{"id":"https://openalex.org/W4282916703","doi":"https://doi.org/10.1158/1538-7445.am2022-1774","title":"Abstract 1774: Circulating IL-6, an early biomarker in HR-positive, HER2-negative metastatic breast cancer patients progressing on CDK4/6 inhibitors","display_name":"Abstract 1774: Circulating IL-6, an early biomarker in HR-positive, HER2-negative metastatic breast cancer patients progressing on CDK4/6 inhibitors","publication_year":2022,"publication_date":"2022-06-15","ids":{"openalex":"https://openalex.org/W4282916703","doi":"https://doi.org/10.1158/1538-7445.am2022-1774"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2022-1774","doi":"https://doi.org/10.1158/1538-7445.am2022-1774","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1774","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026936750","display_name":"Nicole M. Kettner","orcid":"https://orcid.org/0000-0003-2043-4407","observed_orcids":["https://orcid.org/0000-0003-2043-4407"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. Kettner","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000113218","display_name":"Tuyen N. Bui","orcid":"https://orcid.org/0000-0001-8509-3653","observed_orcids":["https://orcid.org/0000-0001-8509-3653"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuyen N. Bui","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017644527","display_name":"Juliana Navarro-Yepes","orcid":"https://orcid.org/0000-0003-0393-3773","observed_orcids":["https://orcid.org/0000-0003-0393-3773"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliana Navarro-Yepes","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073833379","display_name":"Thomas Kris Eckols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Kris Eckols","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016698215","display_name":"Akshara Singareeka Raghavendra","orcid":"https://orcid.org/0000-0002-6425-4400","observed_orcids":["https://orcid.org/0000-0002-6425-4400"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akshara S. Raghavendra","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071331596","display_name":"David John Tweardy","orcid":"https://orcid.org/0000-0001-8492-8460","observed_orcids":["https://orcid.org/0000-0001-8492-8460"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Tweardy","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411324","display_name":"Kelly K. Hunt","orcid":"https://orcid.org/0000-0001-9156-8723","observed_orcids":["https://orcid.org/0000-0001-9156-8723"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly K. Hunt","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083321","display_name":"Debu Tripathy","orcid":"https://orcid.org/0000-0002-5711-2404","observed_orcids":["https://orcid.org/0000-0002-5711-2404"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debu Tripathy","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042960706","display_name":"Khandan Keyomarsi","orcid":"https://orcid.org/0000-0002-5440-0849","observed_orcids":["https://orcid.org/0000-0002-5440-0849"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khandan Keyomarsi","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"12_Supplement","first_page":"1774","last_page":"1774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8379999995231628},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cdk4-6-inhibitor-resistance","display_name":"CDK4/6 inhibitor resistance","score":0.9480000138282776},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.8669999837875366},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.7200000286102295},{"id":"https://openalex.org/keywords/stat3-inhibitor","display_name":"STAT3 inhibitor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7820000052452087},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.621999979019165},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.5120000243186951},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.753000020980835},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.335999995470047},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.9454107880592346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.807674765586853},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6998435258865356},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6958198547363281},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6095080375671387},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5489998459815979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47049450874328613},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46569618582725525},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4218350946903229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08729290962219238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2022-1774","doi":"https://doi.org/10.1158/1538-7445.am2022-1774","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2022-1774","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412708570","https://openalex.org/W3007994228","https://openalex.org/W3013880900","https://openalex.org/W2920948544","https://openalex.org/W4230827581","https://openalex.org/W4387360741","https://openalex.org/W4292866406","https://openalex.org/W4362594228","https://openalex.org/W4220762527","https://openalex.org/W4411290015"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"CDK4/6":[2,446],"inhibitors":[3,447],"(CDK4/6i,":[4],"e.g.":[5],"palbociclib)":[6],"in":[7,16,19,72,90,117,168,180,195,242,285,303,318,337,437],"combination":[8],"with":[9,80,202,212,223,267,332,356,399],"endocrine":[10],"therapy":[11],"(ET)":[12],"have":[13],"proven":[14],"successful":[15],"delaying":[17],"progression":[18,352,389],"hormone":[20],"receptor-positive":[21],"(HR+),":[22],"HER2-negative":[23,439],"(HER2-)":[24],"metastatic":[25,203,224,341,440],"breast":[26,75,105,206,227,344,441],"cancer":[27,76,106,207,228,345,442],"patients;":[28],"however,":[29],"60-70%":[30],"will":[31],"progress":[32],"within":[33],"1-2":[34],"years":[35],"of":[36,42,67,154,193,240,257,283,372,387,451],"treatment.":[37],"Thus,":[38],"understanding":[39],"the":[40,68,137,152,191,275,378,452],"mechanisms":[41],"resistance":[43,61,373],"and":[44,78,156,182,186,234,249,254,278,390],"identifying":[45],"novel":[46],"treatment":[47,79,211,233,398],"strategies":[48],"are":[49,148],"needed":[50,292],"to":[51,127,161,231,252,295,354,374,401],"improve":[52],"survival.":[53],"Our":[54,145],"previously":[55],"published":[56],"data":[57,133],"shows":[58],"that":[59,135,289,363],"palbociclib":[60,111,184,213,243,269,304],"is":[62,140,259,291,368],"marked":[63],"by":[64,263,299,314],"significant":[65],"upregulation":[66,116],"IL6-STAT3":[69],"signaling":[70,365],"pathway":[71,139],"HR+,":[73,103,204,225,342],"HER2-":[74,104,205,226,343],"cells":[77,245,251,266,276,287,294],"TTI-101,":[81],"a":[82,141,323,369,385,394],"small-molecule":[83],"STAT3":[84,119,167,302,367],"inhibitor":[85],"completing":[86],"Phase":[87],"I":[88],"studies":[89,147,361],"solid":[91],"tumor":[92,321,391],"patients,":[93],"significantly":[94,319,348],"decreased":[95],"cell":[96],"viability.":[97],"Additionally,":[98],"matched":[99],"biopsies":[100],"from":[101,200,221,340],"advanced":[102],"patients":[107,169,201,222,346,443],"who":[108,170,208],"progressed":[109,209],"on":[110,122,210,445],"plus":[112],"ET":[113,253],"had":[114],"an":[115,260,434],"activated":[118],"(STAT3":[120],"phosphorylated":[121],"Y705,":[123],"pY-STAT3)":[124],"as":[125,158,384,393],"compared":[126,353],"their":[128],"pre-treatment":[129,355],"biopsy.":[130],"Collectively,":[131,359],"these":[132,360],"suggest":[134,362],"targeting":[136,166],"IL-6/STAT3":[138],"viable":[142],"therapeutic":[143],"strategy.":[144],"ongoing":[146],"directed":[149],"at":[150,235,350],"delineating":[151],"role":[153],"IL-6":[155,177,241,258,284,335,364,383],"pY-STAT3":[157,247,392],"predictive":[159],"biomarkers":[160],"provide":[162,377],"preclinical":[163],"rationale":[164,379],"for":[165,270,293,380,397,455],"develop":[171],"CDK4/6i":[172,232],"resistance.":[173,281,405],"Methods:":[174],"We":[175,189,216,376],"downregulated":[176],"using":[178,309,381],"shRNA":[179],"MCF7":[181],"T47D":[183],"sensitive":[185,265,286],"resistant":[187,244,305],"cells.":[188],"tested":[190],"efficacy":[192],"TTI-101":[194,310,329,400],"patient-derived":[196],"xenograft":[197],"(PDX)":[198],"models":[199,308],"+":[214],"ET.":[215],"also":[217],"collected":[218],"plasma":[219,338],"samples":[220,339],"just":[229],"prior":[230],"disease":[236,351,388],"progression.":[237],"Results:":[238],"Downregulation":[239],"reduced":[246,320],"levels":[248,336],"re-sensitized":[250],"palbociclib.":[255,300,333,375],"Induction":[256],"early":[261,435],"event":[262],"treating":[264],"1uM":[268],"21":[271],"days":[272],"during":[273],"which":[274],"adapted":[277],"eventually":[279],"developed":[280],"Suppression":[282],"revealed":[288],"it":[290],"overcome":[296],"growth":[297],"inhibition":[298],"Targeting":[301],"PDX":[306],"mouse":[307],"(50mg/kg":[311],"twice":[312],"daily":[313],"oral":[315],"gavage),":[316],"resulted":[317],"volume;":[322],"synergistic":[324],"effect":[325],"was":[326,330],"observed":[327],"when":[328],"combined":[331],"Lastly,":[334],"were":[347],"higher":[349],"CDK4/6i.":[357],"Conclusion:":[358],"through":[366],"key":[370],"mediator":[371],"circulating":[382],"biomarker":[386,436],"selection":[395],"criterion":[396],"prevent":[402],"or":[403],"reverse":[404],"Citation":[406],"Format:":[407],"Nicole":[408],"M.":[409],"Kettner,":[410],"Tuyen":[411],"N.":[412],"Bui,":[413],"Juliana":[414],"Navarro-Yepes,":[415],"T":[416],"Kris":[417],"Eckols,":[418],"Akshara":[419],"S.":[420],"Raghavendra,":[421],"David":[422],"J.":[423],"Tweardy,":[424],"Kelly":[425],"K.":[426],"Hunt,":[427],"Debu":[428],"Tripathy,":[429],"Khandan":[430],"Keyomarsi.":[431],"Circulating":[432],"IL-6,":[433],"HR-positive,":[438],"progressing":[444],"[abstract].":[448],"In:":[449],"Proceedings":[450],"American":[453],"Association":[454],"Cancer":[456,467],"Research":[457],"Annual":[458],"Meeting":[459],"2022;":[460],"2022":[461],"Apr":[462],"8-13.":[463],"Philadelphia":[464],"(PA):":[465],"AACR;":[466],"Res":[468],"2022;82(12_Suppl):Abstract":[469],"nr":[470],"1774.":[471]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-06-16T00:00:00"}
