{"id":"https://openalex.org/W4281963268","doi":"https://doi.org/10.1111/xen.12748","title":"Pig\u2010to\u2010human kidney transplantation using brain\u2010dead donors as recipients: One giant leap, or only one small step for transplantkind?","display_name":"Pig\u2010to\u2010human kidney transplantation using brain\u2010dead donors as recipients: One giant leap, or only one small step for transplantkind?","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4281963268","doi":"https://doi.org/10.1111/xen.12748","pmid":"https://pubmed.ncbi.nlm.nih.gov/35616243"},"language":"en","primary_location":{"id":"doi:10.1111/xen.12748","doi":"https://doi.org/10.1111/xen.12748","is_oa":false,"landing_page_url":"https://doi.org/10.1111/xen.12748","pdf_url":null,"source":{"id":"https://openalex.org/S102890116","display_name":"Xenotransplantation","issn_l":"0908-665X","issn":["0908-665X","1399-3089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenotransplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040128706","display_name":"Yoshikazu Ganchiku","orcid":"https://orcid.org/0000-0001-7122-3066","observed_orcids":["https://orcid.org/0000-0001-7122-3066"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshikazu Ganchiku","raw_affiliation_strings":["Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-7122-3066","affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonardo V. Riella","raw_affiliation_strings":["Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083826351"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":2.3865,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.88588912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"29","issue":"3","first_page":"e12748","last_page":"e12748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-dead-donors","display_name":"brain-dead donors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/genetically-modified-pigs","display_name":"genetically modified pigs","score":0.8009999990463257},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/anti-cd154-antibody","display_name":"anti-CD154 antibody","score":0.800000011920929},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.843999981880188},{"id":"https://openalex.org/keywords/hyperacute-rejection","display_name":"hyperacute rejection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/infection-screening","display_name":"infection screening","score":0.6079999804496765},{"id":"https://openalex.org/keywords/crossmatching","display_name":"crossmatch","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.9666393399238586},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6354855298995972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6295048594474792},{"id":"https://openalex.org/C3019123509","wikidata":"https://www.wikidata.org/wiki/Q223867","display_name":"Brain dead","level":3,"score":0.6282027363777161},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5440674424171448},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.508868932723999},{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.4703754782676697},{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.46653062105178833},{"id":"https://openalex.org/C168444539","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Organ transplantation","level":3,"score":0.4495181739330292},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38692766427993774},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3270450234413147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2613489627838135},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24440404772758484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2336162030696869},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.0},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/xen.12748","doi":"https://doi.org/10.1111/xen.12748","is_oa":false,"landing_page_url":"https://doi.org/10.1111/xen.12748","pdf_url":null,"source":{"id":"https://openalex.org/S102890116","display_name":"Xenotransplantation","issn_l":"0908-665X","issn":["0908-665X","1399-3089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenotransplantation","raw_type":"journal-article"},{"id":"pmid:35616243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35616243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenotransplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1583259015","https://openalex.org/W1614547515","https://openalex.org/W1928404074","https://openalex.org/W1954897628","https://openalex.org/W1967414895","https://openalex.org/W1973690651","https://openalex.org/W1986094205","https://openalex.org/W1999177992","https://openalex.org/W2007129229","https://openalex.org/W2018180123","https://openalex.org/W2025551444","https://openalex.org/W2065544328","https://openalex.org/W2068128688","https://openalex.org/W2101043709","https://openalex.org/W2111185199","https://openalex.org/W2114481570","https://openalex.org/W2123965522","https://openalex.org/W2139871983","https://openalex.org/W2158101922","https://openalex.org/W2229998871","https://openalex.org/W2280972418","https://openalex.org/W2315479515","https://openalex.org/W2463822650","https://openalex.org/W2561512876","https://openalex.org/W2575274634","https://openalex.org/W2582530596","https://openalex.org/W2595269307","https://openalex.org/W2605573058","https://openalex.org/W2626888907","https://openalex.org/W2742842976","https://openalex.org/W2765202415","https://openalex.org/W2790232662","https://openalex.org/W2883354828","https://openalex.org/W2913693308","https://openalex.org/W2919104334","https://openalex.org/W2937299144","https://openalex.org/W2962301569","https://openalex.org/W2977120752","https://openalex.org/W3003099222","https://openalex.org/W3031584103","https://openalex.org/W3036731060","https://openalex.org/W3137223939","https://openalex.org/W3154851394","https://openalex.org/W3155752048","https://openalex.org/W3173254299","https://openalex.org/W3185973121","https://openalex.org/W3194824823","https://openalex.org/W3199712082","https://openalex.org/W3213710953","https://openalex.org/W4205658126","https://openalex.org/W4211216709","https://openalex.org/W4214755348"],"related_works":["https://openalex.org/W4403514768","https://openalex.org/W4402741204","https://openalex.org/W4399388890","https://openalex.org/W4387301744","https://openalex.org/W4416177454","https://openalex.org/W2790239358","https://openalex.org/W3213710953","https://openalex.org/W4404732571","https://openalex.org/W4280550957","https://openalex.org/W3096477267"],"abstract_inverted_index":{"Pig":[0],"kidney":[1,79,93,179],"xenotransplantation":[2,50,94,145],"is":[3],"increasingly":[4],"regarded":[5],"as":[6,86],"a":[7,53,63],"realistic":[8],"solution":[9],"to":[10,117,121,143,146,207],"the":[11,25,37,40,49,72,107,114,122,125,131,147,155,176,209,212],"current":[12],"shortage":[13],"of":[14,27,103,124,158,172,178,192,196],"human":[15,151],"organ":[16,22],"donors":[17],"for":[18,48],"patients":[19],"with":[20,170],"end-stage":[21],"failure.":[23],"Recently,":[24],"news":[26],"three":[28],"pig-to-human":[29,92],"transplantation":[30],"cases":[31],"has":[32],"awakened":[33],"public":[34],"interest.":[35],"Notably,":[36],"case":[38],"by":[39],"Alabama":[41],"team":[42],"reported":[43],"detailed":[44],"and":[45,81,88,113,165,182],"important":[46],"findings":[47],"field.":[51],"Using":[52],"genetically":[54],"modified":[55],"pig,":[56],"two":[57],"porcine":[58],"kidneys":[59],"were":[60],"transplanted":[61],"into":[62],"brain-dead":[64,150],"recipient.":[65,126],"They":[66],"applied":[67],"several":[68],"approaches":[69],"established":[70],"in":[71,134,161,168,186,211],"preclinical":[73],"NHP":[74],"study,":[75],"including":[76,201],"gene-edited":[77,159],"pig":[78],"graft":[80],"preoperative":[82],"laboratory":[83],"inspection":[84],"such":[85],"crossmatching":[87],"infection":[89,181],"screening.":[90],"The":[91,190],"had":[95,116],"no":[96],"unexpected":[97],"events":[98],"during":[99],"surgery":[100],"or":[101],"evidence":[102],"hyperacute":[104],"rejection.":[105,189],"Unfortunately,":[106],"grafts":[108],"did":[109],"not":[110],"work":[111],"appropriately,":[112],"study":[115,129],"be":[118,205],"terminated":[119],"due":[120],"decompensation":[123],"While":[127,149],"this":[128,135],"demonstrated":[130],"outstanding":[132],"achievement":[133],"research":[136],"area,":[137],"it":[138],"also":[139],"revealed":[140],"remaining":[141],"gaps":[142],"move":[144],"clinic.":[148],"recipients":[152],"could":[153],"reinforce":[154],"compatibility":[156],"achievements":[157],"pigs":[160],"NHP,":[162],"their":[163],"pro-inflammatory":[164],"pro-coagulant":[166],"environment,":[167],"combination":[169],"short-duration":[171],"experiments":[173,200],"will":[174,204],"limit":[175],"assessment":[177],"function,":[180],"rejection":[183],"risk":[184],"post-transplant,":[185],"particular":[187],"antibody-mediated":[188],"use":[191],"successful":[193],"immunosuppressive":[194],"protocols":[195],"non-human":[197],"primates":[198],"xenotransplant":[199],"anti-CD154":[202],"antibody":[203],"critical":[206],"maximize":[208],"success":[210],"first":[213],"in-human":[214],"trials.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}