{"id":"https://openalex.org/W4282829156","doi":"https://doi.org/10.1097/ajp.0000000000001052","title":"Evaluating the Effect of Duloxetine Premedication on Postoperative Analgesic Requirement in Patients Undergoing Laparoscopic Cholecystectomies","display_name":"Evaluating the Effect of Duloxetine Premedication on Postoperative Analgesic Requirement in Patients Undergoing Laparoscopic Cholecystectomies","publication_year":2022,"publication_date":"2022-06-09","ids":{"openalex":"https://openalex.org/W4282829156","doi":"https://doi.org/10.1097/ajp.0000000000001052","pmid":"https://pubmed.ncbi.nlm.nih.gov/35696698"},"language":"en","primary_location":{"id":"doi:10.1097/ajp.0000000000001052","doi":"https://doi.org/10.1097/ajp.0000000000001052","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ajp.0000000000001052","pdf_url":null,"source":{"id":"https://openalex.org/S102460418","display_name":"Clinical Journal of Pain","issn_l":"0749-8047","issn":["0749-8047","1536-5409"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049596990","display_name":"Shivika Nath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivika Nath","raw_affiliation_strings":["Department of Anesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India","institution_ids":["https://openalex.org/I74885063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027470571","display_name":"Ambhrin Saha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ambhrin Saha","raw_affiliation_strings":["Department of Anesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India","institution_ids":["https://openalex.org/I74885063"]}]},{"author_position":"last","author":{"id":null,"display_name":"Aarti Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aarti Srivastava","raw_affiliation_strings":["Department of Anesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India","institution_ids":["https://openalex.org/I74885063"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74885063"],"apc_list":null,"apc_paid":null,"fwci":1.8549,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83002096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"38","issue":"8","first_page":"528","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.996999979019165},{"id":"https://openalex.org/keywords/premedication","display_name":"premedication","score":0.8009999990463257},{"id":"https://openalex.org/keywords/laparoscopic-cholecystectomy","display_name":"laparoscopic cholecystectomy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9599999785423279},{"id":"https://openalex.org/keywords/analgesic-requirement","display_name":"analgesic requirement","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rescue-analgesia","display_name":"rescue analgesia","score":0.7509999871253967},{"id":"https://openalex.org/keywords/perioperative-hemodynamics","display_name":"perioperative hemodynamics","score":0.8199999928474426},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9528760313987732},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.8101992607116699},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.806858241558075},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7413606643676758},{"id":"https://openalex.org/C2778300832","wikidata":"https://www.wikidata.org/wiki/Q1589604","display_name":"Premedication","level":2,"score":0.7209973931312561},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6280550360679626},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6059352159500122},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.5967092514038086},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.5395262837409973},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5101228356361389},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4498788118362427},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43715721368789673},{"id":"https://openalex.org/C2776641081","wikidata":"https://www.wikidata.org/wiki/Q638774","display_name":"Cholecystectomy","level":2,"score":0.4115332365036011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10896289348602295},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011292","descriptor_name":"Premedication","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017081","descriptor_name":"Cholecystectomy, Laparoscopic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/ajp.0000000000001052","doi":"https://doi.org/10.1097/ajp.0000000000001052","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ajp.0000000000001052","pdf_url":null,"source":{"id":"https://openalex.org/S102460418","display_name":"Clinical Journal of Pain","issn_l":"0749-8047","issn":["0749-8047","1536-5409"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Journal of Pain","raw_type":"journal-article"},{"id":"pmid:35696698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35696698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical journal of pain","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1873305365","https://openalex.org/W1981451826","https://openalex.org/W1984832858","https://openalex.org/W1995797014","https://openalex.org/W2002015440","https://openalex.org/W2006194553","https://openalex.org/W2023128716","https://openalex.org/W2026379771","https://openalex.org/W2031955247","https://openalex.org/W2043859702","https://openalex.org/W2045071790","https://openalex.org/W2051196560","https://openalex.org/W2080234050","https://openalex.org/W2098354008","https://openalex.org/W2106059433","https://openalex.org/W2113578435","https://openalex.org/W2152740846","https://openalex.org/W2155518734","https://openalex.org/W2159522837","https://openalex.org/W2164863281","https://openalex.org/W2209490151","https://openalex.org/W2397762865","https://openalex.org/W2469439241","https://openalex.org/W2562188657","https://openalex.org/W2562940003","https://openalex.org/W2771821395","https://openalex.org/W2778061489","https://openalex.org/W2784128174","https://openalex.org/W2884761363","https://openalex.org/W2966419739","https://openalex.org/W3042890170"],"related_works":["https://openalex.org/W4298001711","https://openalex.org/W4406399817","https://openalex.org/W7217981404","https://openalex.org/W4376872196","https://openalex.org/W4312422470","https://openalex.org/W4225695235","https://openalex.org/W3042890170","https://openalex.org/W4394795256","https://openalex.org/W3164452599","https://openalex.org/W2417024153"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,29,92,117,144,199],"aim":[2],"was":[3,32,59,127,136,152,226],"to":[4,33,138],"evaluate":[5,34],"the":[6,22,26,35,100,218,222,231,235,238],"effect":[7],"of":[8,11,45,76,86,217,262],"oral":[9,247],"administration":[10],"preoperative":[12],"duloxetine":[13,104,134,163,214,248],"on":[14,73],"postoperative":[15,23,254,256],"pain":[16],"and":[17,43,90,108,123,135,193,204,241,259],"total":[18,118],"analgesic":[19,257],"requirement":[20,119],"in":[21,50,67,129,146,158,210,215,221,230],"period":[24],"as":[25,131,160],"primary":[27],"objective.":[28],"secondary":[30],"objective":[31],"perioperative":[36,223],"hemodynamic":[37],"parameters,":[38],"sedation":[39,232],"scores,":[40],"demographic":[41],"data,":[42],"incidence":[44],"side":[46,267],"effects":[47],"(if":[48],"any)":[49],"patients":[51,75,93,101],"undergoing":[52],"laparoscopic":[53,81,250],"cholecystectomy.":[54],"MATERIALS":[55],"AND":[56],"METHODS:":[57],"This":[58],"a":[60,68],"prospective,":[61],"randomized,":[62],"double-blind,":[63],"placebo-controlled":[64],"study":[65],"conducted":[66],"tertiary":[69],"level":[70],"medical":[71],"college":[72],"60":[74,105],"either":[77],"sex":[78],"posted":[79],"for":[80,120],"cholecystectomies":[82],"with":[83,133,162,213],"American":[84],"Society":[85],"Anesthesiologists":[87],"(ASA)":[88],"I":[89],"II.":[91],"were":[94,102,207],"divided":[95],"into":[96],"2":[97,112],"groups":[98,236],"(n=30),":[99],"given":[103],"mg":[106],"capsules":[107,110],"placebo":[109,130,159,211],"(Becosules)":[111],"hours":[113,184,189,195,243],"before":[114],"surgery.":[115],"RESULTS:":[116],"both":[121],"first":[122],"second":[124],"rescue":[125],"analgesics":[126],"higher":[128,157,209],"compared":[132,161,212],"found":[137],"be":[139],"significant":[140,228],"(":[141,154],"P":[142,155],"<0.05).":[143],"difference":[145,229],"mean":[147,200],"visual":[148],"analog":[149],"scale":[150],"score":[151,233],"significantly":[153,208],"<0.001)":[156],"at":[164],"all-time":[165],"intervals":[166,220],"postoperatively":[167],"0":[168],"minute":[169],"(7.6\u00b10.7":[170],"vs.":[171,176,181,186,191,197],"4.6\u00b10.8);":[172],"15":[173],"minutes":[174,179,240],"(5.9\u00b10.8":[175],"4.2\u00b11.0);":[177],"30":[178,239],"(4.4\u00b10.5":[180],"3.6\u00b10.9);":[182],"4":[183],"(6.6\u00b10.06":[185],"5.3\u00b11.3);":[187],"8":[188,242],"(5.2\u00b11.2":[190],"3.9\u00b11.0);":[192],"12":[194],"(5.1\u00b11.3":[196],"2.3\u00b10.7).":[198],"arterial":[201],"blood":[202],"pressure":[203],"heart":[205],"rate":[206],"most":[216],"time":[219],"period.":[224],"There":[225],"no":[227],"between":[234],"except":[237],"postoperative.":[244],"DISCUSSION:":[245],"Preoperative":[246],"during":[249],"cholecystectomy":[251],"could":[252],"reduce":[253],"pain,":[255],"requirements,":[258],"better":[260],"optimization":[261],"hemodynamics":[263],"without":[264],"causing":[265],"major":[266],"effects.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-15T00:00:00"}