{"id":"https://openalex.org/W4282835394","doi":"https://doi.org/10.1038/s41417-022-00484-z","title":"Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition","display_name":"Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition","publication_year":2022,"publication_date":"2022-06-14","ids":{"openalex":"https://openalex.org/W4282835394","doi":"https://doi.org/10.1038/s41417-022-00484-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/35697801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9750861"},"language":"en","primary_location":{"id":"doi:10.1038/s41417-022-00484-z","doi":"https://doi.org/10.1038/s41417-022-00484-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41417-022-00484-z","pdf_url":"https://www.nature.com/articles/s41417-022-00484-z.pdf","source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41417-022-00484-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029016633","display_name":"Chandra C. Ghosh","orcid":"https://orcid.org/0009-0003-7471-0443","observed_orcids":["https://orcid.org/0009-0003-7471-0443"]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra C. Ghosh","raw_affiliation_strings":["Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]},{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046333627","display_name":"Kara R. Heatherton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara R. Heatherton","raw_affiliation_strings":["Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062553501","display_name":"Kyle P. O\u2019 Connell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle P. O\u2019 Connell","raw_affiliation_strings":["Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091049892","display_name":"Ian S. Alexander","orcid":"https://orcid.org/0000-0002-6821-2531","observed_orcids":["https://orcid.org/0000-0002-6821-2531"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian S. Alexander","raw_affiliation_strings":["Northwestern University, Evanston, IL, USA","Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Evanston, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]},{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113495998","display_name":"Deborah A. Greer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Greer","raw_affiliation_strings":["Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069113364","display_name":"Jason P. LaPorte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason LaPorte","raw_affiliation_strings":["Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]},{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059006831","display_name":"Prajna Guha","orcid":"https://orcid.org/0000-0001-6831-9374","observed_orcids":["https://orcid.org/0000-0001-6831-9374"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prajna Guha","raw_affiliation_strings":["Department of Surgery, Boston University Medical Center, Boston, MA, USA. prajna.guha@chartercare.org","Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA. prajna.guha@chartercare.org","TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA. prajna.guha@chartercare.org","TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA"],"raw_orcid":"https://orcid.org/0000-0001-6831-9374","affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston University Medical Center, Boston, MA, USA. prajna.guha@chartercare.org","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA. prajna.guha@chartercare.org","institution_ids":["https://openalex.org/I1336196053"]},{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA. prajna.guha@chartercare.org","institution_ids":[]},{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109977348","display_name":"Bryan F. Cox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan F. Cox","raw_affiliation_strings":["TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040099847","display_name":"Steven C. Katz","orcid":"https://orcid.org/0000-0002-6030-9312","observed_orcids":["https://orcid.org/0000-0002-6030-9312"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Katz","raw_affiliation_strings":["Department of Medicine, Roger Williams Medical Center, Providence, RI, USA","Department of Surgery, Boston University Medical Center, Boston, MA, USA","Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roger Williams Medical Center, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]},{"raw_affiliation_string":"Department of Surgery, Boston University Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Roger Williams Medical Center, Immuno-oncology Institute, Providence, RI, USA","institution_ids":["https://openalex.org/I1336196053"]},{"raw_affiliation_string":"TriSalus\u2122 Life Sciences, Inc., Westminster, CO, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059006831"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081","https://openalex.org/I1336196053"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":0.8596,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67196611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"29","issue":"12","first_page":"1854","last_page":"1865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9-agonist","display_name":"TLR9 agonist","score":0.9330000281333923},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-microenvironment-reprogramming","display_name":"tumor microenvironment reprogramming","score":0.9440000057220459},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/m1-m2-macrophage-ratio","display_name":"M1/M2 macrophage ratio","score":0.8730000257492065},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.675000011920929},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9369999766349792},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.7653192281723022},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5378965139389038},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.495646595954895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4734325408935547},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4570094048976898},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4452981948852539},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44445833563804626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4373958706855774},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4286192059516907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33815568685531616},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33652737736701965},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3071923851966858},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2785424590110779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25707125663757324},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2475109100341797},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41417-022-00484-z","doi":"https://doi.org/10.1038/s41417-022-00484-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41417-022-00484-z","pdf_url":"https://www.nature.com/articles/s41417-022-00484-z.pdf","source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9750861","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9750861","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Ther","raw_type":"Text"},{"id":"pmid:35697801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35697801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer gene therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41417-022-00484-z","doi":"https://doi.org/10.1038/s41417-022-00484-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41417-022-00484-z","pdf_url":"https://www.nature.com/articles/s41417-022-00484-z.pdf","source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282835394.pdf","grobid_xml":"https://content.openalex.org/works/W4282835394.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W808077884","https://openalex.org/W1521496787","https://openalex.org/W1966339569","https://openalex.org/W1972351486","https://openalex.org/W1973060929","https://openalex.org/W1989673842","https://openalex.org/W1998912113","https://openalex.org/W2034028219","https://openalex.org/W2038918212","https://openalex.org/W2039461003","https://openalex.org/W2044227662","https://openalex.org/W2046288401","https://openalex.org/W2051940924","https://openalex.org/W2053102794","https://openalex.org/W2065188053","https://openalex.org/W2072041272","https://openalex.org/W2082575834","https://openalex.org/W2087144130","https://openalex.org/W2087604357","https://openalex.org/W2103422355","https://openalex.org/W2114741192","https://openalex.org/W2117684163","https://openalex.org/W2121044753","https://openalex.org/W2139970952","https://openalex.org/W2158827553","https://openalex.org/W2300492004","https://openalex.org/W2405445310","https://openalex.org/W2406005292","https://openalex.org/W2541860579","https://openalex.org/W2558496610","https://openalex.org/W2755073646","https://openalex.org/W2765886882","https://openalex.org/W2795987080","https://openalex.org/W2808681178","https://openalex.org/W2888823627","https://openalex.org/W2888914203","https://openalex.org/W2889117947","https://openalex.org/W2946503701","https://openalex.org/W2973551292","https://openalex.org/W2978739732","https://openalex.org/W2990621788","https://openalex.org/W3005490880","https://openalex.org/W3010011098","https://openalex.org/W3080292686","https://openalex.org/W3084621851","https://openalex.org/W3091981841","https://openalex.org/W3093826348","https://openalex.org/W3096267580","https://openalex.org/W3109558738","https://openalex.org/W3119086885","https://openalex.org/W3127155476","https://openalex.org/W3143768863","https://openalex.org/W3186359206"],"related_works":["https://openalex.org/W3214248739","https://openalex.org/W4308402868","https://openalex.org/W4400878972","https://openalex.org/W4388047989","https://openalex.org/W2147547193","https://openalex.org/W4292429818","https://openalex.org/W3213543319","https://openalex.org/W4362593346","https://openalex.org/W4362596030","https://openalex.org/W1949708959"],"abstract_inverted_index":{"Myeloid-derived":[0],"suppressor":[1],"cells":[2],"(MDSCs)":[3],"expand":[4],"in":[5,33,37,90,105],"response":[6],"to":[7,12,41,170,188],"malignancy":[8],"and":[9,78,108,122,130,143,180],"suppress":[10],"responsiveness":[11,36,187],"immunotherapy,":[13],"including":[14],"checkpoint":[15],"inhibitors":[16],"(CPIs).":[17],"Within":[18],"the":[19,91,133,145,168,173],"liver,":[20],"MDSCs":[21,77,119,179],"have":[22,29,167],"unique":[23],"immunosuppressive":[24],"features.":[25],"While":[26],"TLR9":[27,51,82,96,127,138,150,165],"agonists":[28,52,128,166],"shown":[30],"promising":[31],"activities":[32],"enhancing":[34],"CPI":[35,190],"superficial":[38],"tumors":[39,49],"amenable":[40],"direct":[42],"needle":[43],"injection,":[44],"clinical":[45],"success":[46],"for":[47],"liver":[48,71,76,174],"with":[50,70,113,124,154],"has":[53],"been":[54],"limited":[55],"by":[56,100],"delivery":[57],"challenges.":[58],"Here,":[59],"we":[60],"report":[61],"that":[62],"regional":[63,84],"intravascular":[64],"infusion":[65,85,152],"of":[66,104,110,135,160,178],"ODN2395":[67],"into":[68],"mice":[69],"metastasis":[72],"(LM)":[73],"partially":[74],"eliminated":[75],"reprogrammed":[79],"residual":[80],"MDSC.":[81],"agonist":[83,151],"also":[86],"induced":[87,140],"an":[88,101],"increase":[89],"M1/M2":[92,146],"macrophage":[93,147,182],"ratio.":[94,148],"Enhanced":[95],"signaling":[97],"was":[98],"demonstrated":[99],"increased":[102,144],"activation":[103],"NF\u03baB":[106],"(pP65)":[107],"production":[109],"IL6":[111],"compared":[112],"systemic":[114,155,189],"infusion.":[115],"Further,":[116],"PBMC-derived":[117],"human":[118],"express":[120],"TLR9,":[121],"treatment":[123],"class":[125],"C":[126],"(ODN2395":[129],"SD101)":[131],"reduced":[132],"expansion":[134],"MDSC":[136,141],"population.":[137],"stimulation":[139],"apoptosis":[142],"Regional":[149],"along":[153],"anti-PD-1":[156],"therapy":[157],"improved":[158],"control":[159],"LM.":[161],"With":[162],"effective":[163],"delivery,":[164],"potential":[169],"favorably":[171],"reprogram":[172],"TME":[175],"through":[176],"reduction":[177],"favorable":[181],"polarization,":[183],"which":[184],"may":[185],"improve":[186],"therapy.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-15T00:00:00"}