{"id":"https://openalex.org/W4281908013","doi":"https://doi.org/10.21203/rs.3.rs-1663438/v1","title":"Trends of hepatitis B notification rates in Guangzhou, China, from 2006 to 2020: An epidemiological study","display_name":"Trends of hepatitis B notification rates in Guangzhou, China, from 2006 to 2020: An epidemiological study","publication_year":2022,"publication_date":"2022-05-31","ids":{"openalex":"https://openalex.org/W4281908013","doi":"https://doi.org/10.21203/rs.3.rs-1663438/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1663438/v1","doi":"https://doi.org/10.21203/rs.3.rs-1663438/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1663438/v1","pdf_url":"https://www.researchsquare.com/article/rs-1663438/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1663438/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100431706","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0001-9439-5100","observed_orcids":["https://orcid.org/0000-0001-9439-5100"]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052578265","display_name":"Zhiqiang Dong","orcid":"https://orcid.org/0000-0002-7692-5128","observed_orcids":["https://orcid.org/0000-0002-7692-5128","https://orcid.org/0000-0002-4742-2679","https://orcid.org/0009-0007-3535-3008"]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Dong","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110135441","display_name":"Wensui Hu","orcid":"https://orcid.org/0000-0002-3704-3069","observed_orcids":["https://orcid.org/0000-0002-3704-3069"]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wensui Hu","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ke Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Li","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614994","display_name":"Lili Sun","orcid":"https://orcid.org/0000-0002-6376-7167","observed_orcids":["https://orcid.org/0000-0002-6376-7167"]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Sun","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianrong Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianrong Hou","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shijie Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Jia","raw_affiliation_strings":["Guangzhou Eighth People's Hospital Guangzhou Medical University","Guangzhou Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100390808","display_name":"Yuan Liu","orcid":"https://orcid.org/0000-0001-6227-024X","observed_orcids":["https://orcid.org/0000-0001-6227-024X"]},"institutions":[{"id":"https://openalex.org/I4210087969","display_name":"Guangzhou Center for Disease Control and Prevention","ror":"https://ror.org/007jnt575","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087969"]},{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Liu","raw_affiliation_strings":["Guangzhou Center for Disease Control and Prevention","Guangzhou Eighth People's Hospital Guangzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210087969"]},{"raw_affiliation_string":"Guangzhou Eighth People's Hospital Guangzhou Medical University","institution_ids":["https://openalex.org/I4210156462","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epidemiological-trends","display_name":"epidemiological trends","score":0.8429999947547913},{"id":"https://openalex.org/keywords/guangzhou","display_name":"Guangzhou","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.4970000088214874},{"id":"https://openalex.org/keywords/age-distribution","display_name":"age distribution","score":0.6209999918937683},{"id":"https://openalex.org/keywords/urban-rural-differences","display_name":"urban-rural differences","score":0.8389999866485596},{"id":"https://openalex.org/keywords/temporal-trends","display_name":"temporal trends","score":0.4410000145435333},{"id":"https://openalex.org/keywords/hepatitis-b-prevention-and-control","display_name":"hepatitis B prevention and control","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hepatitis-b-vaccination","display_name":"hepatitis B vaccination","score":0.3050000071525574},{"id":"https://openalex.org/keywords/average-annual-percentage-change","display_name":"average annual percentage change","score":0.8220000267028809},{"id":"https://openalex.org/keywords/rural-to-urban-migration","display_name":"rural-urban migration","score":0.4749999940395355},{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.34299999475479126},{"id":"https://openalex.org/keywords/hepatitis-d","display_name":"hepatitis D","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hepatitis-e","display_name":"hepatitis E","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hepatitis-f","display_name":"hepatitis F","score":0.5889999866485596},{"id":"https://openalex.org/keywords/hepatitis-g","display_name":"hepatitis G","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.7237911224365234},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6404228210449219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6265078783035278},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5937144160270691},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.5746096968650818},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.49736908078193665},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.4936021566390991},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4678880274295807},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.359209805727005},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.356319785118103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14640364050865173},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1663438/v1","doi":"https://doi.org/10.21203/rs.3.rs-1663438/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1663438/v1","pdf_url":"https://www.researchsquare.com/article/rs-1663438/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1663438/v1","doi":"https://doi.org/10.21203/rs.3.rs-1663438/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1663438/v1","pdf_url":"https://www.researchsquare.com/article/rs-1663438/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335480","display_name":"Guangzhou Municipal Science and Technology Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281908013.pdf","grobid_xml":"https://content.openalex.org/works/W4281908013.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1601582874","https://openalex.org/W2006501927","https://openalex.org/W2145118349","https://openalex.org/W2554615634","https://openalex.org/W2768609419","https://openalex.org/W2805847763","https://openalex.org/W2920998048","https://openalex.org/W2945706062","https://openalex.org/W2965062278","https://openalex.org/W2969549385","https://openalex.org/W2970872004","https://openalex.org/W2974194331"],"related_works":["https://openalex.org/W4311709806","https://openalex.org/W2361671318","https://openalex.org/W3213003455","https://openalex.org/W4399515650","https://openalex.org/W2069936989","https://openalex.org/W914595260","https://openalex.org/W2389909334","https://openalex.org/W2363732044","https://openalex.org/W2964020729","https://openalex.org/W2969549385"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Although":[2,291],"the":[3,13,22,36,45,54,69,83,111,116,170,211,251,278,292,314],"prevalence":[4],"of":[5,24,49,59,87,141,192,218,225,296],"hepatitis":[6,27,60,88,142,297,331],"B":[7,28,61,89,143,298,332],"in":[8,30,62,220,227,232,235,242,250,256,260,299,311,320,334],"Guangzhou,":[9],"China,":[10],"is":[11],"high,":[12],"epidemiological":[14,37],"trends":[15,113],"have":[16],"not":[17],"been":[18,318],"well-documented.":[19],"We":[20],"analysed":[21],"data":[23],"newly":[25],"reported":[26],"cases":[29,58,140],"Guangzhou":[31,63,300],"from":[32,64,68,159,178,215,254,288],"2006\u20132020,":[33],"to":[34,81,109,136,168,185,199,222,258,286,329],"explore":[35],"trend":[38,130,177,231,241,272],"and":[39,47,56,76,98,114,122,154,238,323],"provide":[40],"a":[41,156,174,203,216,223,270],"scientific":[42],"basis":[43],"for":[44,73,127,265,277,282],"prevention":[46],"development":[48],"control":[50,330],"measures.Methods:":[51],"Information":[52,71],"on":[53],"population":[55],"new":[57,139],"2006\u20132020":[65],"was":[66,79,107,152,245,301,307],"obtained":[67],"China":[70],"System":[72],"Disease":[74],"Control":[75],"Prevention,":[77],"which":[78],"used":[80,108],"calculate":[82,115],"annual":[84,118,123,149,190],"notification":[85,171,206,233,263,294,315],"rates":[86],"by":[90,274,304],"gender,":[91],"age":[92,267],"group":[93,279],"(0\u20139;":[94],"10\u201319;":[95],"20\u201359;":[96],"\u226560),":[97],"location":[99],"(urban":[100],"or":[101],"rural).":[102],"The":[103,147,262],"joinpoint":[104],"regression":[105],"analysis":[106],"analyse":[110],"time":[112],"average":[117,148,189],"percentage":[119,124],"change":[120,125],"(AAPC)":[121],"(APC)":[126],"each":[128],"identified":[129],"line":[131],"segment.":[132],"Results:":[133],"From":[134],"2006":[135,221,257],"2020,":[137],"361,909":[138],"were":[144],"cumulatively":[145],"reported.":[146],"reporting":[150],"rate":[151,172,207,234,264,295,316],"189.64/100,000,":[153],"after":[155],"sharp":[157],"increase":[158,249],"2006\u20132008":[160],"(APC:":[161,180],"29.99%;":[162],"95%":[163,182,196],"confidence":[164],"interval":[165],"[CI]:":[166],"12.14%":[167],"50.67%),":[169],"showed":[173,269],"long-term":[175],"downward":[176,230,271],"2008\u20132018":[179],"-7.55%;":[181],"CI:":[183,197],"-8.68%":[184],"-6.40%),":[186],"with":[187,247],"an":[188,239,248],"decrease":[191,287],"1.27%":[193],"(AAPC:":[194],"-1.27%;":[195],"-3.77%":[198],"1.28%).":[200],"Males":[201],"had":[202],"significantly":[204],"higher":[205],"than":[208],"females;":[209],"however,":[210],"gender":[212],"ratio":[213,253],"decreased":[214],"maximum":[217],"2.53":[219],"minimum":[224],"1.54":[226],"2020.":[228,261],"A":[229],"urban":[236],"areas":[237,244],"upward":[240],"rural":[243,312],"observed,":[246],"rural/urban":[252],"0.41":[255],"1.57":[259],"all":[266],"groups":[268],"year":[273,303],"year,":[275,305],"except":[276],"\u226560":[280],"years,":[281,322],"whom":[283],"it":[284,306],"started":[285],"2015.":[289],"Conclusions:":[290],"overall":[293],"decreasing":[302],"still":[308],"high.":[309],"Especially":[310],"areas,":[313],"has":[317],"increasing":[319],"recent":[321],"effective":[324],"measures":[325],"should":[326],"be":[327],"taken":[328],"infection":[333],"Guangzhou.":[335]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-06-13T00:00:00"}