{"id":"https://openalex.org/W4281900986","doi":"https://doi.org/10.1093/cvr/cvac066.194","title":"Understanding the role of RIPK1 kinase activity in atherogenesis: a genetic versus pharmacological approach","display_name":"Understanding the role of RIPK1 kinase activity in atherogenesis: a genetic versus pharmacological approach","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281900986","doi":"https://doi.org/10.1093/cvr/cvac066.194"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvac066.194","doi":"https://doi.org/10.1093/cvr/cvac066.194","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvac066.194","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/118/Supplement_1/cvac066.194/44155539/cvac066.194.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cardiovascres/article-pdf/118/Supplement_1/cvac066.194/44155539/cvac066.194.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080874961","display_name":"Pauline Puylaert","orcid":"https://orcid.org/0000-0002-0316-2916","observed_orcids":["https://orcid.org/0000-0002-0316-2916"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P Puylaert","raw_affiliation_strings":["University of Antwerp , Antwerp , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Antwerp , Antwerp , Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070148989","display_name":"Isabelle Coornaert","orcid":"https://orcid.org/0000-0002-5041-8590","observed_orcids":["https://orcid.org/0000-0002-5041-8590"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"I Coornaert","raw_affiliation_strings":["University of Antwerp , Antwerp , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Antwerp , Antwerp , Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059546075","display_name":"Cedric H. G. Neutel","orcid":"https://orcid.org/0000-0001-7074-226X","observed_orcids":["https://orcid.org/0000-0001-7074-226X"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"CHG Neutel","raw_affiliation_strings":["University of Antwerp , Antwerp , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Antwerp , Antwerp , Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018449456","display_name":"Mathieu J.M. Bertrand","orcid":"https://orcid.org/0000-0001-9000-0626","observed_orcids":["https://orcid.org/0000-0001-9000-0626"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"MJM Bertrand","raw_affiliation_strings":["Ghent University , Ghent , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ghent University , Ghent , Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072677920","display_name":"Pieter\u2010Jan Guns","orcid":"https://orcid.org/0000-0002-8640-6620","observed_orcids":["https://orcid.org/0000-0002-8640-6620"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"PJ Guns","raw_affiliation_strings":["University of Antwerp , Antwerp , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Antwerp , Antwerp , Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044359598","display_name":"GRY De Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"GRY De Meyer","raw_affiliation_strings":["University of Antwerp , Antwerp , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Antwerp , Antwerp , Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076009877","display_name":"Wim Martinet","orcid":"https://orcid.org/0000-0003-1967-9343","observed_orcids":["https://orcid.org/0000-0003-1967-9343"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"W Martinet","raw_affiliation_strings":["University of Antwerp , Antwerp , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Antwerp , Antwerp , Belgium","institution_ids":["https://openalex.org/I149213910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4177,"currency":"EUR","value_usd":4401},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8889999985694885},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.7229999899864197},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.7289999723434448},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.9005558490753174},{"id":"https://openalex.org/C2776550021","wikidata":"https://www.wikidata.org/wiki/Q18033276","display_name":"RIPK1","level":5,"score":0.7853302955627441},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.660938560962677},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49681952595710754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42435675859451294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4186484217643738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41656553745269775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3678067624568939},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2869151830673218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2454373836517334},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.22489917278289795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2243923842906952},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17290708422660828},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/cvr/cvac066.194","doi":"https://doi.org/10.1093/cvr/cvac066.194","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvac066.194","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/118/Supplement_1/cvac066.194/44155539/cvac066.194.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/cvr/cvac066.194","doi":"https://doi.org/10.1093/cvr/cvac066.194","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvac066.194","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/118/Supplement_1/cvac066.194/44155539/cvac066.194.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4281900986.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225132474","https://openalex.org/W4293579142","https://openalex.org/W3132577274","https://openalex.org/W3210678628","https://openalex.org/W3106805418","https://openalex.org/W7212055483","https://openalex.org/W3117800959","https://openalex.org/W2807623955","https://openalex.org/W1966707219","https://openalex.org/W7098040491"],"abstract_inverted_index":{"Abstract":[0],"Funding":[1],"Acknowledgements":[2],"Type":[3],"of":[4,21,29,62,71,97,107,191,205,234,264,273,321,364,410],"funding":[5,9],"sources:":[6],"Foundation.":[7],"Main":[8],"source(s):":[10],"Fonds":[11],"voor":[12],"Wetenschappelijk":[13],"Onderzoek":[14],"(FWO)":[15],"Introduction":[16],"Necroptosis":[17],"is":[18,49],"a":[19,63,94,114,117,137,162,397],"form":[20],"regulated":[22],"necrosis":[23],"mediated":[24],"by":[25,37,86],"the":[26,60,69,105,189,270,407],"kinase":[27,32,42,84,109,194,323,366],"activity":[28,85,367],"receptor-interacting":[30],"serine/threonine-protein":[31],"1":[33],"(RIPK1)":[34],"and":[35,39,116,122,130,146,154,232,292,337,376,415],"executed":[36],"RIPK3":[38],"mixed":[40],"lineage":[41],"domain":[43],"like":[44],"pseudokinase":[45],"(MLKL).":[46],"Because":[47],"necroptosis":[48,148],"involved":[50],"in":[51,55,76,120,244,269,304,326,368,391,412],"necrotic":[52],"core":[53],"development":[54],"atherosclerotic":[56,203],"plaques,":[57],"we":[58,80],"investigated":[59],"effect":[61,106,190],"RIPK1":[64,72,83,108,193,322,365,411],"S25D/S25D":[65,157,208,249,276,307,371],"mutation,":[66],"which":[67],"prevents":[68],"activation":[70],"kinase,":[73],"on":[74,111,196],"atherogenesis":[75,112],"ApoE-/-":[77,90,121,123,129,131,151,155,171,206,216,247,274,305,327,369,392],"mice.":[78,308,395],"Furthermore,":[79],"pharmacologically":[81],"inhibited":[82],"administering":[87],"GSK\u2019547":[88,179,325,390,404],"to":[89,103,143,167,187,215,399],"Fbn1":[91,124,132,172,328,393],"C1039G+/-":[92,125,133,173,329,394],"mice,":[93,126],"mouse":[95],"model":[96],"advanced":[98],"atherosclerosis.":[99],"Purpose":[100],"We":[101],"aimed":[102],"study":[104],"inhibition":[110,195,320,388],"through":[113],"genetic":[115],"pharmacological":[118,192,319,387],"approach":[119],"respectively.":[127],"Methods":[128],"mice":[134,159,174,209,218,250,277,330,372],"were":[135,160,210,242,383],"fed":[136,161],"Western-type":[138],"diet":[139],"(WD)":[140],"for":[141,164,184],"up":[142],"24":[144],"weeks":[145,166,186,201,342],"plaque":[147,169,335,346,374],"was":[149,259,266,311,401],"confirmed.":[150],"Ripk1+/+":[152,217],"(n=16)":[153],"Ripk1":[156,207,248,275,306,370],"(n=12)":[158],"WD":[163,176],"16":[165,200],"induce":[168],"formation.":[170],"received":[175],"supplemented":[177],"with":[178,286,324,389],"(10":[180],"mg/kg":[181],"BW/day,":[182],"n=12-13/group)":[183],"20":[185,341],"evaluate":[188],"atherogenesis.":[197],"Results":[198],"After":[199],"WD,":[202,343],"plaques":[204,245],"significantly":[211,260,333],"larger":[212],"as":[213],"compared":[214],"(167\u00b134":[219],"vs.":[220,229,239,256,281,350,358],"69\u00b118":[221],"103":[222],"\u00b5m2,":[223],"P=0.01).":[224],"Absolute":[225],"cell":[226,413],"numbers":[227],"(350\u00b134":[228],"154\u00b133":[230],"nuclei)":[231],"deposition":[233,263],"glycosaminoglycans":[235,265],"(Alcian":[236,278],"blue:":[237,279],"31\u00b16":[238],"14\u00b14%,":[240],"P=0.023)":[241],"increased":[243,287,293],"from":[246],"while":[251],"macrophage":[252],"content":[253],"(Mac3:":[254],"2.3\u00b10.4":[255],"9.8\u00b12.4%,":[257],"P=0.012)":[258],"decreased.":[261],"Increased":[262],"also":[267],"observed":[268,385,402],"vessel":[271,294,338],"wall":[272,295],"4.3\u00b11.5":[280],"1.4\u00b10.4":[282],"%,":[283],"P=0.04).":[284],"Together":[285],"internal":[288],"elastic":[289],"lamina":[290],"area":[291],"thickness,":[296],"this":[297],"points":[298],"towards":[299],"hypertrophic":[300],"positive":[301,378],"vascular":[302,379],"remodeling":[303],"Plaque":[309],"apoptosis":[310,347,400],"not":[312,332,384],"different":[313],"between":[314],"both":[315],"groups.":[316],"In":[317],"contrast,":[318],"did":[331],"alter":[334],"size":[336],"properties":[339],"after":[340,386,403],"but":[344],"induced":[345,377],"(TUNEL:":[348],"124\u00b117":[349],"68\u00b18":[351],"cells/mm2,":[352],"P=0.018;":[353],"cleaved":[354],"caspase":[355],"3:":[356],"0.49\u00b10.13":[357],"0.14\u00b10.04":[359],"%;":[360],"p=0.021).":[361],"Conclusion":[362],"Inhibition":[363],"accelerated":[373],"progression":[375],"remodeling.":[380],"These":[381],"effects":[382],"However,":[396],"switch":[398],"treatment,":[405],"stressing":[406],"complex":[408],"involvement":[409],"survival":[414],"death.":[416]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-06-13T00:00:00"}
