{"id":"https://openalex.org/W4282841593","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00020","title":"In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1","display_name":"In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1","publication_year":2022,"publication_date":"2022-06-13","ids":{"openalex":"https://openalex.org/W4282841593","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00020","pmid":"https://pubmed.ncbi.nlm.nih.gov/36281303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9585516"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomedchemau.2c00020","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00020","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomedchemau.2c00020","pdf_url":null,"source":{"id":"https://openalex.org/S4210197417","display_name":"ACS Bio & Med Chem Au","issn_l":"2694-2437","issn":["2694-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio &amp; Med Chem Au","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1021/acsbiomedchemau.2c00020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084917498","display_name":"Douglas M. Warui","orcid":"https://orcid.org/0000-0001-8950-9433","observed_orcids":["https://orcid.org/0000-0001-8950-9433"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas M. Warui","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":"https://orcid.org/0000-0001-8950-9433","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014238633","display_name":"Debangsu Sil","orcid":"https://orcid.org/0000-0002-0718-3925","observed_orcids":["https://orcid.org/0000-0002-0718-3925"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debangsu Sil","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":"https://orcid.org/0000-0002-0718-3925","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kyung-Hoon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyung-Hoon Lee","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087812901","display_name":"Syam Sundar Neti","orcid":"https://orcid.org/0000-0003-3343-8642","observed_orcids":["https://orcid.org/0000-0003-3343-8642"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syam Sundar Neti","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064565306","display_name":"Olga A. Esakova","orcid":"https://orcid.org/0000-0001-8377-8368","observed_orcids":["https://orcid.org/0000-0001-8377-8368"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga A. Esakova","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":"https://orcid.org/0000-0001-8377-8368","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistrythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084811716","display_name":"Hayley L. Knox","orcid":"https://orcid.org/0000-0003-1467-309X","observed_orcids":["https://orcid.org/0000-0003-1467-309X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hayley L. Knox","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050467129","display_name":"Carsten Krebs","orcid":"https://orcid.org/0000-0002-3302-7053","observed_orcids":["https://orcid.org/0000-0002-3302-7053"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carsten Krebs","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistry \u00a0and\u00a0 Biochemistry and Molecular Biologythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":"https://orcid.org/0000-0002-3302-7053","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistry \u00a0and\u00a0 Biochemistry and Molecular Biologythe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045998043","display_name":"Squire J. Booker","orcid":"https://orcid.org/0000-0002-7211-5937","observed_orcids":["https://orcid.org/0000-0002-7211-5937"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Squire J. Booker","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistry,\u00a0 Biochemistry and Molecular Biology \u00a0and\u00a0 Howard Hughes Medical Institutethe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":"https://orcid.org/0000-0002-7211-5937","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemistry,\u00a0 Biochemistry and Molecular Biology \u00a0and\u00a0 Howard Hughes Medical Institutethe , The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045998043","https://openalex.org/A5050467129"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I1344073410"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":2.1715,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.87289517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"5","first_page":"456","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.15160000324249268,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoyl-synthase","display_name":"lipoyl synthase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/early-jurassic","display_name":"Lower Jurassic","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nfu1","display_name":"NFU1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/radical-sam-enzymes","display_name":"radical SAM enzymes","score":0.6940000057220459},{"id":"https://openalex.org/keywords/4fe-4s-cluster","display_name":"[4Fe-4S] cluster","score":0.8379999995231628},{"id":"https://openalex.org/keywords/isca1","display_name":"ISCA1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/human-enzyme","display_name":"human enzyme","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7159514427185059},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.6145214438438416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4889132082462311},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4626864194869995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35821670293807983},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28735774755477905}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsbiomedchemau.2c00020","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00020","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomedchemau.2c00020","pdf_url":null,"source":{"id":"https://openalex.org/S4210197417","display_name":"ACS Bio & Med Chem Au","issn_l":"2694-2437","issn":["2694-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio &amp; Med Chem Au","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9585516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9585516","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio Med Chem Au","raw_type":"Text"},{"id":"pmid:36281303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36281303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS bio & med chem Au","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsbiomedchemau.2c00020","doi":"https://doi.org/10.1021/acsbiomedchemau.2c00020","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomedchemau.2c00020","pdf_url":null,"source":{"id":"https://openalex.org/S4210197417","display_name":"ACS Bio & Med Chem Au","issn_l":"2694-2437","issn":["2694-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Bio &amp; Med Chem Au","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1822746958","display_name":"Mechanisms of Iron-Sulfur Dependent Reactions","funder_award_id":"5r35gm122595-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6067138","display_name":null,"funder_award_id":"GM122595","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6184971844","display_name":null,"funder_award_id":"MCB-1716686","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"},{"id":"https://openalex.org/G9000862041","display_name":"Mechanisms of Iron-Containing Enzymes","funder_award_id":"R35GM127079","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W257340931","https://openalex.org/W433983911","https://openalex.org/W1000442924","https://openalex.org/W1480415128","https://openalex.org/W1578537067","https://openalex.org/W1599030128","https://openalex.org/W1651168564","https://openalex.org/W1680026327","https://openalex.org/W1902924213","https://openalex.org/W1966553114","https://openalex.org/W1967185435","https://openalex.org/W1970855127","https://openalex.org/W1971668538","https://openalex.org/W1971722897","https://openalex.org/W1976545490","https://openalex.org/W1979280203","https://openalex.org/W1987437153","https://openalex.org/W1991227065","https://openalex.org/W1995630908","https://openalex.org/W1997217250","https://openalex.org/W2002549784","https://openalex.org/W2004428644","https://openalex.org/W2004821895","https://openalex.org/W2007093553","https://openalex.org/W2012141674","https://openalex.org/W2021064281","https://openalex.org/W2025649507","https://openalex.org/W2028834338","https://openalex.org/W2029147341","https://openalex.org/W2036352618","https://openalex.org/W2041009877","https://openalex.org/W2042301495","https://openalex.org/W2043151685","https://openalex.org/W2043330551","https://openalex.org/W2046380748","https://openalex.org/W2050338175","https://openalex.org/W2052034580","https://openalex.org/W2059133046","https://openalex.org/W2062700139","https://openalex.org/W2067995765","https://openalex.org/W2070375833","https://openalex.org/W2075040966","https://openalex.org/W2075253085","https://openalex.org/W2084192678","https://openalex.org/W2089779289","https://openalex.org/W2090079874","https://openalex.org/W2095347327","https://openalex.org/W2100918802","https://openalex.org/W2107789695","https://openalex.org/W2113439382","https://openalex.org/W2128635872","https://openalex.org/W2129921499","https://openalex.org/W2142364986","https://openalex.org/W2150777523","https://openalex.org/W2151965879","https://openalex.org/W2165911106","https://openalex.org/W2182977810","https://openalex.org/W2256160203","https://openalex.org/W2319461998","https://openalex.org/W2331199532","https://openalex.org/W2337732629","https://openalex.org/W2396643508","https://openalex.org/W2410339214","https://openalex.org/W2415337062","https://openalex.org/W2472206162","https://openalex.org/W2517099392","https://openalex.org/W2518452759","https://openalex.org/W2518509726","https://openalex.org/W2530244460","https://openalex.org/W2549002087","https://openalex.org/W2583796359","https://openalex.org/W2625087901","https://openalex.org/W2626486519","https://openalex.org/W2740414557","https://openalex.org/W2755953613","https://openalex.org/W2766395974","https://openalex.org/W2772709248","https://openalex.org/W2773451537","https://openalex.org/W2778862248","https://openalex.org/W2877748953","https://openalex.org/W2883050635","https://openalex.org/W2904733111","https://openalex.org/W2972234722","https://openalex.org/W2984732598","https://openalex.org/W3000002697","https://openalex.org/W3010007765","https://openalex.org/W3048522053","https://openalex.org/W3091475389","https://openalex.org/W3127977404","https://openalex.org/W3177828909","https://openalex.org/W4200562442","https://openalex.org/W4211151236","https://openalex.org/W4213019664","https://openalex.org/W4248824191","https://openalex.org/W4283276001"],"related_works":["https://openalex.org/W2883184705","https://openalex.org/W2904733111","https://openalex.org/W2319461998","https://openalex.org/W3127977404","https://openalex.org/W4225392835","https://openalex.org/W2766395974","https://openalex.org/W2059133046","https://openalex.org/W2330070371","https://openalex.org/W2770465188","https://openalex.org/W2415337062"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Lipoyl":[7],"synthase":[8],"(LS)":[9],"catalyzes":[10],"the":[11,15,18,23,50,72,75,88,92,113,120,142,152,159,165,174,194,236,254,257],"last":[12],"step":[13],"in":[14,74,112,151,213,228,253,260],"biosynthesis":[16,255],"of":[17,25,32,38,49,56,71,87,91,116,141,154,168,197,239,256],"lipoyl":[19,40,258],"cofactor,":[20],"which":[21,58,131],"is":[22,46,78,110,193],"attachment":[24],"sulfur":[26,97,132],"atoms":[27,82,133],"at":[28,104],"C6":[29,84],"and":[30,85,187,201,222,230,262,284],"C8":[31,86],"an":[33,125],"n":[34],"-octanoyllysyl":[35],"side":[36],"chain":[37],"a":[39,47,62,65,155,225],"carrier":[41,178],"protein":[42,45,179],"(LCP).":[43],"The":[44,69],"member":[48],"radical":[51,100],"S":[52],"-adenosylmethionine":[53],"(SAM)":[54],"superfamily":[55],"enzymes,":[57],"use":[59],"SAM":[60,101,117],"as":[61,181,183,250],"precursor":[63],"to":[64,79,94,118,139,205,277],"5\u2032-deoxyadenosyl":[66],"5\u2032-radical":[67],"(5\u2032-dA\u00b7).":[68],"role":[70],"5\u2032-dA\u00b7":[73],"LS":[76,169,210],"reaction":[77],"abstract":[80],"hydrogen":[81],"from":[83,130,273],"octanoyl":[89],"moiety":[90],"substrate":[93],"initiate":[95],"subsequent":[96],"attachment.":[98],"All":[99],"enzymes":[102,146],"have":[103],"least":[105],"one":[106],"[4Fe\u20134S]":[107,128],"cluster":[108,129,167,177,238,271],"that":[109,157,220,231,246,282],"used":[111],"reductive":[114],"cleavage":[115],"generate":[119],"5\u2032-dA\u00b7;":[121],"however,":[122],"LSs":[123],"contain":[124],"additional":[126],"auxiliary":[127,160,166,237],"are":[134],"extracted":[135],"during":[136,241],"turnover,":[137,289],"leading":[138],"degradation":[140],"cluster.":[143,161],"Therefore,":[144],"these":[145],"catalyze":[147],"only":[148,291],"1":[149],"turnover":[150],"absence":[153],"system":[156],"restores":[158],"In":[162],"Escherichia":[163],"coli,":[164],"can":[170,233,286],"be":[171],"regenerated":[172],"by":[173,190],"iron\u2013sulfur":[175],"(Fe\u2013S)":[176],"NfuA":[180,200],"fast":[182],"catalysis":[184],"takes":[185],"place,":[186],"less":[188],"efficiently":[189,234],"IscU.":[191],"NFU1":[192,221,232,274],"human":[195,209],"ortholog":[196],"E.":[198],"coli":[199],"has":[202,265],"been":[203],"shown":[204],"interact":[206],"directly":[207],"with":[208],"(i.e.,":[211],"LIAS)":[212],"yeast":[214],"two-hybrid":[215],"analyses.":[216],"Herein,":[217],"we":[218,280],"show":[219,245,281],"LIAS":[223,240,288],"form":[224],"tight":[226],"complex":[227],"vitro":[229],"restore":[235],"turnover.":[242],"We":[243],"also":[244],"BOLA3,":[247],"previously":[248],"identified":[249],"being":[251],"critical":[252],"cofactor":[259],"humans":[261],"Saccharomyces":[263],"cerevisiae,":[264],"no":[266],"direct":[267],"effect":[268],"on":[269],"Fe\u2013S":[270],"transfer":[272],"or":[275],"GLRX5":[276],"LIAS.":[278],"Further,":[279],"ISCA1":[283],"ISCA2":[285],"enhance":[287],"but":[290],"slightly.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-06-15T00:00:00"}
