{"id":"https://openalex.org/W4282838207","doi":"https://doi.org/10.1186/s13075-022-02825-7","title":"Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas","display_name":"Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas","publication_year":2022,"publication_date":"2022-06-14","ids":{"openalex":"https://openalex.org/W4282838207","doi":"https://doi.org/10.1186/s13075-022-02825-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35701843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9195362"},"language":"en","primary_location":{"id":"doi:10.1186/s13075-022-02825-7","doi":"https://doi.org/10.1186/s13075-022-02825-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-022-02825-7","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/s13075-022-02825-7","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/s13075-022-02825-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100338258","display_name":"Huihui Li","orcid":"https://orcid.org/0000-0001-6004-3086","observed_orcids":["https://orcid.org/0000-0001-6004-3086"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hui-hui Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China","Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA","Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012049240","display_name":"Lintao Sai","orcid":"https://orcid.org/0000-0003-0377-6667","observed_orcids":["https://orcid.org/0000-0003-0377-6667"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin-tao Sai","raw_affiliation_strings":["Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China","Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705035","display_name":"Yuan Liu","orcid":"https://orcid.org/0000-0001-6792-8442","observed_orcids":["https://orcid.org/0000-0001-6792-8442"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Liu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China","Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038551624","display_name":"Colman Freel","orcid":"https://orcid.org/0000-0003-0820-1221","observed_orcids":["https://orcid.org/0000-0003-0820-1221"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colman I. Freel","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA","Scholars Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA","Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA","Scholars Program, University of Nebraska Medical Center, Omaha, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Scholars Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Scholars Program, University of Nebraska Medical Center, Omaha, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437031","display_name":"Kai Wang","orcid":"https://orcid.org/0000-0002-5585-982X","observed_orcids":["https://orcid.org/0000-0002-5585-982X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210153623","display_name":"Shanghai First Maternity and Infant Hospital","ror":"https://ror.org/05myyzn85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153623"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210153623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004370633","display_name":"Chi Zhou","orcid":"https://orcid.org/0000-0002-3349-9069","observed_orcids":["https://orcid.org/0000-0002-3349-9069"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Zhou","raw_affiliation_strings":["School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, 85719, USA","School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, 85719, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077475488","display_name":"Jing Juan Zheng","orcid":"https://orcid.org/0000-0002-2224-2372","observed_orcids":["https://orcid.org/0000-0002-2224-2372"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zheng","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA","Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011504592","display_name":"Qiang Shu","orcid":"https://orcid.org/0000-0002-3571-4084","observed_orcids":["https://orcid.org/0000-0002-3571-4084"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiang Shu","raw_affiliation_strings":["Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. shuqiang@sdu.edu.cn","Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, 250012, Shandong, China. shuqiang@sdu.edu.cn","Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. shuqiang@sdu.edu.cn","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, 250012, Shandong, China. shuqiang@sdu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063531299","display_name":"Yingjie Zhao","orcid":"https://orcid.org/0000-0002-0367-2908","observed_orcids":["https://orcid.org/0000-0002-0367-2908"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Ying-jie Zhao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA. yzhaoqilu@sdu.edu.cn","Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. yzhaoqilu@sdu.edu.cn","Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, 250012, Shandong, China. yzhaoqilu@sdu.edu.cn","Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA","Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, China"],"raw_orcid":"https://orcid.org/0000-0002-0367-2908","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA. yzhaoqilu@sdu.edu.cn","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. yzhaoqilu@sdu.edu.cn","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, 250012, Shandong, China. yzhaoqilu@sdu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Jinan, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5011504592","https://openalex.org/A5063531299"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I154099455","https://openalex.org/I4210161528"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.635,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.82876037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"142","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9409999847412109},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.6880000233650208},{"id":"https://openalex.org/keywords/lncrna-expression-profiling","display_name":"lncRNA expression profiling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hypoxia-response","display_name":"hypoxia response","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/complement-and-coagulation-pathways","display_name":"complement and coagulation pathways","score":0.8190000057220459},{"id":"https://openalex.org/keywords/th1-th2-differentiation","display_name":"Th1/Th2 differentiation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.591722309589386},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5554317235946655},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5400378108024597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.53400719165802},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.49788546562194824},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4863203465938568},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.473760187625885},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4375418424606323},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.41731229424476624},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3775472044944763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3648502826690674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3159441351890564},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3021334707736969},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3006603717803955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18821296095848083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16682934761047363},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.12538117170333862},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13075-022-02825-7","doi":"https://doi.org/10.1186/s13075-022-02825-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-022-02825-7","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/s13075-022-02825-7","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9195362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9195362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:35701843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35701843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2779275ca2104318b37c298c271ef201","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2779275ca2104318b37c298c271ef201","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13075-022-02825-7","doi":"https://doi.org/10.1186/s13075-022-02825-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-022-02825-7","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/s13075-022-02825-7","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G281528808","display_name":null,"funder_award_id":"2018GSF118025","funder_id":"https://openalex.org/F4320333596","funder_display_name":"Key Technology Research and Development Program of Shandong"},{"id":"https://openalex.org/G3711347457","display_name":null,"funder_award_id":"2018GSF118071","funder_id":"https://openalex.org/F4320333596","funder_display_name":"Key Technology Research and Development Program of Shandong"},{"id":"https://openalex.org/G7612906784","display_name":null,"funder_award_id":"2021SDUCRCB010","funder_id":"https://openalex.org/F4320311026","funder_display_name":"Shandong University"}],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"},{"id":"https://openalex.org/F4320333596","display_name":"Key Technology Research and Development Program of Shandong","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282838207.pdf","grobid_xml":"https://content.openalex.org/works/W4282838207.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1486387446","https://openalex.org/W1582248697","https://openalex.org/W1854322833","https://openalex.org/W1909860613","https://openalex.org/W1971997924","https://openalex.org/W2005636452","https://openalex.org/W2034400748","https://openalex.org/W2040459416","https://openalex.org/W2047647233","https://openalex.org/W2048791273","https://openalex.org/W2057925475","https://openalex.org/W2064999867","https://openalex.org/W2070527591","https://openalex.org/W2082907785","https://openalex.org/W2088118534","https://openalex.org/W2091161969","https://openalex.org/W2095223126","https://openalex.org/W2111977059","https://openalex.org/W2114104545","https://openalex.org/W2120496963","https://openalex.org/W2123150738","https://openalex.org/W2144087336","https://openalex.org/W2148432510","https://openalex.org/W2156797363","https://openalex.org/W2166251028","https://openalex.org/W2177893399","https://openalex.org/W2211603551","https://openalex.org/W2341032293","https://openalex.org/W2414784657","https://openalex.org/W2481915328","https://openalex.org/W2502730894","https://openalex.org/W2591072509","https://openalex.org/W2611773551","https://openalex.org/W2625419804","https://openalex.org/W2747587520","https://openalex.org/W2762204972","https://openalex.org/W2767103518","https://openalex.org/W2776866488","https://openalex.org/W2808670731","https://openalex.org/W2859850329","https://openalex.org/W2874410886","https://openalex.org/W2898194572","https://openalex.org/W2898351291","https://openalex.org/W2928665623","https://openalex.org/W2933047905","https://openalex.org/W2939177056","https://openalex.org/W2942610007","https://openalex.org/W2948939913","https://openalex.org/W2952001873","https://openalex.org/W2957422120","https://openalex.org/W2979750977","https://openalex.org/W2980354200","https://openalex.org/W2982474992","https://openalex.org/W3014691838","https://openalex.org/W3086750680","https://openalex.org/W3161510330","https://openalex.org/W3198476326","https://openalex.org/W4205556677"],"related_works":["https://openalex.org/W6958357310","https://openalex.org/W6939571507","https://openalex.org/W4317907756","https://openalex.org/W2776866488","https://openalex.org/W3172049764","https://openalex.org/W2939177056","https://openalex.org/W2980354200","https://openalex.org/W4220753813","https://openalex.org/W4392519590","https://openalex.org/W6902312504"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systemic":[1],"lupus":[2],"erythematosus":[3],"(SLE)":[4],"can":[5],"cause":[6],"placental":[7],"dysfunctions,":[8],"which":[9],"may":[10,205,217],"result":[11],"in":[12,22,40,55,71,104,184,203,209],"pregnancy":[13],"complications.":[14],"Long":[15],"noncoding":[16],"RNAs":[17],"(lncRNAs)":[18],"are":[19],"actively":[20],"involved":[21],"the":[23,36,51,88,177,181,193,197,210],"regulation":[24,143,153],"of":[25,91,144,154,180,201,212],"immune":[26],"responses":[27],"during":[28],"pregnancy.":[29],"The":[30],"present":[31],"study":[32],"aimed":[33],"to":[34,46,65,86,151,161],"determine":[35],"lncRNA":[37,182],"expression":[38,195],"profiles":[39,183],"placentas":[41,72,185,204],"from":[42,73,186],"women":[43,74],"with":[44,75,135],"SLE":[45,56,76,105,187,213],"gain":[47],"new":[48],"insights":[49],"into":[50],"underlying":[52],"molecular":[53],"mechanisms":[54],"pregnancies.":[57,81,188,214],"METHODS:":[58],"RNA":[59],"sequencing":[60],"(RNA-seq)":[61],"analysis":[62,83,99,128],"was":[63,84],"performed":[64],"identify":[66],"SLE-dysregulated":[67,93,117,131,215],"lncRNAs":[68,94,103,202,216],"and":[69,77,95,112,124,138,165,168,170,196],"mRNAs":[70,118],"normal":[78],"full-term":[79],"(NT)":[80],"Bioinformatics":[82,127],"conducted":[85],"predict":[87],"biological":[89,136],"functions":[90,137],"these":[92],"mRNAs.":[96],"RESULTS:":[97],"RNA-seq":[98],"identified":[100],"52":[101],"dysregulated":[102],"placentas,":[106],"including":[107,121],"37":[108],"that":[109,130,192],"were":[110,119,133],"upregulated":[111,123],"15":[113],"downregulated.":[114,126],"Additional":[115],"130":[116],"discovered,":[120],"122":[122],"8":[125],"revealed":[129],"genes":[132],"associated":[134],"gene":[139],"networks,":[140],"such":[141],"as":[142,220],"type":[145],"I":[146],"interferon-mediated":[147],"signaling":[148],"pathway,":[149],"response":[150,160],"hypoxia,":[152],"MAPK":[155],"(mitogen-activated":[156],"protein":[157],"kinase)":[158],"cascade,":[159],"steroid":[162],"hormone,":[163],"complement":[164],"coagulation":[166],"cascades,":[167],"Th1":[169],"Th2":[171],"cell":[172],"differentiation.":[173],"CONCLUSIONS:":[174],"This":[175],"is":[176],"first":[178],"report":[179],"These":[189],"results":[190],"suggest":[191],"aberrant":[194],"potential":[198],"regulatory":[199],"function":[200],"play":[206],"comprehensive":[207],"roles":[208],"pathogenesis":[211],"potentially":[218],"serve":[219],"biomarkers":[221],"for":[222],"SLE.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-15T00:00:00"}