{"id":"https://openalex.org/W4282829295","doi":"https://doi.org/10.1101/gr.276516.121","title":"Native RNA sequencing in fission yeast reveals frequent alternative splicing isoforms","display_name":"Native RNA sequencing in fission yeast reveals frequent alternative splicing isoforms","publication_year":2022,"publication_date":"2022-05-26","ids":{"openalex":"https://openalex.org/W4282829295","doi":"https://doi.org/10.1101/gr.276516.121","pmid":"https://pubmed.ncbi.nlm.nih.gov/35618415","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9248878"},"language":"en","primary_location":{"id":"doi:10.1101/gr.276516.121","doi":"https://doi.org/10.1101/gr.276516.121","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.276516.121","pdf_url":"https://genome.cshlp.org/content/32/6/1215.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://genome.cshlp.org/content/32/6/1215.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059298244","display_name":"Jos\u00e9 Carlos Monta\u00f1\u00e9s","orcid":"https://orcid.org/0000-0001-6453-9847","observed_orcids":["https://orcid.org/0000-0001-6453-9847"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Carlos Monta\u00f1\u00e9s","raw_affiliation_strings":["Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0001-6453-9847","affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012009390","display_name":"Marta Huertas","orcid":"https://orcid.org/0000-0003-2665-0899","observed_orcids":["https://orcid.org/0000-0003-2665-0899"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Huertas","raw_affiliation_strings":["Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071567642","display_name":"Simone G. Moro","orcid":"https://orcid.org/0000-0001-5199-8390","observed_orcids":["https://orcid.org/0000-0001-5199-8390"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Simone G. Moro","raw_affiliation_strings":["Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032610839","display_name":"William R. Blevins","orcid":"https://orcid.org/0000-0002-5222-2321","observed_orcids":["https://orcid.org/0000-0002-5222-2321"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"William R. Blevins","raw_affiliation_strings":["Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5222-2321","affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048214622","display_name":"Merc\u00e8 Carmona","orcid":"https://orcid.org/0000-0002-1132-9413","observed_orcids":["https://orcid.org/0000-0002-1132-9413"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Merc\u00e8 Carmona","raw_affiliation_strings":["Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","2Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"2Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044576329","display_name":"Jos\u00e9 Ayt\u00e9","orcid":"https://orcid.org/0000-0002-6354-0536","observed_orcids":["https://orcid.org/0000-0002-6354-0536"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Ayt\u00e9","raw_affiliation_strings":["Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","2Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"2Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008368828","display_name":"Elena Hidalgo","orcid":"https://orcid.org/0000-0002-3768-6785","observed_orcids":["https://orcid.org/0000-0002-3768-6785"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Hidalgo","raw_affiliation_strings":["Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","2Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"2Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062672403","display_name":"M. Mar Alb\u00e0","orcid":"https://orcid.org/0000-0002-7963-7375","observed_orcids":["https://orcid.org/0000-0002-7963-7375"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Mar Alb\u00e0","raw_affiliation_strings":["Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain","Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","3Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7963-7375","affiliations":[{"raw_affiliation_string":"Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"1Evolutionary Genomics Group, Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"3Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"6","first_page":"1215","last_page":"1227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9760000109672546},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intron-retention","display_name":"intron retention","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ribosome-profiling","display_name":"ribosome profiling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/poly-a-tail-length","display_name":"poly(A) tail length","score":0.8709999918937683},{"id":"https://openalex.org/keywords/novel-transcripts","display_name":"novel transcripts","score":0.5899999737739563},{"id":"https://openalex.org/keywords/antisense-transcripts","display_name":"antisense transcripts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ribosomal-protein-l22","display_name":"ribosomal protein L22","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8584098219871521},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.726472020149231},{"id":"https://openalex.org/C2779429346","wikidata":"https://www.wikidata.org/wiki/Q2236682","display_name":"Schizosaccharomyces pombe","level":4,"score":0.71302330493927},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6836135983467102},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.633571445941925},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5742056965827942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5425276756286621},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.5315586924552917},{"id":"https://openalex.org/C2776519988","wikidata":"https://www.wikidata.org/wiki/Q1317935","display_name":"Schizosaccharomyces","level":5,"score":0.5315511226654053},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5171841382980347},{"id":"https://openalex.org/C182325514","wikidata":"https://www.wikidata.org/wiki/Q7322425","display_name":"Ribosome profiling","level":5,"score":0.49468156695365906},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4574822783470154},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4270685911178589},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4166531562805176},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.28519344329833984},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.18774211406707764}],"mesh":[{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1101/gr.276516.121","doi":"https://doi.org/10.1101/gr.276516.121","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.276516.121","pdf_url":"https://genome.cshlp.org/content/32/6/1215.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmid:35618415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35618415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9248878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9248878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},{"id":"pmh:oai:repositori-api.upf.edu:10230/56551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/56551","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositori.upf.edu:10230/56544","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/56544","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/gr.276516.121","doi":"https://doi.org/10.1101/gr.276516.121","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.276516.121","pdf_url":"https://genome.cshlp.org/content/32/6/1215.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G162886611","display_name":null,"funder_award_id":"2017 SGR 01020","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G1650125035","display_name":null,"funder_award_id":"B-I00","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G490073602","display_name":null,"funder_award_id":"PGC2018","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G565952006","display_name":null,"funder_award_id":"PGC2018-094091-B-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G6731467812","display_name":null,"funder_award_id":"PGC2018","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282829295.pdf","grobid_xml":"https://content.openalex.org/works/W4282829295.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1519765314","https://openalex.org/W1817659377","https://openalex.org/W2013673778","https://openalex.org/W2019362237","https://openalex.org/W2024625320","https://openalex.org/W2041103217","https://openalex.org/W2052948442","https://openalex.org/W2057726003","https://openalex.org/W2069611040","https://openalex.org/W2076627305","https://openalex.org/W2079517684","https://openalex.org/W2097313047","https://openalex.org/W2102619694","https://openalex.org/W2108234281","https://openalex.org/W2113176563","https://openalex.org/W2115101918","https://openalex.org/W2116402707","https://openalex.org/W2117843359","https://openalex.org/W2128512486","https://openalex.org/W2129883957","https://openalex.org/W2137243854","https://openalex.org/W2139651073","https://openalex.org/W2140729960","https://openalex.org/W2146450575","https://openalex.org/W2159624397","https://openalex.org/W2175136759","https://openalex.org/W2178845268","https://openalex.org/W2205343347","https://openalex.org/W2262417550","https://openalex.org/W2272861280","https://openalex.org/W2493043445","https://openalex.org/W2514613565","https://openalex.org/W2520456405","https://openalex.org/W2751323260","https://openalex.org/W2767360874","https://openalex.org/W2781766672","https://openalex.org/W2789843538","https://openalex.org/W2793022686","https://openalex.org/W2809526652","https://openalex.org/W2810472944","https://openalex.org/W2896319347","https://openalex.org/W2908053922","https://openalex.org/W2946952003","https://openalex.org/W2949662056","https://openalex.org/W2950063384","https://openalex.org/W2951547278","https://openalex.org/W2951731710","https://openalex.org/W2954570623","https://openalex.org/W2964849163","https://openalex.org/W2989499631","https://openalex.org/W2995527562","https://openalex.org/W3004480435","https://openalex.org/W3004933912","https://openalex.org/W3007172120","https://openalex.org/W3010073072","https://openalex.org/W3015416331","https://openalex.org/W3041701849","https://openalex.org/W3059956750","https://openalex.org/W3123647022","https://openalex.org/W3129224649","https://openalex.org/W3144399060","https://openalex.org/W3173374182","https://openalex.org/W3186264726","https://openalex.org/W4254687493"],"related_works":["https://openalex.org/W2951731710","https://openalex.org/W2910622008","https://openalex.org/W1780037920","https://openalex.org/W2047765648","https://openalex.org/W2253933438","https://openalex.org/W2146450575","https://openalex.org/W1977265067","https://openalex.org/W2772224228","https://openalex.org/W2054738599","https://openalex.org/W1996163007"],"abstract_inverted_index":{"The":[0,225],"unicellular":[1],"yeast":[2],"Schizosaccharomyces":[3],"pombe":[4,106],"(fission":[5],"yeast)":[6],"retains":[7],"many":[8],"of":[9,27,38,71,88,93,118,129,148,168,171,219,238],"the":[10,24,31,36,68,85,119,127,149,156,166,236],"splicing":[11,40,103,239],"features":[12],"observed":[13],"in":[14,41,104,126,133,146,159,228,240],"humans":[15],"and":[16,44,74,200],"is":[17,107,155,163],"thus":[18],"an":[19,194],"excellent":[20],"model":[21],"to":[22,66,184,234],"study":[23,235],"basic":[25],"mechanisms":[26],"splicing.":[28],"Nearly":[29],"half":[30],"genes":[32],"contain":[33],"introns,":[34],"but":[35],"impact":[37],"alternative":[39,82,102],"gene":[42,130],"regulation":[43,128,237],"proteome":[45],"diversification":[46],"remains":[47],"largely":[48],"unexplored.":[49],"Here":[50],"we":[51,205],"leverage":[52],"Oxford":[53],"Nanopore":[54],"Technologies":[55],"native":[56],"RNA":[57],"sequencing":[58],"(dRNA),":[59],"as":[60,62,140],"well":[61],"ribosome":[63,143],"profiling":[64,144],"data,":[65],"uncover":[67],"full":[69],"range":[70],"polyadenylated":[72],"transcripts":[73,182,209],"translated":[75],"open":[76,231],"reading":[77],"frames.":[78],"We":[79,176],"identify":[80],"332":[81],"isoforms":[83],"affecting":[84],"coding":[86],"sequences":[87],"262":[89],"different":[90],"genes,":[91],"97":[92],"which":[94,160,220],"occur":[95],"at":[96],"frequencies":[97],">20%,":[98],"indicating":[99],"that":[100,179,210],"functional":[101],"S.":[105],"more":[108],"prevalent":[109],"than":[110,189],"previously":[111],"suspected.":[112],"Intron":[113],"retention":[114,151,162],"events":[115,122],"make":[116],"\u223c80%":[117],"cases;":[120],"these":[121],"may":[123],"be":[124],"involved":[125],"expression":[131,202],"and,":[132],"some":[134,218],"cases,":[135],"generate":[136],"novel":[137,208],"protein":[138,170],"isoforms,":[139],"supported":[141],"by":[142],"data":[145],"18":[147],"intron":[150,161],"isoforms.":[152],"One":[153],"example":[154],"rpl22":[157],"gene,":[158],"associated":[164],"with":[165],"translation":[167,223],"a":[169,241],"only":[172],"13":[173],"amino":[174],"acids.":[175],"also":[177,221],"find":[178],"lowly":[180],"expressed":[181,191],"tend":[183],"have":[185],"longer":[186],"poly(A)":[187,197],"tails":[188],"highly":[190],"transcripts,":[192,217],"highlighting":[193],"interdependence":[195],"between":[196],"tail":[198],"length":[199],"transcript":[201],"level.":[203],"Finally,":[204],"discover":[206],"214":[207],"are":[211],"not":[212],"annotated,":[213],"including":[214],"158":[215],"antisense":[216],"show":[222],"evidence.":[224],"methodologies":[226],"described":[227],"this":[229],"work":[230],"new":[232],"opportunities":[233],"simple":[242],"eukaryotic":[243],"model.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-15T00:00:00"}