{"id":"https://openalex.org/W4281856889","doi":"https://doi.org/10.3390/cells11111852","title":"High Expression of a Cancer Stemness-Related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated with Poor Prognosis of Colorectal Cancer Patients","display_name":"High Expression of a Cancer Stemness-Related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated with Poor Prognosis of Colorectal Cancer Patients","publication_year":2022,"publication_date":"2022-06-06","ids":{"openalex":"https://openalex.org/W4281856889","doi":"https://doi.org/10.3390/cells11111852","pmid":"https://pubmed.ncbi.nlm.nih.gov/35681547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9180723"},"language":"en","primary_location":{"id":"doi:10.3390/cells11111852","doi":"https://doi.org/10.3390/cells11111852","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11111852","pdf_url":"https://www.mdpi.com/2073-4409/11/11/1852/pdf?version=1654510967","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/11/11/1852/pdf?version=1654510967","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089434925","display_name":"Lui Ng","orcid":"https://orcid.org/0000-0002-9010-2654","observed_orcids":["https://orcid.org/0000-0002-9010-2654"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Lui Ng","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":"https://orcid.org/0000-0002-9010-2654","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055999245","display_name":"Hung-Sing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hung-Sing Li","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027871519","display_name":"Abraham Tak-Ka Man","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Abraham Tak-Ka Man","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079566680","display_name":"Ariel Ka-Man Chow","orcid":"https://orcid.org/0000-0002-5729-5415","observed_orcids":["https://orcid.org/0000-0002-5729-5415"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ariel Ka-Man Chow","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":"https://orcid.org/0000-0002-5729-5415","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004946941","display_name":"Chi Chung Foo","orcid":"https://orcid.org/0000-0001-8849-6597","observed_orcids":["https://orcid.org/0000-0001-8849-6597"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Dominic Chi-Chung Foo","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":"https://orcid.org/0000-0001-8849-6597","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066481749","display_name":"Oswens Siu\u2010Hung Lo","orcid":"https://orcid.org/0000-0002-3829-2585","observed_orcids":["https://orcid.org/0000-0002-3829-2585"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Oswens Siu-Hung Lo","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111624702","display_name":"Roberta W. C. Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Roberta Wen-Chi Pang","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112043955","display_name":"Wai\u2010Lun Law","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Wai-Lun Law","raw_affiliation_strings":["Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089434925","https://openalex.org/A5112043955"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":0.3457,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.54294811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"11","first_page":"1852","last_page":"1852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.054999999701976776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cbx8","display_name":"CBX8","score":0.9599999785423279},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.968999981880188},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7260000109672546},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.699999988079071},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":0.7250000238418579},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pluripotency-genes","display_name":"pluripotency genes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6060000061988831},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6460254788398743},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5912547707557678},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5386286973953247},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5122131705284119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4324926435947418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41536518931388855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38492459058761597},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3669283986091614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2824746370315552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08317774534225464}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014574","descriptor_name":"Uronic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells11111852","doi":"https://doi.org/10.3390/cells11111852","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11111852","pdf_url":"https://www.mdpi.com/2073-4409/11/11/1852/pdf?version=1654510967","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9180723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9180723","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:35681547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35681547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bf052c53ee8a456884c62ebfff838b0e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bf052c53ee8a456884c62ebfff838b0e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 11, Iss 11, p 1852 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells11111852","doi":"https://doi.org/10.3390/cells11111852","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells11111852","pdf_url":"https://www.mdpi.com/2073-4409/11/11/1852/pdf?version=1654510967","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335055","display_name":"Health and Medical Research Fund","ror":"https://ror.org/03qh32912"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281856889.pdf","grobid_xml":"https://content.openalex.org/works/W4281856889.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1495534537","https://openalex.org/W1878684234","https://openalex.org/W1907953875","https://openalex.org/W1965254413","https://openalex.org/W1991949008","https://openalex.org/W2007987084","https://openalex.org/W2031882924","https://openalex.org/W2034172398","https://openalex.org/W2041440766","https://openalex.org/W2044695669","https://openalex.org/W2044702943","https://openalex.org/W2058983327","https://openalex.org/W2061460086","https://openalex.org/W2085117308","https://openalex.org/W2112657305","https://openalex.org/W2156555688","https://openalex.org/W2294512444","https://openalex.org/W2324128945","https://openalex.org/W2473696976","https://openalex.org/W2560367415","https://openalex.org/W2605074776","https://openalex.org/W2608958493","https://openalex.org/W2738595852","https://openalex.org/W2766676715","https://openalex.org/W2778787212","https://openalex.org/W2792145055","https://openalex.org/W2795073885","https://openalex.org/W2807432296","https://openalex.org/W2885155365","https://openalex.org/W2892292330","https://openalex.org/W2899175704","https://openalex.org/W2908270033","https://openalex.org/W2913457092","https://openalex.org/W2943966410","https://openalex.org/W2989867137","https://openalex.org/W2995878733","https://openalex.org/W2997565704","https://openalex.org/W3011525264","https://openalex.org/W3027741674","https://openalex.org/W3083692296","https://openalex.org/W3084574220","https://openalex.org/W3088555532","https://openalex.org/W3090072998","https://openalex.org/W3109656868","https://openalex.org/W3146577202","https://openalex.org/W3176203625","https://openalex.org/W3184645349","https://openalex.org/W3195525061","https://openalex.org/W3198705935","https://openalex.org/W3202918508","https://openalex.org/W3208036405","https://openalex.org/W3214724102","https://openalex.org/W3217082735","https://openalex.org/W4298025629","https://openalex.org/W4301159569","https://openalex.org/W6755986453"],"related_works":["https://openalex.org/W3081576045","https://openalex.org/W3200884800","https://openalex.org/W4392964470","https://openalex.org/W3004249686","https://openalex.org/W2893147530","https://openalex.org/W1878684234","https://openalex.org/W3083692296","https://openalex.org/W2899175704","https://openalex.org/W4285018060","https://openalex.org/W4306839875"],"abstract_inverted_index":{"Background:":[0],"Several":[1],"studies":[2],"have":[3],"demonstrated":[4],"that":[5,199],"the":[6,14,29,93,112],"molecular":[7],"profile":[8],"of":[9,32,45,54,157,207],"normal":[10],"tissue":[11,44],"adjacent":[12],"to":[13,186],"tumor":[15,41,125,137,226],"(NAT)":[16],"is":[17,220],"prognostic":[18,223],"for":[19,225],"recurrence":[20],"in":[21,40,56,73,162,230],"patients":[22,64,80],"with":[23,92,122,136,166,192,204,213],"different":[24],"cancers.":[25],"This":[26],"study":[27],"investigated":[28],"clinical":[30],"significance":[31],"CBX8":[33,55,70,85,105,117,147,158,177,200,219],"gene":[34,52,86,118,159,178],"expression,":[35],"a":[36,154,205,221],"cancer":[37,47,214],"stemness-related":[38],"gene,":[39],"and":[42,59,75,87,97,106,130,139,150,160,169,180,184,228],"NAT":[43,60,76,116,146,163,218],"colorectal":[46],"(CRC)":[48],"patients.":[49,232],"Methods:":[50],"The":[51,102],"level":[53,72,119,149,156,179,201],"paired":[57],"CRC":[58,74,231],"specimens":[61,77],"from":[62,78],"95":[63],"was":[65,81,109,142,172,202],"determined":[66,82],"by":[67,83],"quantitative":[68],"PCR.":[69],"protein":[71,88,148,161],"66":[79],"immunohistochemistry.":[84],"levels":[89],"were":[90],"correlated":[91,121,165,203],"patients\u2019":[94],"clinicopathological":[95,151],"parameters":[96],"circulatory":[98],"immune":[99],"cell":[100],"profiles.":[101],"association":[103,135,191,212],"between":[104,145,176],"pluripotency-associated":[107,208],"genes":[108],"analyzed":[110],"using":[111],"TCGA":[113,196],"database.":[114],"Results:":[115],"positively":[120],"TNM":[123],"stage,":[124],"invasion,":[126],"lymph":[127],"node":[128],"metastasis":[129],"distant":[131],"metastasis,":[132],"indicating":[133],"its":[134,190,211],"progression":[138,227],"metastasis.":[140],"There":[141,171],"no":[143],"correlation":[144,175],"parameters.":[152],"Moreover,":[153],"high":[155],"both":[164],"poor":[167,222],"DFS":[168],"OS.":[170],"an":[173],"inverse":[174],"post-operative":[181],"platelet":[182,185],"counts":[183],"lymphocyte":[187],"level,":[188],"suggesting":[189],"systematic":[193],"inflammation.":[194],"Finally,":[195],"analysis":[197],"showed":[198],"couple":[206],"genes,":[209],"supporting":[210],"stemness.":[215],"Conclusions:":[216],"High":[217],"factor":[224],"survival":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-06-13T00:00:00"}