{"id":"https://openalex.org/W4282000","doi":"https://doi.org/10.17077/etd.57godcye","title":"Preparation of neoclerodane diterpenes as probes for the opioid receptor system","display_name":"Preparation of neoclerodane diterpenes as probes for the opioid receptor system","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W4282000","doi":"https://doi.org/10.17077/etd.57godcye","mag":"4282000"},"language":"en","primary_location":{"id":"doi:10.17077/etd.57godcye","doi":"https://doi.org/10.17077/etd.57godcye","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.57godcye","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044534806","display_name":"Anthony Lozama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anthony Lozama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035496277","display_name":"Thomas Edward Prisinzano","orcid":"https://orcid.org/0000-0002-0649-8052","observed_orcids":["https://orcid.org/0000-0002-0649-8052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas E. Prisinzano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080031865","display_name":"David F. Wiemer","orcid":"https://orcid.org/0000-0002-4881-8544","observed_orcids":["https://orcid.org/0000-0002-4881-8544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David F. Wiemer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4881-8544","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040748951","display_name":"Jonathan A. Doorn","orcid":"https://orcid.org/0000-0001-9646-9871","observed_orcids":["https://orcid.org/0000-0001-9646-9871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan A. Doorn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9646-9871","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079302283","display_name":"Horacio F. Olivo","orcid":"https://orcid.org/0000-0002-8082-5285","observed_orcids":["https://orcid.org/0000-0002-8082-5285"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Horacio F. Olivo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002551319","display_name":"Aliasger K. Salem","orcid":"https://orcid.org/0000-0002-1923-6633","observed_orcids":["https://orcid.org/0000-0002-1923-6633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aliasger K. Salem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049983483","display_name":"Michael W. Duffel","orcid":"https://orcid.org/0000-0002-6079-7459","observed_orcids":["https://orcid.org/0000-0002-6079-7459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael W. Duffel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6079-7459","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044534806"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neo-clerodane-diterpenoids","display_name":"neo-clerodane diterpenoids","score":0.953000009059906},{"id":"https://openalex.org/keywords/salvinorin-a","display_name":"salvinorin A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.925000011920929},{"id":"https://openalex.org/keywords/reductive-elimination","display_name":"reductive elimination","score":0.8119999766349792},{"id":"https://openalex.org/keywords/chemical-modification-of-natural-products","display_name":"chemical modification of natural products","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.5833778977394104},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.49726465344429016},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3765868544578552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3732582926750183},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3299970328807831},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3073464334011078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2633516192436218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24794992804527283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24563154578208923}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17077/etd.57godcye","doi":"https://doi.org/10.17077/etd.57godcye","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.57godcye","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},{"id":"pmh:oai:ir.uiowa.edu:etd-1888","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/etd/703","pdf_url":null,"source":{"id":"https://openalex.org/S4377196317","display_name":"Iowa Research Online (University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126827851","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126827851"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.6700000166893005,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":323,"referenced_works":["https://openalex.org/W69934748","https://openalex.org/W93832398","https://openalex.org/W101924362","https://openalex.org/W115976844","https://openalex.org/W223405436","https://openalex.org/W814013141","https://openalex.org/W1492294380","https://openalex.org/W1517315768","https://openalex.org/W1544544025","https://openalex.org/W1544866473","https://openalex.org/W1548467005","https://openalex.org/W1555642591","https://openalex.org/W1557496869","https://openalex.org/W1567149755","https://openalex.org/W1567569917","https://openalex.org/W1585778217","https://openalex.org/W1662894232","https://openalex.org/W1667373896","https://openalex.org/W1670988858","https://openalex.org/W1695322171","https://openalex.org/W1749453950","https://openalex.org/W1832918544","https://openalex.org/W1836729582","https://openalex.org/W1843659135","https://openalex.org/W1871475547","https://openalex.org/W1889264431","https://openalex.org/W1894641937","https://openalex.org/W1903574678","https://openalex.org/W1912527875","https://openalex.org/W1922426788","https://openalex.org/W1922742603","https://openalex.org/W1925504181","https://openalex.org/W1951872310","https://openalex.org/W1965260090","https://openalex.org/W1965689912","https://openalex.org/W1965941558","https://openalex.org/W1966583126","https://openalex.org/W1967456984","https://openalex.org/W1967620621","https://openalex.org/W1968142899","https://openalex.org/W1969790953","https://openalex.org/W1970255234","https://openalex.org/W1970829367","https://openalex.org/W1971020159","https://openalex.org/W1972084368","https://openalex.org/W1972116779","https://openalex.org/W1972295709","https://openalex.org/W1972401663","https://openalex.org/W1972430667","https://openalex.org/W1974336938","https://openalex.org/W1974516847","https://openalex.org/W1976532529","https://openalex.org/W1977127465","https://openalex.org/W1977282539","https://openalex.org/W1978413677","https://openalex.org/W1979297235","https://openalex.org/W1979385488","https://openalex.org/W1979569718","https://openalex.org/W1980545705","https://openalex.org/W1981252279","https://openalex.org/W1981848710","https://openalex.org/W1982679082","https://openalex.org/W1983752733","https://openalex.org/W1984377490","https://openalex.org/W1984414350","https://openalex.org/W1984525563","https://openalex.org/W1984875090","https://openalex.org/W1985667653","https://openalex.org/W1985877415","https://openalex.org/W1985980801","https://openalex.org/W1986781795","https://openalex.org/W1986986717","https://openalex.org/W1988300617","https://openalex.org/W1989073099","https://openalex.org/W1991696252","https://openalex.org/W1991778481","https://openalex.org/W1992916552","https://openalex.org/W1993215044","https://openalex.org/W1993542914","https://openalex.org/W1993599005","https://openalex.org/W1994146471","https://openalex.org/W1994245143","https://openalex.org/W1995243112","https://openalex.org/W1995556774","https://openalex.org/W1995940903","https://openalex.org/W1997513305","https://openalex.org/W1998215428","https://openalex.org/W1998489769","https://openalex.org/W1999018540","https://openalex.org/W1999156240","https://openalex.org/W1999468683","https://openalex.org/W2000125000","https://openalex.org/W2000176602","https://openalex.org/W2001570602","https://openalex.org/W2002330441","https://openalex.org/W2002562207","https://openalex.org/W2004109806","https://openalex.org/W2004620669","https://openalex.org/W2005397960","https://openalex.org/W2005643237","https://openalex.org/W2007918392","https://openalex.org/W2008754951","https://openalex.org/W2009570758","https://openalex.org/W2009833672","https://openalex.org/W2010051841","https://openalex.org/W2011140088","https://openalex.org/W2012930258","https://openalex.org/W2013439044","https://openalex.org/W2014701807","https://openalex.org/W2015002417","https://openalex.org/W2015778368","https://openalex.org/W2018708744","https://openalex.org/W2018843588","https://openalex.org/W2019181379","https://openalex.org/W2023342466","https://openalex.org/W2023650124","https://openalex.org/W2024102644","https://openalex.org/W2025002066","https://openalex.org/W2025075095","https://openalex.org/W2025481021","https://openalex.org/W2026308567","https://openalex.org/W2027517101","https://openalex.org/W2027742106","https://openalex.org/W2028539126","https://openalex.org/W2028959859","https://openalex.org/W2029197384","https://openalex.org/W2029650434","https://openalex.org/W2029918787","https://openalex.org/W2030252531","https://openalex.org/W2031249869","https://openalex.org/W2031733136","https://openalex.org/W2032896346","https://openalex.org/W2033491736","https://openalex.org/W2033640369","https://openalex.org/W2035183545","https://openalex.org/W2036803146","https://openalex.org/W2036926586","https://openalex.org/W2037120935","https://openalex.org/W2037536875","https://openalex.org/W2037923207","https://openalex.org/W2040785900","https://openalex.org/W2041254259","https://openalex.org/W2041444093","https://openalex.org/W2042096580","https://openalex.org/W2042097750","https://openalex.org/W2042100002","https://openalex.org/W2042680233","https://openalex.org/W2044075892","https://openalex.org/W2044778613","https://openalex.org/W2045744643","https://openalex.org/W2046945092","https://openalex.org/W2047108227","https://openalex.org/W2048616979","https://openalex.org/W2050166569","https://openalex.org/W2050569442","https://openalex.org/W2051521999","https://openalex.org/W2051600615","https://openalex.org/W2055123928","https://openalex.org/W2055561625","https://openalex.org/W2055653516","https://openalex.org/W2055682898","https://openalex.org/W2055902014","https://openalex.org/W2056356761","https://openalex.org/W2057212652","https://openalex.org/W2057370050","https://openalex.org/W2058255651","https://openalex.org/W2059321731","https://openalex.org/W2059717332","https://openalex.org/W2059977567","https://openalex.org/W2065987181","https://openalex.org/W2066054862","https://openalex.org/W2066281438","https://openalex.org/W2066337690","https://openalex.org/W2066423907","https://openalex.org/W2066848874","https://openalex.org/W2067169557","https://openalex.org/W2067299834","https://openalex.org/W2067428749","https://openalex.org/W2069030760","https://openalex.org/W2069098438","https://openalex.org/W2070558900","https://openalex.org/W2072201188","https://openalex.org/W2072391550","https://openalex.org/W2072916781","https://openalex.org/W2073162415","https://openalex.org/W2073348815","https://openalex.org/W2074114058","https://openalex.org/W2075159439","https://openalex.org/W2075522979","https://openalex.org/W2075652092","https://openalex.org/W2075811628","https://openalex.org/W2075997495","https://openalex.org/W2077319814","https://openalex.org/W2077541178","https://openalex.org/W2077648124","https://openalex.org/W2077997117","https://openalex.org/W2080355486","https://openalex.org/W2080743317","https://openalex.org/W2081419341","https://openalex.org/W2082965112","https://openalex.org/W2083617764","https://openalex.org/W2084281644","https://openalex.org/W2084951981","https://openalex.org/W2085212484","https://openalex.org/W2086623660","https://openalex.org/W2086654490","https://openalex.org/W2086961054","https://openalex.org/W2087247225","https://openalex.org/W2087396198","https://openalex.org/W2087536428","https://openalex.org/W2089633836","https://openalex.org/W2089978205","https://openalex.org/W2091525040","https://openalex.org/W2092340387","https://openalex.org/W2093053369","https://openalex.org/W2093282680","https://openalex.org/W2093468577","https://openalex.org/W2098025305","https://openalex.org/W2098229382","https://openalex.org/W2098625990","https://openalex.org/W2100173292","https://openalex.org/W2102420653","https://openalex.org/W2104437520","https://openalex.org/W2106926141","https://openalex.org/W2108291259","https://openalex.org/W2108609891","https://openalex.org/W2109663146","https://openalex.org/W2110514788","https://openalex.org/W2111689088","https://openalex.org/W2111738864","https://openalex.org/W2112517214","https://openalex.org/W2113448465","https://openalex.org/W2113737911","https://openalex.org/W2113999888","https://openalex.org/W2114939168","https://openalex.org/W2116485956","https://openalex.org/W2117568169","https://openalex.org/W2118617956","https://openalex.org/W2118867827","https://openalex.org/W2120122043","https://openalex.org/W2121887620","https://openalex.org/W2122150204","https://openalex.org/W2122264682","https://openalex.org/W2123464171","https://openalex.org/W2124184748","https://openalex.org/W2125149319","https://openalex.org/W2126224548","https://openalex.org/W2126659868","https://openalex.org/W2127733438","https://openalex.org/W2127956277","https://openalex.org/W2128086091","https://openalex.org/W2128795911","https://openalex.org/W2129460888","https://openalex.org/W2130839195","https://openalex.org/W2131302772","https://openalex.org/W2132762790","https://openalex.org/W2134148966","https://openalex.org/W2135117833","https://openalex.org/W2136738554","https://openalex.org/W2136890888","https://openalex.org/W2141343547","https://openalex.org/W2141474275","https://openalex.org/W2142270930","https://openalex.org/W2142519612","https://openalex.org/W2142871589","https://openalex.org/W2144353982","https://openalex.org/W2144944019","https://openalex.org/W2148172992","https://openalex.org/W2148364002","https://openalex.org/W2148700237","https://openalex.org/W2150534429","https://openalex.org/W2151205383","https://openalex.org/W2151332369","https://openalex.org/W2152092268","https://openalex.org/W2152293013","https://openalex.org/W2152632692","https://openalex.org/W2154673008","https://openalex.org/W2157356802","https://openalex.org/W2158351380","https://openalex.org/W2158513208","https://openalex.org/W2159042032","https://openalex.org/W2160011379","https://openalex.org/W2161084744","https://openalex.org/W2161282151","https://openalex.org/W2161451803","https://openalex.org/W2162331245","https://openalex.org/W2165041622","https://openalex.org/W2166153441","https://openalex.org/W2168293844","https://openalex.org/W2171161326","https://openalex.org/W2171986671","https://openalex.org/W2175311495","https://openalex.org/W2176833613","https://openalex.org/W2267383282","https://openalex.org/W2268153384","https://openalex.org/W2316970929","https://openalex.org/W2320064572","https://openalex.org/W2320896078","https://openalex.org/W2321779895","https://openalex.org/W2324816039","https://openalex.org/W2327867901","https://openalex.org/W2333793410","https://openalex.org/W2338522515","https://openalex.org/W2398558941","https://openalex.org/W2399779086","https://openalex.org/W2403281078","https://openalex.org/W2414172659","https://openalex.org/W2414655714","https://openalex.org/W2414991892","https://openalex.org/W2461228859","https://openalex.org/W2491396197","https://openalex.org/W2791990668","https://openalex.org/W2942621037","https://openalex.org/W2949169798","https://openalex.org/W2949604087","https://openalex.org/W2951414230","https://openalex.org/W2951963030","https://openalex.org/W2952191613","https://openalex.org/W2953222828","https://openalex.org/W2967953447","https://openalex.org/W4245437819","https://openalex.org/W4254767602","https://openalex.org/W4367485470"],"related_works":["https://openalex.org/W2085973610","https://openalex.org/W2124563076","https://openalex.org/W2414843281","https://openalex.org/W2172074189","https://openalex.org/W2085439006","https://openalex.org/W2096579179","https://openalex.org/W2414667296","https://openalex.org/W2074428237","https://openalex.org/W2075286333","https://openalex.org/W3042986937"],"abstract_inverted_index":{"While":[0],"there":[1],"are":[2,15,139,160],"a":[3,39,56,90,134,153,223],"variety":[4],"of":[5,29,59,64,92,126,141,146,190,229],"therapeutics":[6],"that":[7,211],"interact":[8,51,110,179],"with":[9,38,67],"the":[10,30,75,97,120,124,142,156,161,169,191,199,227],"opioid":[11,31,53,68,76,88,112,186,205,230],"receptor":[12,32,206],"system,":[13],"they":[14],"not":[16,202],"without":[17],"side":[18,41],"effects;":[19],"including":[20,123],"constipation,":[21],"dysphoria":[22],"and":[23,99,104,129,196],"respiratory":[24],"depression.":[25],"A":[26,61,85,171,213],"better":[27,62],"understanding":[28,63],"system":[33],"may":[34],"yield":[35,71],"therapeutic":[36],"agents":[37],"limited":[40],"effect":[42],"profile.":[43],"The":[44,137],"neoclerodane":[45,154],"diterpene,":[46],"salvinorin":[47,84,170,212],"A,":[48],"appears":[49],"to":[50,80,109,118,151,163,178],"at":[52,87,96,111,185],"receptors":[54,69,187],"through":[55],"unique":[57],"mode":[58],"action.":[60],"its":[65,220],"interactions":[66],"will":[70],"valuable":[72],"information":[73],"about":[74],"system.":[77],"In":[78],"order":[79],"probe":[81],"further":[82],"how":[83],"interacts":[86],"receptors,":[89],"series":[91],"novel":[93,224],"analogues":[94,159,175,193],"modified":[95],"C-2":[98,173],"furan":[100,121,200],"ring":[101,158],"were":[102,116,176],"synthesized":[103],"evaluated":[105],"for":[106,204,216,226],"their":[107,182],"ability":[108],"receptors.":[113],"Synthetic":[114],"methods":[115],"identified":[117],"modulate":[119],"ring,":[122],"synthesis":[125],"Diels-Alder":[127,147],"cycloadducts":[128,138],"phenyl":[130,157],"rings":[131,166],"derived":[132],"from":[133],"reductive":[135],"elimination.":[136],"one":[140],"first":[143,162],"reported":[144],"examples":[145],"chemistry":[148],"being":[149],"applied":[150],"modify":[152],"while":[155,188],"have":[164],"aromatic":[165],"directly":[167],"off":[168],"core.":[172],"sulfonate":[174],"found":[177],"differently":[180],"then":[181],"ester":[183],"counterparts":[184],"several":[189],"cycloadduct":[192],"maintained":[194],"affinity":[195],"efficacy":[197],"demonstrating":[198],"is":[201,214],"required":[203],"activity.":[207],"These":[208],"findings":[209],"demonstrate":[210],"amenable":[215],"chemical":[217],"modification,":[218],"illustrating":[219],"potential":[221],"as":[222],"scaffold":[225],"development":[228],"ligands.":[231]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
