{"id":"https://openalex.org/W4281998700","doi":"https://doi.org/10.1016/j.bmcl.2022.128842","title":"WCK 4034: A promising oxazolidinone for treating gram positive infections","display_name":"WCK 4034: A promising oxazolidinone for treating gram positive infections","publication_year":2022,"publication_date":"2022-06-06","ids":{"openalex":"https://openalex.org/W4281998700","doi":"https://doi.org/10.1016/j.bmcl.2022.128842","pmid":"https://pubmed.ncbi.nlm.nih.gov/35680102"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2022.128842","doi":"https://doi.org/10.1016/j.bmcl.2022.128842","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2022.128842","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083382080","display_name":"S. B. BHAWSAR","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Satish Bhawsar","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India. Electronic address: sbhavsar@wockhardt.com","Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India. Electronic address: sbhavsar@wockhardt.com","institution_ids":["https://openalex.org/I4210102159"]},{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108265650","display_name":"Shivaji H. Pawar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivaji Pawar","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085956209","display_name":"Prasad K. Deshpande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasad Deshpande","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031990327","display_name":"Ravindra D Yeole","orcid":"https://orcid.org/0000-0003-4812-4259","observed_orcids":["https://orcid.org/0000-0003-4812-4259"]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravindra Yeole","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089607480","display_name":"Rajesh P. Chavan","orcid":"https://orcid.org/0000-0001-5611-5251","observed_orcids":["https://orcid.org/0000-0001-5611-5251"]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Chavan","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040604961","display_name":"Manohar Nandanwar","orcid":"https://orcid.org/0000-0003-2861-1404","observed_orcids":["https://orcid.org/0000-0003-2861-1404"]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manohar Nandanwar","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075153426","display_name":"Sachin Bhagwat","orcid":"https://orcid.org/0000-0001-5943-5031","observed_orcids":["https://orcid.org/0000-0001-5943-5031"]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sachin Bhagwat","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101470071","display_name":"Mahesh V. Patel","orcid":"https://orcid.org/0000-0002-5128-4061","observed_orcids":["https://orcid.org/0000-0002-5128-4061"]},"institutions":[{"id":"https://openalex.org/I4210102159","display_name":"Wockhardt (India)","ror":"https://ror.org/01djxaj77","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210102159"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahesh Patel","raw_affiliation_strings":["Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wockhardt Research Center, D-4, MIDC, Chikalthana, Aurangabad, MS 431006, India","institution_ids":["https://openalex.org/I4210102159"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083382080"],"corresponding_institution_ids":["https://openalex.org/I4210102159"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.8316,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6210273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"71","issue":null,"first_page":"128842","last_page":"128842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxazolidinones","display_name":"oxazolidinones","score":0.8899999856948853},{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gram-positive-bacterial-infections","display_name":"Gram-positive bacterial infections","score":0.8920000195503235},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9549999833106995},{"id":"https://openalex.org/keywords/methicillin-susceptible-staphylococcus-aureus","display_name":"methicillin-susceptible Staphylococcus aureus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9909999966621399},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5559999942779541},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9139999747276306},{"id":"https://openalex.org/keywords/new-chemical-entities","display_name":"new chemical entities","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.8806836605072021},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5230068564414978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.420119047164917},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4127333462238312},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38196223974227905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3483548164367676},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.33236604928970337},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.23272472620010376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10976195335388184},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08680883049964905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069349","descriptor_name":"Linezolid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069349","descriptor_name":"Linezolid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2022.128842","doi":"https://doi.org/10.1016/j.bmcl.2022.128842","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2022.128842","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:35680102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35680102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1925363657","https://openalex.org/W1966707118","https://openalex.org/W1981826703","https://openalex.org/W2003760989","https://openalex.org/W2023957234","https://openalex.org/W2053522748","https://openalex.org/W2065917614","https://openalex.org/W2082548930","https://openalex.org/W2092973221","https://openalex.org/W2100360020","https://openalex.org/W2109065373","https://openalex.org/W2123363688","https://openalex.org/W2128015417","https://openalex.org/W2130253433","https://openalex.org/W2133043345","https://openalex.org/W2138445568","https://openalex.org/W2148488439","https://openalex.org/W2154068656","https://openalex.org/W2168635615","https://openalex.org/W4230708463"],"related_works":["https://openalex.org/W1541725315","https://openalex.org/W4211144518","https://openalex.org/W2053522748","https://openalex.org/W4237564155","https://openalex.org/W2400601374","https://openalex.org/W4244000927","https://openalex.org/W1994437830","https://openalex.org/W2146532982","https://openalex.org/W2320285551","https://openalex.org/W2098332335"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-06-13T00:00:00"}