{"id":"https://openalex.org/W4282828944","doi":"https://doi.org/10.7554/elife.78387.sa2","title":"Author response: Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction","display_name":"Author response: Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction","publication_year":2022,"publication_date":"2022-05-06","ids":{"openalex":"https://openalex.org/W4282828944","doi":"https://doi.org/10.7554/elife.78387.sa2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.78387.sa2","doi":"https://doi.org/10.7554/elife.78387.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.78387.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.78387.sa2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066680742","display_name":"Matthew R. Blake","orcid":"https://orcid.org/0000-0003-0584-7684","observed_orcids":["https://orcid.org/0000-0003-0584-7684"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R Blake","raw_affiliation_strings":["Department of Chemical Physiology and Biochemistry, Oregon Health and Science University"],"raw_orcid":"https://orcid.org/0000-0003-0584-7684","affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology and Biochemistry, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113699043","display_name":"Diana C. Parrish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana C Parrish","raw_affiliation_strings":["Department of Chemical Physiology and Biochemistry, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology and Biochemistry, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017885618","display_name":"Melanie A. Staffenson","orcid":"https://orcid.org/0000-0003-0433-0691","observed_orcids":["https://orcid.org/0000-0003-0433-0691"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie A Staffenson","raw_affiliation_strings":["Department of Chemical Physiology and Biochemistry, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology and Biochemistry, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087776061","display_name":"Shanice Sueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanice Sueda","raw_affiliation_strings":["Portland State University EXITO Scholars Program, Portland State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland State University EXITO Scholars Program, Portland State University","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076022488","display_name":"William R. Woodward","orcid":"https://orcid.org/0000-0002-1228-8473","observed_orcids":["https://orcid.org/0000-0002-1228-8473"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R Woodward","raw_affiliation_strings":["Department of Chemical Physiology and Biochemistry, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology and Biochemistry, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028832415","display_name":"Beth A. Habecker","orcid":"https://orcid.org/0000-0002-4658-8730","observed_orcids":["https://orcid.org/0000-0002-4658-8730"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth A Habecker","raw_affiliation_strings":["Department of Chemical Physiology and Biochemistry, Oregon Health and Science University"],"raw_orcid":"https://orcid.org/0000-0002-4658-8730","affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology and Biochemistry, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondroitin-sulfate-proteoglycans","display_name":"chondroitin sulfate proteoglycans","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sympathetic-nerve-regeneration","display_name":"sympathetic nerve regeneration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.984000027179718},{"id":"https://openalex.org/keywords/myocardial-scar","display_name":"myocardial scar","score":0.9570000171661377},{"id":"https://openalex.org/keywords/sympathetic-denervation","display_name":"sympathetic denervation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/axon-growth","display_name":"axon growth","score":0.7789999842643738},{"id":"https://openalex.org/keywords/arylsulfatase-b","display_name":"arylsulfatase B","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.921999990940094},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.8068636059761047},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6056500673294067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.478334903717041},{"id":"https://openalex.org/C2775895372","wikidata":"https://www.wikidata.org/wiki/Q5104536","display_name":"Chondroitin sulfate proteoglycan","level":4,"score":0.4583513140678406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4526765048503876},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.452507346868515},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.4104257822036743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.404225617647171},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3715861439704895},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.36889493465423584},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.3425878882408142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3101385235786438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24240261316299438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2147177755832672}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.78387.sa2","doi":"https://doi.org/10.7554/elife.78387.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.78387.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.78387.sa2","doi":"https://doi.org/10.7554/elife.78387.sa2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.78387.sa2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6977275681","https://openalex.org/W4281290991","https://openalex.org/W4378173211","https://openalex.org/W1982439010","https://openalex.org/W2422651156","https://openalex.org/W4400803570","https://openalex.org/W2049332135","https://openalex.org/W1965335618","https://openalex.org/W1527354818","https://openalex.org/W2054992536"],"abstract_inverted_index":{"Article":[0,20],"Figures":[1],"and":[2,11,21,96,174,177,186,198,221,265,286,328,330,336,388,400,460,470,482,531,558,610,654,683,726,843,849,868,890,938,972,1004,1007,1113,1167,1318,1462,1604,1657,1675,1685,1690,1699,1707,1740,1882,1902,1920,1936,1941,2017,2061,2069,2098,2125,2254,2351,2503,2692,2699,2721,2772,2806,2888,2955,2969,2989,3040,3134,3150,3173,3200,3278,3338,3360,3419,3513,3554,3701,3735,3793,3807,3828,3839,3862,3892,3902,3921,4057,4069,4086,4102],"data":[3,1415,2064,3175,3291,3445,3912],"Abstract":[4,25],"Editor's":[5,270],"evaluation":[6,271],"Introduction":[7,314],"Results":[8,911],"Discussion":[9,3094],"Materials":[10,2968,4068],"methods":[12,2970,4070],"Data":[13,1155,1198,1560,1766,2133,2542,2894,2995,3046],"availability":[14],"References":[15],"Decision":[16,306],"letter":[17,307],"Author":[18],"response":[19,3272],"author":[22],"information":[23],"Metrics":[24],"Sympathetic":[26,315,1086],"denervation":[27,316,2620],"of":[28,51,82,90,100,107,144,200,217,333,356,382,435,496,549,593,613,618,704,741,809,893,899,903,913,986,1032,1120,1148,1174,1185,1242,1304,1352,1363,1391,1420,1473,1483,1498,1507,1513,1535,1542,1609,1634,1730,1859,1943,1968,2002,2051,2077,2092,2112,2243,2247,2252,2288,2315,2323,2367,2396,2403,2455,2490,2579,2585,2621,2673,2705,2717,2732,2787,2819,2831,2845,2875,2953,3017,3034,3070,3080,3084,3100,3137,3157,3160,3182,3203,3253,3328,3353,3372,3404,3460,3486,3492,3498,3511,3515,3543,3552,3560,3590,3597,3630,3643,3657,3733,3760,3820,3876,3904,3923,3942,3954,4028,4034,4045,4047,4052],"the":[29,45,65,79,83,93,137,204,235,262,281,376,380,415,518,538,546,594,638,714,762,796,863,879,886,904,917,979,989,1047,1350,1353,1371,1379,1406,1411,1423,1481,1619,1754,1873,1889,1907,1927,2000,2129,2259,2286,2289,2313,2365,2456,2481,2505,2513,2586,2595,2622,2633,2649,2654,2659,2671,2689,2718,2758,2769,2796,2836,2841,2857,2866,2943,3085,3098,3111,3118,3122,3132,3155,3163,3204,3214,3225,3243,3270,3297,3317,3331,3343,3368,3390,3401,3470,3480,3499,3505,3509,3516,3532,3550,3588,3613,3644,3740,3850,3860,3873,3881,3905,3933,3975,3988,3991,4031,4035,4042,4053],"heart":[30,887,918,2950,3076,3112,3481,3614,3976,4054],"following":[31,317,3451],"ischemia/reperfusion":[32,363,771,1725,2103,2485],"induced":[33,241],"myocardial":[34,318,766,1257,1757,2535],"infarction":[35,319,767,1522,1758,2536],"(MI)":[36,320,768,1550,1759],"is":[37,116,273,321,501,541,588,736,872,969,1009,1426,1613,1722,2398,3140,3324,3340,3371,3504,3546,3822,3869,3926,3938,3945,4003],"sustained":[38],"by":[39,74,213,362,418,440,596,637,648,663,711,770,792,895,930,1621,1696,1891,1929,2040,2080,2284,2598,2605,2713,3198,3201,3245,3650,3750,4064],"chondroitin":[40,383,441,2093,3145],"sulfate":[41,384,442,550,756,1716,2094,3146],"proteoglycans":[42,385,1717],"(CSPGs)":[43,386],"in":[44,55,104,203,211,234,261,283,324,393,414,450,526,562,723,761,795,862,878,885,916,949,988,1000,1026,1056,1107,1144,1269,1278,1332,1349,1384,1422,1442,1480,1628,1747,1753,1862,1872,1888,1926,1949,1963,2105,2128,2258,2275,2282,2303,2319,2359,2436,2474,2512,2610,2648,2670,2757,2789,2823,2835,2856,2948,3025,3073,3088,3105,3110,3121,3162,3208,3279,3296,3330,3356,3396,3407,3479,3508,3524,3549,3612,3662,3754,3779,3889,3900,3907,3918,3932,3974,3987,4000,4030,4049,4201,4205,4213,4217],"cardiac":[46,53,66,165,205,236,263,268,338,402,416,708,763,801,864,905,990,1243,1270,1305,1339,1407,1424,1443,1484,1969,2106,2260,2437,2457,2482,2514,2587,2759,2770,2797,2858,3071,3123,3209,3332,3369,3471,3741,3851,3934],"scar.":[47,206,237,906,980,2458,2798,2842,3472,3742],"Denervation":[48],"predicts":[49],"risk":[50,397],"sudden":[52,337,401],"death":[54,339,403],"humans.":[56],"Blocking":[57],"CSPG":[58,126,519,566,586,734,774,924,947,996,1610,1637,1854,1863,1908,2015,2052,2267,3227,3314,3405,3863,4066],"signaling":[59],"restores":[60,719,1178,1248,1448,2255],"sympathetic":[61,129,147,161,231,258,365,394,412,720,973,1023,1071,1123,1141,1187,1249,1275,1306,1430,1449,2256,2270,2427,2453,2477,2506,2602,2764,2792,2814,3107,3183,3476,4105],"axon":[62,130,157,357,528,605,619,693,721,1250,1276,1314,1330,1368,1398,1431,1450,1457,1478,1499,1509,1537,1563,3108,3192,3467,3477,3660],"outgrowth":[63,103,131,143,158,529,620,694,722,1025,1036,1106,1143,1150,1180,1214,1251,1277,1315,1331,1369,1479,1510,1538,3156,3661],"into":[64,2480,2768,2795,3469,3739,3859],"scar,":[67],"decreasing":[68,3186],"arrhythmia":[69,2708,2774,2946,2997,3249,3303],"susceptibility.":[70],"Axon":[71],"growth":[72,1376,3181,3677,3704],"inhibition":[73],"CSPGs":[75,202,420,430,489,859,987,1045,1080,1091,2253,3119,3295,3329,3679],"can":[76,298,659,3347],"depend":[77],"on":[78,309,575,1079,1194,1215,1397,2347,2942,3659,3835,3865],"sulfation":[80,89,115,127,587,735,775,871,892,925,948,1611,1624,1638,1655,1719,1855,1864,1871,1942,2016,2053,2097,2251,2268,2473,2786,3104,3130,3315,3355,3406,3459,3485,3732,3864,3925],"status":[81],"glycosaminoglycan":[84],"(CS-GAG)":[85],"side":[86,444,507,1945,3102,3488,3538],"chains.":[87,3489],"Tandem":[88],"CS-GAGs":[91,210,561,634,658,690,706,894,914,940,1033,1121,1268,1421,1884,2078,2281,2404,2756,2788,3493,3592,3648,3734,4048],"at":[92,1162,1190,1682,1876,1956,2055,2653,3131,3687],"4th":[94],"(4S)":[95,609],"6th":[97],"(6S)":[98,612],"positions":[99,3136],"n-acetyl-galactosamine":[101],"inhibits":[102,1122,3154],"several":[105,3158],"types":[106,3159],"central":[108],"neurons,":[109,1307],"but":[110,372,492,729,3251,3382],"we":[111,854,932,1039,1630,1868,1998,2277,2311,2593,2710,3434,3453,3605,3620,3719,3845,3958,3980],"don\u2019t":[112],"know":[113],"if":[114,125,1906,2266,3312,3607],"similarly":[117],"critical":[118,616,737,1636,3402,4043],"during":[119],"peripheral":[120,742],"nerve":[121,232,259,448,876,2271,2478,2603,2765,2793,2863,3676,3703,3737,3857,3930],"regeneration.":[122,1432,3193],"We":[123,168,207,1254,1647,1904,1952,3115,3238,3743,3832,3855],"asked":[124,1905,3606],"prevented":[128,1034],"after":[132,190,219,249,359,765,805,866,888,919,927,1012,1503,1615,1626,1724,1756,1866,1918,1932,2043,2102,2131,2262,2273,2383,2484,2516,2534,2590,2715,2761,2776,2881,2951,3113,3125,3380,3540,3615,3872,3880,3977,4055],"MI.":[133,191,2132,2777,2882,3114,3541,3978],"Reducing":[134,1018,1137,1240,1439,2470,2784],"4S":[135,153,633,657,825,839,937,1008,1019,1031,1042,1061,1119,1241,1266,1419,1441,1881,3188],"with":[136,154,164,713,746,778,1020,1082,1128,1152,1176,1246,1260,1293,1324,1489,1525,1552,2343,2461,2522,2613,2639,2734,2974,3129,3221,3495,3557,3728,3789,3800,3842,4162],"4-sulfatase":[138,1658,1742],"enzyme":[139,715,1720,3507,3525],"Arylsulfatase-B":[140],"(ARSB)":[141,669],"enhanced":[142],"dissociated":[145,1186],"rat":[146],"neurons":[148,1072,2815,3161],"over":[149],"CSPGs.":[150],"Likewise,":[151],"reducing":[152,224,891,1418,2285,2753,3671],"ARSB":[155,187,1021,1052,1102,1177,1221,1234,1247,1261,1359,1389,1530,1557,1659,1692,1825,2018,2071,3518,3561,3585,3971,3985,4002],"restored":[156,226,1104,1367,2645,2852],"from":[159,681,707,846,977,1043,1073,1267,1288,1378,1464,1540,2440],"mouse":[160,950,1256,1874,3755],"ganglia":[162],"co-cultured":[163,1292,1323],"scar":[166,264,377,417,563,709,764,802,865,958,967,991,1244,1271,1340,1354,1364,1372,1380,1408,1425,1444,1485,1519,1548,1970,2107,2261,2438,2483,2515,2588,2634,2684,2760,2771,2804,3010,3051,3072,3124,3210,3298,3333,3370,3391,3852,3861,3935],"tissue.":[167,959,1296,1607,2108,3211],"quantified":[169],"enzymes":[170,882,1612,1865,2054],"responsible":[171],"for":[172,196,398,425,838,874,1313,1568,1733,1853,2600,2885,2890,2971,2986,2992,2999,3037,3042,3531,3785,3798,4090,4104,4173],"adding":[173],"removing":[175,1265,3383,3456],"sulfation,":[176],"found":[178,222,1921,3116,3454,3621],"that":[179,223,246,279,446,500,517,602,686,856,869,1118,1417,1922,2066,2299,2393,2583,2752,3117,3177,3293,3342,3436,3447,3455,3622,3635,3670,3685,3757,3914,3946],"CHST15":[180,652,1653,1678,1805,2068,2328,2385,2397,3565,3672,3700,3885,3919],"(4S":[181,783,2115,2497],"dependent":[182],"6-sulfotransferase)":[183],"was":[184,188,1054,1092,1382,1468,1679,1915,1924,1960,1979,2037,2433,2530,2667,2686,2800,2810,3023,3196,3463,3610,3853],"upregulated,":[185],"downregulated":[189],"This":[192,272,391,3095,3633],"suggests":[193,516,3634],"a":[194,253,432,497,524,649,963,1108,1300,1310,1964,2003,2356,2523,2614,2628,3014,3274,3375,3387,3528,3558,3694,3721,3751,3780,3794,3809,3897,3915,3951],"mechanism":[195,3530],"production":[197,3510],"maintenance":[199],"sulfated":[201,643,688,858,2280,2755,3536,3647],"decreased":[208,1664,1694,2070,2278,2300,3217,3730],"4S,6S":[209,225,689,2360],"vivo":[212,1253,1447,2283,2475,2790],"transient":[214,896,2394,2517,3916],"siRNA":[215,897,2245,2298,2318,2334,2376,2422,2446,2616,2641,2736,2744,2975,3729,3749,3758,3775,3818,3843,3883,3891,3894],"knockdown":[216,898,2246,2395,2411,2519,3759,3819,4112],"Chst15":[218,900,2248,2290,2301,2317,2518,2591,2643,2735,2850,2891,2977,2993,3026,3043,3074,3725,3774,3821,3893,3908,3955],"MI,":[220,455,867,889,2384,3381,3452],"tyrosine":[227,571],"hydroxylase":[228],"(TH)":[229,2432,2511,2809],"positive":[230],"fibers":[233,2604,2647,2834,2855],"Reinnervation":[238,907,3212],"reduced":[239,2327,2364,2707,2738,2978,3762],"isoproterenol":[240,2720,2954],"arrhythmias.":[242,269,429,910],"Our":[243],"results":[244,1116,2750],"suggest":[245,1416,2065],"modulating":[247,419,3313,4065],"CSPG-sulfation":[248],"MI":[250,360,806,851,928,1579,1606,1933,2762,4056],"may":[251,421,1995,2046,3256,3638,4026],"be":[252,299,661,1996,3639,4027],"therapeutic":[254,409,4006,4032],"target":[255],"to":[256,301,379,504,543,551,590,738,936,945,954,983,1059,1098,1181,1212,1262,1428,1577,1598,1643,1780,1954,1989,2014,2048,2074,2147,2331,2355,2374,2390,2400,2413,2420,2444,2627,2632,2677,2742,2802,2812,2840,2905,2981,3030,3143,3266,3299,3377,3465,3534,3563,3668,3698,3716,3746,3825,3847,3928,3961,3969,3983,4008,4061],"promote":[257,3702,4062],"regeneration":[260,449,740,877,2272,2479,2766,2794,3109,3195,3468,3478,3738,3858],"reduce":[266],"post-MI":[267,428,1641,1687,1894,2372,2851,3841,4036],"an":[274,353,664,1987,2640,3258,3325,3393,3440,3640,3963,4004],"extremely":[275],"well":[276,322,1166],"performed":[277],"study":[278,3096,3753],"advances":[280],"knowledge":[282],"this":[284,870,1993,3437,3943,4039],"area":[285,3016,3022,3050],"will":[287],"foster":[288],"further":[289],"work.":[290],"It":[291,3309],"also":[292,660,1916,2011,3179,3547,3959],"showcases":[293],"how":[294,1992],"basic":[295],"neuroscientific":[296],"work":[297,4040],"applied":[300],"complex":[302],"pathophysiological":[303],"problems.":[304],"https://doi.org/10.7554/eLife.78387.sa0":[305],"Reviews":[308],"Sciety":[310],"eLife's":[311],"review":[312],"process":[313,1994],"documented":[323],"both":[325,1948],"animal":[326,2826],"models":[327],"humans,":[329],"highly":[331,3535,3646],"predictive":[332],"ventricular":[334,2965],"arrhythmias":[335,399,2712,2739,2979],"(Boogers":[340],"et":[341,345,349,405,466,474,478,486,535,554,579,583,622,626,630,673,677,696,700,942,1983,2021,2025,2029,2033,2724,2728,3166,3170,3231,3235,3286,3335,3364,3411,3415,3423,3427,3431,3567,3572,3576,3580,3601,3681,3706,3765,3769,3804,3814,4014,4018,4022],"al.,":[342,346,350,406,467,475,479,487,536,555,580,584,623,627,631,674,678,697,701,943,1984,2022,2026,2030,2034,2725,2729,3167,3171,3232,3236,3287,3336,3365,3412,3416,3424,3428,3432,3568,3573,3577,3581,3602,3682,3707,3766,3770,3805,3815,4015,4019,4023],"2010;":[343],"Fallavollita":[344],"2014;":[347,2031,3578],"Nishisato":[348],"2010).":[351],"Following":[352],"early":[354,3641],"period":[355],"degeneration":[358],"caused":[361,769,929],"(I/R),":[364],"nerves":[366,974,2706,2733],"grow":[367],"back":[368,2767],"through":[369,1404,1702,1896,3483],"undamaged":[370],"myocardium":[371,798,1002,1467,1512,1541],"do":[373,3239],"not":[374,1010,1224,1590,1800,1980,2155,2562,2918,3061,3240],"enter":[375],"due":[378],"presence":[381,1482],"(Gardner":[387,725,1003,1317,2723,3230],"Habecker,":[389,471,727,1005,1319],"2013).":[390,1320],"heterogeneity":[392],"innervation":[395,413,2656,2665,2877,3268,3301],"increases":[396,760,1625,3450],"(Herring":[404],"2019).":[407],"A":[408,3940],"intervention":[410,3441],"restoring":[411],"improve":[422,3378],"health":[423],"outcomes":[424,3379],"patients":[426,3788,3799],"suffering":[427],"are":[431,490,494,615,635,646,860,883,975,998,1156,1199,1403,1561,1767,1885,1947,2134,2543,2895,2996,3047],"diverse":[433],"family":[434],"extracellular":[436],"matrix":[437,3384],"proteins":[438,1940,3385,3545],"modified":[439],"(CS)":[443],"chains":[445,508,1946,3462,3539],"inhibit":[447,739,3348,3699],"numerous":[451],"injury":[452,458,463],"paradigms":[453],"including":[454],"spinal":[456],"cord":[457],"(SCI),":[459],"traumatic":[461],"brain":[462],"(TBI)":[464],"(Brown":[465,621,695,3165,3410,3680],"2012;":[468,624,698,3168,3413],"Gardner":[469],"2013;":[472],"Lang":[473],"2015;":[476,484,2726,3233,3421],"McKeon":[477],"1999;":[480],"Miller":[481,557,3418],"Hsieh-Wilson,":[483,559,655,3151,3420],"Yi":[485,3430],"2012).":[488,3683],"heterogeneous":[491],"all":[493,705,750,1132,1333,1385,2465,2907],"composed":[495],"core":[498,520,1909,1939,1976,2099,2123,2416,2501,3321,3345],"protein":[499,521,845,1632,1731,1745,1860,1910,2100,2329,2386,2417,3206,3322,3346,3920],"covalently":[502],"linked":[503,3548],"repeating":[505],"disaccharide":[506],"known":[509],"as":[510,2658,3013,3144,3374,3844],"glycosaminoglycans":[511],"(GAGs).":[512],"While":[513,3443],"some":[514,3280],"evidence":[515,3341],"itself":[522],"plays":[523,3392],"role":[525,3099,3395,3403],"regulating":[527],"(Dou":[530,3359],"Levine,":[532,3361],"1994;":[533,3362],"Ughrin":[534,3363],"2003),":[537],"primary":[539],"effect":[540,1396,3953],"thought":[542],"occur":[544],"via":[545],"post-translational":[547],"addition":[548],"GAGs":[552,644],"(Mencio":[553],"2021;":[556],"2015).":[560,656,2035,3152,3582],"tissues":[564],"bind":[565],"receptors":[567],"like":[568],"PTP\u03c3":[569,3229,3265],"(protein":[570],"phosphatase":[572],"receptor":[573,3228],"sigma)":[574],"regenerating":[576],"axons":[577,1347,2257],"(Coles":[578],"2011;":[581],"Shen":[582],"2009).":[585],"attached":[589],"specific":[591,935],"locations":[592,1164],"CS-GAG":[595,1138,1440,1623,1870,1944,2471,3101,3461,3924],"sulfotransferase":[597],"enzymes,":[598,1639],"yielding":[599],"unique":[600],"structures":[601],"differentially":[603],"affect":[604],"outgrowth.":[606,1451],"Specifically,":[607,2362],"4-sulfation":[608,1139,1175,2114,2496],"6-sulfation":[611,787,2118,2492],"N-acetyl-galactosamine":[614],"regulators":[617],"Gilbert":[625,699,3169,3414],"2005;":[628,3417,4016],"Wang":[629,676,2727,3426],"2008).":[632,679],"produced":[636,647],"chondroitin-4-sulfotransferase,":[639],"CHST11,":[640,1650],"while":[641,1062,1101,1335,1375,1677,3849],"4,6-tandem":[642,857,2250,2279,2472,2754,2785,3484,3731],"(4S,6S)":[645],"4S-dependent":[650,1651,3500],"chondroitin-6-sulfotransferase,":[651],"(Miller":[653,3149],"removed":[662,1041],"endogenously":[665],"expressed":[666,1962],"4-sulfatase,":[667,1048],"arylsulfatase-B":[668,1153,1492],"(Figure":[670,992,1014,1066,1111,1281,1356,1373,1387,1660,1673,1688,1705,1899,1934,2059,2307,2335,2378,2405,2424,2449,2624,2635,2651,2662,2681,2697,2747],"1A;":[671],"Pearson":[672,3422],"2018;":[675,3425],"Evidence":[680],"SCI":[682],"TBI":[684,3553],"indicate":[685,1117,2751,3176,3446,3913],"tandem":[687],"potently":[691],"suppress":[692],"2005).":[702],"Removal":[703,1173],"tissue":[710,968,1245,1272,1341,1355,1365,1381,1445,1486,1516,1520,1545,1549,1603,1971,2439],"treatment":[712,813,1103,1360,1390,2521,2737],"chondroitinase":[716],"ABC":[717],"(chABC)":[718],"vitro":[724,1027],"2013)":[728],"it":[730,1959,3178,3947],"remains":[731,3310],"unknown":[732,3311],"whether":[733,923,1030,1264,2703],"nerves.":[743],"Figure":[744,1126,1433,1709,2084,2459,2778],"1":[745,747,1129,2462,3782],"supplement":[748,1016,1068,1130,2309,2337,2407,2463],"see":[749,1131,2464],"Download":[751,1133,1435,1711,2086,2466,2780],"asset":[752,754,1134,1136,1436,1438,1712,1714,2087,2089,2467,2469,2781,2783],"Open":[753,1135,1437,1713,2088,2468,2782],"Chondroitin":[755,1715],"proteoglycan":[757,2095],"(CSPG)":[758,1718,2096],"4,6-sulfation":[759,985,2076,2402,3491,4046],"(I/R).":[772,1726,2486],"(A)":[773,1146,1452,1734,2113,2491,2820],"patterning":[776],"schematic":[777],"key":[779,2004],"enzymes.":[780,1856,3632],"(B)":[781,1172,1470,1737,2117,2495,2828],"4-Sulfation":[782],"CS-GAGs)":[784,789],"or":[785,800,1084,1490,1518,1529,1547,1556,1752,1764,2520,2962,3189,3457,4077,4079],"(C)":[786,1505,1741,2121,2499,2860],"(6S":[788,2119,2493],"quantification":[790,1583,1587,1729,2111,2489],"assessed":[791,3012,3856],"western":[793,1850,2240],"blot":[794,836,1728,1851,2110,2241,2488,2577],"healthy":[797,1515,1544],"(unoperated)":[799],"14":[803,956,961,1686,1704,1898],"days":[804,1343,1683,1755,1931,2130,2348,2371,2382,2533,2880,3836,3871,3879],"(MI).":[807],"Quantification":[808,1184,1506,1534,2874,3033],"n=6":[810],"animals":[811,1845,2235,2442,2448,2539,2611,2675,2680,2746,2884,2985,2991,3028,3036,3827],"per":[812,1165,1170,1846,2236,2540,4171],"group,":[814],"mean":[815,1157,1200,1562,1768,2135,2544,2896,3048],"optical":[816,1769,2136,2545],"density":[817,1770,2137,2546,2657,2666,2830,2864,2878],"(OD)":[818,1771,2138,2547],"\u00b1":[819,1160,1203,1565,1772,2139,2548,2899,3052],"SD,":[820],"Student\u2019s":[821,2551,3003,3055],"t-test":[822,2552,3004,3056],"(Welch\u2019s":[823,2553,3057],"test),":[824,3006,3058],"****p-value":[826,2166,2170,2927,2935],"<":[827,2167,2171,2928,2936],"0":[828,1581],".0001,":[829],"6S":[830,841,939,1064,1883,2368,3190,3901],"**p-value":[831,1790,1794,1818,1822,2210,2568],"=":[832,1227,1236,1593,1787,1791,1795,1803,1810,1815,1819,1823,1830,1834,1838,1842,2158,2163,2178,2183,2187,2191,2198,2203,2207,2211,2217,2222,2227,2232,2557,2565,2569,2573,2921,3064],"0.003.":[833],"(D)":[834,1533,1848,2126,2504],"Example":[835,1147,1471,1849,2239,2817,3067],"images":[837,1472,1852,2242,2578],"CS-GAGs,":[840,842,3138],"total":[844,3018],"two":[847,850,2690,4059],"unoperated":[848,951,1325,1644,1781,2148],"animals.":[852,2893,3045,3910],"Here,":[853],"show":[855,1495,3292],"enriched":[861,3128],"important":[873,3259,3326,3394],"preventing":[875,3106,3458,4050],"heart.":[880,4037],"Sulfation-related":[881],"altered":[884,1011,1614,1723,1917,2049,3611],"promotes":[901,1022,1140,2476,2763,2791],"reinnervation":[902,2454,2584,3247,3252,3903,4051,4063],"decreases":[908,3248,3302],"isoproterenol-induced":[909,3218],"4,6-Sulfation":[912],"increased":[915,984,1680,1887,1925,2038,2067,2075,2414,2434,3496,3564,3624,3636],"I/R":[920,981,1013,1258,1616,1627,2263,2274,4091],"To":[921,1028,1617,2264,2581,2701,3617,3684],"establish":[922],"occurs":[926],"I/R,":[931,1867,1919,2044],"used":[933,2801,2811,4089],"antibodies":[934],"(Yi":[941],"2012)":[944],"compare":[946,2906],"left":[952,1294,1326,1597,1645,1749,3019,3215],"ventricle":[953,1295,1327,1750,3020,3216],"day":[955,1671,1697,1703,1892,1897,2081,3651,3866],"post-I/R":[957],"Day":[960],"represents":[962],"time":[964,1879,2057],"point":[965],"when":[966,2740],"relatively":[970,1301],"stable":[971],"excluded":[976],"entering":[978],"led":[982,2412,3666],"1B\u2013D).":[993],"In":[994,1857,1986,3261],"contrast,":[995],"levels":[997,1633,1663,1693,2387,3886],"low":[999,1701],"remote":[1001],"2013),":[1006],"1\u2014figure":[1015],"1).":[1017,1069],"neurite":[1024,1035,1087,1105,1124,1142,1149,1158,1179,1188,1201,1213,3350],"test":[1029,1263,3747],"across":[1037,1089,3678],"CSPGs,":[1038],"enzymatically":[1040],"purified":[1044],"using":[1046,2292,3077],"ARSB.":[1049,1085],"An":[1050],"effective":[1051],"dose":[1053],"identified":[1055],"pilot":[1057,4113],"studies":[1058,1316,3223],"remove":[1060],"leaving":[1063],"intact":[1065],"2\u2014figure":[1067],"Dissociated":[1070],"neonatal":[1074,1289],"rats":[1075],"were":[1076,1291,2340,3127,3627,3744,3887,3981],"then":[1077,2341],"grown":[1078],"treated":[1081,1255,1488,1524,1551,2342,2612,2638,3833],"vehicle":[1083,1526,1553],"extension":[1088,1458,1500,3351],"untreated":[1090],"suppressed":[1093],"40":[1094,1191],"hr":[1095,1192,1502,1785,1807,1827,2042,2152,2175,2195,2215],"post-plating":[1096,1193],"compared":[1097,2330,2373,2419,2443,2626,2676,2741,2980,3029],"laminin":[1099,1216,1229],"alone,":[1100],"dose-dependent":[1109],"manner":[1110],"2A":[1112],"B).":[1114],"These":[1115,2063,2749,3289,3522,3911],"extension.":[1125],"2":[1127],"vitro.":[1145],"experiment":[1151],"(ARSB).":[1154,1493],"length":[1159,1189,1202,1564],"SD":[1161],"9":[1163,3966],"3":[1168,1434,1698,3870],"wells":[1169],"condition.":[1171],"control":[1182,1392,1602,1748,2333,2377,2423,2447,2617,3996],"levels.":[1183],"indicated":[1195],"plate":[1196,4174],"coatings.":[1197],"SD;":[1204],"one-way":[1205,1571,1775,2142],"ANOVA":[1206,1572,1776,2143],"(Dunnett\u2019s":[1207,1573,1777,2144],"post-test).":[1208],"All":[1209],"comparisons":[1210,1575,1779,2146,2910],"made":[1211,1576],"+":[1217,2833,2854],"CSPG;":[1218],"0.3":[1219],"\u03bcg/mL":[1220,1233],"ns":[1222,1588,1798,1808,1813,1828,2153,2161,2176,2181,2196,2201,2220,2225,2230,2560,2916,3059],"\u2013":[1223,1589,1799,2154,2561,2917,3060,4200,4204,4212,4216],"significant":[1225,1591,1801,2156,2357,2563,2694,2919,3062,3898],"p-value":[1226,1592,1802,1809,1814,1829,2157,2162,2177,2182,2197,2202,2221,2226,2231,2564,2920,3063],"0.193,":[1228],"only":[1230],"*p=0.039,":[1231],"0.6":[1232],"*p-value":[1235,1786,1833,1837,1841,2206,2216,2556,2572],"0.042,":[1237],"n=4":[1238,2883,2984,3035],"experiments.":[1239],"ex":[1252,1446],"explants":[1259,1287,1322,1336,1393],"could":[1273],"restore":[1274,3267,3300,3675],"explant":[1279],"co-cultures":[1280],"3A).":[1282],"Superior":[1283],"cervical":[1284,1475],"ganglion":[1285,1476,1508,1536],"(SCG)":[1286,1477],"mice":[1290,3834,4088],"Although":[1297],"SCG":[1298],"contain":[1299],"small":[1302,3696],"number":[1303],"they":[1308],"provide":[1309,3527],"well-characterized":[1311],"model":[1312],"Ganglion":[1321,1456],"displayed":[1328],"uniform":[1329],"directions":[1334],"cultured":[1337],"alongside":[1338],"(10\u201314":[1342],"post-I/R)":[1344],"exhibited":[1345],"shorter":[1346],"growing":[1348],"direction":[1351],"3B\u2013D).":[1357],"Interestingly,":[1358,2409],"(0.6":[1361,1531,1558],"\u00b5g/mL)":[1362],"fully":[1366,3241],"towards":[1370],"3D),":[1374],"away":[1377,1463,1539],"normal":[1383,2391,2829],"conditions":[1386],"3E).":[1388],"had":[1394,2388,2644],"no":[1395,2693,3711],"outgrowth,":[1399],"suggesting":[1400,2392,2451],"its":[1401],"effects":[1402,3656],"altering":[1405,2862,3306],"rather":[1409],"than":[1410],"ganglion.":[1412],"Together,":[1413],"these":[1414,1877,3544],"sufficient":[1427,2399,3464,3927],"enable":[1429],"Explant":[1453],"co-culture":[1454],"schematic.":[1455],"toward":[1459,1511,3273],"(0":[1460],"degree)":[1461,1466],"(180":[1465],"measured.":[1469],"superior":[1474],"(Myo)":[1487],"without":[1491,2861,3305],"Lines":[1494],"example":[1496],"measurement":[1497],"48":[1501],"plating.":[1504],"either":[1514,1543,3187],"(Unop)":[1517,1546],"(myocardial":[1521],"[MI])":[1523],"(5%":[1527,1554],"DMSO)":[1528,1555],"\u03bcg/mL).":[1532,1559],"SD.":[1566,1773,2140,2549,2900,3053],"Statistics":[1567],"C,":[1569],"D:":[1570],"post-test),":[1574,2145],"vehicle-treated":[1578],"tissue;":[1580,1782,2149],"degree":[1582],"****p<0.0001,":[1584],"180":[1585],"degrees":[1586],"0.204,":[1594],"0.467,":[1595],"0.355":[1596],"right":[1599],"respectively,":[1600],"n=13":[1601],"n=9":[1605],"Expression":[1608],"understand":[1618,1991,3242],"mechanisms":[1620,3244],"which":[1622,2009,2045,3139,3246,3503,3519,3593,3868,4025],"mice,":[1629,2276],"examined":[1631,1648,1869,1999,2594,2687,2711],"three":[1635],"comparing":[1640],"expression":[1642,1721,1732,1746,2001,2019,2050,2072,2101,2287,2418,3202,3449,3497,3526,3609,3629,3727,3972,3986,3999],"ventricle.":[1646],"chondroitin-4-sulfotransferase":[1649,1735],"chondroitin-6-sulfotransferase":[1652,1738],"(4,6-tandem":[1654],"enzyme),":[1656],"1A).":[1661],"CHST11":[1662,1783],"significantly":[1665,1681,1695,1886,2039,2435,2668],"within":[1666],"24":[1667,1784,1806,1826,2041,2151,2174,2194,2214],"hr,":[1668,1761],"persisting":[1669],"until":[1670],"7":[1672,1684,1893,1930,2082,2352,2779,3652,3840],"4A":[1674],"D),":[1676],"4B":[1689],"D).":[1691,1708],"remained":[1700],"4C":[1706],"4":[1710,3133],"Western":[1727,2109,2487,2576],"(CHST11),":[1736],"(CHST15),":[1739],"(arylsulfatase-B":[1743],"[ARSB])":[1744],"(Unop),":[1751],"(24":[1760],"D3,":[1762],"D7,":[1763],"D14).":[1765],"Statistics:":[1774,2141,2550,3002,3054],"post-test)":[1778],"0.015,":[1788],"D3":[1789,1812,1832,2160,2180,2200,2219],"0.002,":[1792,1820],"D7":[1793,1817,1836,2165,2185,2205,2224],"0.001,":[1796],"D14":[1797,1821,1840,2169,2189,2209,2229],"0.068;":[1804],"0.073,":[1811],"0.164,":[1816],"0.004;":[1824,2570],"0.554,":[1831],"0.018,":[1835],"0.012,":[1839],"0.035;":[1843],"n=5":[1844,2234,2889,2990,3041],"group.":[1847,2237,2541],"light":[1858],"changes":[1861,3523,3599,3626],"infarct":[1875,1890,1928,2596,2623,2650,2672,2822,2859,2867,2913,2924,2931,2934,3283,3307,3906],"same":[1878,2655],"points.":[1880],"extending":[1895],"5A,":[1900],"B":[1901],"E).":[1903,1937,2062],"NG2":[1911,1923,1957,2122,2415,2500,3323,3344,3448,3474],"(also":[1912],"called":[1913],"CSPG4)":[1914],"5C":[1935],"Thus,":[1938,3473,3817],"greater":[1950],"abundance.":[1951],"chose":[1953],"look":[1955],"because":[1958],"prominently":[1961],"recent":[1965],"glycoproteomics":[1966],"analysis":[1967,2609],"whereas":[1972],"another":[1973],"commonly":[1974],"studied":[1975],"proteoglycan,":[1977],"Aggrecan,":[1978],"detected":[1981],"(Tian":[1982,3334],"2014).":[1985,2730,3603],"effort":[1988],"better":[1990],"coordinated,":[1997],"wound":[2005],"healing":[2006],"regulator,":[2007],"Galectin-3,":[2008,2213],"has":[2010,3691,3776,3808],"been":[2012,3777],"connected":[2013],"(Bhattacharyya":[2020,3566,3600],"2020;":[2023],"Bhattacharyya":[2024,2028,2032,3571,3575,3579],"2017;":[2027,3574],"Galectin-3":[2036,2127,3595,3608,3623,3637],"contribute":[2047,2073],"later":[2056],"points":[2058],"5D":[2060],"observed":[2079,2947,3628,3649],"post-MI.":[2083,3653],"5":[2085],"Time":[2090],"course":[2091],"(I/R)":[2104],"CS-GAGs),":[2116,2120,2494,2498],"protein,":[2124,2502],"4S,":[2150,2559],"0.804,":[2159],"0.124,":[2164],"0.0001,":[2168,2188,2929],"0.0001;":[2172],"6S,":[2173,2555],"0.999,":[2179,2199],"0.905,":[2184],"***p-value":[2186,2190],"0.0003;":[2192],"NG2,":[2193,2567],"0.977,":[2204],"0.031,":[2208],"0.007;":[2212],"0.013,":[2218],"0.172,":[2223],"0.974,":[2228],"0.998;":[2233],"(E)":[2238,2575,2873],"A\u2013D.":[2244,2580],"reduces":[2249,2773,3584],"determine":[2265],"suppresses":[2269],"gene":[2291,3726],"silencing":[2293,2525,2846],"RNA":[2294,2526,2847],"(siRNA).":[2295],"After":[2296],"identifying":[2297],"mRNA":[2302],"myoblast-like":[2304],"C2C12":[2305],"cells":[2306],"6\u2014figure":[2308,2336,2406],"1A,B),":[2310],"tested":[2312,3778],"efficacy":[2314],"our":[2316,3174,3444,3618,3717],"vivo.":[2320],"Intravenous":[2321],"delivery":[2322,2844],"100":[2324,2344,2871],"\u00b5g":[2325,2345],"siChst15":[2326,2346,2363,2410,2912,2933],"non-targeting":[2332,2375,2421,2445,2524,2615,2678,2743,2824,2886,2923,2930,2982,2987,3031,3038,3890],"1C).":[2338],"Mice":[2339],"3,":[2349,3837],"5,":[2350,3838],"post-MI,":[2353],"leading":[2354,3562],"reduction":[2358,3899],"CS-GAGs.":[2361],"amount":[2366],"present":[2369,3120,3439],"10":[2370,2381,2532,2879],"6A).":[2379],"By":[2380],"returned":[2389],"alter":[2401],"1D,E).":[2408],"6C).":[2425],"The":[2426,3320,3654],"neuron":[2428,2507,4106],"marker":[2429,2508],"Tyrosine":[2430,2509,2807],"Hydroxylase":[2431,2510,2808],"siChst15-treated":[2441],"6D),":[2450],"successful":[2452],"6":[2460,3135],"(siRNA)":[2527,2848],"control.":[2528],"Tissue":[2529],"collected":[2531],"(MI),":[2537],"n=7":[2538],"test);":[2554],"0.028;":[2558],"0.826;":[2566],"TH,":[2571],"0.043.":[2574],"ensure":[2582],"occurred":[2589],"knockdown,":[2592],"(labeled":[2597],"fibrinogen)":[2599],"TH-positive":[2601,2646],"immunohistochemistry":[2606],"(IHC).":[2607],"IHC":[2608],"showed":[2618],"clear":[2619],"7A)":[2625],"peri-infarct":[2629,2660,2837],"region":[2630,2661,2838,3083],"adjacent":[2631,2839],"7B).":[2636],"Animals":[2637],"targeting":[2642,3224,3264,3294],"7C)":[2652],"7D).":[2663],"TH":[2664,2832,2853,2876,2898,3207],"higher":[2669],"Chst15-targeted":[2674],"siRNA-treated":[2679,2892,3027,3044,3075,3909],"7E).":[2682],"Cardiac":[2683,3009],"size":[2685,3011,3284],"between":[2688],"groups":[2691],"difference":[2695],"existed":[2696],"7G":[2698],"H).":[2700],"examine":[2702],"restoration":[2704,3931],"susceptibility,":[2709,3250],"ECG":[2714],"administration":[2716],"\u03b2-agonist":[2719],"caffeine":[2722,2956],"Restoration":[2731],"control-treated":[2745,2825],"7F).":[2748],"susceptibility":[2775,3304],"Fibrinogen":[2799],"label":[2803,2813],"(magenta)":[2805],"(cyan).":[2816],"image":[2818,3069],"denervated":[2821],"versus":[2827],"Systemic":[2843],"against":[2849,2976],"outside":[2865],"(D).":[2868],"Scale":[2869,3090],"bar,":[2870,3091],"\u03bcm.":[2872,3093],"controls":[2887,2988,3039],"percent":[2897,3015,3049],"Two-way":[2901],"ANOVA,":[2902],"Tukey\u2019s":[2903],"post-test":[2904],"groups,":[2908],"select":[2909],"shown;":[2911],"vs.":[2914,2925,2932],"peri-nfarct":[2915,2926],"0.668,":[2922],"0.0001.":[2937],"(F)":[2938],"Arrhythmia":[2939],"scores":[2940],"based":[2941],"most":[2944],"severe":[2945],"each":[2949,3000],"injection":[2952,3875],"(0=no":[2957],"PVCs,":[2958,2960],"1=single":[2959],"2=bigeminy":[2961],"salvos,":[2963],"3=non-sustained":[2964],"tachycardia).":[2966],"See":[2967],"details.":[2972],"Treatment":[2973],"controls.":[2983,3032],"siRNA.":[2994,3877],"score":[2998],"animal.":[3001],"(Mann-Whitney":[3005],"*p<0.047.":[3007],"(G)":[3008],"(LV)":[3021],"unaltered":[3024],"0.283.":[3065],"(H)":[3066],"2\u00d7":[3068],"autofluorescence,":[3078],"absence":[3079],"autofluorescence":[3081],"indicates":[3082],"infarct,":[3086],"outlined":[3087],"white.":[3089],"500":[3092],"investigated":[3097],"chain":[3103],"ischemia-reperfusion":[3126],"often":[3141],"referred":[3142],"E":[3147],"(CS-E)":[3148],"CS-E":[3153,3658,3763],"CNS":[3164],"2005),":[3172],"prevents":[3180,3475],"axons,":[3184],"since":[3185,3389,3710],"allowed":[3191,3736],"Nerve":[3194],"confirmed":[3197],"histology":[3199],"neuronal":[3205,3226,3664],"throughout":[3213],"arrhythmias,":[3219],"consistent":[3220],"previous":[3222],"Sepe":[3234],"2022).":[3237,3288],"borderzone":[3254],"myocytes":[3255],"play":[3257],"role.":[3260],"addition,":[3262],"therapeutics":[3263],"shift":[3269,3533],"inflammatory":[3271,3318],"more":[3275],"reparative":[3276],"phenotype,":[3277],"cases":[3281],"decrease":[3282,3917],"(Sepe":[3285],"new":[3290],"size.":[3308],"alters":[3316],"response.":[3319],"source":[3327],"2014),":[3337],"there":[3339],"sensory":[3349],"independent":[3352],"CS":[3354,3487],"certain":[3357,3663],"contexts":[3358,3409],"2003).":[3366],"Modulating":[3367],"interest":[3373],"strategy":[3376],"presents":[3386],"challenge":[3388],"maintaining":[3397],"structural":[3398],"integrity.":[3399],"Given":[3400],"other":[3408,3555],"2008;":[3429],"2012),":[3433],"postulated":[3435],"might":[3438],"point.":[3442],"allow":[3466,3929],"exclusively":[3482],"Increased":[3490],"coincided":[3494],"6-sulfotransferase":[3501],"CHST15,":[3502],"final":[3506,3874],"CS-E,":[3512],"depletion":[3514,3922],"sulfatase":[3517],"removes":[3520],"4S.":[3521],"potential":[3529],"GAG":[3537],"Regulation":[3542],"context":[3551,4033],"diseases":[3556],"downregulation":[3559],"2020":[3569],";":[3570],"Hypoxia":[3583],"activity,":[3586],"increasing":[3587],"abundance":[3589],"4-sulfated":[3591],"enables":[3594],"mediation":[3596],"transcriptional":[3598],"Therefore,":[3604],"ischemia-reperfusion.":[3616],"surprise,":[3619],"before":[3625],"sulfation-related":[3631],"driver":[3642],"accumulating":[3645],"inhibitory":[3655],"subtypes":[3665],"many":[3667],"hypothesize":[3669],"activity":[3673],"would":[3674],"end":[3686],"least":[3688],"one":[3689],"group":[3690],"even":[3692],"generated":[3693,3997],"novel":[3695],"molecule":[3697],"(Cheung":[3705],"2017).":[3708,3771,3816],"However,":[3709,3979],"commercially":[3712],"available":[3713],"inhibitor":[3714],"exists":[3715],"knowledge,":[3718],"sought":[3720],"different":[3722],"method.":[3723],"Targeting":[3724],"inspired":[3745],"chst15":[3748,3761],"colitis":[3752],"showing":[3756],"(Suzuki":[3764,3813]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-06-15T00:00:00"}