{"id":"https://openalex.org/W4281999294","doi":"https://doi.org/10.1038/s41467-022-30673-1","title":"Structural basis for broad anti-phage immunity by DISARM","display_name":"Structural basis for broad anti-phage immunity by DISARM","publication_year":2022,"publication_date":"2022-05-27","ids":{"openalex":"https://openalex.org/W4281999294","doi":"https://doi.org/10.1038/s41467-022-30673-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/35624106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142583"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-30673-1","doi":"https://doi.org/10.1038/s41467-022-30673-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-30673-1","pdf_url":"https://www.nature.com/articles/s41467-022-30673-1.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-30673-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033740376","display_name":"Jack P. K. Bravo","orcid":"https://orcid.org/0000-0003-0456-0753","observed_orcids":["https://orcid.org/0000-0003-0456-0753"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack P. K. Bravo","raw_affiliation_strings":["Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040276796","display_name":"Cristian Aparicio-Maldonado","orcid":"https://orcid.org/0000-0003-1247-8661","observed_orcids":["https://orcid.org/0000-0003-1247-8661"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Cristian Aparicio-Maldonado","raw_affiliation_strings":["Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands","Kavli Institute of Nanoscience, Delft, The Netherlands","School of Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Kavli Institute of Nanoscience, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"School of Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012680193","display_name":"Franklin L. N\u00f3brega","orcid":"https://orcid.org/0000-0002-8238-1083","observed_orcids":["https://orcid.org/0000-0002-8238-1083"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Franklin L. Nobrega","raw_affiliation_strings":["School of Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051219873","display_name":"Stan J. J. Brouns","orcid":"https://orcid.org/0000-0002-9573-1724","observed_orcids":["https://orcid.org/0000-0002-9573-1724"]},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Stan J. J. Brouns","raw_affiliation_strings":["Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands. stanbrouns@gmail.com","Kavli Institute of Nanoscience, Delft, The Netherlands. stanbrouns@gmail.com","Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9573-1724","affiliations":[{"raw_affiliation_string":"Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands. stanbrouns@gmail.com","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Kavli Institute of Nanoscience, Delft, The Netherlands. stanbrouns@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029542971","display_name":"David Ward Taylor","orcid":"https://orcid.org/0000-0002-6198-1194","observed_orcids":["https://orcid.org/0000-0002-6198-1194","https://orcid.org/0000-0003-3433-7595","https://orcid.org/0009-0003-5482-5446"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W. Taylor","raw_affiliation_strings":["Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX, 78712, USA. dtaylor@utexas.edu","Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA. dtaylor@utexas.edu","Interdisciplinary Life Sciences Graduate Programs, University of Texas at Austin, Austin, TX, 78712, USA. dtaylor@utexas.edu","LIVESTRONG Cancer Institutes, Dell Medical School, Austin, TX, 78712, USA. dtaylor@utexas.edu","Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA"],"raw_orcid":"https://orcid.org/0000-0002-6198-1194","affiliations":[{"raw_affiliation_string":"Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX, 78712, USA. dtaylor@utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA. dtaylor@utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Interdisciplinary Life Sciences Graduate Programs, University of Texas at Austin, Austin, TX, 78712, USA. dtaylor@utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"LIVESTRONG Cancer Institutes, Dell Medical School, Austin, TX, 78712, USA. dtaylor@utexas.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029542971","https://openalex.org/A5051219873"],"corresponding_institution_ids":["https://openalex.org/I86519309","https://openalex.org/I98358874"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":2.155,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.89593102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"2987","last_page":"2987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/restriction-modification-systems","display_name":"restriction-modification systems","score":0.8539999723434448},{"id":"https://openalex.org/keywords/phage-immunity","display_name":"phage immunity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/trigger-loop","display_name":"trigger loop","score":0.7260000109672546},{"id":"https://openalex.org/keywords/autoinhibition","display_name":"autoinhibition","score":0.972000002861023},{"id":"https://openalex.org/keywords/structural-reorganization","display_name":"structural rearrangement","score":0.5879999995231628},{"id":"https://openalex.org/keywords/anti-phage-defense","display_name":"anti-phage defense","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6058960556983948},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5344573259353638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5245411992073059},{"id":"https://openalex.org/C2989419327","wikidata":"https://www.wikidata.org/wiki/Q322348","display_name":"Arms race","level":2,"score":0.4678327143192291},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.4450819790363312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35160475969314575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3323330581188202},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15625059604644775},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.10163772106170654},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C6303427","wikidata":"https://www.wikidata.org/wiki/Q47398","display_name":"Economic history","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015280","descriptor_name":"DNA Restriction-Modification Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41467-022-30673-1","doi":"https://doi.org/10.1038/s41467-022-30673-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-30673-1","pdf_url":"https://www.nature.com/articles/s41467-022-30673-1.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2021.12.26.474123","doi":"https://doi.org/10.1101/2021.12.26.474123","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.12.26.474123","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/12/27/2021.12.26.474123.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9142583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142583","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:35624106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35624106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:456379","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1101/2021.12.26.474123>).","pdf_url":"https://eprints.soton.ac.uk/456379/2/s41467_022_30673_1.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30673-1","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-30673-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:dced8bd6877849529f57e7386dedd6cf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dced8bd6877849529f57e7386dedd6cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)","raw_type":"article"},{"id":"pmh:oai:tudelft.nl:uuid:26a616c8-2039-48f5-aa8e-84725972db38","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:26a616c8-2039-48f5-aa8e-84725972db38","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:tud:oai:tudelft.nl:uuid:26a616c8-2039-48f5-aa8e-84725972db38","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:26a616c8-2039-48f5-aa8e-84725972db38","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 13(1)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-30673-1","doi":"https://doi.org/10.1038/s41467-022-30673-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-30673-1","pdf_url":"https://www.nature.com/articles/s41467-022-30673-1.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1449763142","display_name":null,"funder_award_id":"W911NF\u201019\u20101\u20100021","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G2279853913","display_name":null,"funder_award_id":"W911NF-19-1","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G2661318238","display_name":null,"funder_award_id":"101003229","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3024053924","display_name":null,"funder_award_id":"RR160088","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G3038985174","display_name":"Uncovering the molecular basis of Cas4-mediated CRISPR memory formation","funder_award_id":"VI.C.182.027","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5610185537","display_name":null,"funder_award_id":"R35GM138348","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7134325564","display_name":"Imaging macromolecular machines in gene regulation","funder_award_id":"R35GM138348","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7327799275","display_name":"Recruitment of First-Time, Tenure-Track Faculty Members","funder_award_id":"RR160088","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7334195024","display_name":null,"funder_award_id":"RR160088","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G8415477955","display_name":null,"funder_award_id":"W911NF-19","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G8872807966","display_name":null,"funder_award_id":"W911NF-19-1-0021","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281999294.pdf","grobid_xml":"https://content.openalex.org/works/W4281999294.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1577451703","https://openalex.org/W1998566510","https://openalex.org/W2019197162","https://openalex.org/W2024963213","https://openalex.org/W2027603822","https://openalex.org/W2037978116","https://openalex.org/W2038524374","https://openalex.org/W2046298637","https://openalex.org/W2062015078","https://openalex.org/W2065104453","https://openalex.org/W2072730564","https://openalex.org/W2109830330","https://openalex.org/W2118022632","https://openalex.org/W2123781955","https://openalex.org/W2131730777","https://openalex.org/W2132440004","https://openalex.org/W2140585409","https://openalex.org/W2142161929","https://openalex.org/W2155703790","https://openalex.org/W2169708194","https://openalex.org/W2171434257","https://openalex.org/W2290514713","https://openalex.org/W2340376277","https://openalex.org/W2376573086","https://openalex.org/W2515497383","https://openalex.org/W2515821078","https://openalex.org/W2561155035","https://openalex.org/W2587625522","https://openalex.org/W2728385286","https://openalex.org/W2766750388","https://openalex.org/W2774541277","https://openalex.org/W2781865485","https://openalex.org/W2784532673","https://openalex.org/W2786390877","https://openalex.org/W2789098577","https://openalex.org/W2790114318","https://openalex.org/W2792803089","https://openalex.org/W2801376357","https://openalex.org/W2897254003","https://openalex.org/W2899714098","https://openalex.org/W2904490504","https://openalex.org/W2924349878","https://openalex.org/W2950424426","https://openalex.org/W2953798760","https://openalex.org/W2977933365","https://openalex.org/W2982635835","https://openalex.org/W2990631972","https://openalex.org/W2997234557","https://openalex.org/W2997287640","https://openalex.org/W2999639869","https://openalex.org/W3003287532","https://openalex.org/W3007039579","https://openalex.org/W3013683123","https://openalex.org/W3030046774","https://openalex.org/W3083406432","https://openalex.org/W3108495343","https://openalex.org/W3111285977","https://openalex.org/W3119327522","https://openalex.org/W3177828909","https://openalex.org/W3183755809","https://openalex.org/W3197208223","https://openalex.org/W3201894557","https://openalex.org/W4212924548","https://openalex.org/W4214881544","https://openalex.org/W4229051450","https://openalex.org/W4246901968"],"related_works":["https://openalex.org/W4212924548","https://openalex.org/W2766750388","https://openalex.org/W7124443156","https://openalex.org/W4391610347","https://openalex.org/W4414252107","https://openalex.org/W4396799042","https://openalex.org/W7161170781","https://openalex.org/W4319728686","https://openalex.org/W4403127929","https://openalex.org/W4408498580"],"abstract_inverted_index":{"In":[0],"the":[1,18,38,57,99,120],"evolutionary":[2],"arms":[3],"race":[4],"against":[5,32],"phage,":[6,37],"bacteria":[7],"have":[8],"assembled":[9],"a":[10,33,83,95,102],"diverse":[11],"arsenal":[12],"of":[13,36,56,122,129],"antiviral":[14,44,132],"immune":[15],"strategies.":[16],"While":[17],"recently":[19],"discovered":[20],"DISARM":[21,59],"(Defense":[22],"Island":[23],"System":[24],"Associated":[25],"with":[26,67,110],"Restriction-Modification)":[27],"systems":[28],"can":[29],"provide":[30],"protection":[31],"wide":[34],"range":[35],"molecular":[39],"mechanisms":[40],"that":[41,76],"underpin":[42],"broad":[43],"targeting":[45],"but":[46],"avoiding":[47],"autoimmunity":[48],"remain":[49],"enigmatic.":[50],"Here,":[51],"we":[52],"report":[53],"cryo-EM":[54],"structures":[55,74],"core":[58,78],"complex,":[60],"DrmAB,":[61],"both":[62],"alone":[63],"and":[64,89,126],"in":[65,112],"complex":[66,79],"an":[68],"unmethylated":[69],"phage":[70,123],"DNA":[71,92,124],"mimetic.":[72],"These":[73],"reveal":[75],"DrmAB":[77,107],"is":[80],"autoinhibited":[81],"by":[82],"trigger":[84],"loop":[85],"(TL)":[86],"within":[87],"DrmA":[88],"binding":[90],"to":[91],"substrates":[93],"containing":[94],"5'":[96],"overhang":[97],"dislodges":[98],"TL,":[100],"initiating":[101],"long-range":[103],"structural":[104],"rearrangement":[105],"for":[106],"activation.":[108],"Together":[109],"structure-guided":[111],"vivo":[113],"studies,":[114],"our":[115],"work":[116],"provides":[117],"insights":[118],"into":[119],"mechanism":[121],"recognition":[125],"specific":[127],"activation":[128],"this":[130],"widespread":[131],"defense":[133],"system.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":8},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-06-13T00:00:00"}