{"id":"https://openalex.org/W4282034433","doi":"https://doi.org/10.7554/elife.71533","title":"Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells","display_name":"Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells","publication_year":2022,"publication_date":"2022-05-19","ids":{"openalex":"https://openalex.org/W4282034433","doi":"https://doi.org/10.7554/elife.71533","pmid":"https://pubmed.ncbi.nlm.nih.gov/35621159","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142147"},"language":"en","primary_location":{"id":"doi:10.7554/elife.71533","doi":"https://doi.org/10.7554/elife.71533","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.71533","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.71533","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019944202","display_name":"Le Xiong","orcid":"https://orcid.org/0000-0001-8180-768X","observed_orcids":["https://orcid.org/0000-0001-8180-768X"]},"institutions":[{"id":"https://openalex.org/I4387154714","display_name":"Max Planck Institute for Multidisciplinary Sciences","ror":"https://ror.org/03av75f26","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Le Xiong","raw_affiliation_strings":["Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology"],"raw_orcid":"https://orcid.org/0000-0001-8180-768X","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology","institution_ids":["https://openalex.org/I4387154714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051789515","display_name":"Erik A Tolen","orcid":"https://orcid.org/0000-0002-7147-7506","observed_orcids":["https://orcid.org/0000-0002-7147-7506"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erik A Tolen","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology"],"raw_orcid":"https://orcid.org/0000-0002-7147-7506","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101868690","display_name":"Jinmi Choi","orcid":"https://orcid.org/0000-0002-4909-9473","observed_orcids":["https://orcid.org/0000-0002-4909-9473"]},"institutions":[{"id":"https://openalex.org/I4387154714","display_name":"Max Planck Institute for Multidisciplinary Sciences","ror":"https://ror.org/03av75f26","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jinmi Choi","raw_affiliation_strings":["Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology","institution_ids":["https://openalex.org/I4387154714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036570118","display_name":"Sergiy Velychko","orcid":"https://orcid.org/0000-0002-6227-3966","observed_orcids":["https://orcid.org/0000-0002-6227-3966"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sergiy Velychko","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology"],"raw_orcid":"https://orcid.org/0000-0002-6227-3966","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039441972","display_name":"Livia Caizzi","orcid":"https://orcid.org/0000-0001-9723-6893","observed_orcids":["https://orcid.org/0000-0001-9723-6893"]},"institutions":[{"id":"https://openalex.org/I4387154714","display_name":"Max Planck Institute for Multidisciplinary Sciences","ror":"https://ror.org/03av75f26","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Livia Caizzi","raw_affiliation_strings":["Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology"],"raw_orcid":"https://orcid.org/0000-0001-9723-6893","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology","institution_ids":["https://openalex.org/I4387154714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043913286","display_name":"Taras Velychko","orcid":"https://orcid.org/0000-0003-4087-3730","observed_orcids":["https://orcid.org/0000-0003-4087-3730"]},"institutions":[{"id":"https://openalex.org/I4387154714","display_name":"Max Planck Institute for Multidisciplinary Sciences","ror":"https://ror.org/03av75f26","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Taras Velychko","raw_affiliation_strings":["Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology","institution_ids":["https://openalex.org/I4387154714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104521400","display_name":"Kenjiro Adachi","orcid":"https://orcid.org/0009-0003-0161-1508","observed_orcids":["https://orcid.org/0009-0003-0161-1508"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kenjiro Adachi","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009077731","display_name":"Caitlin M. MacCarthy","orcid":"https://orcid.org/0000-0001-8434-5441","observed_orcids":["https://orcid.org/0000-0001-8434-5441"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caitlin M MacCarthy","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology"],"raw_orcid":"https://orcid.org/0000-0001-8434-5441","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041268911","display_name":"Michael Lidschreiber","orcid":"https://orcid.org/0000-0002-6740-2755","observed_orcids":["https://orcid.org/0000-0002-6740-2755"]},"institutions":[{"id":"https://openalex.org/I4387154714","display_name":"Max Planck Institute for Multidisciplinary Sciences","ror":"https://ror.org/03av75f26","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Lidschreiber","raw_affiliation_strings":["Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology"],"raw_orcid":"https://orcid.org/0000-0002-6740-2755","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology","institution_ids":["https://openalex.org/I4387154714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008281609","display_name":"Patrick Cramer","orcid":"https://orcid.org/0000-0001-5454-7755","observed_orcids":["https://orcid.org/0000-0001-5454-7755","https://orcid.org/0009-0009-8366-1325"]},"institutions":[{"id":"https://openalex.org/I4387154714","display_name":"Max Planck Institute for Multidisciplinary Sciences","ror":"https://ror.org/03av75f26","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Patrick Cramer","raw_affiliation_strings":["Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology"],"raw_orcid":"https://orcid.org/0000-0001-5454-7755","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology","institution_ids":["https://openalex.org/I4387154714"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hans R Sch\u00f6ler","orcid":"https://orcid.org/0000-0002-7422-8847","observed_orcids":["https://orcid.org/0000-0002-7422-8847"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans R Sch\u00f6ler","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology"],"raw_orcid":"https://orcid.org/0000-0002-7422-8847","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology","institution_ids":["https://openalex.org/I4210152666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008281609"],"corresponding_institution_ids":["https://openalex.org/I4210152666","https://openalex.org/I4387154714"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":2.6932,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.92280187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":1.0},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/enhancer-transcription","display_name":"enhancer transcription","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9739999771118164},{"id":"https://openalex.org/keywords/enhancer-binding","display_name":"enhancer binding","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8667565584182739},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.8067632913589478},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7800014019012451},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.683556079864502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6527622938156128},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6202707886695862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5826793313026428},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5730506181716919},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.5274165868759155},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4854450821876526},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4428856670856476},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.4402838349342346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31625130772590637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20451921224594116},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.7554/elife.71533","doi":"https://doi.org/10.7554/elife.71533","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.71533","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2021.06.28.450119","doi":"https://doi.org/10.1101/2021.06.28.450119","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.28.450119","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/28/2021.06.28.450119.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9142147","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142147","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:35621159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35621159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/1881952","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2318/1881952","pdf_url":"https://iris.unito.it/bitstream/2318/1881952/4/elife-71533-compresso.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1d5965331e63415ea1891c5a5bf6e818","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1d5965331e63415ea1891c5a5bf6e818","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 11 (2022)","raw_type":"article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/108626","doi":null,"is_oa":true,"landing_page_url":"https://mbexc.uni-goettingen.de/literature/publications/506","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.7554/elife.71533","doi":"https://doi.org/10.7554/elife.71533","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.71533","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2161706771","display_name":null,"funder_award_id":"SPP\u20101935","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3445732291","display_name":null,"funder_award_id":"EXC 2067","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4227863749","display_name":null,"funder_award_id":"882357","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G584537252","display_name":null,"funder_award_id":"EXC 2067\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6004418582","display_name":"EXC 2067: Multiscale Bioimaging: Von molekularen Maschinen zu Netzwerken erregbarer Zellen","funder_award_id":"390729940","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7761887727","display_name":null,"funder_award_id":"390729940","funder_id":"https://openalex.org/F4320322434","funder_display_name":"Max-Planck-Gesellschaft"},{"id":"https://openalex.org/G7987891391","display_name":null,"funder_award_id":"EXC 2067/1390729940","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8109831571","display_name":null,"funder_award_id":"SFB 860","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8141962476","display_name":null,"funder_award_id":"669168","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G8369190549","display_name":null,"funder_award_id":"EXC 2067/1","funder_id":"https://openalex.org/F4320322434","funder_display_name":"Max-Planck-Gesellschaft"}],"funders":[{"id":"https://openalex.org/F4320317967","display_name":"International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","ror":null},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320323017","display_name":"G\u00f6ttinger Graduiertenschule f\u00fcr Neurowissenschaften, Biophysik und Molekulare Biowissenschaften","ror":"https://ror.org/01y9bpm73"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W233481338","https://openalex.org/W1608762409","https://openalex.org/W1971451591","https://openalex.org/W1971578941","https://openalex.org/W1978173381","https://openalex.org/W1978901723","https://openalex.org/W1979513200","https://openalex.org/W1979594866","https://openalex.org/W1981059575","https://openalex.org/W1981088384","https://openalex.org/W1988294855","https://openalex.org/W1988571169","https://openalex.org/W1998871958","https://openalex.org/W2004966039","https://openalex.org/W2014787267","https://openalex.org/W2015845481","https://openalex.org/W2028200156","https://openalex.org/W2030030642","https://openalex.org/W2036897871","https://openalex.org/W2043399100","https://openalex.org/W2047182840","https://openalex.org/W2067956561","https://openalex.org/W2080251115","https://openalex.org/W2082161548","https://openalex.org/W2089285124","https://openalex.org/W2090567401","https://openalex.org/W2095580103","https://openalex.org/W2096010243","https://openalex.org/W2097049188","https://openalex.org/W2107575419","https://openalex.org/W2108234281","https://openalex.org/W2110015307","https://openalex.org/W2111099379","https://openalex.org/W2117757143","https://openalex.org/W2118290853","https://openalex.org/W2125987139","https://openalex.org/W2133465414","https://openalex.org/W2134526812","https://openalex.org/W2140022443","https://openalex.org/W2140952049","https://openalex.org/W2146648243","https://openalex.org/W2147231609","https://openalex.org/W2151880666","https://openalex.org/W2152144700","https://openalex.org/W2163421223","https://openalex.org/W2166810745","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2171609896","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2259708197","https://openalex.org/W2295037017","https://openalex.org/W2312755091","https://openalex.org/W2413043813","https://openalex.org/W2560205456","https://openalex.org/W2573731673","https://openalex.org/W2578822114","https://openalex.org/W2591956860","https://openalex.org/W2595380755","https://openalex.org/W2618657542","https://openalex.org/W2775166823","https://openalex.org/W2786204582","https://openalex.org/W2898598946","https://openalex.org/W2901209536","https://openalex.org/W2915040067","https://openalex.org/W2915985519","https://openalex.org/W2942020966","https://openalex.org/W2950077732","https://openalex.org/W2965365583","https://openalex.org/W2969118999","https://openalex.org/W2977654387","https://openalex.org/W2986751328","https://openalex.org/W2988716798","https://openalex.org/W2989046613","https://openalex.org/W2992086063","https://openalex.org/W2992322647","https://openalex.org/W2994994786","https://openalex.org/W2997704617","https://openalex.org/W3018363245","https://openalex.org/W3019281170","https://openalex.org/W3033842668","https://openalex.org/W3037538172","https://openalex.org/W3046950215","https://openalex.org/W3080775827","https://openalex.org/W3123079145","https://openalex.org/W3136167697","https://openalex.org/W3158597952","https://openalex.org/W3166702695","https://openalex.org/W3216751620","https://openalex.org/W4210520048","https://openalex.org/W4213317589","https://openalex.org/W4225377993","https://openalex.org/W4282034433"],"related_works":["https://openalex.org/W4220959869","https://openalex.org/W2992322647","https://openalex.org/W3189091039","https://openalex.org/W7042280499","https://openalex.org/W2595380755","https://openalex.org/W4415965260","https://openalex.org/W2043399100","https://openalex.org/W2965365583","https://openalex.org/W4415371379","https://openalex.org/W1526544419"],"abstract_inverted_index":{"The":[0],"transcription":[1,97,116,138],"factor":[2],"Oct4":[3,29,48,84,104,134,145],"is":[4],"essential":[5],"for":[6,137],"the":[7,26,75,92],"maintenance":[8],"and":[9,32,42],"induction":[10],"of":[11,28,55,74,83,98,103,127,133,139,144],"stem":[12,39],"cell":[13],"pluripotency,":[14],"but":[15,95],"its":[16,56,68],"functional":[17],"roles":[18],"are":[19,72,135,146],"not":[20,89,118],"fully":[21,119],"understood.":[22],"Here,":[23],"we":[24],"investigate":[25],"functions":[27],"by":[30,61],"depleting":[31],"subsequently":[33],"recovering":[34],"it":[35],"in":[36,64,107,111],"mouse":[37],"embryonic":[38],"cells":[40],"(ESCs)":[41],"conducting":[43],"a":[44,62,108],"time-resolved":[45],"multiomics":[46],"analysis.":[47],"depletion":[49],"leads":[50],"to":[51,58,86,148],"an":[52],"immediate":[53],"loss":[54],"binding":[57,85],"enhancers,":[59,141],"accompanied":[60],"decrease":[63,82],"mRNA":[65],"synthesis":[66],"from":[67],"target":[69],"genes":[70],"that":[71,78],"part":[73],"transcriptional":[76],"network":[77],"maintains":[79],"pluripotency.":[80],"Gradual":[81],"enhancers":[87],"does":[88,117],"immediately":[90],"change":[91],"chromatin":[93,112,150],"accessibility":[94],"reduces":[96],"enhancers.":[99],"Conversely,":[100],"partial":[101],"recovery":[102],"expression":[105],"results":[106,122],"rapid":[109],"increase":[110],"accessibility,":[113,151],"whereas":[114],"enhancer":[115],"recover.":[120],"These":[121],"indicate":[123],"different":[124],"concentration-dependent":[125],"activities":[126],"Oct4.":[128],"Whereas":[129],"normal":[130],"ESC":[131],"levels":[132,143],"required":[136],"pluripotency":[140],"low":[142],"sufficient":[147],"retain":[149],"likely":[152],"together":[153],"with":[154],"other":[155],"factors":[156],"such":[157],"as":[158],"Sox2.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}