{"id":"https://openalex.org/W4282590239","doi":"https://doi.org/10.3390/cancers14122896","title":"Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism","display_name":"Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism","publication_year":2022,"publication_date":"2022-06-12","ids":{"openalex":"https://openalex.org/W4282590239","doi":"https://doi.org/10.3390/cancers14122896","pmid":"https://pubmed.ncbi.nlm.nih.gov/35740562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9221533"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14122896","doi":"https://doi.org/10.3390/cancers14122896","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14122896","pdf_url":"https://www.mdpi.com/2072-6694/14/12/2896/pdf?version=1655025361","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/12/2896/pdf?version=1655025361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022000456","display_name":"Mengfang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengfang Liu","raw_affiliation_strings":["Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389746","display_name":"Na Liu","orcid":"https://orcid.org/0000-0001-8654-3636","observed_orcids":["https://orcid.org/0000-0001-8654-3636"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Liu","raw_affiliation_strings":["Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101604317","display_name":"Jinlei Wang","orcid":"https://orcid.org/0000-0003-0632-7293","observed_orcids":["https://orcid.org/0000-0003-0632-7293"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlei Wang","raw_affiliation_strings":["Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090301206","display_name":"Shengqiao Fu","orcid":"https://orcid.org/0000-0001-6955-2928","observed_orcids":["https://orcid.org/0000-0001-6955-2928"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengqiao Fu","raw_affiliation_strings":["Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017396752","display_name":"Xu Wang","orcid":"https://orcid.org/0000-0002-3768-777X","observed_orcids":["https://orcid.org/0000-0002-3768-777X","https://orcid.org/0009-0001-8342-1534"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu Wang","raw_affiliation_strings":["Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101898123","display_name":"Deyu Chen","orcid":"https://orcid.org/0000-0002-4862-1450","observed_orcids":["https://orcid.org/0000-0002-4862-1450"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Deyu Chen","raw_affiliation_strings":["Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, China","institution_ids":["https://openalex.org/I4210111628"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017396752","https://openalex.org/A5101898123"],"corresponding_institution_ids":["https://openalex.org/I4210111628"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":0.8551,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.709005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"14","issue":"12","first_page":"2896","last_page":"2896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-coa-synthetase-2","display_name":"acetyl-CoA synthetase 2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/acss2","display_name":"ACSS2","score":0.824999988079071},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.9850000143051147},{"id":"https://openalex.org/keywords/acetate-metabolism","display_name":"acetate metabolism","score":0.718999981880188},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7730000019073486},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.5849999785423279},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6570000052452087},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5980233550071716},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.556017279624939},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.523060142993927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.514495849609375},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5073437094688416},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47615811228752136},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4528913199901581},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4504011869430542},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44485020637512207},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4177654981613159},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38094764947891235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2538370192050934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2245381474494934},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.16506603360176086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09254711866378784}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers14122896","doi":"https://doi.org/10.3390/cancers14122896","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14122896","pdf_url":"https://www.mdpi.com/2072-6694/14/12/2896/pdf?version=1655025361","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:35740562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35740562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9221533","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9221533/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8038398270c041d3b77407aacda8da79","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8038398270c041d3b77407aacda8da79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 14, Iss 2896, p 2896 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers14122896","doi":"https://doi.org/10.3390/cancers14122896","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14122896","pdf_url":"https://www.mdpi.com/2072-6694/14/12/2896/pdf?version=1655025361","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1761089608","display_name":null,"funder_award_id":"81572956","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3070371016","display_name":null,"funder_award_id":"CXTDC2016009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4514880973","display_name":null,"funder_award_id":"SH2020067","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4822045060","display_name":null,"funder_award_id":"81701945","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6865879017","display_name":null,"funder_award_id":"BE2017696","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282590239.pdf","grobid_xml":"https://content.openalex.org/works/W4282590239.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W1917156503","https://openalex.org/W1923951368","https://openalex.org/W1972254548","https://openalex.org/W1975200363","https://openalex.org/W1981403111","https://openalex.org/W1984136850","https://openalex.org/W1991978562","https://openalex.org/W1992524428","https://openalex.org/W1993180174","https://openalex.org/W1995869628","https://openalex.org/W2004053427","https://openalex.org/W2006104470","https://openalex.org/W2010552629","https://openalex.org/W2016177837","https://openalex.org/W2025176940","https://openalex.org/W2035738326","https://openalex.org/W2038049117","https://openalex.org/W2039999119","https://openalex.org/W2041237929","https://openalex.org/W2044515618","https://openalex.org/W2058424966","https://openalex.org/W2063920469","https://openalex.org/W2069193571","https://openalex.org/W2076428518","https://openalex.org/W2077499130","https://openalex.org/W2083650135","https://openalex.org/W2089728480","https://openalex.org/W2091457094","https://openalex.org/W2099787654","https://openalex.org/W2107766941","https://openalex.org/W2122772601","https://openalex.org/W2125872855","https://openalex.org/W2126483755","https://openalex.org/W2127222960","https://openalex.org/W2133540162","https://openalex.org/W2144625075","https://openalex.org/W2147044753","https://openalex.org/W2148378558","https://openalex.org/W2154955668","https://openalex.org/W2155175976","https://openalex.org/W2162140736","https://openalex.org/W2163252030","https://openalex.org/W2170602872","https://openalex.org/W2323751645","https://openalex.org/W2461760410","https://openalex.org/W2483925606","https://openalex.org/W2513249090","https://openalex.org/W2516363685","https://openalex.org/W2523687917","https://openalex.org/W2527298422","https://openalex.org/W2527719044","https://openalex.org/W2554433662","https://openalex.org/W2563551015","https://openalex.org/W2574444241","https://openalex.org/W2579290699","https://openalex.org/W2604724184","https://openalex.org/W2605832243","https://openalex.org/W2619419337","https://openalex.org/W2619622432","https://openalex.org/W2747316634","https://openalex.org/W2766449951","https://openalex.org/W2779031106","https://openalex.org/W2781967127","https://openalex.org/W2782668330","https://openalex.org/W2783366082","https://openalex.org/W2789557649","https://openalex.org/W2791097988","https://openalex.org/W2794406366","https://openalex.org/W2806111894","https://openalex.org/W2884379945","https://openalex.org/W2886694173","https://openalex.org/W2889924499","https://openalex.org/W2890113582","https://openalex.org/W2898415660","https://openalex.org/W2902335495","https://openalex.org/W2912991678","https://openalex.org/W2914525558","https://openalex.org/W2917837889","https://openalex.org/W2944167324","https://openalex.org/W2969538494","https://openalex.org/W2979291688","https://openalex.org/W2979675231","https://openalex.org/W2981384026","https://openalex.org/W2987284967","https://openalex.org/W2987980037","https://openalex.org/W2990323558","https://openalex.org/W2998022192","https://openalex.org/W3004268891","https://openalex.org/W3005857648","https://openalex.org/W3010473572","https://openalex.org/W3020099303","https://openalex.org/W3025778829","https://openalex.org/W3034809608","https://openalex.org/W3097087197","https://openalex.org/W3103696396","https://openalex.org/W3106806530","https://openalex.org/W3114796419","https://openalex.org/W3118527580","https://openalex.org/W3118723303","https://openalex.org/W3120041426","https://openalex.org/W3131861897","https://openalex.org/W3133977518","https://openalex.org/W3135796166","https://openalex.org/W3174454453","https://openalex.org/W3184325305","https://openalex.org/W3193883069","https://openalex.org/W3212962988","https://openalex.org/W3216951188","https://openalex.org/W4206841660","https://openalex.org/W4210636939","https://openalex.org/W4210774372","https://openalex.org/W4210934897","https://openalex.org/W4245635761","https://openalex.org/W6640044210","https://openalex.org/W6749380716","https://openalex.org/W6751910964","https://openalex.org/W6768819664","https://openalex.org/W6773144368"],"related_works":["https://openalex.org/W4284670621","https://openalex.org/W3120041426","https://openalex.org/W2163252030","https://openalex.org/W1972254548","https://openalex.org/W2886933155","https://openalex.org/W4254119211","https://openalex.org/W2044515618","https://openalex.org/W3131669688","https://openalex.org/W2604724184","https://openalex.org/W2146649054"],"abstract_inverted_index":{"Acetyl-CoA":[0],"Synthetase":[1],"2":[2],"(ACSS2)":[3],"belongs":[4],"to":[5,53,76,95,127,153,166],"a":[6,69],"member":[7],"of":[8,61,93,99,107,116,121,149],"the":[9,19,57,91,97,102,105,110,114,128,146],"acyl-CoA":[10],"short-chain":[11],"synthase":[12],"family,":[13],"which":[14],"can":[15],"convert":[16],"acetate":[17],"in":[18,34,101,109,130,157],"cytoplasm":[20],"and":[21,46,49,56,68,112,125,155,160,171],"nucleus":[22],"into":[23],"acetyl-CoA.":[24],"It":[25],"has":[26],"been":[27],"proven":[28],"that":[29,66],"ACSS2":[30,74,94,122,135,162],"is":[31,50],"highly":[32],"expressed":[33],"glioblastoma,":[35],"breast":[36],"cancer,":[37,39,41,43,45],"liver":[38],"prostate":[40],"bladder":[42],"renal":[44],"other":[47],"tumors,":[48,159],"closely":[51],"related":[52],"tumor":[54,78,132,141,168],"stage":[55],"overall":[58],"survival":[59,154],"rate":[60],"patients.":[62],"Accumulating":[63],"studies":[64],"show":[65],"hypoxia":[67],"low":[70],"serum":[71],"level":[72],"induce":[73,104],"expression":[75,115],"help":[77],"cells":[79],"cope":[80],"with":[81,90],"this":[82],"nutrient-poor":[83],"environment.":[84],"The":[85],"potential":[86],"mechanisms":[87],"are":[88,123],"associated":[89],"ability":[92],"promote":[96,167],"synthesis":[98],"lipids":[100],"cytoplasm,":[103],"acetylation":[106],"histones":[108],"nucleus,":[111],"facilitate":[113],"autophagy":[117],"genes.":[118],"Novel-specific":[119],"inhibitors":[120],"developed":[124],"confirmed":[126],"effectiveness":[129],"pre-clinical":[131],"models.":[133],"Targeting":[134],"may":[136],"provide":[137],"novel":[138],"approaches":[139],"for":[140],"treatment.":[142],"This":[143],"review":[144],"summarizes":[145],"biological":[147],"function":[148],"ACSS2,":[150],"its":[151],"relation":[152],"prognosis":[156],"different":[158,164],"how":[161],"mediates":[163],"pathways":[165],"metastasis,":[169],"invasion,":[170],"drug":[172],"resistance.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-06-14T00:00:00"}
