{"id":"https://openalex.org/W4281903531","doi":"https://doi.org/10.1016/j.intimp.2022.108889","title":"Metformin modulate immune fitness in hepatocellular carcinoma: Molecular and cellular approach","display_name":"Metformin modulate immune fitness in hepatocellular carcinoma: Molecular and cellular approach","publication_year":2022,"publication_date":"2022-06-06","ids":{"openalex":"https://openalex.org/W4281903531","doi":"https://doi.org/10.1016/j.intimp.2022.108889","pmid":"https://pubmed.ncbi.nlm.nih.gov/35679661"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2022.108889","doi":"https://doi.org/10.1016/j.intimp.2022.108889","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2022.108889","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108137419","display_name":"Eslam E. Abd El-Fattah","orcid":"https://orcid.org/0000-0003-2611-4797","observed_orcids":["https://orcid.org/0000-0003-2611-4797"]},"institutions":[{"id":"https://openalex.org/I882248123","display_name":"Delta University for Science and Technology","ror":"https://ror.org/0481xaz04","country_code":"EG","type":"education","lineage":["https://openalex.org/I882248123"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Eslam E. Abd El-Fattah","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. Electronic address: islam.alsayed@deltauniv.edu.eg","Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. Electronic address: islam.alsayed@deltauniv.edu.eg","institution_ids":["https://openalex.org/I882248123"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt","institution_ids":["https://openalex.org/I882248123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070012805","display_name":"Amr Y. Zakaria","orcid":"https://orcid.org/0000-0002-6966-0504","observed_orcids":["https://orcid.org/0000-0002-6966-0504"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]},{"id":"https://openalex.org/I4405268078","display_name":"Horus University \u2013 Egypt","ror":"https://ror.org/05qh69251","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405268078"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amr Y. Zakaria","raw_affiliation_strings":["Clinical Pharmacy Department, Faculty of Pharmacy Beni-Suef University, Beni-Suef, Egypt; Pharmacy Practice, Department, Faculty of Pharmacy, Horus University (HUE), New Damietta, Egypt","Clinical Pharmacy Department, Faculty of Pharmacy Beni-Suef University, Beni-Suef, Egypt","Pharmacy Practice, Department, Faculty of Pharmacy, Horus University (HUE), New Damietta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Department, Faculty of Pharmacy Beni-Suef University, Beni-Suef, Egypt; Pharmacy Practice, Department, Faculty of Pharmacy, Horus University (HUE), New Damietta, Egypt","institution_ids":["https://openalex.org/I113643904","https://openalex.org/I4405268078"]},{"raw_affiliation_string":"Clinical Pharmacy Department, Faculty of Pharmacy Beni-Suef University, Beni-Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]},{"raw_affiliation_string":"Pharmacy Practice, Department, Faculty of Pharmacy, Horus University (HUE), New Damietta, Egypt","institution_ids":["https://openalex.org/I4405268078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108137419"],"corresponding_institution_ids":["https://openalex.org/I882248123"],"apc_list":{"value":2660,"currency":"USD","value_usd":2660},"apc_paid":null,"fwci":0.552,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.50087138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"109","issue":null,"first_page":"108889","last_page":"108889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immune-fitness","display_name":"immune fitness","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6159999966621399},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6499999761581421},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9179999828338623},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":1.0},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9150000214576721},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8999999761581421},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5289999842643738},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.7640169858932495},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.740352213382721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5643892288208008},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5536049604415894},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5224931836128235},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.4670143723487854},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.44622135162353516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4426974356174469},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4418950378894806},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4391739070415497},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.43876218795776367},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.42365315556526184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3755051791667938},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.22212684154510498},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15711408853530884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.intimp.2022.108889","doi":"https://doi.org/10.1016/j.intimp.2022.108889","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2022.108889","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:35679661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35679661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W1189326744","https://openalex.org/W1551688690","https://openalex.org/W1578199028","https://openalex.org/W1836878602","https://openalex.org/W1975276011","https://openalex.org/W1980638418","https://openalex.org/W2002004237","https://openalex.org/W2002300721","https://openalex.org/W2002876990","https://openalex.org/W2026982091","https://openalex.org/W2066404804","https://openalex.org/W2078490888","https://openalex.org/W2086130643","https://openalex.org/W2094156327","https://openalex.org/W2107209324","https://openalex.org/W2110342205","https://openalex.org/W2110924091","https://openalex.org/W2122656254","https://openalex.org/W2138565228","https://openalex.org/W2154774088","https://openalex.org/W2157160375","https://openalex.org/W2166678602","https://openalex.org/W2186209069","https://openalex.org/W2306717712","https://openalex.org/W2341608290","https://openalex.org/W2367392059","https://openalex.org/W2461650599","https://openalex.org/W2465997311","https://openalex.org/W2467725380","https://openalex.org/W2494764414","https://openalex.org/W2494958745","https://openalex.org/W2499029168","https://openalex.org/W2515707341","https://openalex.org/W2529646902","https://openalex.org/W2530790566","https://openalex.org/W2585139079","https://openalex.org/W2606367731","https://openalex.org/W2766222804","https://openalex.org/W2767159687","https://openalex.org/W2769460630","https://openalex.org/W2784044161","https://openalex.org/W2788271038","https://openalex.org/W2791369805","https://openalex.org/W2793286226","https://openalex.org/W2793513538","https://openalex.org/W2795636496","https://openalex.org/W2796081998","https://openalex.org/W2804480996","https://openalex.org/W2884615937","https://openalex.org/W2885288866","https://openalex.org/W2898314774","https://openalex.org/W2901981972","https://openalex.org/W2903012995","https://openalex.org/W2903708727","https://openalex.org/W2910936036","https://openalex.org/W2913397364","https://openalex.org/W2923394609","https://openalex.org/W2931391344","https://openalex.org/W2938787379","https://openalex.org/W2943218134","https://openalex.org/W2943966322","https://openalex.org/W2945645468","https://openalex.org/W2948475148","https://openalex.org/W2954541277","https://openalex.org/W2955745348","https://openalex.org/W2960078024","https://openalex.org/W2960078925","https://openalex.org/W2963299585","https://openalex.org/W2966279416","https://openalex.org/W2970088184","https://openalex.org/W2973659497","https://openalex.org/W2979448139","https://openalex.org/W2982579556","https://openalex.org/W2983881420","https://openalex.org/W2993205341","https://openalex.org/W2994719595","https://openalex.org/W2998529313","https://openalex.org/W3004157183","https://openalex.org/W3005326482","https://openalex.org/W3005689864","https://openalex.org/W3005803699","https://openalex.org/W3008550537","https://openalex.org/W3012090156","https://openalex.org/W3012638502","https://openalex.org/W3041121590","https://openalex.org/W3041426930","https://openalex.org/W3049646301","https://openalex.org/W3091791157","https://openalex.org/W3092751291","https://openalex.org/W3093367081","https://openalex.org/W3094082926","https://openalex.org/W3107356420","https://openalex.org/W3119022780","https://openalex.org/W3121884486","https://openalex.org/W3127895014","https://openalex.org/W3141447410","https://openalex.org/W3147708321","https://openalex.org/W3150108792","https://openalex.org/W3176025865","https://openalex.org/W3179197592","https://openalex.org/W3193265179","https://openalex.org/W3193402490","https://openalex.org/W3195274569","https://openalex.org/W3205215157","https://openalex.org/W3205249421","https://openalex.org/W3205349619","https://openalex.org/W3208850534","https://openalex.org/W3210813105","https://openalex.org/W3215236688","https://openalex.org/W3217482247","https://openalex.org/W4205208754","https://openalex.org/W4210499803","https://openalex.org/W4388982486","https://openalex.org/W6745977074","https://openalex.org/W6772766512"],"related_works":["https://openalex.org/W4380538119","https://openalex.org/W1901407464","https://openalex.org/W4245079765","https://openalex.org/W2910936036","https://openalex.org/W4312158520","https://openalex.org/W2102414144","https://openalex.org/W4225120249","https://openalex.org/W4388982486","https://openalex.org/W4366579932","https://openalex.org/W3026920984"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-06-13T00:00:00"}
