-0001-5759-0935","observed_orcids":["https://orcid.org/0000-0001-5759-0935"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405282248","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405282248"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bill X. Wu","raw_affiliation_strings":["Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048986591","display_name":"Hakan \u00c7am","orcid":"https://orcid.org/0000-0002-5057-9757","observed_orcids":["https://orcid.org/0000-0002-5057-9757"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405282248","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405282248"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hakan Cam","raw_affiliation_strings":["Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020238544","display_name":"Pierre Giglio","orcid":"https://orcid.org/0000-0001-5165-0984","observed_orcids":["https://orcid.org/0000-0001-5165-0984"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre Giglio","raw_affiliation_strings":["Department of Neuro-Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002360335","display_name":"Zihai Li","orcid":"https://orcid.org/0000-0003-4603-927X","observed_orcids":["https://orcid.org/0000-0003-4603-927X"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405282248","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405282248"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zihai Li","raw_affiliation_strings":["Department of Medical Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA. zihai.li@osumc.edu","Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA. zihai.li@osumc.edu","Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Ohio State University Wexner Medical Center, James Cancer Center, Columbus, OH, USA. zihai.li@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA. zihai.li@osumc.edu","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 W 12th Avenue, BRT 550, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248","https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002360335"],"corresponding_institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I2802841970","https://openalex.org/I4405282248","https://openalex.org/I52357470"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.4315,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92840779,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"80","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adoptive-cellular-therapy","display_name":"adoptive cellular therapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.5860000252723694},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7699999809265137},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9610000252723694},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5099999904632568},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8289999961853027},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6060000061988831},{"id":"https://openalex.org/keywords/nucleic-acid-therapy","display_name":"nucleic acid therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nanoparticle-therapy","display_name":"nanoparticle therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6763894557952881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6512786149978638},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6021008491516113},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5288504362106323},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5013065338134766},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46384671330451965},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.46218952536582947},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4337879717350006},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4238699674606323},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3773246705532074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3594515323638916},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33317241072654724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21737921237945557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1827063262462616}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010820","descriptor_name":"Physicians","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13045-022-01298-0","doi":"https://doi.org/10.1186/s13045-022-01298-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-022-01298-0","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-022-01298-0","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9188021","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188021","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmid:35690784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35690784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5c89ef181a664b1f8a3be54c291b7f46","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5c89ef181a664b1f8a3be54c291b7f46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-30 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13045-022-01298-0","doi":"https://doi.org/10.1186/s13045-022-01298-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-022-01298-0","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-022-01298-0","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1858189645","display_name":null,"funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320316230","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282918642.pdf","grobid_xml":"https://content.openalex.org/works/W4282918642.grobid-xml"},"referenced_works_count":244,"referenced_works":["https://openalex.org/W1521384669","https://openalex.org/W1579863504","https://openalex.org/W1588685142","https://openalex.org/W1604141497","https://openalex.org/W1604619549","https://openalex.org/W1653244371","https://openalex.org/W1815157104","https://openalex.org/W1823780969","https://openalex.org/W1828443506","https://openalex.org/W1858631806","https://openalex.org/W1945007559","https://openalex.org/W1965748088","https://openalex.org/W1967923698","https://openalex.org/W1980441719","https://openalex.org/W1994024849","https://openalex.org/W2001717792","https://openalex.org/W2006862425","https://openalex.org/W2006863456","https://openalex.org/W2010893633","https://openalex.org/W2012430921","https://openalex.org/W2013637325","https://openalex.org/W2016821076","https://openalex.org/W2017364703","https://openalex.org/W2020604769","https://openalex.org/W2024672608","https://openalex.org/W2026480865","https://openalex.org/W2030212896","https://openalex.org/W2038709470","https://openalex.org/W2040773741","https://openalex.org/W2043451794","https://openalex.org/W2045796964","https://openalex.org/W2054626405","https://openalex.org/W2055988323","https://openalex.org/W2056628849","https://openalex.org/W2056679169","https://openalex.org/W2073911364","https://openalex.org/W2077508806","https://openalex.org/W2093705034","https://openalex.org/W2094998207","https://openalex.org/W2096287682","https://openalex.org/W2099886521","https://openalex.org/W2103634316","https://openalex.org/W2106511606","https://openalex.org/W2107731685","https://openalex.org/W2110592777","https://openalex.org/W2113024959","https://openalex.org/W2114701172","https://openalex.org/W2115240522","https://openalex.org/W2116376294","https://openalex.org/W2117728670","https://openalex.org/W2124736921","https://openalex.org/W2125061065","https://openalex.org/W2128345996","https://openalex.org/W2129481598","https://openalex.org/W2132174136","https://openalex.org/W2132452208","https://openalex.org/W2135843336","https://openalex.org/W2137605317","https://openalex.org/W2144952279","https://openalex.org/W2146881779","https://openalex.org/W2148977460","https://openalex.org/W2149398709","https://openalex.org/W2154568166","https://openalex.org/W2155402153","https://openalex.org/W2156330848","https://openalex.org/W2161289668","https://openalex.org/W2169869816","https://openalex.org/W2190672185","https://openalex.org/W2192976324","https://openalex.org/W2204420463","https://openalex.org/W2205491921","https://openalex.org/W2220215167","https://openalex.org/W2236375555","https://openalex.org/W2253972308","https://openalex.org/W2296457333","https://openalex.org/W2346941018","https://openalex.org/W2366536035","https://openalex.org/W2426347188","https://openalex.org/W2436534309","https://openalex.org/W2511743252","https://openalex.org/W2526471112","https://openalex.org/W2536983481","https://openalex.org/W2547310148","https://openalex.org/W2567424265","https://openalex.org/W2572174216","https://openalex.org/W2591531756","https://openalex.org/W2591880289","https://openalex.org/W2592133876","https://openalex.org/W2600281432","https://openalex.org/W2605626471","https://openalex.org/W2606625852","https://openalex.org/W2610204288","https://openalex.org/W2611950171","https://openalex.org/W2612034094","https://openalex.org/W2620423263","https://openalex.org/W2687707072","https://openalex.org/W2725126138","https://openalex.org/W2725858612","https://openalex.org/W2737209177","https://openalex.org/W2738678436","https://openalex.org/W2744206077","https://openalex.org/W2748217844","https://openalex.org/W2748739447","https://openalex.org/W2749747068","https://openalex.org/W2751210549","https://openalex.org/W2752227448","https://openalex.org/W2752314762","https://openalex.org/W2753432434","https://openalex.org/W2763751953","https://openalex.org/W2765633257","https://openalex.org/W2766048952","https://openalex.org/W2766649683","https://openalex.org/W2767198352","https://openalex.org/W2770661082","https://openalex.org/W2771352624","https://openalex.org/W2772664652","https://openalex.org/W2778283729","https://openalex.org/W2783137027","https://openalex.org/W2787278337","https://openalex.org/W2787301955","https://openalex.org/W2788898403","https://openalex.org/W2790035192","https://openalex.org/W2790574591","https://openalex.org/W2790865199","https://openalex.org/W2790923203","https://openalex.org/W2792937256","https://openalex.org/W2800544499","https://openalex.org/W2803170025","https://openalex.org/W2803225762","https://openalex.org/W2805359783","https://openalex.org/W2807901909","https://openalex.org/W2811300508","https://openalex.org/W2831487285","https://openalex.org/W2837320447","https://openalex.org/W2887361912","https://openalex.org/W2889092098","https://openalex.org/W2892876553","https://openalex.org/W2894102714","https://openalex.org/W2894584497","https://openalex.org/W2896027205","https://openalex.org/W2896179230","https://openalex.org/W2901262057","https://openalex.org/W2901442011","https://openalex.org/W2903062212","https://openalex.org/W2904210127","https://openalex.org/W2904803926","https://openalex.org/W2908722991","https://openalex.org/W2911455769","https://openalex.org/W2912342382","https://openalex.org/W2912411620","https://openalex.org/W2913625932","https://openalex.org/W2913863501","https://openalex.org/W2916254412","https://openalex.org/W2921993697","https://openalex.org/W2922661875","https://openalex.org/W2925307360","https://openalex.org/W2927282330","https://openalex.org/W2937453479","https://openalex.org/W2937732940","https://openalex.org/W2937823726","https://openalex.org/W2941630943","https://openalex.org/W2945788231","https://openalex.org/W2950471695","https://openalex.org/W2951880440","https://openalex.org/W2952126206","https://openalex.org/W2957974627","https://openalex.org/W2963242540","https://openalex.org/W2963730372","https://openalex.org/W2964103826","https://openalex.org/W2966381366","https://openalex.org/W2969983729","https://openalex.org/W2974227664","https://openalex.org/W2976744492","https://openalex.org/W2979472290","https://openalex.org/W2983134909","https://openalex.org/W2983179918","https://openalex.org/W2985370419","https://openalex.org/W2990269792","https://openalex.org/W2990654167","https://openalex.org/W2995486427","https://openalex.org/W2995682532","https://openalex.org/W2998838014","https://openalex.org/W2999066612","https://openalex.org/W3000560268","https://openalex.org/W3003555565","https://openalex.org/W3004921365","https://openalex.org/W3008946692","https://openalex.org/W3009187475","https://openalex.org/W3009244677","https://openalex.org/W3010932118","https://openalex.org/W3011587695","https://openalex.org/W3017270631","https://openalex.org/W3017329354","https://openalex.org/W3019492846","https://openalex.org/W3026551532","https://openalex.org/W3028392872","https://openalex.org/W3029211707","https://openalex.org/W3032451916","https://openalex.org/W3032465961","https://openalex.org/W3035091904","https://openalex.org/W3036872506","https://openalex.org/W3040064610","https://openalex.org/W3043703771","https://openalex.org/W3045620658","https://openalex.org/W3046958019","https://openalex.org/W3047968167","https://openalex.org/W3089667275","https://openalex.org/W3093491547","https://openalex.org/W3094771195","https://openalex.org/W3101861808","https://openalex.org/W3107050167","https://openalex.org/W3109678089","https://openalex.org/W3110528877","https://openalex.org/W3111382402","https://openalex.org/W3112427849","https://openalex.org/W3114152106","https://openalex.org/W3114773357","https://openalex.org/W3117300156","https://openalex.org/W3123632399","https://openalex.org/W3125945798","https://openalex.org/W3127125452","https://openalex.org/W3127182391","https://openalex.org/W3127383553","https://openalex.org/W3131204999","https://openalex.org/W3131460561","https://openalex.org/W3139145797","https://openalex.org/W3140882615","https://openalex.org/W3142013426","https://openalex.org/W3154431974","https://openalex.org/W3164896384","https://openalex.org/W3165520347","https://openalex.org/W3165863602","https://openalex.org/W3166677931","https://openalex.org/W3171571522","https://openalex.org/W3174246647","https://openalex.org/W3174421288","https://openalex.org/W3180351435","https://openalex.org/W3181844424","https://openalex.org/W3194247868","https://openalex.org/W3194971451","https://openalex.org/W3198041401","https://openalex.org/W3200758003","https://openalex.org/W3202901824","https://openalex.org/W4211132876"],"related_works":["https://openalex.org/W4403844535","https://openalex.org/W4207070503","https://openalex.org/W3015150584","https://openalex.org/W4378695292","https://openalex.org/W4378226817","https://openalex.org/W4393202405","https://openalex.org/W4401946297","https://openalex.org/W4389346219","https://openalex.org/W4417081252","https://openalex.org/W4285684476"],"abstract_inverted_index":{"Despite":[0],"recent":[1],"advances":[2],"in":[3,17,71,91,142,170,220],"cancer":[4],"therapeutics,":[5],"glioblastoma":[6],"(GBM)":[7],"remains":[8],"one":[9],"of":[10,34,41,52,67,74,96,117,165,253,256],"the":[11,19,31,35,38,42,50,72,82,166,221,249,254],"most":[12,250],"difficult":[13],"cancers":[14],"to":[15,78,85,119,247,268],"treat":[16],"both":[18,262],"primary":[20],"and":[21,37,57,65,105,108,124,151,176,189,210,223,237,240,260,265],"recurrent":[22],"settings.":[23],"GBM":[24,259],"presents":[25],"a":[26,114,161,199],"unique":[27],"therapeutic":[28],"challenge":[29],"given":[30],"immune-privileged":[32],"environment":[33,168],"brain":[36],"aggressive":[39],"nature":[40],"disease.":[43],"Furthermore,":[44],"it":[45],"can":[46],"change":[47],"phenotypes":[48],"throughout":[49],"course":[51],"disease-switching":[53],"between":[54],"mesenchymal,":[55],"neural,":[56],"classic":[58],"gene":[59],"signatures,":[60],"each":[61],"with":[62,93,113,144,198],"specific":[63],"markers":[64],"mechanisms":[66],"resistance.":[68],"Recent":[69],"advancements":[70],"field":[73,222,255],"immunotherapy-which":[75],"utilizes":[76],"strategies":[77],"reenergize":[79],"or":[80],"alter":[81],"immune":[83,167,203],"system":[84],"target":[86],"cancer-have":[87],"shown":[88],"striking":[89],"results":[90],"patients":[92],"many":[94],"types":[95],"malignancy.":[97],"Immune":[98],"checkpoint":[99,204],"inhibitors,":[100,205],"adoptive":[101],"cellular":[102,104],"therapy,":[103,209,239],"peptide":[106],"vaccines,":[107],"other":[109],"technologies":[110],"provide":[111,160,248],"clinicians":[112],"vast":[115],"array":[116],"tools":[118],"design":[120],"highly":[121],"individualized":[122],"treatment":[123,147],"potential":[125],"for":[126,139,258],"combination":[127,143,230],"strategies.":[128],"There":[129],"are":[130],"currently":[131,225],"over":[132],"80":[133],"active":[134,226],"clinical":[135,227,271],"trials":[136],"evaluating":[137],"immunotherapies":[138],"GBM,":[140,171],"often":[141],"standard":[145],"secondary":[146],"options":[148],"including":[149,229],"re-resection":[150],"anti-angiogenic":[152],"agents,":[153],"such":[154],"as":[155],"bevacizumab.":[156],"This":[157,244],"review":[158,245],"will":[159,192,216],"clinically":[162],"focused":[163],"overview":[164],"present":[169],"which":[172],"is":[173],"frequently":[174],"immunosuppressive":[175],"characterized":[177],"by":[178],"M2":[179],"macrophages,":[180],"T":[181],"cell":[182,212],"exhaustion,":[183],"enhanced":[184],"transforming":[185],"growth":[186],"factor-\u03b2":[187],"signaling,":[188],"others.":[190],"We":[191],"also":[193],"outline":[194],"existing":[195],"immunotherapeutic":[196],"strategies,":[197,231],"special":[200],"focus":[201],"on":[202],"chimeric":[206],"antigen":[207],"receptor":[208],"dendritic":[211],"vaccines.":[213,243],"Finally,":[214],"we":[215],"summarize":[217],"key":[218],"discoveries":[219],"discuss":[224],"trials,":[228],"burgeoning":[232],"technology":[233],"like":[234],"nucleic":[235],"acid":[236],"nanoparticle":[238],"novel":[241],"anticancer":[242],"aims":[246],"updated":[251],"summary":[252],"immunotherapy":[257],"offer":[261],"historical":[263],"perspective":[264],"future":[266],"directions":[267],"help":[269],"inform":[270],"practice.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-16T00:00:00"}
