{"id":"https://openalex.org/W4282034792","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9072","title":"Association of depth of target lesion response to brigatinib with outcomes in patients with ALK inhibitor-naive ALK+ NSCLC in ALTA-1L.","display_name":"Association of depth of target lesion response to brigatinib with outcomes in patients with ALK inhibitor-naive ALK+ NSCLC in ALTA-1L.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4282034792","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9072"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.9072","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9072","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.9072","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082517668","display_name":"D. Ross Camidge","orcid":"https://orcid.org/0000-0003-3430-3213","observed_orcids":["https://orcid.org/0000-0003-3430-3213"]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Ross Camidge","raw_affiliation_strings":["University of Colorado Cancer Center, Aurora, CO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Cancer Center, Aurora, CO;","institution_ids":["https://openalex.org/I4210134151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047490140","display_name":"Hye Ryun Kim","orcid":"https://orcid.org/0000-0002-1842-9070","observed_orcids":["https://orcid.org/0000-0002-1842-9070"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Ryun Kim","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea;","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034739279","display_name":"Myung\u2010Ju Ahn","orcid":"https://orcid.org/0000-0002-5740-9654","observed_orcids":["https://orcid.org/0000-0002-5740-9654","https://orcid.org/0000-0002-5376-5109"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung-Ju Ahn","raw_affiliation_strings":["Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, South Korea;","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":["National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan;","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023055777","display_name":"Ji\u2010Youn Han","orcid":"https://orcid.org/0000-0001-5033-0006","observed_orcids":["https://orcid.org/0000-0001-5033-0006","https://orcid.org/0000-0001-6290-5751"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Youn Han","raw_affiliation_strings":["National Cancer Center, Goyang-Si, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center, Goyang-Si, South Korea;","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012226414","display_name":"Maximilian Johannes Hochmair","orcid":"https://orcid.org/0000-0002-8673-2450","observed_orcids":["https://orcid.org/0000-0002-8673-2450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maximilian Hochmair","raw_affiliation_strings":["Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Department of Respiratory and Critical Care Medicine, Krankenhaus Nord, Klinik Floridsdorf, Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Department of Respiratory and Critical Care Medicine, Krankenhaus Nord, Klinik Floridsdorf, Vienna, Austria;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005962138","display_name":"Ki Hyeong Lee","orcid":"https://orcid.org/0000-0002-7830-5950","observed_orcids":["https://orcid.org/0000-0002-7830-5950"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]},{"id":"https://openalex.org/I4210161026","display_name":"Chungbuk National University Hospital","ror":"https://ror.org/05529q263","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki Hyeong Lee","raw_affiliation_strings":["Chungbuk National University Hospital, Cheongju, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chungbuk National University Hospital, Cheongju, South Korea;","institution_ids":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064222874","display_name":"Angelo Delmonte","orcid":"https://orcid.org/0000-0001-9065-6123","observed_orcids":["https://orcid.org/0000-0001-9065-6123"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Delmonte","raw_affiliation_strings":["Istituto Romagnolo per lo Studio dei Tumori Dino Amadori-RCCS, Meldola, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori-RCCS, Meldola, Italy;","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110838557","display_name":"Rosario Garc\u00eda Campelo","orcid":"https://orcid.org/0000-0002-5067-7533","observed_orcids":["https://orcid.org/0000-0002-5067-7533"]},"institutions":[{"id":"https://openalex.org/I4210140856","display_name":"Complexo Hospitalario Universitario A Coru\u00f1a","ror":"https://ror.org/044knj408","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210140856"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosario Garcia Campelo","raw_affiliation_strings":["University Hospital A Coru\u00f1a, CHUAC, A Coru\u00f1a, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital A Coru\u00f1a, CHUAC, A Coru\u00f1a, Spain;","institution_ids":["https://openalex.org/I4210140856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638261","display_name":"Dong\u2010Wan Kim","orcid":"https://orcid.org/0000-0001-5124-7132","observed_orcids":["https://orcid.org/0000-0001-5124-7132"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Wan Kim","raw_affiliation_strings":["Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea;","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052962511","display_name":"Frank Griesinger","orcid":"https://orcid.org/0000-0002-6822-5498","observed_orcids":["https://orcid.org/0000-0002-6822-5498"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]},{"id":"https://openalex.org/I4210125974","display_name":"Pius Hospital Oldenburg","ror":"https://ror.org/03avbdx23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125974"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Griesinger","raw_affiliation_strings":["Pius-Hospital Oldenburg, University of Oldenburg, Oldenburg, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pius-Hospital Oldenburg, University of Oldenburg, Oldenburg, Germany;","institution_ids":["https://openalex.org/I129877168","https://openalex.org/I4210125974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090324173","display_name":"Enriqueta Felip","orcid":"https://orcid.org/0000-0002-7620-0098","observed_orcids":["https://orcid.org/0000-0002-7620-0098"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enriqueta Felip","raw_affiliation_strings":["Vall d\u2019Hebron University Hospital, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vall d\u2019Hebron University Hospital, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025910383","display_name":"Raffaele Califano","orcid":"https://orcid.org/0000-0003-2611-5319","observed_orcids":["https://orcid.org/0000-0003-2611-5319"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raffaele Califano","raw_affiliation_strings":["The Christie NHS Foundation Trust, Manchester, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Christie NHS Foundation Trust, Manchester, United Kingdom;","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044613951","display_name":"Alexander I. Spira","orcid":"https://orcid.org/0000-0003-1303-0447","observed_orcids":["https://orcid.org/0000-0003-1303-0447"]},"institutions":[{"id":"https://openalex.org/I4210122908","display_name":"Virginia Cancer Specialists","ror":"https://ror.org/03tbabt10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122908"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander I. Spira","raw_affiliation_strings":["Virginia Cancer Specialists and US Oncology Research, Fairfax, VA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Cancer Specialists and US Oncology Research, Fairfax, VA;","institution_ids":["https://openalex.org/I4210122908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492076","display_name":"Michael Thomas","orcid":"https://orcid.org/0000-0001-9511-055X","observed_orcids":["https://orcid.org/0000-0001-9511-055X","https://orcid.org/0009-0008-0971-388X"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Thomas","raw_affiliation_strings":["Internistische Onkologie der Thoraxtumoren, Thoraxklinik im Universit\u00e4tsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internistische Onkologie der Thoraxtumoren, Thoraxklinik im Universit\u00e4tsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany;","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070967174","display_name":"Scott N. Gettinger","orcid":"https://orcid.org/0000-0003-0886-6880","observed_orcids":["https://orcid.org/0000-0003-0886-6880"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott N. Gettinger","raw_affiliation_strings":["Yale Cancer Center, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, New Haven, CT;","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071783009","display_name":"Marcello Tiseo","orcid":"https://orcid.org/0000-0002-9553-8465","observed_orcids":["https://orcid.org/0000-0002-9553-8465"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcello Tiseo","raw_affiliation_strings":["Medical Oncology Unit, University Hospital of Parma, Parma, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, University Hospital of Parma, Parma, Italy;","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009512812","display_name":"Yuyin Liu","orcid":"https://orcid.org/0000-0002-4995-832X","observed_orcids":["https://orcid.org/0000-0002-4995-832X","https://orcid.org/0000-0002-6450-6364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuyin Liu","raw_affiliation_strings":["Takeda Development Center Americas, Inc., Lexington, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Lexington, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047349474","display_name":"Pingkuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pingkuan Zhang","raw_affiliation_strings":["Takeda Development Center Americas, Inc., Lexington, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Lexington, MA;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048231332","display_name":"Sanjay Popat","orcid":"https://orcid.org/0000-0003-2087-4963","observed_orcids":["https://orcid.org/0000-0003-2087-4963"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sanjay Popat","raw_affiliation_strings":["Royal Marsden Hospital, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden Hospital, London, United Kingdom;","institution_ids":["https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":25,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"9072","last_page":"9072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brigatinib","display_name":"brigatinib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.9890000224113464},{"id":"https://openalex.org/keywords/alk-positive-non-small-cell-lung-cancer","display_name":"ALK-positive non-small cell lung cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/alta-1l-trial","display_name":"ALTA-1L trial","score":0.8539999723434448},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9300000071525574},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/recist-1-1","display_name":"RECIST 1.1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8224971890449524},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.6948215961456299},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6656553149223328},{"id":"https://openalex.org/C2781464078","wikidata":"https://www.wikidata.org/wiki/Q7685898","display_name":"Target lesion","level":4,"score":0.5105584859848022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5007545948028564},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4853702783584595},{"id":"https://openalex.org/C2778347629","wikidata":"https://www.wikidata.org/wiki/Q4652380","display_name":"ALK inhibitor","level":5,"score":0.44579434394836426},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39879554510116577},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32783639430999756},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.1961440145969391},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.9072","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9072","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.9072","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767967204","https://openalex.org/W4318318111","https://openalex.org/W2991075386","https://openalex.org/W2891080905","https://openalex.org/W3167603053","https://openalex.org/W2613309827","https://openalex.org/W2979998908","https://openalex.org/W2494947788","https://openalex.org/W3019141767","https://openalex.org/W2991627091"],"abstract_inverted_index":{"9072":[0],"Background:":[1],"In":[2,178,338],"patients":[3],"(pts)":[4],"with":[5,28,43,61,91,202,206,231,254,258,311,329,354,369],"crizotinib":[6],"(CRZ)-refractory":[7],"advanced":[8,64],"ALK+":[9,65],"NSCLC":[10],"in":[11,40,47,59,118,131,149,156,185,191,196,239,248,333],"the":[12,18,35,119,127,132,150,157,240],"phase":[13,52],"2":[14],"ALTA":[15],"trial":[16,54,375],"(NCT02094573),":[17],"depth":[19,330],"of":[20,37,55,187,237,266,331,361],"target":[21,41,92,121,163,207,245,259,348,371],"lesion":[22,93,122,164,208,246,260,349,372],"response":[23,223,332,350],"to":[24,72,317],"brigatinib":[25],"(BRG)":[26],"correlated":[27],"PFS":[29,44,268,318,363],"and":[30,45,114,134,153,193,215,319,321],"OS.":[31],"Here,":[32],"we":[33],"examine":[34],"association":[36],"maximum":[38],"decrease":[39,106],"lesions":[42],"OS":[46,291,320,325,365],"ALTA-1L":[48],"(NCT02737501),":[49],"a":[50,216,267,362],"randomized":[51,70],"3":[53],"BRG":[56,74,151,199,229,241,255,344],"vs":[57,211,351,367],"CRZ":[58,85,158,212,232,257],"pts":[60,148,155,205,238,310,368],"ALK":[62],"inhibitor-naive":[63],"NSCLC.":[66],"Methods:":[67],"Pts":[68,90,252,353],"were":[69,101,327],"1:1":[71],"receive":[73],"180":[75],"mg":[76,87],"qd":[77],"(7-day":[78],"lead-in":[79],"at":[80],"90":[81],"mg;":[82],"n=137)":[83],"or":[84,256,289,364],"250":[86],"bid":[88],"(n=138).":[89],"assessment":[94],"by":[95],"blinded":[96],"independent":[97],"review":[98],"committee":[99],"(BIRC)":[100],"grouped":[102],"based":[103],"on":[104],"greatest":[105],"from":[107],"baseline":[108],"per":[109],"RECIST":[110],"v1.1:":[111],"none\u201350%,":[112],"51%\u201375%,":[113],"76%\u2013100%":[115,135,244],"shrinkage.":[116,313,373],"Outcomes":[117],"\u226450%":[120,194,312,370],"shrinkage":[123,182,190,195,209,226,247,261,356],"group":[124],"served":[125],"as":[126],"comparator":[128],"for":[129,228],"outcomes":[130],"51%\u201375%":[133,274,282,294,302],"groups.":[136],"Results:":[137],"At":[138],"study":[139],"end":[140],"(last":[141],"pt":[142],"contact:":[143],"Jan":[144],"29,":[145],"2021),":[146],"124/137":[147],"arm":[152,159,242],"125/138":[154],"had":[160,263,357],"\u22651":[161],"evaluable":[162],"assessment;":[165],"female":[166],"(BRG/CRZ),":[167],"51%/59%;":[168],"median":[169,315],"age,":[170],"57.5/60.0":[171],"years.":[172],"Median":[173],"follow-up":[174],"was":[175,183,200],"40.8/15.7":[176],"months.":[177],"BRG/CRZ":[179],"arms,":[180],"76%-100%":[181],"observed":[184],"56%/34%":[186],"pts,":[188],"51%-75%":[189],"27%/30%,":[192],"16%/35%,":[197],"respectively.":[198],"associated":[201,328],"significantly":[203,221,346,358],"more":[204],">75%":[210,355],"(":[213,233],"P=0.0005),":[214],"Cochran-Armitage":[217],"trend":[218],"analysis":[219],"demonstrated":[220,345],"deeper":[222,347],"across":[224],"all":[225,249],"groups":[227],"compared":[230],"P<0.0001).":[234],"A":[235],"majority":[236],"experienced":[243],"subgroups":[250],"analyzed.":[251],"treated":[253],">50%":[262],"lower":[264],"risk":[265,360],"event":[269,292,366],"(BRG":[270],"HR":[271],"[95%":[272],"CI]:":[273],"shrinkage,":[275,283,295,303],"0.58":[276],"[0.29\u20131.18];":[277],"76%\u2013100%,":[278,286,298,306],"0.23":[279,307],"[0.12\u20130.46];":[280],"CRZ:":[281,301],"0.68":[284],"[0.41\u20131.12];":[285],"0.26":[287],"[0.15\u20130.45])":[288],"an":[290],"(BRG:":[293],"0.39":[296],"[0.17\u20130.89];":[297],"0.15":[299],"[0.07\u20130.35];":[300],"0.43":[304],"[0.21\u20130.85];":[305],"[0.10\u20130.50])":[308],"than":[309],"Longer":[314],"time":[316],"higher":[322],"4-year":[323],"estimated":[324],"rates":[326],"both":[334],"arms":[335],"(Table).":[336],"Conclusions:":[337],"this":[339],"exploratory":[340],"post":[341],"hoc":[342],"analysis,":[343],"CRZ.":[352],"reduced":[359],"Clinical":[374],"information:":[376],"NCT02737501.":[377],"[Table:":[378],"see":[379],"text]":[380]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-06-13T00:00:00"}
