{"id":"https://openalex.org/W4281972309","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9560","title":"Safety and efficacy of combined melphalan percutaneous hepatic perfusion (M-PHP) and ipilimumab plus nivolumab (IPI+NIVO) in metastasized uveal melanoma (mUM): First results of the phase Ib part of the CHOPIN trial.","display_name":"Safety and efficacy of combined melphalan percutaneous hepatic perfusion (M-PHP) and ipilimumab plus nivolumab (IPI+NIVO) in metastasized uveal melanoma (mUM): First results of the phase Ib part of the CHOPIN trial.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281972309","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9560"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.9560","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9560","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.9560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036884421","display_name":"Tha\u00efs M. L. Tong","orcid":"https://orcid.org/0000-0002-7381-6858","observed_orcids":["https://orcid.org/0000-0002-7381-6858"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tha\u00efs M.L. Tong","raw_affiliation_strings":["Leiden University Medical Center, Department of Medical Oncology/Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Medical Oncology/Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000763487","display_name":"Mark Christiaan Burgmans","orcid":"https://orcid.org/0000-0001-5258-291X","observed_orcids":["https://orcid.org/0000-0001-5258-291X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark C. Burgmans","raw_affiliation_strings":["Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067669644","display_name":"Frank M. Speetjens","orcid":"https://orcid.org/0000-0003-2065-9593","observed_orcids":["https://orcid.org/0000-0003-2065-9593"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank M. Speetjens","raw_affiliation_strings":["Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022435760","display_name":"Arian R. van Erkel","orcid":"https://orcid.org/0000-0002-0298-2015","observed_orcids":["https://orcid.org/0000-0002-0298-2015"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arian R. van Erkel","raw_affiliation_strings":["Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059214458","display_name":"Rutger W. van der Meer","orcid":"https://orcid.org/0000-0001-7831-6986","observed_orcids":["https://orcid.org/0000-0001-7831-6986"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rutger W. van der Meer","raw_affiliation_strings":["Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110780670","display_name":"Carla S. P. van Rijswijk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Carla S.P. van Rijswijk","raw_affiliation_strings":["Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064422052","display_name":"Mare A. Jonker","orcid":"https://orcid.org/0009-0004-9053-5945","observed_orcids":["https://orcid.org/0009-0004-9053-5945"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mare A. Jonker","raw_affiliation_strings":["Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041980286","display_name":"Inge C.F.M. Roozen","orcid":"https://orcid.org/0009-0006-1352-5684","observed_orcids":["https://orcid.org/0009-0006-1352-5684"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Inge C.F.M. Roozen","raw_affiliation_strings":["Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055751563","display_name":"Jacob Lutjeboer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jacob Lutjeboer","raw_affiliation_strings":["Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110234932","display_name":"Els L. van Persijn van Meerten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Els L. van Persijn-van Meerten","raw_affiliation_strings":["Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Radiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103430283","display_name":"Christian H. Martini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christian H. Martini","raw_affiliation_strings":["Leiden University Medical Center, Department of Anesthesiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Anesthesiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111720359","display_name":"Remco W. M. Zoethout","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Remco W.M. Zoethout","raw_affiliation_strings":["Leiden University Medical Center, Department of Anesthesiology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Anesthesiology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025372183","display_name":"Fred G. J. Tijl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Fred G.J. Tijl","raw_affiliation_strings":["Leiden University Medical Center, Department of Extra Corporal Circulation, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Extra Corporal Circulation, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088390068","display_name":"Christian U. Blank","orcid":"https://orcid.org/0000-0002-7945-5846","observed_orcids":["https://orcid.org/0000-0002-7945-5846"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christian U. Blank","raw_affiliation_strings":["Netherlands Cancer Institute, Amsterdam, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Cancer Institute, Amsterdam, Netherlands;","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031300611","display_name":"Ellen Kapiteijn","orcid":"https://orcid.org/0000-0002-4814-6426","observed_orcids":["https://orcid.org/0000-0002-4814-6426"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ellen Kapiteijn","raw_affiliation_strings":["Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Department of Medical Oncology, Leiden, Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"9560","last_page":"9560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-uveal-melanoma","display_name":"metastatic uveal melanoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9779999852180481},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9160000085830688},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/phase-ib","display_name":"phase Ib","score":0.3869999945163727},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.42500001192092896},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7390000224113464},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8240000009536743},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7979999780654907},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.3709999918937683},{"id":"https://openalex.org/keywords/extrahepatic-disease","display_name":"extrahepatic disease","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.935312807559967},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.6971483826637268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.649559497833252},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6477346420288086},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.6315345764160156},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5392434000968933},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.4392446279525757},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4144539535045624},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4119323790073395},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3960547149181366},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3833114504814148},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.33833372592926025},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3230782747268677},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2858913540840149},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.18524736166000366},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.08946684002876282},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08368578553199768}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.9560","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.9560","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.9560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313837504","https://openalex.org/W3172592056","https://openalex.org/W7005169167","https://openalex.org/W4226128950","https://openalex.org/W7133218735","https://openalex.org/W4379281425","https://openalex.org/W4416391795","https://openalex.org/W4400228063","https://openalex.org/W4400272337","https://openalex.org/W4401257353"],"abstract_inverted_index":{"9560":[0],"Background:":[1],"Uveal":[2],"melanoma":[3],"(UM)":[4],"is":[5,30,47,297,311,343],"the":[6,25,54,92,96,105,111,149,294],"most":[7,83],"frequent":[8],"intraocular":[9],"malignant":[10],"tumor":[11],"in":[12,24,75,219,222,226,229,250],"adults.":[13],"Approximately":[14],"50%":[15],"of":[16,56,98,110,115,133,169,233,277,284,316],"all":[17,251,301],"patients":[18],"(pts)":[19],"will":[20],"develop":[21],"metastatic":[22],"disease":[23,61,88,269],"liver.":[26],"Until":[27],"now,":[28],"there":[29],"no":[31,207],"systemic":[32],"therapy":[33],"that":[34,79],"has":[35,65,89],"been":[36,66,332],"shown":[37,67],"to":[38,68,71,91,157,181],"improve":[39],"overall":[40,177],"survival":[41,185],"(OS),":[42],"apart":[43],"from":[44,151],"tebentafusp.":[45],"M-PHP":[46,99,308,340],"frequently":[48],"applied":[49],"for":[50,271],"liver-only":[51],"UM.":[52],"However,":[53],"majority":[55],"pts":[57,119,191,221,228,252,288,302],"eventually":[58],"develops":[59],"extrahepatic":[60,86],"after":[62],"M-PHP.":[63,172],"IPI+NIVO":[64,146,154,170,310],"induce":[69],"up":[70],"20%":[72],"response":[73,178,274],"rates":[74],"mUM.":[76],"Our":[77],"observations":[78],"checkpoint":[80],"inhibition":[81],"was":[82,167,259],"effective":[84],"on":[85],"UM":[87],"led":[90],"CHOPIN":[93],"trial":[94,347],"testing":[95],"combination":[97],"and":[100,107,125,187,225,243,256,266,300,320,324,329],"IPI+NIVO.":[101],"Here":[102],"we":[103],"present":[104],"safety":[106,168],"efficacy":[108],"data":[109],"phase":[112,336],"1b":[113],"part":[114,338],"CHOPIN.":[116],"Methods:":[117],"Adult":[118],"with":[120,143,206,309],"confirmed":[121],"measurable":[122],"hepatic":[123],"mUM":[124],"WHO":[126],"PS":[127],"0-1":[128],"were":[129,141,175,192,204,217],"included.":[130],"Two":[131],"courses":[132,145],"6":[134],"weekly":[135],"M-PHPs":[136],"(melphalan":[137],"3mg/kg,":[138],"max":[139],"220mg)":[140],"combined":[142],"four":[144],"three-weekly":[147],"escalating":[148],"dosing":[150,315],"1mg/kg":[152,159],"each":[153],"(cohort":[155,163],"1)":[156],"IPI":[158,317],"+":[160],"NIVO":[161,321],"3mg/kg":[162],"2).":[164],"Primary":[165],"endpoint":[166],"plus":[171],"Secondary":[173],"endpoints":[174],"best":[176],"(BOR)":[179],"according":[180],"RECIST":[182],"1.1,":[183],"progression-free":[184],"(PFS),":[186],"OS.":[188],"Results:":[189],"7":[190],"included":[193],"(4":[194],"male,":[195],"median":[196,281,295],"age":[197],"63.6":[198],"years":[199],"(range":[200],"50-74)).":[201],"Both":[202],"cohorts":[203],"tolerated":[205],"dose-limiting":[208],"toxicities":[209],"or":[210],"deaths.":[211],"Grade":[212,245],"III/IV":[213],"adverse":[214],"events":[215],"(AE)":[216],"observed":[218],"2/3":[220],"cohort":[223,230],"1":[224,260,267,318],"3/4":[227],"2":[231],"consisting":[232],"SIRS,":[234],"febrile":[235],"neutropenia,":[236,238],"cholecystitis,":[237],"thrombopenia,":[239],"leukopenia,":[240],"increased":[241],"transaminases":[242],"fever.":[244],"I/II":[246],"immune-related":[247],"AEs":[248],"occurred":[249],"(myositis,":[253],"hypothyroidism,":[254],"hepatitis":[255],"dermatitis).":[257],"BOR":[258],"complete":[261],"response,":[262],"5":[263],"partial":[264],"responses":[265],"stable":[268],"accounting":[270],"an":[272,290],"objective":[273],"rate":[275],"(ORR)":[276],"85.7%.":[278],"At":[279],"a":[280,314],"FU":[282],"time":[283],"20.2":[285],"months,":[286,299],"4":[287],"have":[289,331],"ongoing":[291],"response.":[292],"Currently":[293],"PFS":[296,328],"22.4":[298],"are":[303],"still":[304],"alive.":[305],"Conclusions:":[306],"Combining":[307],"safe":[312],"at":[313],"mg/kg":[319,323],"3":[322],"very":[325],"promising":[326],"ORR,":[327],"OS":[330],"observed.":[333],"The":[334],"randomized":[335],"II":[337],"comparing":[339],"versus":[341],"M-PHP+IPI+NIVO":[342],"currently":[344],"recruiting.":[345],"Clinical":[346],"information:":[348],"NCT04283890.":[349]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-06-13T00:00:00"}