{"id":"https://openalex.org/W4281917062","doi":"https://doi.org/10.2337/db22-859-p","title":"859-P: Effects of Ertugliflozin on Uric Acid and Gout-Related Outcomes: Post Hoc Analyses from VERTIS CV","display_name":"859-P: Effects of Ertugliflozin on Uric Acid and Gout-Related Outcomes: Post Hoc Analyses from VERTIS CV","publication_year":2022,"publication_date":"2022-05-31","ids":{"openalex":"https://openalex.org/W4281917062","doi":"https://doi.org/10.2337/db22-859-p"},"language":"en","primary_location":{"id":"doi:10.2337/db22-859-p","doi":"https://doi.org/10.2337/db22-859-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-859-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061406786","display_name":"Vikas S. Sridhar","orcid":"https://orcid.org/0000-0001-7947-1822","observed_orcids":["https://orcid.org/0000-0001-7947-1822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VIKAS S. SRIDHAR","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070855397","display_name":"Francesco Cosentino","orcid":"https://orcid.org/0000-0002-6967-5685","observed_orcids":["https://orcid.org/0000-0002-6967-5685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FRANCESCO COSENTINO","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033587716","display_name":"Samuel E. Dagogo-Jack","orcid":"https://orcid.org/0000-0001-5318-9677","observed_orcids":["https://orcid.org/0000-0001-5318-9677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SAMUEL DAGOGO-JACK","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RICHARD E. PRATLEY","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051174907","display_name":"Robert C. Frederich","orcid":"https://orcid.org/0000-0002-5175-3112","observed_orcids":["https://orcid.org/0000-0002-5175-3112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ROBERT FREDERICH","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045506289","display_name":"Margaret Noyes Essex","orcid":"https://orcid.org/0000-0001-8168-9791","observed_orcids":["https://orcid.org/0000-0001-8168-9791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARGARET N. ESSEX","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113588010","display_name":"Mario Maldonado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARIO MALDONADO","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002978698","display_name":"CHIH-CHIN LIU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHIH-CHIN LIU","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112568961","display_name":"James P. Mancuso","orcid":"https://orcid.org/0000-0002-5722-1360","observed_orcids":["https://orcid.org/0000-0002-5722-1360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JAMES P. MANCUSO","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065752446","display_name":"DAVID CHERNEY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAVID CHERNEY","raw_affiliation_strings":["Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stockholm, Sweden, Memphis, TN, Orlando, FL, Collegeville, PA, New York, NY, London, United Kingdom, Kenilworth, NJ, Groton, CT, Toronto, ON, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1592,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43899949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"71","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ertugliflozin","display_name":"ertugliflozin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.9800000190734863},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8090000152587891},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.6909999847412109},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/sglt2-inhibitor-safety","display_name":"SGLT2 inhibitor safety","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.7828370332717896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6966887712478638},{"id":"https://openalex.org/C3017906399","wikidata":"https://www.wikidata.org/wiki/Q48973845","display_name":"Pooled analysis","level":3,"score":0.5238696932792664},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.48852336406707764},{"id":"https://openalex.org/C2992886853","wikidata":"https://www.wikidata.org/wiki/Q18381816","display_name":"Post hoc","level":2,"score":0.4734717905521393},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4221530854701996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41198620200157166},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.10848820209503174},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db22-859-p","doi":"https://doi.org/10.2337/db22-859-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-859-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402140134","https://openalex.org/W4397044465","https://openalex.org/W3159772021","https://openalex.org/W4281694200","https://openalex.org/W3159566593","https://openalex.org/W3135510359","https://openalex.org/W3015074668","https://openalex.org/W3199674324","https://openalex.org/W4214893005","https://openalex.org/W4286311985"],"abstract_inverted_index":{"The":[0,91,298],"effect":[1],"of":[2,49,54,98,315],"ertugliflozin":[3],"(ERTU)":[4],"on":[5],"serum":[6],"uric":[7],"acid":[8],"(SUA)":[9],"and":[10,22,47,75,82,122,160,176,302,323],"gout-related":[11,99,127],"outcomes":[12,100],"in":[13,45,63,79,120,126],"VERTIS":[14,299],"CV":[15,300],"(NCT01986881)":[16],"was":[17,101,114],"investigated.":[18],"Patients":[19],"with":[20,112,116,131],"T2D":[21],"ASCVD":[23],"were":[24,57,71,305],"randomized":[25],"to":[26],"ERTU":[27,81,113],"5":[28],"mg":[29,33],"(n=2752)":[30],",":[31,39,105,162],"15":[32],"(n=2747)":[34],"(doses":[35],"pooled":[36],"for":[37,95],"analyses)":[38],"placebo":[40],"(PBO;":[41],"n=2747)":[42],".":[43,90,110],"Changes":[44],"SUA":[46,64,121],"composite":[48,97],"gout":[50],"onset":[51],"or":[52],"initiation":[53],"anti-gout":[55],"medication":[56],"assessed.":[58],"LSM":[59],"changes":[60],"from":[61,118],"baseline":[62,119],"(mg/dL":[65],"[95%":[66],"CI])":[67],"at":[68],"week":[69],"260":[70],"\u22120.":[72],"(\u22120.25,":[73],"\u22120.13)":[74],"0.":[76],"(\u22120.02,":[77],"0.15)":[78],"the":[80,96],"PBO":[83],"groups,":[84],"respectively,":[85],"nominal":[86,106],"P<0.0":[87],"(Fig.":[88,108],"1)":[89],"HR":[92],"(95%":[93],"CI)":[94],"0.76":[102],"(0.580,":[103],"1.002)":[104],"P=0.052":[107],"2)":[109],"Treatment":[111],"associated":[115],"reductions":[117],"a":[123,313],"non-significant":[124],"reduction":[125],"outcome":[128],"events":[129],"compared":[130],"PBO.":[132],"Disclosure":[133],"V.S.Sridhar:":[134],"None.":[135],"D.Cherney:":[136],"Other":[137,225],"Relationship;":[138,226],"AbbVie":[139],"Inc.,":[140,187,217,222,232,240,245,251,259,269,284,293,319,325],"AstraZeneca,":[141,190,208],"Bayer":[142,209,227],"AG,":[143,210,228],"Boehringer":[144,170,191,211],"Ingelheim":[145,192,212],"International":[146,193,213],"GmbH,":[147,194,214],"Janssen":[148,215],"Research":[149,168],"&":[150,183,201,220,238,276,282,287,310,317],"Development,":[151],"LLC,":[152],"Lilly,":[153,198],"Maze,":[154],"BMS,":[155],"CSL-Behring,":[156],"Merck,":[157,172],"Otsuka,":[158],"Novartis":[159],"Novo-Nordisk":[161],"Mitsubishi":[163],"Tanabe":[164],"Pharma":[165,250],"Corporation,":[166],"Sanofi,":[167,174,248],"Support;":[169],"Ingelheim-Lilly,":[171],"Janssen,":[173],"AstraZeneca":[175],"Novo-Nordisk.":[177],"F.Cosentino:":[178],"Advisory":[179],"Panel;":[180],"Merck":[181,199,219,237,275,281,286,308,316],"Sharp":[182,200,309],"Dohme":[184,202,311],"Corp.,":[185,203,312],"Pfizer":[186,244,258,264,268,271,292,295,324],"Speaker's":[188],"Bureau;":[189],"Bristol-Myers":[195,261],"Squibb":[196,262],"Company,":[197,263],"Novo":[204,242],"Nordisk.":[205],"S.Dagogo-jack:":[206],"Consultant;":[207],"Pharmaceuticals,":[216],"Medtronic,":[218],"Co.,":[221,235,239,277,283,288,318],"Sanofi.":[223],"R.E.Pratley:":[224],"Corcept":[229],"Therapeutics,":[230],"Dexcom,":[231],"Hanmi":[233],"Pharm.":[234],"Ltd.,":[236],"Metavention,":[241],"Nordisk,":[243],"Poxel":[246],"SA,":[247],"Scohia":[249],"Sun":[252],"Pharmaceutical":[253],"Industries":[254],"Ltd.":[255],"R.Frederich:":[256],"Employee;":[257,267,274,280,291],"Stock/Shareholder;":[260,270,285,294],"Inc.":[265,272,278,289,296],"M.N.Essex:":[266],"M.Maldonado:":[273],"C.Liu:":[279],"J.P.Mancuso:":[290],"Funding":[297],"study":[301],"this":[303],"analysis":[304],"sponsored":[306],"by":[307],"subsidiary":[314],"Kenilworth,":[320],"NJ,":[321],"USA,":[322],"New":[326],"York,":[327],"NY,":[328],"USA.":[329]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-06-13T00:00:00"}