{"id":"https://openalex.org/W4282003010","doi":"https://doi.org/10.3390/biomedicines10061257","title":"Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis","display_name":"Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4282003010","doi":"https://doi.org/10.3390/biomedicines10061257","pmid":"https://pubmed.ncbi.nlm.nih.gov/35740279"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines10061257","doi":"https://doi.org/10.3390/biomedicines10061257","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10061257","pdf_url":"https://www.mdpi.com/2227-9059/10/6/1257/pdf?version=1653649093","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/10/6/1257/pdf?version=1653649093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063260030","display_name":"John M. Barbaro","orcid":"https://orcid.org/0000-0002-2324-1582","observed_orcids":["https://orcid.org/0000-0002-2324-1582"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Barbaro","raw_affiliation_strings":["Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA"],"raw_orcid":"https://orcid.org/0000-0002-2324-1582","affiliations":[{"raw_affiliation_string":"Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060898511","display_name":"Simone Sidoli","orcid":"https://orcid.org/0000-0001-9073-6641","observed_orcids":["https://orcid.org/0000-0001-9073-6641"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simone Sidoli","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA"],"raw_orcid":"https://orcid.org/0000-0001-9073-6641","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063410689","display_name":"Ana Mar\u00eda Cuervo","orcid":"https://orcid.org/0000-0002-0771-700X","observed_orcids":["https://orcid.org/0000-0002-0771-700X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Maria Cuervo","raw_affiliation_strings":["Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057650635","display_name":"Joan W. Berman","orcid":"https://orcid.org/0000-0003-0635-4072","observed_orcids":["https://orcid.org/0000-0003-0635-4072"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joan W. Berman","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA","Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057650635"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":0.6553,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68446215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"6","first_page":"1257","last_page":"1257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hiv-neuropathogenesis","display_name":"HIV neuropathogenesis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7749999761581421},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7680000066757202},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9990000128746033},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.6359999775886536},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.7940000295639038},{"id":"https://openalex.org/keywords/redox-metabolism","display_name":"redox metabolism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/perivascular-macrophages","display_name":"perivascular macrophages","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2780114369","wikidata":"https://www.wikidata.org/wiki/Q6823535","display_name":"Meth-","level":5,"score":0.7720457911491394},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7638553380966187},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.7039178609848022},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6902074217796326},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.6566109657287598},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6231889724731445},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6053858399391174},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5988273024559021},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5458515286445618},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.445454865694046},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4441136121749878},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43635135889053345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.419209748506546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41664063930511475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40260976552963257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3283658027648926},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28496721386909485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27187293767929077},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.15270349383354187},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.10238054394721985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08537071943283081},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07889905571937561},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07117268443107605},{"id":"https://openalex.org/C2779989194","wikidata":"https://www.wikidata.org/wiki/Q343016","display_name":"Acrylate","level":4,"score":0.0},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines10061257","doi":"https://doi.org/10.3390/biomedicines10061257","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10061257","pdf_url":"https://www.mdpi.com/2227-9059/10/6/1257/pdf?version=1653649093","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmid:35740279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35740279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9220012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9220012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a92bb1506dae43a983bdb1c71c0a1306","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a92bb1506dae43a983bdb1c71c0a1306","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 10, Iss 6, p 1257 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines10061257","doi":"https://doi.org/10.3390/biomedicines10061257","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10061257","pdf_url":"https://www.mdpi.com/2227-9059/10/6/1257/pdf?version=1653649093","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1159308821","display_name":null,"funder_award_id":"P30AI124414","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G1275800971","display_name":null,"funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320318902","funder_display_name":"Instituto Nacional de Cancerolog\u00eda"},{"id":"https://openalex.org/G1372999414","display_name":null,"funder_award_id":"1S10OD030286-01","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G1557182087","display_name":null,"funder_award_id":"P30 AI124414","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1583220925","display_name":null,"funder_award_id":"P30 AI124414","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G16306045","display_name":"Orbitrap Exploris 480 Basic System","funder_award_id":"1s10od030286-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1857499104","display_name":null,"funder_award_id":"P30AI124414","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G1924491507","display_name":null,"funder_award_id":"P30AI124414","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2051864048","display_name":null,"funder_award_id":"T32GM007288-44","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2192564234","display_name":null,"funder_award_id":"R01DA044584","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2211944594","display_name":null,"funder_award_id":"1-S10-OD030286-01","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G2425984972","display_name":null,"funder_award_id":"T32GM007288-44","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G2463638256","display_name":null,"funder_award_id":"P01 AG031782","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G252335265","display_name":null,"funder_award_id":"1S10OD030286-01","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2576755164","display_name":null,"funder_award_id":"F30DA053118","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G2692686562","display_name":null,"funder_award_id":"P30AI124414","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G2745100336","display_name":null,"funder_award_id":"P30 AG038072","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2810722554","display_name":null,"funder_award_id":"R01DA044584","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G3041630884","display_name":null,"funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G3099666453","display_name":null,"funder_award_id":"R01DA048609","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3117890672","display_name":null,"funder_award_id":"T32GM007288-44","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G3228787220","display_name":null,"funder_award_id":"T32GM007288-44","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G323459592","display_name":null,"funder_award_id":"P30AG038072","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G3433515134","display_name":null,"funder_award_id":"R01DA044584","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G3622433565","display_name":null,"funder_award_id":"T32GM007288-44","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3687786437","display_name":"Advanced Confocal Microscope in a multi-user facility","funder_award_id":"1s10od023591-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3795979262","display_name":null,"funder_award_id":"RF1 AG054108","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3798720003","display_name":null,"funder_award_id":"R01DA048609","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3849861977","display_name":null,"funder_award_id":"R01DA044584","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3901712998","display_name":null,"funder_award_id":"F30DA053118","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3914350421","display_name":null,"funder_award_id":"P30AG038072","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G4022881664","display_name":null,"funder_award_id":"F30DA053118","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G422565461","display_name":null,"funder_award_id":"P30AG038072","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G423460813","display_name":null,"funder_award_id":"R01DA048609","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G4611183783","display_name":null,"funder_award_id":"R01DA044584","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G4733156781","display_name":null,"funder_award_id":"R01DA048609","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G4941441753","display_name":null,"funder_award_id":"1S10OD030286-01","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5006641767","display_name":null,"funder_award_id":"R01 DA041931","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G503200962","display_name":null,"funder_award_id":"T32GM-007288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G513155522","display_name":null,"funder_award_id":"S10OD023591-01","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5490547647","display_name":null,"funder_award_id":"1S10OD030286-01","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G6314222485","display_name":null,"funder_award_id":"P30AG038072","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6412745977","display_name":null,"funder_award_id":"S10OD023591-01","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G6451293773","display_name":null,"funder_award_id":"F30DA053118","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G651132157","display_name":null,"funder_award_id":"S10OD023591-01","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6834020828","display_name":null,"funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G6933228818","display_name":null,"funder_award_id":"T32GM007288-44","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G7054978880","display_name":null,"funder_award_id":"R01DA048609","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G7219920267","display_name":null,"funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G7770470996","display_name":null,"funder_award_id":"S10OD023591-01","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G8020057958","display_name":null,"funder_award_id":"S10OD023591-01","funder_id":"https://openalex.org/F4320308842","funder_display_name":"Leukemia Research Foundation"},{"id":"https://openalex.org/G8772567148","display_name":null,"funder_award_id":"F30DA053118","funder_id":"https://openalex.org/F656214160","funder_display_name":"Services Industriels de Gen\u00e8ve"},{"id":"https://openalex.org/G9000877850","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308842","display_name":"Leukemia Research Foundation","ror":"https://ror.org/036wcgd38"},{"id":"https://openalex.org/F4320318902","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/02hdnbe80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F656214160","display_name":"Services Industriels de Gen\u00e8ve","ror":"https://ror.org/053c2dj66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282003010.pdf","grobid_xml":"https://content.openalex.org/works/W4282003010.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W1499984715","https://openalex.org/W1538080804","https://openalex.org/W1597391547","https://openalex.org/W1768740107","https://openalex.org/W1852882672","https://openalex.org/W1965350402","https://openalex.org/W1967111894","https://openalex.org/W1969019747","https://openalex.org/W1978611773","https://openalex.org/W1980475945","https://openalex.org/W1981056356","https://openalex.org/W1981934045","https://openalex.org/W1990974472","https://openalex.org/W1992532731","https://openalex.org/W1992643412","https://openalex.org/W1997962806","https://openalex.org/W2002893295","https://openalex.org/W2016532044","https://openalex.org/W2017346008","https://openalex.org/W2020337923","https://openalex.org/W2022361831","https://openalex.org/W2034857494","https://openalex.org/W2042767581","https://openalex.org/W2048030072","https://openalex.org/W2057274775","https://openalex.org/W2067672361","https://openalex.org/W2071481601","https://openalex.org/W2085610247","https://openalex.org/W2089082039","https://openalex.org/W2089936534","https://openalex.org/W2091277662","https://openalex.org/W2093880239","https://openalex.org/W2102354517","https://openalex.org/W2113010696","https://openalex.org/W2115901840","https://openalex.org/W2131731344","https://openalex.org/W2133843607","https://openalex.org/W2151433848","https://openalex.org/W2154076020","https://openalex.org/W2155313245","https://openalex.org/W2157381639","https://openalex.org/W2162703492","https://openalex.org/W2168591440","https://openalex.org/W2273184168","https://openalex.org/W2295774726","https://openalex.org/W2329655738","https://openalex.org/W2395446774","https://openalex.org/W2404185225","https://openalex.org/W2558031281","https://openalex.org/W2582294715","https://openalex.org/W2598879155","https://openalex.org/W2606375388","https://openalex.org/W2610895525","https://openalex.org/W2625333625","https://openalex.org/W2757483971","https://openalex.org/W2767405596","https://openalex.org/W2767921140","https://openalex.org/W2769071992","https://openalex.org/W2773258360","https://openalex.org/W2773436899","https://openalex.org/W2790114408","https://openalex.org/W2794808269","https://openalex.org/W2891587714","https://openalex.org/W2910527963","https://openalex.org/W2914443670","https://openalex.org/W2922318839","https://openalex.org/W2945777288","https://openalex.org/W2955084980","https://openalex.org/W2965060798","https://openalex.org/W2970860254","https://openalex.org/W2977072036","https://openalex.org/W2988677878","https://openalex.org/W2989042800","https://openalex.org/W2998718682","https://openalex.org/W3004915253","https://openalex.org/W3007300319","https://openalex.org/W3013748728","https://openalex.org/W3015671804","https://openalex.org/W3022694800","https://openalex.org/W3025182966","https://openalex.org/W3026927696","https://openalex.org/W3027308563","https://openalex.org/W3035138533","https://openalex.org/W3036114918","https://openalex.org/W3046094191","https://openalex.org/W3046316787","https://openalex.org/W3087227941","https://openalex.org/W3106521736","https://openalex.org/W3108936441","https://openalex.org/W3121022587","https://openalex.org/W3130508003","https://openalex.org/W3131190077","https://openalex.org/W3134048740","https://openalex.org/W3134327264","https://openalex.org/W3135211510","https://openalex.org/W3137124421","https://openalex.org/W3139615586","https://openalex.org/W3154414512","https://openalex.org/W3168061992","https://openalex.org/W3194333496","https://openalex.org/W3213921944","https://openalex.org/W4205678809","https://openalex.org/W4210307967","https://openalex.org/W4210894454"],"related_works":["https://openalex.org/W1968048495","https://openalex.org/W2953482605","https://openalex.org/W1909258307","https://openalex.org/W1964582928","https://openalex.org/W2084726585","https://openalex.org/W2157570964","https://openalex.org/W2061584893","https://openalex.org/W2665329839","https://openalex.org/W2090033920","https://openalex.org/W2287363125"],"abstract_inverted_index":{"HIV-neurocognitive":[0],"impairment":[1],"(HIV-NCI)":[2],"can":[3,93],"be":[4,133,185],"a":[5,25,88],"debilitating":[6],"condition":[7],"for":[8,62,188],"people":[9,202],"with":[10,27,122,140,203],"HIV":[11,28,63],"(PWH),":[12],"despite":[13],"the":[14,49,65,163],"success":[15],"of":[16,32,52,70,76,111,149],"antiretroviral":[17],"therapy":[18],"(ART).":[19],"Substance":[20],"use":[21,31],"disorder":[22],"is":[23,87],"often":[24],"comorbidity":[26],"infection.":[29],"The":[30,67],"methamphetamine":[33],"(meth)":[34],"increases":[35,114],"systemic":[36],"inflammation":[37],"and":[38,73,117,179],"CNS":[39],"damage":[40],"in":[41,64,95,102,136,154,167,173,195,201],"PWH.":[42],"Meth":[43],"may":[44,132,184],"also":[45],"increase":[46],"neuropathogenesis":[47],"through":[48],"functional":[50,193],"dysregulation":[51],"cells":[53],"that":[54,92,107,171,191],"harbor":[55],"HIV.":[56],"Perivascular":[57],"macrophages":[58,83,106,170,197],"are":[59],"long-lived":[60],"reservoirs":[61],"CNS.":[66],"impaired":[68],"clearance":[69],"extracellular":[71],"debris":[72],"increased":[74,152],"release":[75],"reactive":[77],"oxygen":[78],"species":[79],"(ROS)":[80],"by":[81],"HIV-infected":[82,103,169,196],"cause":[84],"neurotoxicity.":[85],"Macroautophagy":[86],"vital":[89],"intracellular":[90],"pathway":[91],"regulate,":[94],"part,":[96],"these":[97],"deleterious":[98],"processes.":[99,120],"We":[100],"found":[101],"primary":[104],"human":[105],"meth":[108],"inhibits":[109],"phagocytosis":[110,137],"aggregated":[112],"amyloid-\u03b2,":[113],"total":[115],"ROS,":[116],"dysregulates":[118],"autophagic":[119],"Treatment":[121],"widely":[123],"prescribed":[124],"ART":[125],"drugs":[126],"had":[127],"minimal":[128],"effects,":[129],"although":[130],"there":[131],"an":[134],"improvement":[135],"when":[138],"co-administered":[139],"meth.":[141,157,206],"Pharmacologically":[142],"inhibited":[143],"lysosomal":[144],"degradation,":[145],"but":[146],"not":[147],"induction":[148],"autophagy,":[150],"further":[151],"ROS":[153],"response":[155],"to":[156,198],"Using":[158],"mass":[159],"spectrometry,":[160],"we":[161],"identified":[162],"differentially":[164],"expressed":[165],"proteins":[166,183],"meth-treated,":[168],"participate":[172],"phagocytosis,":[174],"mitochondrial":[175],"function,":[176],"redox":[177],"metabolism,":[178],"autophagy.":[180],"Significantly":[181],"altered":[182],"novel":[186],"targets":[187],"interventional":[189],"strategies":[190],"restore":[192],"homeostasis":[194],"improve":[199],"neurocognition":[200],"HIV-NCI":[204],"using":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
