{"id":"https://openalex.org/W4281850404","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e15031","title":"Analysis of MET genetic aberrations in Chinese solid tumor patients.","display_name":"Analysis of MET genetic aberrations in Chinese solid tumor patients.","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4281850404","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e15031"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2022.40.16_suppl.e15031","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e15031","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.e15031","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101938045","display_name":"Guanglong Huang","orcid":"https://orcid.org/0000-0002-1589-9202","observed_orcids":["https://orcid.org/0000-0002-1589-9202"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanglong Huang","raw_affiliation_strings":["Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China;","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071355181","display_name":"Zhengying Bian","orcid":"https://orcid.org/0009-0003-4478-0141","observed_orcids":["https://orcid.org/0009-0003-4478-0141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengying Bian","raw_affiliation_strings":["Jiangsu Simcere Diagnostics Co., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Simcere Diagnostics Co., Nanjing, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101738425","display_name":"Juan Ma","orcid":"https://orcid.org/0000-0001-6121-2486","observed_orcids":["https://orcid.org/0000-0001-6121-2486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Ma","raw_affiliation_strings":["Jiangsu Simcere Diagnostics Co., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Simcere Diagnostics Co., Nanjing, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460981","display_name":"Siqi Chen","orcid":"https://orcid.org/0000-0002-9498-3823","observed_orcids":["https://orcid.org/0000-0002-9498-3823","https://orcid.org/0009-0002-2779-8326","https://orcid.org/0009-0002-6239-9240","https://orcid.org/0009-0003-5956-3123","https://orcid.org/0009-0008-6124-286X","https://orcid.org/0009-0009-0829-1897"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Chen","raw_affiliation_strings":["Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110473358","display_name":"Guanghua Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanghua Lu","raw_affiliation_strings":["Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022496548","display_name":"Ran Ding","orcid":"https://orcid.org/0000-0001-6870-5646","observed_orcids":["https://orcid.org/0000-0001-6870-5646"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Ding","raw_affiliation_strings":["Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089674189","display_name":"Fanfeng Bu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanfeng Bu","raw_affiliation_strings":["Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China;","institution_ids":["https://openalex.org/I4210096870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"16_suppl","first_page":"e15031","last_page":"e15031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.2957000136375427,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.12210000306367874,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/met-amplification","display_name":"MET amplification","score":0.8410000205039978},{"id":"https://openalex.org/keywords/met-exon-14-skipping","display_name":"MET exon 14 skipping","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6690000295639038},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/splice-site-variant","display_name":"splice site mutation","score":0.5059999823570251},{"id":"https://openalex.org/keywords/oncogenic-mutations","display_name":"oncogenic mutations","score":0.5870000123977661},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.7509999871253967},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.4440000057220459},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.6050000190734863},{"id":"https://openalex.org/keywords/targeted-therapy-biomarkers","display_name":"targeted therapy biomarkers","score":0.4699999988079071},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.6190000176429749},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8610000014305115},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6686461567878723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5966693162918091},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5837820768356323},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5658001899719238},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5449998378753662},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5420166254043579},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5135335922241211},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5083217024803162},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.48740866780281067},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.4766429364681244},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4488808512687683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3900219798088074},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33618080615997314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32305487990379333},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.28641360998153687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25963109731674194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1714910864830017},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2022.40.16_suppl.e15031","doi":"https://doi.org/10.1200/jco.2022.40.16_suppl.e15031","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2022.40.16_suppl.e15031","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4281775810","https://openalex.org/W6964625975","https://openalex.org/W2891969324","https://openalex.org/W2892264042","https://openalex.org/W3204304188","https://openalex.org/W3093170656","https://openalex.org/W3202132411","https://openalex.org/W4309524159","https://openalex.org/W2981636516","https://openalex.org/W3029823049"],"abstract_inverted_index":{"e15031":[0],"Background:":[1],"Mesenchymal-epithelial":[2],"transition":[3],"(MET)":[4],"gene":[5,22,97,115,128,145,321],"encodes":[6],"a":[7,19],"member":[8],"of":[9,15,60,83,104,126,217,337,349,378],"the":[10,58,105,224,253,271,376],"receptor":[11],"tyrosine":[12],"kinase":[13],"family":[14],"proteins":[16],"and":[17,33,41,56,140,175,200,237,245,256,281,313,323,362],"is":[18],"proto-oncogene.":[20],"MET":[21,48,61,72,114,127,144,168,180,185,205,241,293,309,314,320,338,344,358,363,390],"takes":[23],"part":[24],"in":[25,51,64,74,79,99,172,191,211,292,334,346,352,366,384],"various":[26],"signaling":[27,380],"pathways":[28],"such":[29],"as":[30],"PI3K/AKT,":[31],"Ras/MAPK,":[32],"JAK/STAT":[34],"which":[35,218,386],"are":[36],"associated":[37],"with":[38,113,120],"tumor":[39,54,77,100,214],"development":[40],"progression.":[42],"This":[43,68],"study":[44,69],"aimed":[45],"to":[46,95,252],"reveal":[47],"aberrated":[49],"characteristics":[50],"Chinese":[52],"solid":[53,65,76,121,213,350,367],"patients":[55,78,112,119,177,215,220,307,318],"explore":[57],"occurrence":[59],"oncogenic":[62],"variants":[63,146],"tumors.":[66],"Methods:":[67],"retrospectively":[70],"analyzed":[71,240],"alterations":[73,116,129,244,261,345],"1856":[75,111],"China":[80],"from":[81,117,389],"laboratory":[82],"Simcere":[84],"Diagnosis":[85],"(Nanjing,":[86],"China)":[87],"during":[88],"2019-2021.":[89],"Next-generation":[90],"sequencing":[91],"(NGS)":[92],"was":[93,130,170,187,209,382],"performed":[94],"detect":[96],"mutations":[98],"or":[101,290,296],"blood":[102],"samples":[103],"patients.":[106],"Results:":[107],"We":[108,239,342,355],"screened":[109],"out":[110],"45717":[118],"tumor.":[122],"The":[123,258,330],"high":[124],"frequency":[125],"lung":[131,192,222,305,326,371],"cancer":[132,135,138,142,193,197,202,236,306,327],"(72.8%),":[133],"colorectal":[134,229],"(10.7%),":[136],"gastric":[137,196,231],"(4.9%),":[139],"liver":[141,201,227],"(2.7%).":[143],"included":[147,288],"missense":[148],"(61.7%),":[149],"copy":[150],"number":[151],"variation":[152],"(copy":[153,182],"number\u22655)":[154],"(15.4%),":[155],"truncation":[156],"(7.9%),":[157],"splicing":[158],"site":[159,278],"variant":[160],"(7.2%),fusion":[161],"(1.7%),and":[162],"in-frame":[163],"insertion/deletions":[164],"(0.9%).":[165],"Among":[166],"them,":[167],"amplification":[169,181,186,315,365],"detected":[171,190,210],"285":[173],"patients,":[174],"93":[176],"carried":[178,308,319],"high-level":[179,364],"number\u226510).":[183],"High-level":[184],"most":[188,259],"frequently":[189],"(41,":[194],"44.1%),":[195],"(17,":[198],"18.3%)":[199],"(14,":[203],"15.1%).":[204],"exon":[206,242,310,335,359],"14":[207,243,311,360],"skipping":[208,312,361],"287":[212],"(15.5%),":[216],"277":[219],"were":[221,226,262,325],"cancer,":[223,228,230,232],"remaining":[225],"osteosarcoma,":[233],"melanoma,":[234],"bladder":[235],"glioma.":[238],"classified":[246],"them":[247],"into":[248],"4":[249],"subgroups":[250],"according":[251],"alteration":[254],"types":[255,283,287,348],"locations.":[257],"common":[260],"at":[263],"splice":[264,272],"donor":[265],"sites":[266,274],"(215,":[267],"74.91%),":[268],"followed":[269],"by":[270],"acceptor":[273],"(35,":[275],"12.20%),":[276],"Y1003":[277],"(5,":[279],"1.74%),":[280],"other":[282],"(32,":[284],"11.15%).":[285],"Other":[286],"insertion":[289],"deletion":[291],"intron":[294],"13":[295],"14,":[297],"for":[298,370],"example,":[299],"c.3028+21_3028+65del,":[300],"c.2888-20_2888-11del,":[301],"c.2888-27_2888-9del,":[302],"etc.":[303],"7":[304],"simultaneously.":[316],"36":[317],"fusions,":[322],"mostly":[324],"(22,":[328],"61.1%).":[329],"breakpoints":[331],"often":[332],"located":[333],"2":[336],"(4,":[339],"11.1%).":[340],"Conclusions:":[341],"discovered":[343],"multiple":[347],"tumors":[351,368],"this":[353],"study.":[354],"found":[356],"classic":[357],"except":[369],"cancer.":[372],"It":[373],"suggested":[374],"that":[375],"activation":[377],"MET-driven":[379],"pathway":[381],"ubiquitous":[383],"pan-cancer,":[385],"might":[387],"benefit":[388],"inhibitors.":[391]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-06-13T00:00:00"}
