{"id":"https://openalex.org/W4282913283","doi":"https://doi.org/10.1631/jzus.b2101075","title":"Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis","display_name":"Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4282913283","doi":"https://doi.org/10.1631/jzus.b2101075","pmid":"https://pubmed.ncbi.nlm.nih.gov/35686524","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9198233"},"language":"en","primary_location":{"id":"doi:10.1631/jzus.b2101075","doi":"https://doi.org/10.1631/jzus.b2101075","is_oa":false,"landing_page_url":"https://doi.org/10.1631/jzus.b2101075","pdf_url":null,"source":{"id":"https://openalex.org/S47715536","display_name":"Journal of Zhejiang University SCIENCE B","issn_l":"1673-1581","issn":["1673-1581","1862-1783"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University-SCIENCE B","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9198233/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011667234","display_name":"Jiaqi Lu","orcid":"https://orcid.org/0000-0002-7574-638X","observed_orcids":["https://orcid.org/0000-0002-7574-638X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Lu","raw_affiliation_strings":["Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China","Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]},{"raw_affiliation_string":"Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100679069","display_name":"Jingyuan Liu","orcid":"https://orcid.org/0000-0002-0592-9789","observed_orcids":["https://orcid.org/0000-0002-0592-9789"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyuan Liu","raw_affiliation_strings":["Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China","Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]},{"raw_affiliation_string":"Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100413594","display_name":"Ang Li","orcid":"https://orcid.org/0000-0002-1478-3072","observed_orcids":["https://orcid.org/0000-0002-1478-3072"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ang Li","raw_affiliation_strings":["Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. liang@ccmu.edu.cn","Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-1478-3072","affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. liang@ccmu.edu.cn","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]},{"raw_affiliation_string":"Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100413594"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.0875,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.76715289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"23","issue":"6","first_page":"437","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.875},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9559999704360962},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9470000267028809},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/host-response-to-infection","display_name":"host response to infection","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.9358789324760437},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.8027519583702087},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7972893714904785},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6855683922767639},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6159414052963257},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6048375368118286},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.571134626865387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4770297706127167},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4552059471607208},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.44218388199806213},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.4398462772369385},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42036187648773193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3112460970878601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1319308876991272},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.058688342571258545}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1631/jzus.b2101075","doi":"https://doi.org/10.1631/jzus.b2101075","is_oa":false,"landing_page_url":"https://doi.org/10.1631/jzus.b2101075","pdf_url":null,"source":{"id":"https://openalex.org/S47715536","display_name":"Journal of Zhejiang University SCIENCE B","issn_l":"1673-1581","issn":["1673-1581","1862-1783"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University-SCIENCE B","raw_type":"journal-article"},{"id":"pmid:35686524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35686524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University. Science. B","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9198233","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9198233/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Zhejiang Univ Sci B","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9198233","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9198233/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Zhejiang Univ Sci B","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W58765508","https://openalex.org/W1121929814","https://openalex.org/W1507533499","https://openalex.org/W1561837651","https://openalex.org/W1562137275","https://openalex.org/W1965737875","https://openalex.org/W1970420280","https://openalex.org/W1973371660","https://openalex.org/W1973645774","https://openalex.org/W1980308944","https://openalex.org/W1984747276","https://openalex.org/W1986970772","https://openalex.org/W1992969522","https://openalex.org/W2005744390","https://openalex.org/W2006847107","https://openalex.org/W2010568558","https://openalex.org/W2011597935","https://openalex.org/W2037614372","https://openalex.org/W2039515230","https://openalex.org/W2039930671","https://openalex.org/W2040427814","https://openalex.org/W2045819100","https://openalex.org/W2057585285","https://openalex.org/W2062054105","https://openalex.org/W2065538306","https://openalex.org/W2066025123","https://openalex.org/W2073821065","https://openalex.org/W2076598575","https://openalex.org/W2077916251","https://openalex.org/W2081278295","https://openalex.org/W2082922491","https://openalex.org/W2086667809","https://openalex.org/W2088220499","https://openalex.org/W2090450008","https://openalex.org/W2102619095","https://openalex.org/W2104934425","https://openalex.org/W2107718568","https://openalex.org/W2111760435","https://openalex.org/W2114513999","https://openalex.org/W2121528729","https://openalex.org/W2121730308","https://openalex.org/W2123095004","https://openalex.org/W2123799914","https://openalex.org/W2135022648","https://openalex.org/W2139871065","https://openalex.org/W2143152020","https://openalex.org/W2148637873","https://openalex.org/W2151311812","https://openalex.org/W2159245434","https://openalex.org/W2164346358","https://openalex.org/W2164664027","https://openalex.org/W2165464440","https://openalex.org/W2172680325","https://openalex.org/W2254045887","https://openalex.org/W2280404143","https://openalex.org/W2286673285","https://openalex.org/W2296014169","https://openalex.org/W2320328374","https://openalex.org/W2341401669","https://openalex.org/W2342393790","https://openalex.org/W2424963702","https://openalex.org/W2465535949","https://openalex.org/W2498397599","https://openalex.org/W2519315265","https://openalex.org/W2522038806","https://openalex.org/W2526871237","https://openalex.org/W2546000389","https://openalex.org/W2581605534","https://openalex.org/W2596939733","https://openalex.org/W2598907887","https://openalex.org/W2606085540","https://openalex.org/W2607431574","https://openalex.org/W2620241325","https://openalex.org/W2745222589","https://openalex.org/W2765373214","https://openalex.org/W2766224958","https://openalex.org/W2766842280","https://openalex.org/W2780954662","https://openalex.org/W2786711651","https://openalex.org/W2789689723","https://openalex.org/W2790056846","https://openalex.org/W2792991954","https://openalex.org/W2800713110","https://openalex.org/W2803204535","https://openalex.org/W2889367571","https://openalex.org/W2891506196","https://openalex.org/W2905958764","https://openalex.org/W2910405444","https://openalex.org/W2914937980","https://openalex.org/W2923372709","https://openalex.org/W2932908941","https://openalex.org/W2950811882","https://openalex.org/W2998853022","https://openalex.org/W3005329779","https://openalex.org/W3116053870","https://openalex.org/W4211227031","https://openalex.org/W4212970750","https://openalex.org/W4213007627","https://openalex.org/W4213217796","https://openalex.org/W4213294868","https://openalex.org/W4213310883","https://openalex.org/W4213426823"],"related_works":["https://openalex.org/W4391067560","https://openalex.org/W7052349423","https://openalex.org/W3136006354","https://openalex.org/W2547803682","https://openalex.org/W1997395962","https://openalex.org/W4292482612","https://openalex.org/W2141678261","https://openalex.org/W3107698508","https://openalex.org/W2026432359","https://openalex.org/W3199001400"],"abstract_inverted_index":{"Sepsis":[0],"is":[1,20],"a":[2,21,40,66,81,86],"condition":[3],"of":[4,13,43,83,89,110,119],"severe":[5,22,32,95],"organ":[6,70,115],"failure":[7],"caused":[8],"by":[9],"the":[10,14,44,103,107],"maladaptive":[11],"response":[12],"host":[15],"to":[16,31,73,94],"an":[17],"infection.":[18],"It":[19],"complication":[23],"affecting":[24],"critically":[25],"ill":[26],"patients,":[27],"which":[28,91],"can":[29,92],"progress":[30,93],"sepsis,":[33,90],"septic":[34,98],"shock,":[35],"and":[36,57,97],"ultimately":[37],"death.":[38],"As":[39],"vital":[41],"part":[42],"human":[45,114],"innate":[46],"immune":[47,58],"system,":[48],"neutrophils":[49],"are":[50],"essential":[51],"in":[52,69,113],"resisting":[53],"pathogen":[54],"invasion,":[55],"infection,":[56],"surveillance.":[59],"Neutrophil-produced":[60],"reactive":[61],"oxygen":[62],"species":[63],"(ROS)":[64],"play":[65],"pivotal":[67],"role":[68],"dysfunction":[71],"related":[72],"sepsis.":[74,120],"In":[75],"recent":[76],"years,":[77],"ROS":[78,112],"have":[79],"received":[80],"lot":[82],"attention":[84],"as":[85],"major":[87],"cause":[88],"sepsis":[96],"shock.":[99],"This":[100],"paper":[101],"reviews":[102],"existing":[104],"knowledge":[105],"on":[106],"production":[108],"mechanism":[109],"neutrophil":[111],"function":[116],"impairment":[117],"because":[118]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-16T00:00:00"}
