{"id":"https://openalex.org/W4281900226","doi":"https://doi.org/10.1093/cid/ciac466","title":"Immunological, Cognitive, and Psychiatric Outcomes After Initiating Efavirenz- and Dolutegravir-based Antiretroviral Therapy During Acute Human Immunodeficiency Virus Infection","display_name":"Immunological, Cognitive, and Psychiatric Outcomes After Initiating Efavirenz- and Dolutegravir-based Antiretroviral Therapy During Acute Human Immunodeficiency Virus Infection","publication_year":2022,"publication_date":"2022-06-10","ids":{"openalex":"https://openalex.org/W4281900226","doi":"https://doi.org/10.1093/cid/ciac466","pmid":"https://pubmed.ncbi.nlm.nih.gov/35687498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9907536"},"language":"en","primary_location":{"id":"doi:10.1093/cid/ciac466","doi":"https://doi.org/10.1093/cid/ciac466","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cid/ciac466","pdf_url":"https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac466/44817988/ciac466.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac466/44817988/ciac466.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027993515","display_name":"Phillip Chan","orcid":"https://orcid.org/0000-0002-4071-4409","observed_orcids":["https://orcid.org/0000-0002-4071-4409"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Chan","raw_affiliation_strings":["Department of Neurology, Yale School of Medicine , New Haven, Connecticut , USA","South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand"],"raw_orcid":"https://orcid.org/0000-0002-4071-4409","affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale School of Medicine , New Haven, Connecticut , USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013294404","display_name":"Bohyung Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bohyung Yoon","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080251553","display_name":"Donn J. Colby","orcid":"https://orcid.org/0000-0003-3931-5926","observed_orcids":["https://orcid.org/0000-0003-3931-5926"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donn Colby","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068536301","display_name":"Eugene D. M. B. Kroon","orcid":"https://orcid.org/0000-0002-8235-7155","observed_orcids":["https://orcid.org/0000-0002-8235-7155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eug\u00e8ne Kroon","raw_affiliation_strings":["South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053087484","display_name":"Carlo Sacdalan","orcid":"https://orcid.org/0000-0002-5839-4837","observed_orcids":["https://orcid.org/0000-0002-5839-4837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlo Sacdalan","raw_affiliation_strings":["South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059411570","display_name":"Somchai Sriplienchan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Somchai Sriplienchan","raw_affiliation_strings":["South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052505122","display_name":"Suteeraporn Pinyakorn","orcid":"https://orcid.org/0000-0003-3880-4381","observed_orcids":["https://orcid.org/0000-0003-3880-4381"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suteeraporn Pinyakorn","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054253267","display_name":"Jintanat Ananworanich","orcid":"https://orcid.org/0000-0003-1369-3224","observed_orcids":["https://orcid.org/0000-0003-1369-3224"]},"institutions":[{"id":"https://openalex.org/I4210124406","display_name":"Amsterdam Institute for Global Health and Development","ror":"https://ror.org/037n2rm85","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210124406"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jintanat Ananworanich","raw_affiliation_strings":["Department of Global Health, Amsterdam University Medical Centers, Amsterdam Institute for Global Health and Development, University of Amsterdam , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, Amsterdam University Medical Centers, Amsterdam Institute for Global Health and Development, University of Amsterdam , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4210124406","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057274213","display_name":"Victor Valcour","orcid":"https://orcid.org/0000-0003-1981-4832","observed_orcids":["https://orcid.org/0000-0003-1981-4832"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Valcour","raw_affiliation_strings":["Department of Neurology, Memory and Aging Center, University of California\u2013San Francisco, San Francisco, California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Memory and Aging Center, University of California\u2013San Francisco, San Francisco, California , USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039272834","display_name":"Sandhya Vasan","orcid":"https://orcid.org/0000-0002-6378-6288","observed_orcids":["https://orcid.org/0000-0002-6378-6288"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandhya Vasan","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079411115","display_name":"Denise C. Hsu","orcid":"https://orcid.org/0000-0001-7530-0508","observed_orcids":["https://orcid.org/0000-0001-7530-0508"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Hsu","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"US Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052362702","display_name":"Nittaya Phanuphak","orcid":"https://orcid.org/0000-0002-0036-3165","observed_orcids":["https://orcid.org/0000-0002-0036-3165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nittaya Phanuphak","raw_affiliation_strings":["South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South East Asia Research Collaboration in HIV, Institute of HIV Research and Innovation , Bangkok , Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076777565","display_name":"Robert H. Paul","orcid":"https://orcid.org/0000-0003-4225-6103","observed_orcids":["https://orcid.org/0000-0003-4225-6103"]},"institutions":[{"id":"https://openalex.org/I208333798","display_name":"University of Missouri\u2013St. Louis","ror":"https://ror.org/037cnag11","country_code":"US","type":"education","lineage":["https://openalex.org/I208333798"]},{"id":"https://openalex.org/I4210119170","display_name":"Missouri Institute of Mental Health","ror":"https://ror.org/02gw4vz38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210119170"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Paul","raw_affiliation_strings":["Faculty of Psychological Sciences, Missouri Institute of Mental Health, University of Missouri-St. Louis , St. Louis, Missouri , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Psychological Sciences, Missouri Institute of Mental Health, University of Missouri-St. Louis , St. Louis, Missouri , USA","institution_ids":["https://openalex.org/I208333798","https://openalex.org/I4210119170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083290723","display_name":"Serena Spudich","orcid":"https://orcid.org/0000-0001-6032-3950","observed_orcids":["https://orcid.org/0000-0001-6032-3950"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Serena Spudich","raw_affiliation_strings":["Department of Neurology, Yale School of Medicine , New Haven, Connecticut , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale School of Medicine , New Haven, Connecticut , USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5083290723"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":4320,"currency":"USD","value_usd":4320},"apc_paid":{"value":4320,"currency":"USD","value_usd":4320},"fwci":1.2203,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79951038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"76","issue":"3","first_page":"e718","last_page":"e726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-hiv-1-infection","display_name":"acute HIV-1 infection","score":0.9700000286102295},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":1.0},{"id":"https://openalex.org/keywords/maraviroc","display_name":"maraviroc","score":0.9449999928474426},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cd8-t-cell-count","display_name":"CD8+ T-cell count","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neuropsychological-performance","display_name":"neuropsychological performance","score":0.7059999704360962},{"id":"https://openalex.org/keywords/depressed-mood","display_name":"depressive mood","score":0.6299999952316284},{"id":"https://openalex.org/keywords/mental-health-outcomes","display_name":"mental health outcomes","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8858786821365356},{"id":"https://openalex.org/C2779502633","wikidata":"https://www.wikidata.org/wiki/Q937224","display_name":"Dolutegravir","level":5,"score":0.8358019590377808},{"id":"https://openalex.org/C2781432083","wikidata":"https://www.wikidata.org/wiki/Q422645","display_name":"Efavirenz","level":5,"score":0.8139714002609253},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6762681603431702},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.586646556854248},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5122498869895935},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.41907021403312683},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39854657649993896},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32492595911026},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.1939464509487152}],"mesh":[{"descriptor_ui":"D000099226","descriptor_name":"Dolutegravir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006575","descriptor_name":"Heterocyclic Compounds, 3-Ring","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D048588","descriptor_name":"Benzoxazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/cid/ciac466","doi":"https://doi.org/10.1093/cid/ciac466","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cid/ciac466","pdf_url":"https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac466/44817988/ciac466.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9907536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9907536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Infect Dis","raw_type":"Text"},{"id":"pmid:35687498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35687498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/c4b90047-07ec-4d7c-929f-2f57cd86631a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/c4b90047-07ec-4d7c-929f-2f57cd86631a","pdf_url":"https://pure.amsterdamumc.nl/files/139455447/Immunological-cognitive-and-psychiatric-outcomes-after-initiating-efavirenz--and-dolutegravir-based-antiretroviral-the.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chan, P, Yoon, B, Colby, D, Kroon, E, Sacdalan, C, Sriplienchan, S, Pinyakorn, S, Ananworanich, J, Valcour, V, Vasan, S, Hsu, D, Phanuphak, N, Paul, R & Spudich, S 2023, 'Immunological, Cognitive, and Psychiatric Outcomes After Initiating Efavirenz- and Dolutegravir-based Antiretroviral Therapy During Acute Human Immunodeficiency Virus Infection', Clinical infectious diseases, vol. 76, no. 3, pp. e718-e726. https://doi.org/10.1093/cid/ciac466, https://doi.org/10.1093/cid/ciac466","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/c9a74e37-7d62-4251-875d-c11e1544ae2c","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/immunological-cognitive-and-psychiatric-outcomes-after-initiating-efavirenz-and-dolutegravirbased-antiretroviral-therapy-during-acute-human-immunodeficiency-virus-infection(c9a74e37-7d62-4251-875d-c11e1544ae2c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical infectious diseases, 76(3), e718 - e726. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/cid/ciac466","doi":"https://doi.org/10.1093/cid/ciac466","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cid/ciac466","pdf_url":"https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac466/44817988/ciac466.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1126939517","display_name":"Therapeutic Interventions during Acute Infection to Address the CNS Reservoir for","funder_award_id":"R01NS084911","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1939473322","display_name":"Critical Role of Cytotoxic T Cells in HIV Neuropathogenesis","funder_award_id":"R01MH106466","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G357772367","display_name":"Impact of Treatment on Brain Integrity in the Earliest Stages of HIV Infection","funder_award_id":"R01MH113560","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281900226.pdf","grobid_xml":"https://content.openalex.org/works/W4281900226.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1577268719","https://openalex.org/W1979036222","https://openalex.org/W1996214734","https://openalex.org/W1998353416","https://openalex.org/W2001765285","https://openalex.org/W2003991954","https://openalex.org/W2008008244","https://openalex.org/W2010298035","https://openalex.org/W2048759154","https://openalex.org/W2094241860","https://openalex.org/W2126141460","https://openalex.org/W2132322340","https://openalex.org/W2144361427","https://openalex.org/W2252811454","https://openalex.org/W2293382714","https://openalex.org/W2323381689","https://openalex.org/W2416732024","https://openalex.org/W2562322368","https://openalex.org/W2595070481","https://openalex.org/W2608989554","https://openalex.org/W2770710270","https://openalex.org/W2794679562","https://openalex.org/W2889612530","https://openalex.org/W2901906814","https://openalex.org/W2909444233","https://openalex.org/W2936364142","https://openalex.org/W2960398343","https://openalex.org/W2968277691","https://openalex.org/W2971369227","https://openalex.org/W2994756038","https://openalex.org/W3001389296","https://openalex.org/W3047617082","https://openalex.org/W3049666276","https://openalex.org/W3092115006","https://openalex.org/W3093018885","https://openalex.org/W3112784825","https://openalex.org/W3133680411","https://openalex.org/W3154343697"],"related_works":["https://openalex.org/W3001389296","https://openalex.org/W4402503741","https://openalex.org/W4367059151","https://openalex.org/W4379793405","https://openalex.org/W7162529484","https://openalex.org/W4324021016","https://openalex.org/W4313890888","https://openalex.org/W7116969230","https://openalex.org/W7122708331","https://openalex.org/W2951224640"],"abstract_inverted_index":{"BACKGROUND:":[0],"Efavirenz":[1],"(EFV)-":[2],"and":[3,12,31,83,90,96,119,133,156,198,207,252,256],"dolutegravir":[4],"(DTG)-based":[5],"antiretroviral":[6],"therapy":[7],"(ART)":[8],"is":[9],"the":[10,29,110,138,142,145,178,187,203,213,220,228,232],"former":[11],"current":[13],"recommended":[14],"regimen":[15],"for":[16,86,219,227],"treatment-naive":[17],"individuals":[18,237],"with":[19,70,141,238,247],"human":[20],"immunodeficiency":[21],"virus":[22],"type":[23],"1":[24,52],"(HIV-1).":[25],"Whether":[26],"they":[27],"impact":[28],"immunological":[30],"neuropsychiatric":[32],"profile":[33],"differentially":[34],"remains":[35],"unclear.":[36],"METHODS:":[37],"This":[38],"retrospective":[39],"analysis":[40],"included":[41,78],"258":[42],"participants":[43],"enrolled":[44,122],"during":[45,57,123],"acute":[46],"HIV-1":[47],"infection":[48],"(AHI).":[49],"Participants":[50],"initiated":[51],"of":[53,151,167,242,250],"3":[54],"ART":[55,244],"regimens":[56,77],"AHI:":[58],"EFV-based":[59],"(n":[60,64],"=":[61,65,74,159,194],"131),":[62],"DTG-based":[63,243],"92),":[66],"or":[67],"DTG":[68,146,188,229],"intensified":[69],"maraviroc":[71],"(DTG/MVC,":[72],"n":[73],"35).":[75],"All":[76],"2":[79,179,214],"nucleoside":[80],"reverse-transcriptase":[81],"inhibitors":[82],"were":[84,105,117,121,210,223],"maintained":[85],"96":[87,134,192,240],"weeks.":[88],"CD4+":[89,152,251],"CD8+":[91,157,253],"T-cell":[92,161,254],"counts,":[93],"mood":[94,197],"symptoms,":[95],"composite":[97],"score":[98],"on":[99,202],"a":[100,164],"4-test":[101],"neuropsychological":[102],"battery":[103],"(NPZ-4)":[104],"compared.":[106],"RESULTS:":[107],"At":[108],"baseline,":[109],"median":[111],"age":[112],"was":[113,135,175,245],"26":[114],"years,":[115],"99%":[116],"male,":[118],"36%":[120],"Fiebig":[124],"stage":[125],"I-II.":[126],"Plasma":[127],"viral":[128],"suppression":[129],"at":[130,170,181,190,216],"weeks":[131,241],"24":[132,183],"similar":[136,165,176,211],"between":[137,177,212],"groups.":[139],"Compared":[140],"EFV":[143,233],"group,":[144],"group":[147,189,222,230],"showed":[148],"greater":[149,185,248],"increments":[150,249],"(P":[153,158,193],"<":[154],".001)":[155],".015)":[160],"counts":[162,255],"but":[163,184],"increment":[166],"CD4/CD8":[168],"ratio":[169],"week":[171,182,191],"96.":[172],"NPZ-4":[173],"improvement":[174,257],"groups":[180,215],"in":[186,258],".005).":[195],"Depressive":[196],"distress":[199,208],"symptoms":[200],"based":[201],"Patient":[204],"Health":[205],"Questionnaire":[206],"thermometer":[209],"follow-up.":[217],"Findings":[218],"DTG/MVC":[221],"comparable":[224],"to":[225],"those":[226],"vs":[231],"group.":[234],"CONCLUSIONS:":[235],"Among":[236],"AHI,":[239],"associated":[246],"cognitive":[259],"performance.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-06-13T00:00:00"}