{"id":"https://openalex.org/W4282913696","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","title":"Aerobic training improves blood-brain barrier and neuronal apoptosis in experimental autoimmune encephalomyelitis.","display_name":"Aerobic training improves blood-brain barrier and neuronal apoptosis in experimental autoimmune encephalomyelitis.","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4282913696","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","pmid":"https://pubmed.ncbi.nlm.nih.gov/35655596","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9124528"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9124528","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030414136","display_name":"Omid Razi","orcid":"https://orcid.org/0000-0002-6364-7309","observed_orcids":["https://orcid.org/0000-0002-6364-7309"]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Omid Razi","raw_affiliation_strings":["Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081295450","display_name":"Abdolhossein Parnow","orcid":"https://orcid.org/0000-0003-1965-2626","observed_orcids":["https://orcid.org/0000-0003-1965-2626"]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abdolhossein Parnow","raw_affiliation_strings":["Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028332153","display_name":"Iraj Rashidi","orcid":"https://orcid.org/0000-0003-3516-1464","observed_orcids":["https://orcid.org/0000-0003-3516-1464","https://orcid.org/0000-0002-9463-2388"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Iraj Rashidi","raw_affiliation_strings":["Department of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048987103","display_name":"Nafiseh Pakravan","orcid":"https://orcid.org/0000-0002-9355-1738","observed_orcids":["https://orcid.org/0000-0002-9355-1738"]},"institutions":[{"id":"https://openalex.org/I4387153077","display_name":"Alborz University of Medical Sciences","ror":"https://ror.org/03hh69c20","country_code":"IR","type":"education","lineage":["https://openalex.org/I4387153077"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nafiseh Pakravan","raw_affiliation_strings":["Department of Immunology, School of Medicine, Alborz University of Medical Science, Karaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Alborz University of Medical Science, Karaj, Iran","institution_ids":["https://openalex.org/I4387153077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011988529","display_name":"Seyed Ershad Nedaei","orcid":"https://orcid.org/0000-0001-6068-5812","observed_orcids":["https://orcid.org/0000-0001-6068-5812"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Ershad Nedaei","raw_affiliation_strings":["Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033579432","display_name":"Robert Wayne Motl","orcid":"https://orcid.org/0000-0002-5894-2290","observed_orcids":["https://orcid.org/0000-0002-5894-2290"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W Motl","raw_affiliation_strings":["Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, United States of America","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7751,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84894178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"25","issue":"2","first_page":"245","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.8640000224113464},{"id":"https://openalex.org/keywords/blood-brain-barrier-integrity","display_name":"blood-brain barrier integrity","score":0.843999981880188},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.968999981880188},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.7979999780654907},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":1.0},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8960000276565552},{"id":"https://openalex.org/keywords/treadmill-training","display_name":"treadmill training","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.8469274044036865},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7057027816772461},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.5958439707756042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5515048503875732},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.5388723015785217},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5276502370834351},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5022141933441162},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.47368624806404114},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4633975327014923},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.35306674242019653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3290916085243225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2171618938446045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20840224623680115},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.17627131938934326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07780033349990845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0657505989074707},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:9124528","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},{"id":"pmid:35655596","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35655596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of basic medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c929b634c61c4ce3b3eb23fadac82a6c","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","is_oa":false,"landing_page_url":"https://doaj.org/article/c929b634c61c4ce3b3eb23fadac82a6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Basic Medical Sciences, Vol 25, Iss 2, Pp 245-253 (2022)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9124528","doi":"https://doi.org/10.22038/ijbms.2022.61671.13645","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9124528/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282913696.pdf","grobid_xml":"https://content.openalex.org/works/W4282913696.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W123990481","https://openalex.org/W1506045573","https://openalex.org/W1741664031","https://openalex.org/W1806730902","https://openalex.org/W1821766353","https://openalex.org/W1967115349","https://openalex.org/W1978453599","https://openalex.org/W1984118219","https://openalex.org/W1985989596","https://openalex.org/W1989049076","https://openalex.org/W1989290237","https://openalex.org/W1991000015","https://openalex.org/W2015541518","https://openalex.org/W2019353207","https://openalex.org/W2037393298","https://openalex.org/W2040105845","https://openalex.org/W2070155357","https://openalex.org/W2070476787","https://openalex.org/W2084406633","https://openalex.org/W2085424855","https://openalex.org/W2105263565","https://openalex.org/W2111764443","https://openalex.org/W2117982300","https://openalex.org/W2127634810","https://openalex.org/W2135776824","https://openalex.org/W2149511379","https://openalex.org/W2159208106","https://openalex.org/W2168375386","https://openalex.org/W2318898023","https://openalex.org/W2415892735","https://openalex.org/W2478088592","https://openalex.org/W2519606940","https://openalex.org/W2614673012","https://openalex.org/W2700330585","https://openalex.org/W2791398439","https://openalex.org/W2893320044","https://openalex.org/W2898816123","https://openalex.org/W2924301109","https://openalex.org/W2945802720","https://openalex.org/W2971245262","https://openalex.org/W2971390942","https://openalex.org/W3014063216","https://openalex.org/W3021933400","https://openalex.org/W3025526823","https://openalex.org/W3041003406","https://openalex.org/W3138973161","https://openalex.org/W4207014326"],"related_works":["https://openalex.org/W6999894297","https://openalex.org/W2924301109","https://openalex.org/W4304166158","https://openalex.org/W1998165644","https://openalex.org/W2478088592","https://openalex.org/W3014458270","https://openalex.org/W4400929140","https://openalex.org/W2055253068","https://openalex.org/W1565852497","https://openalex.org/W4415679735"],"abstract_inverted_index":{"Objectives:":[0],"Blood-brain":[1],"barrier":[2],"(BBB)":[3],"permeability":[4],"is":[5],"central":[6],"in":[7,36,117],"multiple":[8],"sclerosis":[9],"(MS)":[10],"pathophysiology,":[11],"and":[12,42,72,79,100,109,139],"exercise":[13,30,65,75,88],"may":[14],"improve":[15],"BBB":[16,34,107,137],"integrity.":[17],"The":[18,54,77,122],"current":[19],"study":[20],"investigated":[21],"the":[22,110,131],"prophylactic":[23],"and/":[24],"or":[25],"therapeutic":[26],"role":[27],"of":[28,85,98,106,112,124,134],"aerobic":[29,87,128],"(EX)":[31],"training":[32,129],"on":[33,136],"integrity":[35,108,138],"experimental":[37,55],"autoimmune":[38],"encephalomyelitis":[39],"(EAE).":[40],"Materials":[41],"Methods:":[43],"Forty":[44],"female":[45],"Lewis":[46],"rats":[47],"were":[48,102],"randomly":[49],"divided":[50],"into":[51],"four":[52],"groups.":[53],"groups":[56,81],"included:":[57],"no-EAE":[58,63],"induction+":[59,64,68,74],"no-exercise":[60,69],"(no-EAE+":[61],"no-EX),":[62,71],"(no-EAE+EX),":[66],"EAE":[67,73,135],"(EAE+":[70],"(EAE+EX).":[76],"no-EAE+EX":[78],"EAE+EX":[80],"performed":[82],"six":[83],"weeks":[84],"progressive":[86],"training.":[89],"GFAP,":[90],"angiopoietin":[91],"1":[92],"(Ang-1)":[93],"expression,":[94],"tight-junction":[95],"(TJ)":[96],"proteins":[97],"claudin-5":[99],"occludin":[101],"measured":[103],"as":[104],"components":[105],"rate":[111],"neuronal":[113,141],"apoptosis":[114],"was":[115],"evaluated":[116],"hippocampi.":[118],"Results:":[119],"<0.001).":[120],"Conclusion:":[121],"provision":[123],"a":[125],"six-week":[126],"treadmill":[127],"buffered":[130],"detrimental":[132],"effects":[133],"consequently":[140],"apoptosis.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-06-16T00:00:00"}
